Cited by 385Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder

Spencer, Thomas, Biederman, Joseph, Wilens, Timothy, Doyle, Robert, Surman, Craig, Prince, Jefferson, Mick, Eric, Aleardi, Megan +2 more·2005·Biological Psychiatry

Abstract

Background The few controlled studies of methylphenidate (MPH) in adults with attention deficit/hyperactivity disorder (ADHD) have reported equivocal results. A previous, pilot study by our group suggested that these results were due to inadequate dosing. Method We conducted a randomized, 6-week, placebo-controlled, parallel study of MPH in 146 adult patients with DSM-IV ADHD using standardized instruments for diagnosis, separate assessments of ADHD, depressive and anxiety symptoms, and a robust average oral daily dose of 1.1 mg/kg/day. Results We found a marked therapeutic response for the MPH treatment of ADHD symptoms that exceeded the placebo response (76% vs. 19%). Treatment was safe and well tolerated. Response to MPH was independent of socioeconomic status, gender, and lifetime history of psychiatric comorbidity. Conclusions These results confirm that robust doses of MPH are effective in the treatment of adult ADHD.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2004.11.043

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S.
Affiliations
Harvard University (US)
Corresponding author
Spencer, Thomas
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-03
Volume
57
Issue
5
Pages
456-463
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2053924394
Cited by
385
References
60
Citations by year
2026: 6 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 15 · 2016: 12 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 25
FWCI
21.35
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R29MH57511, R29MH057511)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
methylphenidate, adult ADHD, ADHD medication, placebo response, dose-response relationship, depressive symptoms, anxiety symptoms, psychiatric comorbidity, treatment safety
MeSH terms
Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Demography, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Methylphenidate, Middle Aged, Neuropsychological Tests, Placebos, Psychiatric Status Rating Scales, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review