The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy
Open accessAbstract
Abstract: Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RAS V12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid reactive oxygen species (L-ROS) in an iron-dependent manner. Erastin can mediate ferroptosis through a variety of molecules including the cystine-glutamate transport receptor (system X C − ), the voltage-dependent anion channel (VDAC), and p53. Erastin is able to enhance the sensitivity of chemotherapy and radiotherapy, suggesting a promising future in cancer therapy. We hope that this review will help to better understand the role of erastin in ferroptosis and lay the foundation for further research and the development of erastin-based cancer therapies in the future. Keywords: erastin, ferroptosis, system X C − , p53, VDAC, cancer
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1 retracted
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RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Ferroptosis: process and function
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Ferroptosis as a p53-mediated activity during tumour suppression
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FSP1 is a glutathione-independent ferroptosis suppressor
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
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Cited by
The interaction between ferroptosis and inflammatory signaling pathways
Chen, Y., Fang, Z.-M., Yi, X., Wei, X., & Jiang, D.-S. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05716-0 · Cited by 567
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
Reichert, C. O., de Freitas, F. A., Sampaio-Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 422
Molecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402
Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
Yao, X., Li, W., Fang, D., Xiao, C., Wu, X., Li, M., & Luo, Z. (2021) · Advanced Science · doi:10.1002/advs.202100997 · Cited by 282
Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway
Tossetta, G., & Marzioni, D. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106365 · Cited by 115
Metadata
- Authors
- Zhao, Y., Li, Y., Zhang, R., Wang, F., Wang, T., & Jiao, Y.
- Venue
- OncoTargets and Therapy
- Publisher
- Informa UK Limited
- Published
- 2020-06
- Volume
- Volume 13
- Pages
- 5429-5441
- ISSN
- 1178-6930 (ISSN-L)
- OpenAlex
- W3034193580
- Cited by
- 458
- References
- 111
- FWCI
- 25.98
- Type
- journal article
- Language
- en
- Open access
- gold
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