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Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method
Open accessAbstract
BACKGROUND: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. METHODS: Different methods, such as single and double solvent evaporation emulsion, ion pairing, and nanoprecipitation were used to prepare both PLGA and PEGylated PLGA nanoparticles. The resulting nanoparticles were analyzed for their morphology, particle size and size distribution, drug loading and entrapment efficiency, thermal properties, and antibacterial activity. RESULTS: The nanoparticles prepared in this study were spherical, with an average particle size of 85-424 nm. The entrapment efficiency of the nanoparticles prepared using different methods was as follows: solid/oil/water ion pairing (29.9%) > oil/oil (5.5%) > water/oil/water (4.7%) > modified oil/water (4.1%) > nano precipitation (0.8%). Addition of dextran sulfate as an ion pairing agent, acting as an ionic spacer between PEGylated PLGA and minocycline, decreased the water solubility of minocycline, hence increasing the drug entrapment efficiency. Entrapment efficiency was also increased when low molecular weight PLGA and high molecular weight dextran sulfate was used. Drug release studies performed in phosphate buffer at pH 7.4 indicated slow release of minocycline from 3 days to several weeks. On antibacterial analysis, the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles was at least two times lower than that of the free drug. CONCLUSION: Novel minocycline-PEGylated PLGA nanoparticles prepared by the ion pairing method had the best drug loading and entrapment efficiency compared with other prepared nanoparticles. They also showed higher in vitro antibacterial activity than the free drug.
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Esmaeili, F., Ghahremani, M. H., Esmaeili, B., Khoshayand, M. R., Atyabi, F., & Dinarvand, R. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.07.038 · Cited by 159
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Cited by
Recent applications of PLGA based nanostructures in drug delivery
Mir, M., Ahmed, N., & Rehman, A. U. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.07.038 · Cited by 621
Zhang, T., Qiu, Y., Song, J., Zhou, P., Liao, H., Cheng, Y., & Wu, X. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1902020 · Cited by 36
Wei, P.-F., Yuan, Z.-Y., Jing, W., Guan, B.-B., Liu, Z.-H., Zhang, X., Mao, J.-P., Chen, D.-F., Cai, Q., & Yang, X.-P. (2019) · Biomaterials Science · doi:10.1039/c8bm00903a · Cited by 27
Wang, N., Huang, Z., Wang, S., Lang, M., & Zhang, X. (2021) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911521992795 · Cited by 3
Patiyananuwat, N., Chartpitak, T., Tancharoen, S., & Nasongkla, N. (2023) · 2023 IEEE 23rd International Conference on Nanotechnology (NANO) · doi:10.1109/nano58406.2023.10231250 · Cited by 1
Metadata
- Authors
- Dinarvand, R., Jafarzadeh Kashi, T., Eskandarion, Esfandyari-Manesh, Samadi, Atyabi, F., & Eshraghi
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2012-01
- Volume
- 7
- Pages
- 221
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W2128069305
- Cited by
- 216
- References
- 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dinarvand, R., Jafarzadeh Kashi, T., Eskandarion, Esfandyari-Manesh, Samadi, Atyabi, F., & Eshraghi. (2012). Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s27709
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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