Cited by 129Antioxidant Activity and Oxidative StressRedox biology and oxidative stressNitric Oxide and Endothelin Effects

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Potential Therapeutic Effect of Antioxidant Therapy in Shock and Inflammation

Cuzzocrea, Salvatore, Thiemermann, Christoph, Salvemini, Daniela·2004·Current Medicinal Chemistry

DOI 10.2174/0929867043365396

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Abstract

Oxidative stress results from an oxidant/antioxidant imbalance, an excess of oxidants and/or a depletion of antioxidants. A considerable body of recent evidence suggests that oxidant stress plays a major role in several aspects of acute and chronic inflammation and is the subject of this review. Immunohistochemical and biochemical evidence demonstrate the significant role of reactive oxygen species (ROS) in acute and chronic inflammation. Initiation of lipid peroxidation, direct inhibition of mitochondrial respiratory chain enzymes, inactivation of glyceraldehyde-3-phosphate dehydrogenase, inhibition of membrane Na+/K+ ATP-ase activity, inactivation of membrane sodium channels, and other oxidative protein modifications contribute to the cytotoxic effect of ROS. All these toxicities are likely to play a role in the pathophysiology of shock, inflammation and ischemia and reperfusion. (2) Treatment with either peroxynitrite decomposition catalysts, which selectively inhibit peroxynitrite, or with SODm's, which selectively mimic the catalytic activity of the human superoxide dismutase (SOD) enzymes, have been shown to prevent in vivo the delayed tissue injury and the cellular energetic failure associated with inflammation. ROS (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly (ADP ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Antioxidant treatment inhibits the activation of PARS, and prevents the organ injury associated with acute and chronic inflammation.

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Authors: Cuzzocrea, S., Thiemermann, C., & Salvemini, D.
Affiliations: University of Messina (IT)
ORCID: Cuzzocrea, Salvatore
Thiemermann, Christoph
Salvemini, Daniela
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2004-05-01
Volume: 11
Issue: 9
Pages: 1147-1162
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/0929867043365396
OpenAlex: W2330570895
Cited by: 129
References: 0
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 4
FWCI: 7.70
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: antioxidant therapy, oxidative stress, reactive oxygen species, shock, inflammation, ischemia-reperfusion injury, lipid peroxidation, mitochondrial respiratory chain, superoxide dismutase mimetic, peroxynitrite decomposition, poly(ADP-ribose) polymerase, single-strand breaks, necrosis
MeSH terms: Poly(ADP-ribose) Polymerase Inhibitors, Animals, Antioxidants, Glutathione, Humans, Inflammation, Melatonin, Shock, Structure-Activity Relationship, Superoxide Dismutase, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress, Reactive Nitrogen Species, Peroxynitrous Acid

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Potential Therapeutic Effect of Antioxidant Therapy in Shock and Inflammation

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