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Cited by 108Sleep and related disordersCircadian rhythm and melatoninTreatment of Major Depression

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Antidepressants for the Treatment of Insomnia: A Suitable Approach?

Wiegand, Michael H·2008·Drugs
DOI 10.2165/0003495-200868170-00001
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Abstract

The popularity of antidepressants in the treatment of insomnia is not supported by a large amount of convincing data, but rather by opinions and beliefs of the prescribing physicians on the advantages of these agents compared with drugs acting on the benzodiazepine receptor or other drugs used for the treatment of insomnia. The existing data do not allow for clear-cut, evidence-based recommendations concerning the use of antidepressants in insomnia. Our conclusions result from a few short-term studies on single agents, clinical experience and inferences from knowledge on the effect of antidepressants in other indications. At present, prescribing antidepressants for short-term treatment of insomnia can be useful if there is some amount of concomitant depressive symptomology or a history of depression, raising the impression that the present insomnia may be a prodromal sign for a new depressive episode. In all other cases, benzodiazepine receptor agonists, especially the nonbenzodiazepines among them (the so-called 'z drugs') should be the drugs of choice. For long-term treatment, antidepressants are among the pharmacological options, in addition to other groups of psychotropics. Off-label use of antidepressants may be considered for chronic insomnia if there is a concomitant depressive symptomalogy (which is not so pronounced that an antidepressant treatment with adequate higher doses would be required) and if there is no specific indication for one of the other groups of psyc…

Overview

Integrity signals

Registry

Crossref · 10.2165/0003495-200868170-00001

Cites

7 of 7 references verified0 citation errors · 0 not checkable

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Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Trazodone is very often used as a sleep-promoting drug.

    “This is especially true for trazodone that is very often used as a sleep-promoting drug [3, 39 -42].”

    From Effects of Antidepressants on Sleep (2017) · cites this paper as [41]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 18

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Metadata

Authors
Wiegand, M. H.
Affiliations
Technical University of Munich (DE)
Corresponding author
Wiegand, Michael H
Venue
Drugs
Publisher
Springer Science and Business Media LLC
Published
2008
Volume
68
Issue
17
Pages
2411-2417
ISSN
0012-6667 (ISSN-L)
DOI
10.2165/0003495-200868170-00001
OpenAlex
W173454967
Cited by
108
References
7
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 15 · 2013: 5 · 2012: 13
FWCI
7.49
Type
journal article
Language
en
Open access
closed
Locations
  • Drugs (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
antidepressants, insomnia, chronic insomnia, off-label drug use, benzodiazepine receptor agonists, Z-drugs, depressive symptoms, doxepin, mirtazapine, trazodone, trimipramine, serotonin reuptake inhibitors, antihistamines, cholinergic activity, sedatives
MeSH terms
Antidepressive Agents, Depression, Feasibility Studies, Humans, Sleep Initiation and Maintenance Disorders

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