Fatigue in lung cancer patients: symptom burden and management of challenges
Open accessAbstract
Lung cancer (LC) remains the most common cause of cancer death in several countries across the world. Fatigue is the most frequently reported symptom in LC patients throughout the entire course of disease, and all international guidelines recommend early screening for cancer-related fatigue (CRF) and symptoms that can affect patients' quality of life. In patients with LC, fatigue belongs to the symptom cluster of pain, depression, and insomnia, which are commonly observed simultaneously, but are typically treated as separate although they may have common biological mechanisms. The treatment of CRF remains one of the difficult areas in the oncology field: scarce evidence supports pharmacological therapies, while some interesting data arising indicates alternative remedies and physical exercise seem to be one of the most effective approaches for CRF at any stage of LC.
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Emotional responses to cancer, especially difficulty accepting cancer diagnosis, increase the sense of powerlessness and influence the level of cancer-related fatigue.
“Emotional responses to cancer, especially the experienced difficulty in accepting cancer diagnosis,14,15 increases the sense of powerlessness and influences the level of CRF.”
From Effects of Acceptance and Commitment Therapy on fatigue interference and health-related quality of life among patients with advanced lung cancer: A pilot randomized controlled trial (2022) · cites this paper as [14]
The Introduction and Summary and conclusion describe anxiety and depression as associated with cancer-related fatigue. Our copy does not say that difficulty accepting a cancer diagnosis increases powerlessness or that this response causes fatigue; the cited passages establish an association, not that causal chain. No page numbers are available in our copy. (LLM, conf=0.85)
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- Authors
- Carnio, S., Di Stefano, R., & Novello, S.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Carnio, Simona
- Novello, Silvia
- Venue
- Lung Cancer Targets and Therapy
- Publisher
- Informa UK Limited
- Published
- 2016-05
- Volume
- 7
- Pages
- 73
- ISSN
- 1179-2728 (ISSN-L)
- PMC
- PMC5310693
- OpenAlex
- W2346562677
- Cited by
- 69
- References
- 98
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 3 · 2016: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Lung Cancer Targets and Therapy (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- lung cancer, cancer-related fatigue, symptom burden, quality of life, pain, depression, insomnia, fatigue management, pharmacotherapy, physical activity, alternative remedies
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