Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
Open accessAbstract
BACKGROUND: The cognitive profile of children with neurofibromatosis type 1 (NF1) and attention deficit hyperactivity disorder (ADHD) has been well characterized, but few studies have evaluated the cognitive abilities of adults with NF1 and ADHD. OBJECTIVES: We investigated 1) the cognitive profile of an adult patient with NF1 and inattention problems, 2) changes in his cognition after 14 months of follow-up, and 3) whether the patient exhibited comorbid NF1 and ADHD or secondary ADHD-like symptoms. METHODS: We administered neuropsychological tests of executive function, attention, verbal and visual memory, visuospatial function, and language during two evaluations separated by 14 months. RESULTS: We found no changes in sustained attention, language, or verbal memory. Visual memory, verbal learning, selective attention inhibitory control, and problem solving declined over time, whereas visual search, psychomotor speed, visuospatial function, and mental flexibility improved. CONCLUSION: Our patient exhibited a cognitive profile characteristic of both NF1 and ADHD, leading to the hypothesis that the patient had comorbid ADHD instead of secondary ADHD-like symptoms. More studies are necessary to characterize the cognition of patients with NF1 and ADHD.
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Patients with NF1 exhibit high rates of attention-deficit/hyperactivity disorder.
“Patients with NF1 exhibit high rates of attention-deficit/hyperactivity disorder (Mautner et al., 2015; Miguel et al., 2015)”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Miguel et al., 2015
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Neurofibromatosis Type 1 with Superior Oblique Palsy: A Case Report
Alotaibi, R. T., Alhussein, G. A., Aljaloud, A. M., & Dlaim, M. S. B. (2026) · Journal of Nature and Science of Medicine · doi:10.4103/jnsm.jnsm_236_25
- Authors
- Miguel, C., Chaim, T., Silva, M. A., & Louzã, M. R.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Miguel, Carmen
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2015-03
- Volume
- 11
- Pages
- 815
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC4378869
- OpenAlex
- W2013232610
- Cited by
- 20
- References
- 44
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Neurology › Neurofibromatosis and Schwannoma Cases
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- neurofibromatosis type 1, attention deficit hyperactivity disorder, comorbidities, executive function, visual memory, verbal memory, visuospatial ability, inhibitory control, sustained attention, psychomotor speed, cognitive change over time
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