Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
Open accessAbstract
Purpose: This study proposes the utilization of multispectral optoacoustic tomography (MSOT) to investigate the intratumoral distribution of polymeric micelles and effect of size on the biodistribution and antitumor efficacy (ATE). Materials and methods: Docetaxel and/or optoacoustic agent-loaded polymeric micelles (with diameters of 22, 48, and 124 nm) were prepared using amphiphilic block copolymers poly (ethylene glycol) methyl ether-block-poly (D,L lactide) (PEG 2000 –PDLLA x ). Subcutaneous 4T1 tumor-bearing mice were monitored with MSOT imaging and IVIS ® Spectrum in vivo live imaging after tail vein injection of micelles. The in vivo results and ex vivo confocal imaging results were then compared. Next, ATE of the three micelles was found and compared. Results: We found that MSOT imaging offers spatiotemporal and quantitative information on intratumoral distribution of micelles in living animals. All the polymeric micelles rapidly extravasated into tumor site after intravenous injection, but only the 22-nm micelle preferred to distribute into the inner tumor tissues, leading to a superior ATE than that of 48- and 124-nm micelles. Conclusion: This study demonstrated that MSOT is theranostically a powerful imaging modality, offering quantitative information on size-dependent spatiotemporal distribution patterns after the extravasation of nanomedicine from tumor blood vessels. Keywords: multispectral optoacoustic tomography, MSOT, polymeric micelle, in vivo imaging, intratumoral distribution, particle size, tumor model
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Numerous studies have shown that the enhanced permeability and retention (EPR) effects of micelles cause them to preferentially collect in leaky circulatory beds of solid tumors.
“Numerous studies have shown that the enhanced permeability and retention (EPR) effects of micelles cause them to preferentially collect in leaky circulatory beds of solid tumors.38”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [38]
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Smart nanoparticles for cancer therapy
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- Authors
- Cong, Z., Yang, F., Cao, L., Wen, H., Fu, T., Ma, S., Liu, C., Quan, L., & Liao, Y.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Liao, Yonghong
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2018-12
- Volume
- Volume 13
- Pages
- 8549-8560
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC6296692
- OpenAlex
- W2903792383
- Cited by
- 23
- References
- 48
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- National Natural Science Foundation of China (2016-I2M-1-012, -I2M-1-012, 81603052)
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- multispectral optoacoustic tomography, polymeric micelles, intratumoral distribution, particle size dependence, tissue distribution, antitumor efficacy, docetaxel, 4T1 breast tumor, extravasation, theranostics, nanomedicine
- MeSH terms
- Animals, Antineoplastic Agents, Female, Humans, Mice, Inbred BALB C, Micelles, Neoplasms, Particle Size, Polyethylene Glycols, Polymers, Tissue Distribution, Tomography, Imaging, Three-Dimensional, Cell Line, Tumor, Photoacoustic Techniques
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