Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340
Open accessAbstract
BACKGROUND: Dexmedetomidine (Dex) was reported to exhibit anti-inflammatory effect in the nervous system. However, the mechanism by which Dex exhibits anti-inflammation effects on LPS-stimulated BV2 microglia cells remains unclear. Thus, this study aimed to investigate the role of Dex in LPS-stimulated BV2 cells. METHODS: The BV2 cells were stimulated by lipopolysaccharides (LPS). BV2 cells were infected with short-hairpin RNAs targeting NF-κB (NF-κB-shRNAs) and NF-κB overexpression lentivirus, respectively. In addition, miR-340 mimics or miR-340 inhibitor was transfected into BV2 cells, respectively. Meanwhile, the dual-luciferase reporter system assay was used to explore the interaction of miR-340 and NF-κB in BV2 cells. CCK-8 was used to detect the viability of BV2 cells. In addition, Western blotting was used to detect the level of NF-κB in LPS-stimulated BV2 cells. The levels of TNF-α, IL-6, IL-1β, IL-2, IL-12, IL-10 and MCP-1 in LPS-stimulated BV2 cells were measured with ELISA. RESULTS: The level of miR-340 was significantly upregulated in Dex-treated BV2 cells. Meanwhile, the level of NF-κB was significantly increased in BV2 cells following infection with lenti-NF-κB, which was markedly reversed by Dex. LPS markedly increased the expression of NF-κB and proinflammatory cytokines in BV2 cells, which were reversed in the presence of Dex. Moreover, miR-340 mimics enhanced the anti-inflammatory effects of Dex in LPS-stimulated BV2 cells via inhibiting NF-κB and proinflammatory cytokines. Furthermore, Dex obviously inhibited LPS-induced phagocytosis in BV2 cells. CONCLUSION: Taken together, our results suggested that Dex might exert anti-inflammatory effects in LPS-stimulated BV2 cells via upregulation of miR-340. Therefore, Dex might serve as a potential agent for the treatment of neuroinflammation.
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Dexmedetomidine's anti-inflammatory effect is mediated by miR-340, which targets NF-κB, suppresses pro-inflammatory cytokines, induces IL-10, and decreases phagocytosis.
“Using a BV2 cell line, it was demonstrated that its anti-inflammatory effect is mediated by miR-340, which targets NF-κB, and thus suppresses pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IL-2 and IL-12), inducing anti-inflammatory IL-10, and decreasing phagocytosis [241].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [241]
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- Authors
- Bao, Y., Zhu, Y., He, G., Ni, H., Liu, C., Ma, L., Zhang, L., & Shi, D.
- Affiliations
- Jiading District Central Hospital (CN)
- Corresponding author
- Shi, Dongping
- Venue
- Drug Design, Development and Therapy
- Publisher
- Informa UK Limited
- Published
- 2019-10
- Volume
- Volume 13
- Pages
- 3465-3475
- ISSN
- 1177-8881 (ISSN-L)
- PMC
- PMC6781164
- OpenAlex
- W2978104355
- Cited by
- 84
- References
- 49
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 12 · 2022: 24 · 2021: 11 · 2020: 5
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Drug Design Development and Therapy (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- dexmedetomidine, neuroinflammation, microglia, BV-2 cells, lipopolysaccharide, miR-340, NF-κB, inflammatory cytokines, anti-inflammatory activity, phagocytosis, microRNA
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Survival, Cells, Cultured, Inflammation, Lipopolysaccharides, Up-Regulation, Cytokines, NF-kappa B, Microglia, Dexmedetomidine, MicroRNAs, Mice
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