Cited by 217Sperm and Testicular FunctionHormonal and reproductive studiesPrenatal Substance Exposure Effects

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The Insults of Illicit Drug Use on Male Fertility

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Fronczak, Carolyn M., Kim, Edward D., Barqawi, Al B.·2012·Journal of Andrology

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Abstract

Abstract:One‐third of infertile couples may have a male factor present. Illicit drug use can be an important cause of male factor infertility and includes use of anabolic‐androgenic steroids, marijuana, opioid narcotics, cocaine, and methamphetamines. The use of these illicit drugs is common in the United States, with a yearly prevalence rate for any drug consistently higher in males compared with females. We aim to provide a review of recent literature on the prevalence and effects of illicit drug use on male fertility and to aid health professionals when counseling infertile men whose social history suggests illicit drug use. Anabolic‐androgenic steroids, marijuana, cocaine, methamphetamines, and opioid narcotics all negatively impact male fertility, and adverse effects have been reported on the hypothalamic‐pituitary‐testicular axis, sperm function, and testicular structure. The use of illicit drugs is prevalent in our society and likely adversely impacting the fertility of men who abuse drugs.

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Authors: Fronczak, C. M., Kim, E. D., & Barqawi, A. B.
Affiliations: University of Colorado Anschutz (US)
University of Tennessee at Knoxville (US)
Corresponding author: Barqawi, Al B.
ORCID: Kim, Edward D.
Barqawi, Al B.
Venue: Journal of Andrology
Publisher: Wiley
Published: 2012-07-08
Volume: 33
Issue: 4
Pages: 515-528
ISSN: 0196-3635 (ISSN-L)
1939-4640
DOI: 10.2164/jandrol.110.011874
OpenAlex: W2095564951
Cited by: 217
References: 88
Citations by year: 2026: 2 · 2025: 11 · 2024: 17 · 2023: 23 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 12 · 2018: 17 · 2017: 18 · 2016: 10 · 2015: 20 · 2014: 24 · 2013: 11 · 2012: 3
FWCI: 2.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 178 d)
Locations: Journal of Andrology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: illicit drug use, male infertility, male factor infertility, anabolic steroids, cannabis, cocaine, methamphetamine, sperm function, hypothalamic-pituitary-testicular axis, testicular structure, drug use prevalence, infertility counseling
MeSH terms: Adolescent, Adult, Analgesics, Opioid, Androgens, Animals, Marijuana Abuse, Cocaine, Fertility, Humans, Infertility, Male, Male, Methamphetamine, Middle Aged, Spermatogenesis, Illicit Drugs, Testosterone, United States, Prevalence, N-Methyl-3,4-methylenedioxyamphetamine, Substance-Related Disorders, Anabolic Agents, Rats

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The Insults of Illicit Drug Use on Male Fertility

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