Candidaemia in Patients with an Inserted Medical Device
Abstract
The importance of medical devices as a source of infection has been increasingly appreciated. Candida spp. are responsible for a significantly increasing number of device-related infections, particularly those involving the bloodstream and urinary tract. A wide range of devices may be colonized by Candida spp., including central venous catheters, cardiac devices, and knee and hip prostheses. Medical device infections invariably require antifungal therapy and, in many cases, device removal, with associated hazards to some patients. Currently recommended treatments include amphotericin B formulations, azoles and echinocandins. The echinocandins, with efficacy against Candida biofilms, may have a role in the future in improved lock therapy for the treatment of device-associated candidal infections.
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Urinary and central venous catheters, pacemakers, mechanical heart valves, joint prostheses, contact lenses, and dentures are all susceptible to C. albicans biofilms.
“Urinary and central venous catheters, pacemakers, mechanical heart valves, joint prostheses, contact lenses, and dentures are all susceptible to C. albicans biofilms (22, 45, 90, 175).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [22]
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- Authors
- Cauda, R.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Cauda, Roberto
- ORCID
- Cauda, Roberto
- Venue
- Drugs
- Published
- 2009-11
- Volume
- 69
- Issue
- Supplement 1
- Pages
- 33-38
- ISSN
- 0012-6667 (ISSN-L)
- OpenAlex
- W2066615848
- Cited by
- 48
- References
- 21
- Citations by year
- 2023: 2 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 2
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drugs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Infectious Diseases Society of America
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
- Keywords
- candidemia, Candida, medical device-related infections, central venous catheters, cardiac devices, periprosthetic joint infection, antifungal therapy, echinocandins, amphotericin B, azoles, Candida biofilms, catheter lock therapy, device removal
- MeSH terms
- Antifungal Agents, Candidiasis, Catheterization, Central Venous, Equipment and Supplies, Humans, Urinary Tract Infections, Fungemia, Prostheses and Implants
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