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Cited by 89Sexual function and dysfunction studiesTreatment of Major DepressionSexuality, Behavior, and Technology

Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives

Open access
Atmaca, Murad·2020·Neuropsychiatric Disease and Treatment
DOI 10.2147/ndt.s185757PMC PMC7182464
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Abstract

Any type of sexual dysfunction is an important problem in half of the patients with depressive disorder. On the other hand, one to a quarter of people without any depressive disorder experience sexual dysfunction. Antidepressant agents can lead to all types of sexual side effects including arousal, libido, orgasm and ejaculation problems. Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drugs which are prescribed for the treatment of a variety of disorders, including major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, generalized anxiety disorder, and impulse control disorders. It has been reported that one in eight people have utilized one of the SSRIs in the past 10 years. Some studies reported up to 80% of SSRI-induced sexual side effects. Management of SSRI-induced sexual dysfunction seems to be complex and hard. In this paper, SSRI-induced sexual dysfunction and new perspectives in the management of this problem were reviewed.

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Crossref · 10.2147/ndt.s185757

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  • SSRIs-induced sexual dysfunction was observed in 25 to 73% of patients who use these medications for depression treatment.

    “Based on some studies, SSRIs-induced sexual dysfunction was observed in 25 to 73% of the patients who use these medications for depression treatment [22].”

    From Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial (2024) · cites this paper as [22]

    The Antidepressant-Induced Sexual Dysfunction section reports a 25%–73% rate of sexual side effects among patients taking an SSRI. It does not specify that this range applies to patients taking SSRIs for depression, although the Conclusions identify depression as a common reason for antidepressant treatment. The indexed passages provide no page numbers. (LLM, conf=0.84)

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  • One of the most critical challenges to treat depressed patients with SSRIs is the sexual disorders induced by these medications, and there are few options for managing this complication.

    “For this reason, one of the most critical challenges to treat depressed patients with selective serotonin reuptake inhibitors is the sexual disorders induced by these medications, and there are few options for managing this complication [22].”

    From Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial (2024) · cites this paper as [22]

    The SSRI-Induced Sexual Dysfunction section describes sexual side effects as a frequent cause of poor adherence and says their management is complex, supporting the claim that they are a major treatment challenge. But the Management and Conclusions sections describe a variety of treatment alternatives, rather than few options. The paper says evidence for some alternatives is limited. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Atmaca, M.
Affiliations
Fırat University (TR)
Corresponding author
Atmaca, Murad
ORCID
Atmaca, Murad
Venue
Neuropsychiatric Disease and Treatment
Publisher
Informa UK Limited
Published
2020-04
Volume
Volume 16
Pages
1043-1050
ISSN
  • 1176-6328 (ISSN-L)
  • 1178-2021
DOI
10.2147/ndt.s185757
PMC
PMC7182464
OpenAlex
W3017335805
Cited by
89
References
77
Citations by year
2026: 15 · 2025: 16 · 2024: 11 · 2023: 20 · 2022: 11 · 2021: 13 · 2020: 3
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
  • DSpace - FIRAT (Fırat University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Keywords
selective serotonin reuptake inhibitors, sexual arousal, sexual desire, orgasm, ejaculatory dysfunction, major depressive disorder

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