Achieving Remission as a Routine Goal of Pharmacotherapy in Attention-Deficit Hyperactivity Disorder
Abstract
Remission should be the goal of attention-deficit hyperactivity disorder (ADHD) treatment. However, there is no universally accepted definition of remission in ADHD, although clinical studies use a number of criteria. This article examines current research into the concept of remission in ADHD by reviewing the literature for definition and achievement of remission in children and adults with ADHD. Results demonstrate that the concept of remission in ADHD has been proposed by several study groups, using thresholds of validated rating scales to indicate syndromic, symptomatic and functional remission. Several studies have demonstrated the achievement of remission in ADHD children utilizing methylphenidate delivered by an osmotic, controlled-release formulation (OROS®) and atomoxetine. However, none has defined a time period over which these criteria must be met for an individual with ADHD to be considered 'in remission'. Standardized remission criteria in ADHD will provide a tool for assessing the effectiveness of treatments for ADHD, and raise treatment standards.
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LDX treatment might result in improvements in multiple functional areas affected by ADHD, and researchers and clinicians have available tools to monitor such improvements.
“Overall, these findings suggest that LDX treatment might result in improvements in multiple functional areas affected by ADHD, and that researchers as well as clinicians have available tools and resources to monitor such improvements [41].”
Cites
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
FARAONE, S. V., BIEDERMAN, J., & MICK, E. (2006) · Psychological Medicine · doi:10.1017/s003329170500471x · Cited by 2,267 · see citing works
Frank, E. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810330075011 · Cited by 1,959 · see citing works
Assessment of social adjustment by patient self report.
Weissman, M. M. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770090101010 · Cited by 1,782 · see citing works
Biederman, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.816 · Cited by 1,498 · see citing works
Hyperactive Boys Almost Grown Up: I. Psychiatric Status
Gittelman, R. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790330017002 · Cited by 977 · see citing works
Kessler, R. C., Adler, L. A., Barkley, R., Biederman, J., Conners, C. K., Faraone, S. V., Greenhill, L. L., Jaeger, S., Secnik, K., Spencer, T., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.001 · Cited by 663 · see citing works
Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis
Faraone, S. V., & Buitelaar, J. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0054-3 · Cited by 485 · see citing works
Kelsey, D. K., Sumner, C. R., Casat, C. D., Coury, D. L., Quintana, H., Saylor, K. E., Sutton, V. K., Gonzales, J., Malcolm, S. K., Schuh, K. J., et al. (2004) · Pediatrics · doi:10.1542/peds.114.1.e1 · Cited by 464 · see citing works
Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.043 · Cited by 385 · see citing works
Pelham, W. E., Gnagy, E. M., Burrows-Maclean, L., Williams, A., Fabiano, G. A., Morrisey, S. M., Chronis, A. M., Forehand, G. L., Nguyen, C. A., Hoffman, M. T., et al. (2001) · Pediatrics · doi:10.1542/peds.107.6.e105 · Cited by 378 · see citing works
Spencer, T., Heiligenstein, J. H., Biederman, J., Faries, D. E., Kratochvil, C. J., Conners, C. K., & Potter, W. Z. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1209 · Cited by 333 · see citing works
Injuries to children with attention deficit hyperactivity disorder
DiScala, C., Lescohier, I., Barthel, M., & Li, G. (1998) · PEDIATRICS · doi:10.1542/peds.102.6.1415 · Cited by 305 · see citing works
Cardiovascular Effects of Atomoxetine in Children, Adolescents, and Adults
Wernicke, J. F., Faries, D., Girod, D., Brown, J. W., Gao, H., Kelsey, D., Quintana, H., Lipetz, R., Michelson, D., & Heiligenstein, J. (2003) · Drug Safety · doi:10.2165/00002018-200326100-00006 · Cited by 191 · see citing works
Biederman, J., Petty, C. R., Fried, R., Doyle, A. E., Spencer, T., Seidman, L. J., Gross, L., Poetzl, K., & Faraone, S. V. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01008.x · Cited by 159 · see citing works
Slowing of growth in height and weight on stimulants: A characteristic pattern
Poulton, A., & Cowell, C. (2003) · Journal of Paediatrics and Child Health · doi:10.1046/j.1440-1754.2003.00107.x · Cited by 132 · see citing works
Hepatic Events Associated with Atomoxetine Treatment for??Attention-Deficit??Hyperactivity Disorder
Bangs, M. E., Jin, L., Zhang, S., Desaiah, D., Allen, A. J., Read, H. A., Regev, A., & Wernicke, J. F. (2008) · Drug Safety · doi:10.2165/00002018-200831040-00008 · Cited by 68 · see citing works
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Fredriksen, M., Halmøy, A., Faraone, S. V., & Haavik, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.016 · Cited by 173 · see citing works
Janssen, L., Kan, C. C., Carpentier, P. J., Sizoo, B., Hepark, S., Schellekens, M. P. J., Donders, A. R. T., Buitelaar, J. K., & Speckens, A. E. M. (2019) · Psychological Medicine · doi:10.1017/s0033291718000429 · Cited by 78 · see citing works
Cunill, R., Castells, X., Tobias, A., & Capellà, D. (2013) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3473 · Cited by 70 · see citing works
Adler, L. A., Dirks, B., Deas, P., Raychaudhuri, A., Dauphin, M., Saylor, K., & Weisler, R. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-253 · Cited by 45 · see citing works
Toward Quality Care in ADHD: Defining the Goals of Treatment
Rostain, A., Jensen, P. S., Connor, D. F., Miesle, L. M., & Faraone, S. V. (2015) · Journal of Attention Disorders · doi:10.1177/1087054712473835 · Cited by 33 · see citing works
- Authors
- Ramos-Quiroga, J. A., & Casas, M.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- ORCID
- Casas, Miguel
- Venue
- CNS Drugs
- Published
- 2011-01
- Volume
- 25
- Issue
- 1
- Pages
- 17-36
- ISSN
- 1172-7047 (ISSN-L)
- OpenAlex
- W2048875335
- Cited by
- 33
- References
- 17
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 1 · 2018: 2 · 2015: 4 · 2014: 7 · 2013: 10 · 2012: 7
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Drugs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- attention deficit hyperactivity disorder, remission, remission criteria, pharmacotherapy, methylphenidate, atomoxetine, OROS methylphenidate, children, adults, rating scales, treatment effectiveness
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Child, Humans, Remission Induction, Treatment Outcome
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