A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
Abstract
Background The few controlled studies of methylphenidate (MPH) in adults with attention deficit/hyperactivity disorder (ADHD) have reported equivocal results. A previous, pilot study by our group suggested that these results were due to inadequate dosing. Method We conducted a randomized, 6-week, placebo-controlled, parallel study of MPH in 146 adult patients with DSM-IV ADHD using standardized instruments for diagnosis, separate assessments of ADHD, depressive and anxiety symptoms, and a robust average oral daily dose of 1.1 mg/kg/day. Results We found a marked therapeutic response for the MPH treatment of ADHD symptoms that exceeded the placebo response (76% vs. 19%). Treatment was safe and well tolerated. Response to MPH was independent of socioeconomic status, gender, and lifetime history of psychiatric comorbidity. Conclusions These results confirm that robust doses of MPH are effective in the treatment of adult ADHD.
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Stimulants are effective in about 70% of patients with ADHD in controlled studies, depending on the study design and maximum drug dosage.
“Stimulants are effective in about 70% of patients with ADHD in controlled studies [265-267] depending on the study design and maximum drug dosage.”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [267]
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Self-citation
- Authors
- Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S.
- Affiliations
- Harvard University (US)
- Corresponding author
- Spencer, Thomas
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 57
- Issue
- 5
- Pages
- 456-463
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2053924394
- Cited by
- 385
- References
- 60
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 15 · 2016: 12 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 25
- FWCI
- 21.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R29MH57511, R29MH057511)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- methylphenidate, adult ADHD, ADHD medication, placebo response, dose-response relationship, depressive symptoms, anxiety symptoms, psychiatric comorbidity, treatment safety
- MeSH terms
- Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Demography, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Methylphenidate, Middle Aged, Neuropsychological Tests, Placebos, Psychiatric Status Rating Scales, Treatment Outcome
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