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Cited by 324Reproductive Biology and FertilityOvarian function and disordersReproductive Health and Technologies

Smoke, alcohol and drug addiction and male fertility

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Sansone, Andrea, Di Dato, Carla, de Angelis, Cristina, Menafra, Davide, Pozza, Carlotta, Pivonello, Rosario, Isidori, Andrea, Gianfrilli, Daniele·2018·Reproductive Biology and Endocrinology
DOI 10.1186/s12958-018-0320-7PMC PMC5769315
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Abstract

BACKGROUND: Considerable interest has been gathered on the relevant impact of preventable factors, including incorrect lifestyle and unhealthy habits, on female fertility. Smoking, alcohol and addictive drugs consumption represent a major concern, given the broad range of diseases which might be favored or exacerbated by these dependable attitudes. Despite the well-characterized effects of prenatal exposure on pregnancy outcomes and fetus health, a substantial proportion of women of reproductive age is still concerned with these habits. At present, the impact of smoke, alcohol and addictive drugs on women fertility, and, particularly, the specific targets and underlying mechanisms, are still poorly understood or debated, mainly due to the scarcity of well-designed studies, and to numerous biases. OBJECTIVE: The current review will provide a comprehensive overview of clinical and experimental studies in humans and animals addressing the impact of smoke, alcohol and addictive drugs on female fertility, by also embracing effects on ovary, oviduct, and uterus, with particular reference to primary endpoints such as ovarian reserve, steroidogenesis, ovulation and menstrual cycle, oviduct function and uterus receptivity and implantation. A brief focus on polycystic ovary syndrome and endometriosis will be also included. METHODS: A Pubmed literature search was performed with selected keywords; articles were individually retrieved by each author. No limitation was set for publication date. Articles in languages other than English were excluded. Additional articles were retrieved from references list of selected manuscripts. RESULTS AND CONCLUSIONS: Currently, the most consistent evidences of a detrimental effect of smoke, alcohol and addictive drugs on specific domains of the female reproductive function are provided by experimental studies in animals. Overall, clinical studies suggest that smoking is associated to decreased fertility, although causal inference should be further demonstrated. Studies addressing the effect of alcohol consumption on female fertility provide conflicting results, although the majority reported lack of a correlation. Extremely scarce studies investigated the effects of addictive drugs on female fertility, and the specific actions of selected drugs have been difficult to address, due to multidrug consumption.

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Authors
Sansone, A., Di Dato, C., de Angelis, C., Menafra, D., Pozza, C., Pivonello, R., Isidori, A., & Gianfrilli, D.
Affiliations
  • Sapienza University of Rome (IT)
  • University of Naples Federico II (IT)
Corresponding author
Sansone, Andrea
ORCID
Venue
Reproductive Biology and Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2018-01-15
Volume
16
Issue
1
Pages
21-21
ISSN
1477-7827 (ISSN-L)
DOI
10.1186/s12958-018-0320-7
PMC
PMC5769315
OpenAlex
W2783428649
Cited by
324
References
8
Citations by year
2026: 27 · 2025: 38 · 2024: 61 · 2023: 63 · 2022: 45 · 2021: 31 · 2020: 34 · 2019: 17 · 2018: 6 · 2017: 1 · 2016: 1
FWCI
3.95
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Reproductive Biology and Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
smoking, alcohol consumption, drug addiction, female fertility, ovarian reserve, steroidogenesis, ovulation, menstrual cycle, endometrial receptivity, implantation, polycystic ovary syndrome, endometriosis, reproductive toxicity
MeSH terms
Adult, Alcohol Drinking, Fertility, Humans, Infertility, Male, Male, Smoke, Smoking, Prevalence, Substance-Related Disorders

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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