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Cited by 24Antibiotic Resistance in BacteriaSalmonella and Campylobacter epidemiologyAntibiotic Use and Resistance

Antimicrobial Resistance Profiles of Diarrheagenic E. coli (DEC) and Salmonella Species Recovered from Diarrheal Patients in Selected Rural Communities of the Amathole District Municipality, Eastern Cape Province, South Africa

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Msolo, Luyanda, Iweriebor, Benson C, Okoh, Anthony I·2020·Infection and Drug Resistance
DOI 10.2147/idr.s269219PMC PMC7764871
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Abstract

Purpose: The emergence of multidrug-resistant bacteria remains as one of the major impediments towards the prevention and treatment of microbial infections and continues to be a serious threat to medicine. Henceforth, this study aimed at elucidating the antimicrobial resistance profiles of diarrheagenic E. coli (DEC) and Salmonella species recovered from diarrheal patients in selected rural communities of the Amathole District Municipality (ADM), Eastern Cape Province, South Africa (SA). Methods: The antimicrobial resistance profiles of diarrheagenic E. coli (DEC) and Salmonella isolates were evaluated using antimicrobial susceptibility tests and the relevant antimicrobial resistance factors were elucidated by the Polymerase Chain Reaction technique. Results: A sum of 324 diarrheagenic E. coli (DEC) and 62 Salmonella isolates were recovered from diarrheal stool specimens collected amongst diarrheal patients admitted in medical facilities/health-care centers within the ADM in the Eastern Cape Province, South Africa. Multiple antimicrobial resistance index mean values of 0.7 and 0.5 for DEC and Salmonella isolates, respectively, were observed in this study, indicating that these isolates were from sources where antimicrobials were frequently used. The antimicrobial resistance factors ampC, blaTEM, Sul I and II, tet A and aad A were detected among antimicrobial-resistant DEC pathotypes and Salmonella isolates recovered in this study. Conclusion: The occurrence of the multiple antimicrobial-resistant DEC and Salmonella isolates with the relevant antimicrobial resistance factors in this study suggests a portentous human health threat associated with diarrhea and a major deterrent in medicine. Keywords: diarrheagenic E. coli , Salmonella , antimicrobials, resistance

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Cited by

Sorted by citations

Authors
Msolo, L., Iweriebor, B. C., & Okoh, A. I.
Affiliations
  • University of Fort Hare (ZA)
  • Sefako Makgatho Health Sciences University (ZA)
Corresponding author
Msolo, Luyanda
ORCID
Venue
Infection and Drug Resistance
Publisher
Informa UK Limited
Published
2020-12
Volume
Volume 13
Pages
4615-4626
ISSN
1178-6973 (ISSN-L)
DOI
10.2147/idr.s269219
PMC
PMC7764871
OpenAlex
W3116481423
Cited by
24
References
1
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 2 · 2021: 1
FWCI
1.09
Type
journal article
Language
en
Open access
Licence
Locations
  • Infection and Drug Resistance (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Research Foundation
  • South African Medical Research Council
  • University of Fort Hare
  • Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords
antimicrobial resistance, diarrheagenic Escherichia coli, Salmonella, multidrug resistance, diarrheal disease, rural communities, Amathole District Municipality, antimicrobial resistance genes, AmpC beta-lactamase, blaTEM, sul genes, tetA, aadA, antimicrobial susceptibility

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