Healthcare Applications of pH-Sensitive Hydrogel-Based Devices: A Review
Open accessAbstract
Abstract: pH-sensitive hydrogels have been developed greatly over the past few years. This has been possible due to the synthesis of new hydrogel systems with increased sensitivity – a sensitivity of up to 10 − 5 pH units has already been established. Recently, pH-sensitive hydrogels have shown to be very useful in biomedical applications, such as targeted cancer treatment and treatment of skin lesions. Prolonged drug release has been made available through the use of such hydrogels. The synthesis of pH-sensitive hydrogels is also quick and cost-effective. This review presents a background on the properties of pH-sensitive hydrogels and discusses some of the hydrogels with different sensitivity ranges and their possible applications. A range of synthesis processes have also been briefly introduced along with the fabrication of different structures such as microcantilevers and contact lenses. Keywords: pH-sensitive, sensors, hydrogels, biomedical applications, biocompatible
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Nanoparticles, nanoaggregates, nanogels, nanocapsules, core-shell particles, micelles, liposomes, polymersomes, hydrogels, layer-by-layer films, and bioconjugates have been developed as pH-sensitive polymer-based drug delivery devices.
“Nanoparticles, nanoaggregates, nanogels, nanocapsules, core-shell particles, micelles, liposomes, polymersomes, hydrogels, layer-by-layer films, and bioconjugates have been developed as pH-sensitive polymer-based drug delivery devices (Hendi et al., 2020; Li et al., 2021; Ofridam et al., 2021).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Hendi et al., 2020
The Applications > Drug Delivery section describes pH-sensitive hydrogels used for drug delivery, and Hydrogel Compositions and Synthesis describes pH-sensitive hydrogel particles. These passages do not support the sentence’s full list of other device types, including micelles, liposomes, polymersomes, layer-by-layer films, and bioconjugates. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredDiclofenac release was more regulated in GG-g-AA nanocomposites than in guar gum.
“Diclofenac release was more regulated in GG-g-AA nanocomposites than in guar gum (Hendi et al., 2020; Zhuo et al., 2020).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Hendi et al., 2020
The Drug Delivery and Hydrogel Compositions and Synthesis sections discuss release from other hydrogels, including doxorubicin and insulin systems. Searches for diclofenac, guar gum, and GG-g-AA found no passage comparing their release, so our copy does not verify this claim. The available passages have no page numbers. (LLM, conf=0.72)
Experimental — accuracy not yet measuredThe composition 10/0.1/0.5 had the highest water uptake of all the compositions in nanosilica/acrylic acid grafted guar gum membranes.
“The composition 10/0.1/0.5 had the highest water uptake of all the compositions.”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Hendi et al., 2020
The Hydrogel Compositions and Synthesis section and the Fabrication Processes section (page numbers unavailable) discuss other hydrogels and water-uptake curves, but do not identify a 10/0.1/0.5 composition or compare its uptake with other compositions. Searches for that ratio, nanosilica/acrylic-acid-grafted guar gum membranes, and highest water uptake found no passage addressing the claim. (LLM, conf=0.76)
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pH-sensitive biomaterials for drug delivery
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“Diclofenac release was more regulated in GG-g-AA nanocomposites than in guar gum (Hendi et al., 2020; Zhuo et al., 2020).”
Background
- Authors
- Hendi, A., Umair Hassan, M., Elsherif, M., Alqattan, B., Park, S., Yetisen, A. K., & Butt, H.
- Affiliations
- University of Birmingham (GB)
- Egyptian Atomic Energy Authority (EG)
- Khalifa University of Science and Technology (AE)
- Korea Advanced Institute of Science and Technology (KR)
- Imperial College London (GB)
- Corresponding author
- Elsherif, Mohamed
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2020-06
- Volume
- Volume 15
- Pages
- 3887-3901
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC7276332
- OpenAlex
- W3032158130
- Cited by
- 151
- References
- 58
- Citations by year
- 2026: 14 · 2025: 31 · 2024: 28 · 2023: 34 · 2022: 29 · 2021: 13 · 2020: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc-nd)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc)
- Funders
- Korea Advanced Institute of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Keywords
- pH-responsive hydrogels, pH sensor, targeted cancer therapy, skin lesion treatment, controlled drug release, hydrogel synthesis, microcantilever, contact lenses, biomaterials, biomedical applications
- MeSH terms
- Animals, Bandages, Humans, Hydrogen-Ion Concentration, Wound Healing, Drug Delivery Systems, Food Industry, Hydrogels, Drug Liberation
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