Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice
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The dorsal hippocampus (DH) and medial prefrontal cortex (mPFC) are brain regions essential for processing and storing episodic memory. In rodents, the DH has a well-established role in supporting the consolidation of episodic-like memory in tasks such as object recognition and object placement. However, the role of the mPFC in the consolidation of episodic-like memory tasks remains controversial. Therefore, the present study examined involvement of the DH and mPFC, alone and in combination, in object and spatial recognition memory consolidation in ovariectomized female mice. To this end, we utilized two types of inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to inactivate the DH alone, the mPFC alone, or both brain regions concurrently immediately after object training to assess the role of each region in the consolidation of object recognition and spatial memories. Our results using single and multiplexed DREADDS suggest that excitatory activity in the DH and mPFC, alone or in combination, is required for the successful consolidation of object recognition and spatial memories. Together, these studies provide critical insight into how the DH and mPFC work in concert to facilitate memory consolidation in female mice.
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Chemogenetic inhibition (KORD), but not hM4Di, of the dorsal hippocampus impaired NOP consolidation tested 24 hours later.
“A recent study showed that chemogenetic inhibition (KORD), but not hM4Di, of the dorsal hippocampus impaired NOP consolidation tested 24 hours later (Tuscher et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Tuscher et al., 2018
The majority of chemogenetic studies showed no influence in the 24 hours-delayed NOP test by overall excitation or inhibition on the dorsal hippocampus, or selectively on the excitatory glutamatergic neurons or inhibitory interneurons in the region.
“The majority of chemogenetic studies, either activated before or after the sample trial, showed no influence in the 24 hours-delayed NOP test by overall excitation or inhibition on the dorsal hippocampus, or selectively on the excitatory glutamatergic neurons or inhibitory interneurons in the region (Lopez et al., 2016; Tuscher et al., 2018; Yu et al., 2018; Zou et al., 2016).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Tuscher et al., 2018
Deficits in OPP memory (4-hour inter-trial interval) were found when the dorsal hippocampus was, either pre- or post-sample, chemogenetic inhibited (M4Di or KORD) in ovariectomized female mice.
“Deficits in OPP memory (4-hour inter-trial interval) were also found when the dorsal hippocampus was, either pre- or post-sample, chemogenetic inhibited (M4Di or KORD) in the ovariectomized female mice (Tuscher et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Tuscher et al., 2018
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- Authors
- Tuscher, J. J., Taxier, L. R., Fortress, A. M., & Frick, K. M.
- Affiliations
- University of Wisconsin–Milwaukee (US)
- Corresponding author
- Frick, Karyn M.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 156
- Pages
- 103-116
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC7310386
- OpenAlex
- W2899938484
- Cited by
- 88
- References
- 88
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 17 · 2021: 17 · 2020: 12 · 2019: 6
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Learning and Memory (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Funders
- University of Wisconsin-Milwaukee College of Letters & Science
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dorsal hippocampus, medial prefrontal cortex, memory consolidation, object recognition memory, spatial memory, episodic memory, chemogenetic inactivation, DREADD
- MeSH terms
- Memory Consolidation, Animals, Behavior, Animal, Female, Genetic Techniques, Hippocampus, Mice, Inbred C57BL, Prefrontal Cortex, Recognition, Psychology, Mice, Memory, Episodic, Spatial Memory
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