The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs
Open accessAbstract
The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.
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Cites
Modeling and comparison of dissolution profiles
Costa, P., & Sousa Lobo, J. M. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00095-1 · Cited by 5,509
Cited by
Unnithan, A. R., Barakat, N. A. M., Tirupathi Pichiah, P. B., Gnanasekaran, G., Nirmala, R., Cha, Y.-S., Jung, C.-H., El-Newehy, M., & Kim, H. Y. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.07.071 · Cited by 466
Recent Advances in Electrospun Nanofibers for Wound Healing
Chen, S., Liu, B., Carlson, M. A., Gombart, A. F., Reilly, D. A., & Xie, J. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0017 · Cited by 409
Fahimirad, S., Abtahi, H., Satei, P., Ghaznavi-Rad, E., Moslehi, M., & Ganji, A. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117640 · Cited by 339
Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
Bhattarai, R. S., Bachu, R. D., Boddu, S. H. S., & Bhaduri, S. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics11010005 · Cited by 322
Mechanical Properties of Electrospun Fibers—A Critical Review
Rashid, T. U., Gorga, R. E., & Krause, W. E. (2021) · Advanced Engineering Materials · doi:10.1002/adem.202100153 · Cited by 268
Metadata
- Authors
- Varshosaz, J., Jannesari, M., Morshed, M., & Zamani, M.
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2011-05
- Volume
- 6
- Pages
- 993
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W2046564987
- Cited by
- 392
- References
- 1
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
