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Cited by 137Pain Management and TreatmentMusculoskeletal pain and rehabilitationPain Mechanisms and Treatments

Economic and humanistic burden of post-trauma and post-surgical neuropathic pain among adults in the United States

Open access
Sadosky, Alesia, Parsons, Bruce, Schaefer, Caroline, Mann, Rachael, Daniel, Shoshana, Nalamachu, Srinivas, Stacey, Brett R., Nieshoff, Edward +2 more·2013·Journal of Pain Research
DOI 10.2147/jpr.s44939PMC PMC3698142
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Abstract

BACKGROUND: Neuropathic pain (NeP) can be chronic, debilitating, and can interfere with sleep, functioning, and emotional well being. While there are multiple causes of NeP, few studies have examined the disease burden and treatment patterns associated with post-traumatic/post-surgical (PTPS) NeP. OBJECTIVE: To characterize pain, health status, function, health care resource utilization, lost productivity, and costs among subjects with PTPS NeP in the United States. METHODS: This observational study enrolled 100 PTPS NeP subjects recruited during routine visits from general practitioner and specialist sites. Subjects completed a one-time questionnaire with validated measures of pain severity and pain interference, health status, sleep, anxiety and depression, productivity, and study-specific items on demographics, employment status, and out-of-pocket expenses. Investigators completed a case report form based on a 6-month retrospective chart review, recording subjects' clinical characteristics as well as current and previous medications/treatments for NeP. Subjects were stratified into mild, moderate, and severe pain groups. RESULTS: Subjects' demographic characteristics were: mean age of 54.9 years, 53% female, and 22% employed for pay. Mean pain severity score was 5.6 (0-10 scale), with 48% and 35% classified as having moderate and severe pain, respectively. The mean number of comorbidities increased with greater pain severity (P = 0.0009). Patient-reported outcomes were worse among PTPS NeP subjects with more severe pain, including pain interference with function, health state utility, sleep, and depression (P < 0.0001). Eighty-two percent of subjects were prescribed two or more NeP medications. The total mean annualized adjusted direct and indirect costs per subject were $11,846 and $29,617, respectively. Across pain severity levels, differences in annualized adjusted direct and indirect costs were significant (P < 0.0001). CONCLUSION: PTPS NeP subjects reported high pain scores, which were associated with poor health utility, sleep, mood, and function, as well as high health care resource utilization and costs. The quality of life impact and costs attributable to PTPS NeP suggest an unmet need for effective and comprehensive management.

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  • Chronic postsurgical pain is a highly prevalent public health problem associated with substantial emotional, social, and economic costs.

    “Chronic postsurgical pain is a highly prevalent public health problem associated with substantial emotional, social, and economic costs.”

    From Chronic postsurgical pain: From risk factor identification to multidisciplinary management at the Toronto General Hospital Transitional Pain Service (2019) · cites this paper as [4]

    The Conclusion (page unavailable) reports substantial economic costs and impaired health, functioning, and well-being among patients with post-traumatic or post-surgical neuropathic pain. But the study did not separate surgical from traumatic cases or establish how prevalent chronic postsurgical pain is in the general population, as the Discussion’s Limitations explain. (LLM, conf=0.88)

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  • Chronic postsurgical pain is a significant driver of chronic pain cost given the high rates of chronic postsurgical pain.

    “Chronic postsurgical pain (CPSP) is a significant driver of this cost4 given the high rates of CPSP.”

    From Chronic postsurgical pain: From risk factor identification to multidisciplinary management at the Toronto General Hospital Transitional Pain Service (2019) · cites this paper as [4]

    The Results > Costs and Conclusion report substantial direct and indirect costs among adults with post-trauma or post-surgical neuropathic pain. But the Discussion > Limitations says the study did not distinguish surgical from trauma cases, and it does not establish high rates of chronic postsurgical pain or its share of overall chronic-pain costs. Page numbers are not provided in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 1

  1. [24]Ware JE KM Turner-Bowker DM Sundaram M Gandek B Maruish ME User’s Manual for the SF-12v2 Health Survey Second Edition QualityMetric, Incorporated 2009

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Authors
Sadosky, A., Parsons, B., Schaefer, C., Mann, R., Daniel, S., Nalamachu, S., Stacey, B. R., Nieshoff, E., Tuchman, M., & Anschel, A.
Affiliations
  • Pfizer (United States) (US)
  • Covance (United States) (US)
  • International Clinical Research Institute (US)
  • Oregon Health & Science University (US)
  • Wayne State University (US)
  • Palm Beach Neurological Center (US)
  • Northwestern University (US)
Corresponding author
Sadosky, Alesia
ORCID
Venue
Journal of Pain Research
Publisher
Informa UK Limited
Published
2013-06
Volume
6
Pages
459
ISSN
1178-7090 (ISSN-L)
DOI
10.2147/jpr.s44939
PMC
PMC3698142
OpenAlex
W1975967578
Cited by
137
References
32
Citations by year
2026: 4 · 2025: 10 · 2024: 8 · 2023: 14 · 2022: 5 · 2021: 11 · 2020: 14 · 2019: 11 · 2018: 12 · 2017: 9 · 2016: 15 · 2015: 12 · 2014: 12
FWCI
16.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
post-traumatic neuropathic pain, disease burden, health care costs, productivity loss, pain intensity, pain interference, health-related quality of life, sleep disorders, depression, comorbidities, healthcare resource utilization, neuropathic pain medications, out-of-pocket costs

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