Stem cell tracking using iron oxide nanoparticles
Open accessAbstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are an exciting advancement in the field of nanotechnology. They expand the possibilities of noninvasive analysis and have many useful properties, making them potential candidates for numerous novel applications. Notably, they have been shown that they can be tracked by magnetic resonance imaging (MRI) and are capable of conjugation with various cell types, including stem cells. In-depth research has been undertaken to establish these benefits, so that a deeper level of understanding of stem cell migratory pathways and differentiation, tumor migration, and improved drug delivery can be achieved. Stem cells have the ability to treat and cure many debilitating diseases with limited side effects, but a main problem that arises is in the noninvasive tracking and analysis of these stem cells. Recently, researchers have acknowledged the use of SPIONs for this purpose and have set out to establish suitable protocols for coating and attachment, so as to bring MRI tracking of SPION-labeled stem cells into common practice. This review paper explains the manner in which SPIONs are produced, conjugated, and tracked using MRI, as well as a discussion on their limitations. A concise summary of recently researched magnetic particle coatings is provided, and the effects of SPIONs on stem cells are evaluated, while animal and human studies investigating the role of SPIONs in stem cell tracking will be explored.
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MSC are capable of differentiating into adipocytes, osteoblasts, chondrocytes, myoblasts and neuron-like cells, making them useful in regenerative medicine.
“Since MSC are capable of differentiating into a variety of other cells, including adipocytes, osteoblasts, chondrocytes, myoblasts and neuron-like cells, they are highly useful and often employed in regenerative medicine applications [264, 265].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [265]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
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- Authors
- Seifalian, A., Bull, E., Madani, Sheth, Green, M., & Seifalian, A.
- Affiliations
- National Health Service (GB)
- University College London (GB)
- King's College London (GB)
- Corresponding author
- Seifalian, Amelia
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2014-03
- Volume
- 9
- Pages
- 1641
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC3976208
- OpenAlex
- W2089368480
- Cited by
- 136
- References
- 3
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 12 · 2019: 19 · 2018: 11 · 2017: 12 · 2016: 15 · 2015: 21 · 2014: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Lincoln Repository (University of Lincoln) (acceptedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by-nc)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, stem cell tracking, magnetic resonance imaging, nanoparticle conjugation, stem cell migration, stem cell differentiation, tumor cell tracking, drug delivery, nanoparticle toxicity
- MeSH terms
- Animals, Cells, Cultured, Dextrans, Humans, Image Enhancement, Magnetic Resonance Imaging, Stem Cells, Magnetite Nanoparticles, Cell Tracking
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