Smoking-Induced Elevations in Blood Carboxyhaemoglobin Levels
Abstract
Many people engage in physical activity to reduce their cardiovascular risk associated with smoking. These people should be made aware of the metabolic and cardiorespiratory changes induced by chronic and acute smoking and, in particular, the exercise ramifications of increased levels of blood carbon monoxide (CO). Smoking-induced elevations in the CO content of the blood can reduce exercise tolerance and maximal aerobic capacity. Smoking also increases the reliance upon glycolytic metabolism during exercise. Together, these factors contribute to earlier fatigue in smokers compared with nonsmokers who exercise. Similar effects upon exercise tolerance are noted in those who inhale environmental tobacco smoke.
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Cellular mechanisms of muscle fatigue
Fitts, R. H. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.49 · Cited by 1,537 · see citing works
Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609092951101 · Cited by 1,101 · see citing works
Rowell, L. B. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199312000-00021 · Cited by 1,099 · see citing works
Comparison of tests used to distinguish smokers from nonsmokers
Jarvis, M. J., Tunstall-Pedoe, H., Feyerabend, C., Vesey, C., & Saloojee, Y. (1987) · American Journal of Public Health · doi:10.2105/ajph.77.11.1435 · Cited by 994 · see citing works
Metabolic and respiratory profile of the upper limit for prolonged exercise in man
Poole, D. C., Ward, S. A., Gardner, G. W., & Whipp, B. J. (1988) · Ergonomics · doi:10.1080/00140138808966766 · Cited by 780 · see citing works
Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers
Chance, B., Dait, M. T., Zhang, C., Hamaoka, T., & Hagerman, F. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.3.c766 · Cited by 528 · see citing works
Wittenberg, B. A., & Wittenberg, J. B. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.004233 · Cited by 468 · see citing works
Contribution of excising legs to the slow component of oxygen uptake kinetics in humans
Poole, D. C., Schaffartzik, W., Knight, D. R., Derion, T., Kennedy, B. P., Guy, H. J., Prediletto, R., & Wagner, P. D. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1245 · Cited by 394 · see citing works
Mechanical constraints on exercise hyperpnea in endurance athletes
Johnson, B. D., Saupe, K. W., & Dempsey, J. A. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.3.874 · Cited by 382 · see citing works
The slow component of O2 uptake kinetics during heavy exercise
Whipp, B. J. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199411000-00005 · Cited by 285 · see citing works
Increased dependence on blood glucose after acclimatization to 4,300 m
Brooks, G. A., Butterfield, G. E., Wolfe, R. R., Groves, B. Μ., Mazzeo, R. S., Sutton, J. R., Wolfel, E. E., & Reeves, J. Τ. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.2.919 · Cited by 270 · see citing works
Effects of training on muscle O2 transport at VO2max
Roca, J., Agustí, A. G. N., Alonso, A., Poole, D. C., Viegas, C., Barberà, J. A., Rodriguez‐Roisin, R., Ferrer, A., & Wagner, P. D. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.3.1067 · Cited by 253 · see citing works
Is the lung built for exercise?
Dempsey, J. A. (1986) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198604000-00001 · Cited by 252 · see citing works
Acute effects of inhalation of cigarette smoke on airway conductance
Nadel, J. A., & Comroe, J. H. (1961) · Journal of Applied Physiology · doi:10.1152/jappl.1961.16.4.713 · Cited by 241 · see citing works
Effects of incomplete pulmonary gas exchange on VO2 max
Powers, S. K., Lawler, J., Dempsey, J. A., Dodd, S., & Landry, G. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.6.2491 · Cited by 238 · see citing works
McCully, K. K., Iotti, S., Kendrick, K., Wang, Z., Posner, J. D., Leigh, J. S., & Chance, B. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.1.5 · Cited by 228 · see citing works
Belardinelli, R., Barstow, T. J., Porszasz, J., & Wasserman, K. (1995) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00634377 · Cited by 213 · see citing works
Effects of hypoxic hypoxia on O<sub>2</sub>uptake and heart rate kinetics during heavy exercise
Engelen, M., Porszasz, J., Riley, M., Wasserman, K., Maehara, K., & Barstow, T. J. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.6.2500 · Cited by 207 · see citing works
Regulation of lactic acid production during exercise.
Katz, A., & Sahlin, K. (1988) · Journal of applied physiology · doi:10.1152/jappl.1988.65.2.509 · Cited by 196 · see citing works
Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise
Stringer, W., Wasserman, K., Casaburi, R., Porszasz, J., Maehara, K., & French, W. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.4.1462 · Cited by 187 · see citing works
Oxygen uptake kinetics and lactate concentration during exercise in humans.
Roston, W. L., Whipp, B. J., Davis, J. A., Cunningham, D. A., Effros, R. M., & Wasserman, K. (1987) · PubMed · doi:10.1164/arrd.1987.135.5.1080 · Cited by 180 · see citing works
Determinants of maximal exercise VO2 during single leg knee-extensor exercise in humans
Richardson, R. S., Knight, D. R., Poole, D. C., Kurdak, S. S., Hogan, M. C., Grassi, B., & Wagner, P. D. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.4.h1453 · Cited by 176 · see citing works
VO2 slow component: physiological and functional significance.
Poole, D. C., Barstow, T. J., Gaesser, G. A., Willis, W. T., & Whipp, B. J. (1994) · PubMed · Cited by 162 · see citing works
Decreased reliance on lactate during exercise after acclimatization to 4,300 m
Brooks, G. A., Butterfield, G. E., Wolfe, R. R., Groves, B. Μ., Mazzeo, R. S., Sutton, J. R., Wolfel, E. E., & Reeves, J. Τ. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.1.333 · Cited by 151 · see citing works
Cross-Cultural Comparisons of Family Environments of Anglo-, Greek-, and Italian-Australians
Marjoribanks, K. (1994) · Psychological Reports · doi:10.2466/pr0.1994.74.1.49 · Cited by 138 · see citing works
13 Baroreflex Regulation of Blood Pressure during Dynamic Exercise
Raven, P. B., Potts, J. T., & SWI, X. (1997) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199700250-00015 · Cited by 129 · see citing works
VA/Q distribution during heavy exercise and recovery in humans: implications for pulmonary edema
Schaffartzik, W., Poole, D. C., Derion, T., et al. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.5.1657 · Cited by 127 · see citing works
Stray‐Gundersen, J., Musch, T. I., Haidet, G. C., Swain, D. P., Ordway, G. A., & Mitchell, J. H. (1986) · Circulation Research · doi:10.1161/01.res.58.4.523 · Cited by 124 · see citing works
Coupling of external to cellular respiration during exercise: the wisdom of the body revisited
Wasserman, K. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.4.e519 · Cited by 121 · see citing works
Effect of carbon monoxide on oxygen transport during exercise
Vogel, J. A., & Gleser, M. A. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.2.234 · Cited by 109 · see citing works
Evidence that the metabolic acidosis threshold is the anaerobic threshold
Koike, A., Weiler‐Ravell, D., McKenzie, D. K., et al. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.6.2521 · Cited by 88 · see citing works
Myoglobin O2 tension determined from measurement of carboxymyoglobin in skeletal muscle
Coburn, R. F., & Mayers, L. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.220.1.66 · Cited by 87 · see citing works
High field electrical conduction and breakdown in silicon incorporated polyethylene films
Liu, D., Kan, L., & Kao, K. C. (1991) · Journal of Applied Physics · doi:10.1063/1.349599 · Cited by 86 · see citing works
Skeletal muscle oxygenation during constant work rate exercise
Belardinelli, R., Barstow, T. J., Pórszász, J., & Wasserman, K. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199504000-00008 · Cited by 85 · see citing works
Intracellular PO2 in long axis of individual fibers in working dog gracilis muscle
Gayeski, T. E., & Honig, C. R. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.254.6.h1179 · Cited by 84 · see citing works
Maximal aerobic capacity at different levels of carboxyhemoglobin
Horvath, S. M., Raven, P. B., Dahms, T. E., et al. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.38.2.300 · Cited by 80 · see citing works
Application of biochemical intake markers to passive smoking measurement and risk estimation
Jarvis, M. J. (1989) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(89)90023-2 · Cited by 77 · see citing works
Muscular fatigue: effects of hydrogen ions and inorganic phosphate.
Dr, W. (1986) · PubMed · Cited by 74 · see citing works
Immediate effects of cigarette smoking on cardiorespiratory responses to exercise
Hirsch, G. L., Sue, D. Y., Wasserman, K., et al. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.58.6.1975 · Cited by 74 · see citing works
Muscle O2 transport and O2 dependent control of metabolism
Wagner, P. D. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199501000-00010 · Cited by 69 · see citing works
Effect of reduced hemoglobin concentration on leg oxygen uptake during maximal exercise in humans
Schaffartzik, W., Barton, E. D., Poole, D. C., Tsukimoto, K., Hogan, M. C., Bebout, D. E., & Wagner, P. D. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.2.491 · Cited by 67 · see citing works
Acute effects of cigarette smoking and inhalation of carbon monoxide during maximal exercise
Klausen, K., Andersen, C., & Nandrup, S. (1983) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00429074 · Cited by 65 · see citing works
Effect of Carbon Monoxide on Maximal Treadmill Exercise
Aronow, W. S., & CASSIDY, J. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-4-496 · Cited by 63 · see citing works
Rate at which CO replaces O2 from O2Hb in red cells of different species
Holland, R. A. B. (1969) · Respiration Physiology · doi:10.1016/0034-5687(69)90068-1 · Cited by 63 · see citing works
Muscle blood flow in humans: how high can it go?
Rowell, L. B. (1988) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198810001-00001 · Cited by 62 · see citing works
Evidence that diffusion limitation determines oxygen uptake kinetics during exercise in humans.
Koike, A., Wasserman, K., McKenzie, D. K., Zanconato, S., & Weiler‐Ravell, D. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114894 · Cited by 61 · see citing works
Muscular exercise during intoxication by carbon monoxide.
Pirnay, F., Dujardin, J., Deroanne, R., et al. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.4.573 · Cited by 59 · see citing works
The effects of passive inhalation of cigarette smoke on exercise performance
McMurray, R. G., Hicks, L. L., & Thompson, D. L. (1985) · European Journal of Applied Physiology · doi:10.1007/bf02335929 · Cited by 52 · see citing works
ACTION OF NICOTINE ON THE HEART
Burn, J. H. (1960) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1960.tb32618.x · Cited by 50 · see citing works
Oxygen transport: air to muscle cell
Richardson, R. S. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199801000-00008 · Cited by 48 · see citing works
O2 delivery to contracting muscle during hypoxic or CO hypoxia
King, C. E., Dodd, S. L., & Cain, S. M. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.2.726 · Cited by 46 · see citing works
Oxygen transport in rest-work transition illustrates new functions for myoglobin
Gayeski, T. E., Connett, R. J., & Honig, C. R. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.6.h914 · Cited by 46 · see citing works
Reaction of Nonsmokers to Carbon Monoxide Inhalation
Chevalier, R. B. (1966) · JAMA · doi:10.1001/jama.1966.03110230077016 · Cited by 44 · see citing works
Rietbrock, N., Kunkel, S. A., W�rner, W., et al. (1992) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00175479 · Cited by 42 · see citing works
Effect of Hypoxia and Carbon Monoxide on Muscle Oxygenation During Exercise
Maehara, K., Riley, M., Galassetti, P. R., Barstow, T. J., & Wasserman, K. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001317 · Cited by 42 · see citing works
Effect of carbon monoxide and peroxyacetyl nitrate on man's maximal aerobic capacity.
Raven, P. B., Drinkwater, B. L., Ruhling, R. O., et al. (1974) · Journal of Applied Physiology · doi:10.1152/jappl.1974.36.3.288 · Cited by 36 · see citing works
Morton, A. R., & Holmik, E. V. (1985) · European Journal of Applied Physiology · doi:10.1007/bf00422852 · Cited by 35 · see citing works
CIGARETTE SMOKING AND CARDIAC OUTPUT
Irving, D. W., & Yamamoto, T. (1963) · Heart · doi:10.1136/hrt.25.1.126 · Cited by 33 · see citing works
Influence of worksite environmental tobacco smoke on serum lipoprotein profiles of female nonsmokers
Moffatt, R. J., Stamford, B. A., & Biggerstaff, K. D. (1995) · Metabolism · doi:10.1016/0026-0495(95)90071-3 · Cited by 31 · see citing works
Self-citationO2 uptake kinetics above and below the lactic acidosis threshold during sinusoidal exercise
Haouzi, P. A., Fukuba, Y., Casaburi, R. H., Stringer, W. W., & Wasserman, K. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.4.1683 · Cited by 30 · see citing works
Smoking increases conversion of lactate to glucose during submaximal exercise
Huie, M. J., Casazza, G. A., Horning, M. A., et al. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.5.1554 · Cited by 27 · see citing works
Wagner, J. A., Horvath, S. M., & Dahms, T. E. (1975) · Respiration Physiology · doi:10.1016/0034-5687(75)90070-5 · Cited by 25 · see citing works
Increased dependence on blood glucose in smokers during rest and sustained exercise
Colberg, S. R., Casazza, G. A., Horning, M. A., et al. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.1.26 · Cited by 25 · see citing works
Effect of the slow-component rise in oxygen uptake on ??VO2max
Sloniger, M. A., Cureton, K. J., Carrasco, D. I., Prior, B. M., Rowe, D. A., & Thompson, R. W. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199601000-00016 · Cited by 24 · see citing works
The Circulatory Response to Cigarette Smoking at Rest and After Exercise
Kerrigan, R., Jain, A. C., & Doyle, J. T. (1968) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196802000-00004 · Cited by 24 · see citing works
The work-rate-dependent effect of carbon monoxide on ventilatory control during exercise
Koike, A., Wasserman, K., Armon, Y., et al. (1991) · Respiration Physiology · doi:10.1016/0034-5687(91)90059-r · Cited by 24 · see citing works
Thermoregulation during Work in Carbon Monoxide Poisoning
Nielsen, B. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1971.tb04946.x · Cited by 24 · see citing works
Acute effects of cigarette smoking on left ventricular function at rest and exercise.
Behr, M. J., Leong, K.-H., & Jones, R. H. (1981) · PubMed · Cited by 22 · see citing works
Maximal aerobic capacity at several ambient concentrations of CO at several altitudes
Horvath, S. M., Bedi, J. F., Wagner, J. A., et al. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.6.2696 · Cited by 18 · see citing works
The influence of cigarette smoking upon the oxygen cost of breathing in near-maximal exercise
Rode, A., & Shephard, R. J. (1971) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-197100320-00001 · Cited by 18 · see citing works
Acute Effect of Cigarette Smoking on Physiologic Response to Graded Exercise
Rotstein, A., & Sagiv, M. S. (1986) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025784 · Cited by 17 · see citing works
Smoking Effect on Exercise Response Kinetics of Oxygen Uptake and Related Variables
Rotstein, A., Sagiv, M. S., Yaniv-Tamir, A., et al. (1991) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024681 · Cited by 17 · see citing works
The effect of nicotine and carbon monoxide on exercise performance in normal subjects
Turner, J. A. M., & McNicol, M. W. (1993) · Respiratory Medicine · doi:10.1016/0954-6111(93)90068-b · Cited by 17 · see citing works
Mechanisms which control VO2 near VO2max: an overview.
Cain, S. M. (1995) · PubMed · Cited by 6 · see citing works
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- Authors
- McDonough, P., & Moffatt, R. J.
- Affiliations
- Florida State University (US)
- Corresponding author
- Moffatt, Robert J.
- Venue
- Sports Medicine
- Published
- 1999
- Volume
- 27
- Issue
- 5
- Pages
- 275-283
- ISSN
- 0112-1642 (ISSN-L)
- OpenAlex
- W1972687098
- Cited by
- 63
- References
- 74
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- smoking, carbon monoxide, exercise tolerance, maximal aerobic capacity, glycolytic metabolism, exercise fatigue, environmental tobacco smoke, cardiovascular risk, physical activity
- MeSH terms
- Hypoxia, Carboxyhemoglobin, Clinical Trials as Topic, Female, Humans, Male, Oxygen Consumption, Reference Values, Smoking, Sports, Exercise Tolerance, Risk Assessment, Muscle Fatigue
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