The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles
Abstract
In this study, the electrospun poly(ε-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber was fabricated successfully with curcumin loaded chitosan nano-encapsulated particles (CURCSNPs). The morphology of the produced CURCSNPs, PCL, PCL/CS, PCL/CS/CUR, and PCL/CS/CUR electrosprayed with CURCSNPs were analyzed by scanning electron microscopy (SEM). The physicochemical properties and biological characteristics of fabricated nanofibers such as antibacterial, antioxidant, cell viability, and in vivo wound healing efficiency and histological assay were tested. The electrospraying of CURCSNPs on surface PCL/CS/CUR nanofiber resulted in the enhanced antibacterial, antioxidant, cell proliferation efficiencies and higher swelling and water vapor transition rates. In vivo examination and Histological analysis showed PCL/CS/CUR electrosprayed with CURCSNPs led to significant improvement of complete well-organized wound healing process in MRSA infected wounds. These results suggest that the application of PCL/CS/CUR electrosprayed with CURCSNPs as a wound dressing significantly facilitates wound healing with notable antibacterial, antioxidant, and cell proliferation properties.
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Cites
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Chitosan as a starting material for wound healing applications
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Current strategies for sustaining drug release from electrospun nanofibers
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Cited by
Electrospun Medicated Nanofibers for Wound Healing: Review
Liu, X., Xu, H., Zhang, M., & Yu, D.-G. (2021) · Membranes · doi:10.3390/membranes11100770 · Cited by 311
Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches
Cavallo, I., Sivori, F., Mastrofrancesco, A., Abril, E., Pontone, M., Di Domenico, E. G., & Pimpinelli, F. (2024) · Biology · doi:10.3390/biology13020109 · Cited by 213
Li, K., Kabir, M., Rahman, M., & Chen, S. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.114251 · Cited by 3
Metadata
- Authors
- Fahimirad, S., Abtahi, H., Satei, P., Ghaznavi-Rad, E., Moslehi, M., & Ganji, A.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 259
- Pages
- 117640
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W3124399199
- Cited by
- 339
- References
- 48
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fahimirad, S., Abtahi, H., Satei, P., Ghaznavi-Rad, E., Moslehi, M., & Ganji, A. (2021). Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles. Carbohydrate Polymers. https://doi.org/10.1016/j.carbpol.2021.117640
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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