Physiological Roles of Amyloid-?? and Implications for its Removal in Alzheimer???s Disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160

The molecular pathology of Alzheimer's disease

Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,365

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Cai, H., Wang, Y., McCarthy, D. B., Wen, H., Borchelt, D., Price, D. L., & Wong, P. C. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 1,087

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., & Klein, W. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834302100 · Cited by 1,061

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M. E., Romano, D. M., Hartshorn, M. A., Tanzi, R. E., & Bush, A. I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12817 · Cited by 1,009

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer’s disease therapeutics

Roberds, S. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1317 · Cited by 705

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R., & Disterhoft, J. F. (2004) · Neuron · doi:10.1016/s0896-6273(03)00810-9 · Cited by 549

Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain

Balin, B. J., Gérard, H. C., Arking, E. J., Appelt, D. M., Branigan, P. J., Abrams, J. T., Whittum-Hudson, J. A., & Hudson, A. P. (1998) · Medical Microbiology and Immunology · doi:10.1007/s004300050071 · Cited by 506

Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay

Ida, N., Hartmann, T., Pantel, J., Schrüder, J., Zerfaß, R., Fürstl, H., Sandbrink, R., Masters, C. L., & Beyreuther, K. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22908 · Cited by 478

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

Whitson, J. S., Selkoe, D. J., & Cotman, C. W. (1989) · Science · doi:10.1126/science.2928783 · Cited by 469

Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces

Feng, R., Rampon, C., Tang, Y., Shrom, D., Jin, J., Kyin, M., Sopher, B. L., Martin, G. M., Kim, S., Langdon, R. B., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00523-2 · Cited by 467

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

Mantyh, P. W., Ghilardi, J. R., Rogers, S. D., DeMaster, E., Allen, C. J., Stimson, E. R., & Maggio, J. E. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03639.x · Cited by 466

Amyloid Peptide Aβ1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors

Wang, H.-Y., Lee, D. H. S., Davis, C. B., & Shank, R. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751155.x · Cited by 441

Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

Schenk, D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn938 · Cited by 436

Plasma Aβ40 and Aβ42 and Alzheimer’s disease: Relation to age, mortality, and risk

Mayeux, R., Honig, L. S., Tang, M.-X., Manly, J., Stern, Y., Schupf, N., & Mehta, P. D. (2003) · Neurology · doi:10.1212/01.wnl.0000091890.32140.8f · Cited by 434

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

Dawson, G. R., Seabrook, G. R., Zheng, H., Smith, D. W., Graham, S. J., O'Dowd, G., Bowery, B. J., Boyce, S., Trumbauer, M. E., Chen, H. Y., et al. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00410-2 · Cited by 394

Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367

The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

Plant, L. D., Boyle, J. P., Smith, I. F., Peers, C., & Pearson, H. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05531.2003 · Cited by 326

A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage

Zou, K., Gong, J.-S., Yanagisawa, K., & Michikawa, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04833.2002 · Cited by 305

Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease

Höck, C., Konietzko, U., Papassotiropoulos, A., Wollmer, A., Streffer, J. R., von Rotz, R. C., Davey, G. E., Moritz, E., & Nitsch, R. M. (2002) · Nature Medicine · doi:10.1038/nm783 · Cited by 284

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

Seabrook, G. R., Smith, D. W., Bowery, B. J., Easter, A., Reynolds, T., Fitzjohn, S. M., Morton, R. A., Zheng, H., Dawson, G. R., SIRINATHSINGHJI, D. J. S., et al. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00204-4 · Cited by 281

APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice

Yu, H., Saura, C. A., Choi, S., Sun, L. D., Yang, X., Handler, M., Kawarabayashi, T., Younkin, L. H., Fedeles, B. I., Wilson, M. A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00417-2 · Cited by 261

Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice

Sigurdsson, E. M., Scholtzova, H., Mehta, P. D., Frangione, B., & Wısnıewskı, T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61715-4 · Cited by 260

Amyloid β-peptide induces apoptosis-related events in synapses and dendrites

Mattson, M. P., Partin, J. V., & Begley, J. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00763-x · Cited by 258

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

Mackic, J. B., Stins, M., McComb, J. G., Calero, M., Ghiso, J., Kim, K. S., Yan, S. D., Stern, D., Schmidt, A. M., Frangione, B., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2029 · Cited by 242

Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

Dewachter, I., Reversé, D., Caluwaerts, N., Ris, L., Kuipéri, C., den Haute, C. V., Spittaels, K., Umans, L., Serneels, L., Thiry, E., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03445.2002 · Cited by 238

Reduced levels of amyloid β-peptide antibody in Alzheimer disease

Du, Y., Dodel, R. C., Hampel, H. J., Büerger, K., Lin, S., Eastwood, B. J., Bales, K. R., Gao, F., Moeller, H. –., Oertel, W. H., et al. (2001) · Neurology · doi:10.1212/wnl.57.5.801 · Cited by 236

Combination assay of CSF Tau, Aβ1-40 and Aβ1-42(43) as a biochemical marker of Alzheimer's disease

Shoji, M., Matsubara, E., Kanai, M., Watanabe, M., Nakamura, T., Tomidokoro, Y., Shizuka, M., Wakabayashi, K., Igeta, Y., Ikeda, Y., et al. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00122-1 · Cited by 221

β-Amyloid Regulation of Presynaptic Nicotinic Receptors in Rat Hippocampus and Neocortex

Dougherty, J. J., Wu, J., & Nichols, R. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06740.2003 · Cited by 213

Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester

Savage, M. J., Trusko, S. P., Howland, D. S., Pinsker, L. R., Mistretta, S., Reaume, A. G., Greenberg, B. D., Siman, R., & Scott, R. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01743.1998 · Cited by 213

What the evolution of the amyloid protein precursor supergene family tells us about its function

Coulson, E. J., Paliga, K., Beyreuther, K. T., & Masters, C. L. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00125-4 · Cited by 209

Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals

Weksler, M. E., Relkin, N. R., Turkenich, R., LaRusse, S., Zhou, L., & Szabo, P. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00029-3 · Cited by 200

Aluminum Promotes the Aggregation of Alzheimer′s Amyloid β-Protein in Vitro

Kawahara, M., Muramoto, K., Kobayashi, K., Mori, H., & Kuroda, Y. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1078 · Cited by 194

Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice

Phinney, A. L., Deller, T., Stalder, M., Calhoun, M. E., Frotscher, M., Sommer, B., Staufenbiel, M., & Jucker, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08552.1999 · Cited by 188

Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat HippocampusIn Vivo

Kim, J., Anwyl, R., Suh, Y., Djamgoz, M. B. A., & Rowan, M. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01327.2001 · Cited by 186

Amyloid-β is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

Kontush, A., Berndt, C., Weber, W., Akopyan, V., Arlt, S., Schippling, S., & Beisiegel, U. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00458-5 · Cited by 180

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

Luo, Y. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00104-9 · Cited by 178

Nerve inflammation halts trial for Alzheimer's drug

Check, E. (2002) · Nature · doi:10.1038/415462a · Cited by 176

Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

Koistinaho, M., Ort, M., Cimadevilla, J. M., Vondrous, R., Cordell, B., Koıstınaho, J., Bureš, J., & Higgins, L. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261562998 · Cited by 160

Secretion of Alzheimer's disease Abeta amyloid peptide by activated human platelets.

Li, Q., Whyte, S., Tanner, J. E., Evin, G. M., Beyreuther, K. T., & Masters, C. L. (1998) · PubMed · Cited by 155

Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer’s disease

Robinson, S. R., & Bishop, G. M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00342-6 · Cited by 155

Amyloid β protein in plasma from patients with sporadic Alzheimer's disease

Tamaoka, A., Fukushima, T., Sawamura, N., Ishikawa, K., Oguni, E., Komatsuzaki, Y., & Shoji, S. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00143-8 · Cited by 154

Binding of Zn(II), Cu(II), and Fe(II) ions to alzheimer's Aß peptide studied by fluorescence

Garzon-Rodriguez, W., Yatsimirsky, A. K., & Glabe, C. G. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(99)00357-1 · Cited by 148

Autoantibodies to amyloid-? and Alzheimer's disease

Hyman, B. T., Smith, C. R., Buldyrev, I., Whelan, C. M., Brown, H., Tang, M., & Mayeux, R. P. (2001) · Annals of Neurology · doi:10.1002/ana.1061 · Cited by 144

Impairments of long-term potentiation in hippocampal slices of β-amyloid-infused rats

Itoh, A., Akaike, T., Sokabe, M., Nitta, A., Iida, R., Olariu, A., Yamada, K., & Nabeshima, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00601-9 · Cited by 122

Autoantibodies to Amyloid β-Peptide (Aβ) are Increased in Alzheimer's Disease Patients and Aβ Antibodies Can Enhance Aβ Neurotoxicity: Implications for Disease Pathogenesis and Vaccine Development

Nath, A., Hall, E., Tuzova, M., Dobbs, M., Jones, M., Anderson, C., Woodward, J. G., Guo, Z., Fu, W., Kryscio, R. J., et al. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:1:29 · Cited by 107

Lessons from the AN 1792 Alzheimer vaccine: lest we forget

Robinson, S. R., Bishop, G. M., Lee, H., & Münch, G. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.020 · Cited by 102

Amyloid β binding proteins in vitro and in normal human cerebrospinal fluid

Golabek, A., Marques, M. A., Lalowski, M., & Wisniewski, T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11565-7 · Cited by 99

Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts

Armogida, M., Petit-Paitel, A., Vincent, B., Scarzello, S., da Costa, C. A., & Checler, F. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1030 · Cited by 96

Glutamine synthetase, hemoglobin α-chain, and macrophage migration inhibitory factor binding to amyloid β-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimer’s disease brain by immunoprecipitation

Oyama, R., Yamamoto, H., & Titani, K. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00057-1 · Cited by 96

NMDA receptor regulation by amyloid-β does not account for its inhibition of LTP in rat hippocampus

Raymond, C. R., Ireland, D. R., & Abraham, W. C. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02269-8 · Cited by 94

β-amyloid-(1–40) increases long-term potentiation in rat hippocampus in vitro

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Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach

Huber, G., Martin, J. R., Löffler, J., & Moreau, J. (1993) · Brain Research · doi:10.1016/0006-8993(93)91261-p · Cited by 76

The amyloid hypothesis: let sleeping dogmas lie?

Bishop, G. M., & Robinson, S. R. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00050-7 · Cited by 67

APP is required during an early phase of memory formation

Mileusnić, R., Lancashire, C. L., Johnston, A. N. B., & Rose, S. P. R. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01344.x · Cited by 66

Serum Amyloid P Component Bound to Gram-Negative Bacteria Prevents Lipopolysaccharide-Mediated Classical Pathway Complement Activation

de Haas, C. J. C., van Leeuwen, E. M. M., van Bommel, T., Verhoef, J., van Kessel, K. P. M., & van Strijp, J. A. G. (2000) · Infection and Immunity · doi:10.1128/iai.68.4.1753-1759.2000 · Cited by 65

Serum Amyloid P Component Binds to Influenza A Virus Haemagglutinin and Inhibits the Virus Infection In Vitro

Andersen, O., Vilsgaard, K., Sørensen, I. J., Jonson, G., Nielsen, E. H., & Svehag, S. (1997) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1997.d01-147.x · Cited by 51

The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently

Shoji, M., Kanai, M., Matsubara, E., Tomidokoro, Y., Shizuka, M., Ikeda, Y., Ikeda, M., Harigaya, Y., Okamoto, K., & Hirai, S. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00229-3 · Cited by 50

New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein.

de Haas, C. D. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1999.tb01390.x · Cited by 46

Nicotine Enhances the Depressive Actions of Aβ1–40 on Long-Term Potentiation in the Rat Hippocampal CA1 Region In Vivo

Freir, D. B., & Herron, C. E. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00996.2002 · Cited by 45

Administration of Aggregated Beta-Amyloid Peptide (25–35) Induces Changes in Long-Term Potentiation in the Hippocampus in Vivo

Trubetskaya, V. V., Stepanichev, M. Y., Onufriev, M. V., Лазарева, Н. А., Markevich, V. A., & Gulyaeva, N. V. (2003) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1021761310435 · Cited by 43

Human Aβ1–42 reduces iron‐induced toxicity in rat cerebral cortex

Bishop, G. M., & Robinson, S. R. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10661 · Cited by 43

Regenerative Failure: A Potential Mechanism for Neuritic Dystrophy in Alzheimer's Disease

DeWitt, D. A., & Silver, J. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0182 · Cited by 42

The effects of age, apolipoprotein E phenotype and gender on the concentration of amyloid-β (Aβ) 40, Aβ42, apolipoprotein E and transthyretin in human cerebrospinal fluid

Kunicki, S., Richardson, J., Mehta, P. D., Kim, K. S., & Zorychta, E. (1998) · Clinical Biochemistry · doi:10.1016/s0009-9120(98)00027-7 · Cited by 41

Potential neurotoxic inflammatory responses to Aβ vaccination in humans

Münch, G. W., & Robinson, S. R. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200091 · Cited by 40

Resistance of human cerebrospinal fluid toin vitrooxidation is directly related to its amyloid-β content

Kontush, A., Donarski, N., & Beisiegel†, U. (2001) · Free Radical Research · doi:10.1080/10715760100301521 · Cited by 39

β-Amyloid Enhances Glial Glutamate Uptake Activity and Attenuates Synaptic Efficacy

Ikegaya, Y., Matsuura, S., Ueno, S., Baba, A., Yamada, M. K., Nishiyama, N., & Matsuki, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203764200 · Cited by 39

Deposits of Aβ fibrils are not toxic to cortical and hippocampal neurons in vitro

Wujek, J. R., Dority, M. D., Frederickson, R. C. A., & Brunden, K. R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02020-9 · Cited by 36

Antibodies to β-Amyloid Decrease the Blood-to-Brain Transfer of β-Amyloid Peptide 1

Pan, W., Solomon, B., Maness, L. M., & Kastin, A. J. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700808 · Cited by 34

Alzheimer's disease and related disorders: research advances

Checler, F., & Petit-Paitel, A. (2003) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 30

New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein

de Haas, C. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(99)00148-0 · Cited by 29

Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Aβ1–40

Wang, C.-S., Wurtman, R. J., & Lee, R. K. K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02183-1 · Cited by 28

Alzheimer vaccine: amyloid‐β on trial

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