A low fT3 level as a prognostic marker in patients with acute myocardial infarctions
Open accessAbstract
OBJECTIVE: To investigate the association between low free triiodothyronine (fT3) levels and the severity and prognosis of patients with acute myocardial infarction. METHODS: A total of 501 patients with acute myocardial infarctions were enrolled in our study. The circulating levels of thyroid hormones and clinical parameters were assayed. The patients were categorized into either the low fT3 group or the normal fT3 group according to the fT3 level on admission. All patients underwent a follow-up for 10±2 months for mortality from any cause and the occurrence of any adverse major cardiac events (MACE). RESULTS: There were 171 patients in the low fT3 group (fT3<3.5 pmol/L) and 330 patients in the normal fT3 group (≥3.5 pmol/L). During the follow-up period, 33 patients died (6.6%) and the overall survival rates were 86.0% and 97.3% in patients with a low fT3 level and a normal fT3 level, respectively. The rates of MACE were 66.7% and 45.5% in the patients with and those without low fT3 levels, respectively. Using a multivariable Cox proportional hazards model, the fT3 level was found to be the most important predictor of cumulative death and MACE (hazard ratio [HR] for death: 0.142, p<0.001 and HR for major adverse cardiac events: 0.748, p=0.007). A Kaplan-Meier analysis revealed that those patients with low fT3 levels had higher rates of MACE and death. CONCLUSION: A low fT3 level, a common phenomenon in patients with acute myocardial infarctions, is a strong predictor of short-term and long-term poor prognoses in patients with acute myocardial infarctions.
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Free T3 was the most important predictor of subsequent cardiac events.
“FT 3 was the most important predictor of subsequent cardiac events (119).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [119]
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Thyroid hormones and cardiovascular disease
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Thyroid Hormones and Cardiovascular Function and Diseases
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- Authors
- Zhang, B., Peng, W., Wang, C., Li, W., & Xu, Y.
- Affiliations
- Tongji University (CN)
- Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China
- Venue
- Internal Medicine
- Published
- 2012
- Volume
- 51
- Issue
- 21
- Pages
- 3009-3015
- ISSN
- 0918-2918 (ISSN-L)
- 1349-7235
- OpenAlex
- W1972669138
- Cited by
- 59
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 3
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30900520, 81070107)
- Shanghai Rising-Star Program (10QA1405500)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- free triiodothyronine, acute myocardial infarction, prognostic factors, thyroid hormones, major adverse cardiac events, mortality, overall survival, thyroid dysfunction
- MeSH terms
- Aged, Aged, 80 and over, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Myocardial Infarction, Peptide Fragments, Prognosis, Triiodothyronine, Biomarkers, Ventricular Function, Left, Natriuretic Peptide, Brain, Troponin T, Kaplan-Meier Estimate
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