Protective effects of 20‐hydroxyecdysone on CoCl2‐induced cell injury in PC12 cells

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Untitled work

(2001) · PubMed · Cited by 2,381 · see citing works

Mechanisms of Caspase Activation and Inhibition during Apoptosis

Shi, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00482-3 · Cited by 1,824 · see citing works

Mechanisms of caspase activation

Boatright, K. M., & Salvesen, G. S. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.009 · Cited by 1,374 · see citing works

Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury

Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01484-4 · Cited by 1,087 · see citing works

Substrate Specificities of Caspase Family Proteases

Talanian, R. V., Quinlan, C., Trautz, S., Hackett, M. C., Mankovich, J. A., Banach, D. L., Ghayur, T., Brady, K. D., & Wong, W. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9677 · Cited by 879 · see citing works

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

Korsmeyer, S. J., Shutter, J. R., Novack, D. V., Merry, D. E., & Oltvai, Z. N. (1993) · PubMed · Cited by 865 · see citing works

Mitochondrial control of apoptosis: the role of cytochrome c.

Cai, J.-Y., Yang, J., & Jones, D. P. (1998) · Biochimica et Biophysica Acta · doi:10.1016/s0005-2728(98)00109-1 · Cited by 777 · see citing works

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

Borner, C. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00252-3 · Cited by 700 · see citing works

Oxidative Stress in Brain Ischemia

Love, S. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00214.x · Cited by 684 · see citing works

Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress

Floyd, R. A., & Carney, J. M. (1992) · Annals of Neurology · doi:10.1002/ana.410320706 · Cited by 541 · see citing works

Cell death regulation by the Bcl‐2 protein family in the mitochondria

Tsujimoto, Y. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10254 · Cited by 497 · see citing works

Regulation of apoptosis by Bcl‐2 family proteins

Burlacu, A. (2003) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2003.tb00225.x · Cited by 469 · see citing works

Multiple pathways of cytochrome c release from mitochondria in apoptosis

Gogvadze, V. G., Orrenius, S., & Zhivotovsky, B. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.016 · Cited by 466 · see citing works

Reactive Oxygen Species in Mitochondria-Mediated Cell Death

Orrenius, S. (2007) · Drug metabolism reviews (Softcover ed.) · doi:10.1080/03602530701468516 · Cited by 455 · see citing works

Potential markers of oxidative stress in stroke

Cherubini, A., Ruggiero, C., Polidori, M. C., & Mecocci, P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.025 · Cited by 427 · see citing works

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

Yang, J. C., & Cortopassi, G. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00367-5 · Cited by 219 · see citing works

Practical uses for ecdysteroids in mammals including humans: and update

Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1093/jis/3.1.7 · Cited by 196 · see citing works

Practical uses for ecdysteroids in mammals including humans: And update

Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1673/031.003.0701 · Cited by 196 · see citing works

Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP‐1 activation

Zou, W., Yan, M., Xu, W., Huo, H., Sun, L., Zheng, Z., & Liu, X. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1118 · Cited by 185 · see citing works

Molecules in focus Bax. The pro-apoptotic Bcl-2 family member, Bax

Brady, H. J. M., & Gil‐Gómez, G. (1998) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00006-5 · Cited by 178 · see citing works

Acteoside protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell injury

Wang, H., Xu, Y., Yan, J., Zhao, X., Sun, X., Zhang, Y., Guo, J., & Zhu, C. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.101 · Cited by 173 · see citing works

Bcl-2: an antidote to programmed cell death.

Korsmeyer, S. (1992) · PubMed · Cited by 153 · see citing works

Potential Therapeutic Effect of Antioxidant Therapy in Shock and Inflammation

Cuzzocrea, S., Thiemermann, C., & Salvemini, D. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365396 · Cited by 129 · see citing works

Phytoecdysteroids - From Isolation to Their Effects on Humans

Báthori, M., & Pongrácz, Z. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053363450 · Cited by 111 · see citing works

Evidence for Activation of Caspase‐3‐Like Protease in Excitotoxin‐ and Hypoxia/Hypoglycemia‐Injured Neurons

Nath, R., Probert, A. W., McGinnis, K., et al. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010186.x · Cited by 97 · see citing works

Untitled work

(2013) · European Journal of Entomology · Cited by 72 · see citing works

Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism

Sai, Y., Wu, Q., Le, W., et al. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.04.019 · Cited by 71 · see citing works

Inhibition by epigallocatechin gallate of CoCl2-induced apoptosis in rat PC12 cells

Jung, J., Mo, H.-C., Yang, K.-H., Jeong, Y.-J., Yoo, H. G., Choi, N., Oh, W., Oh, H.-K., Kim, S.-H., Lee, J. H., et al. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.033 · Cited by 67 · see citing works

Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome

Alexandrova, M. L., Bochev, P. G., Markova, V. I., et al. (2004) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2003.10.015 · Cited by 64 · see citing works

Hydrogen sulphide protects H9c2 cells against chemical hypoxia‐induced injury

Chen, S., Yang, C., Yang, Z., et al. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05289.x · Cited by 53 · see citing works

Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO

Oehme, I., Bösser, S., & Zörnig, M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401730 · Cited by 48 · see citing works

Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells

Wu, Y., Shang, Y., Sun, S., & Liu, R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.020 · Cited by 46 · see citing works

Estradiol protects PC12 cells against CoCl2-induced apoptosis

Jung, J. Y., Roh, K. H., Jeong, Y. J., Kim, S. H., Lee, E. J., Kim, M. S., Oh, W. M., Oh, H. K., & Kim, W. J. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.04.006 · Cited by 44 · see citing works

Ischemia/Reperfusion-induced oxidative stress causes structural changes of brain membrane proteins and lipids.

Murín, R., Drgova, A., Kaplán, P., et al. (2001) · PubMed · Cited by 44 · see citing works

Antioxidative and free radical scavenging effects of ecdysteroids from<i>Serratula strangulata</i>

Cai, Y.-J., Dai, J.-Q., Fang, J.-G., Ma, L.-P., Hou, L.-F., Yang, L., & Liu, Z.-L. (2002) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y02-152 · Cited by 43 · see citing works

Effects of vitamin D3 and ecdysterone on free-radical lipid peroxidation.

Kuzmenko, A. I., Morozova, R. P., Nikolenko, I. A., Gv, K., & YuD, K. (1997) · PubMed · Cited by 36 · see citing works

20‐hydroxyecdysone prevents oxidative stress damage in adultPyrrhocoris apterus

Krishnan, N., Večeřa, J., Kodrı́k, D., & Sehnal, F. (2007) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20182 · Cited by 35 · see citing works

Ginkgolides protect PC12 cells against hypoxia‐induced injury by p42/p44 MAPK pathway‐dependent upregulation of HIF‐1α expression and HIF‐1DNA‐binding activity

Zhu, L., Ke, Y., Wu, X., Yang, L., Yang, L., & Ming, Q. Z. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21427 · Cited by 35 · see citing works

The critical role of caspases activation in hypoxia/reoxygenation induced apoptosis

Ho, F. Y., Tsang, W. P., Kong, S. K., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.178 · Cited by 32 · see citing works

Ecdysteroid activity during metamorphosis and in male and female adults of four blowfly species

Briers, T. W., van Beek, E., & LOOF, A. D. (1983) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(83)90541-8 · Cited by 31 · see citing works

All‐trans retinoic acid inhibits cobalt chloride‐induced apoptosis in PC12 cells: Role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway

Wang, S., Hu, C., Jiang, D., Peng, J., Zhou, Z., Yuan, Q., Nie, S., Jiang, J., Li, Y., & Huang, K. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21999 · Cited by 24 · see citing works

Role of nitroso radicals as drug targets in circulatory shock

Esposito, E., & Cuzzocrea, S. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00255.x · Cited by 22 · see citing works

Pharmacological studies of insect metamorphosing steroids from Achyranthis radix

Matsuda (1970) · Folia Pharmacologica Japonica · doi:10.1254/fpj.66.551 · Cited by 19 · see citing works

The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage<i>in vitro</i>and<i>in vivo</i>

Tang, W.-H., Chen, Z., Liu, Z., Zhang, J. H., Xi, G., & Feng, H. (2008) · Neurological Research · doi:10.1179/174313208x297986 · Cited by 15 · see citing works

Bcl-2/Bax ratio, mitochondrial membranes and aerobic enzyme activity in cardiomyocytes of rats after submaximal training.

Delchev, S., Georgieva, K. N., Koeva, Y. A., et al. (2006) · PubMed · Cited by 14 · see citing works

[Antioxidant effect of 20-hydroxyecdysone in a model system].

Kuz'menko, A. I., Rp, M., Nikolenko, I. A., & Gv, D. (1999) · PubMed · Cited by 8 · see citing works

Ecdysterone attenuates vasospasm following experimental subarachnoid haemorrhage in rabbits

Liu, Z., Zhu, G., Zhang, J. H., Chen, Z., Tang, W. H., Wang, X. R., & Hua, F. (2008) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-75718-5_61 · Cited by 3 · see citing works

Nutritional and Health Benefits of Quinoa (Chenopodium quinoa Willd.)

Navruz-Varli, S., & Sanlier, N. (2016) · Journal of Cereal Science · doi:10.1016/j.jcs.2016.05.004 · Cited by 380 · see citing works

Ecdysteroids: Production in plant in vitro cultures

Thiem, B., Kikowska, M., Maliński, M. P., Kruszka, D., Napierała, M., & Florek, E. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-016-9483-z · Cited by 77 · see citing works

20-Hydroxyecdysone Protects against Oxidative Stress-Induced Neuronal Injury by Scavenging Free Radicals and Modulating NF-κB and JNK Pathways

Hu, J., Luo, C. X., Chu, W. H., Shan, Y. A., Qian, Z.-M., Zhu, G., Yu, Y. B., & Feng, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050764 · Cited by 67 · see citing works

The insect molting hormone 20-hydroxyecdysone protects dopaminergic neurons against MPTP-induced neurotoxicity in a mouse model of Parkinson’s disease

Lim, H.-S., Moon, B. C., Lee, J., Choi, G., & Park, G. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.010 · Cited by 30 · see citing works

Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound?

Zádor, E. (2025) · Cells · doi:10.3390/cells14060431 · Cited by 9 · see citing works

Effects of 20-hydroxyecdysone on UVB-induced photoaging in hairless mice

Lim, H.-S., Yoon, K., Lee, D. H., Lee, Y.-S., Chung, J. H., & Park, G. (2023) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2023.114899 · Cited by 8 · see citing works

Up‐Regulation of an Adult Cuticular Gene by 20‐Hydroxyecdysone in Insect Metamorphosing Epidermis Cultured in vitro

Braquart, C., Bouhin, H., Quennedey, A., et al. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0336h.x · Cited by 35 · see citing works

Distribution and Biosynthesis of 20-Hydroxyecdysone in Plants ofAchyranthes japonicaNakai

Boo, K.-H., Lee, D., Jeon, G. L., Ko, S. H., Cho, S. K., Kim, J. H., Park, S., Hong, Q. C., Lee, S., Lee, D., et al. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100410 · Cited by 21 · see citing works

Uptake and metabolism of ecdysone and 20-hydroxyecdysone in a lepidopteran cell line derived from wing discs of Plodia interpunctella

Sommé‐Martin, G., Lafont, R., Colardeau, J., et al. (1992) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(92)90151-4 · Cited by 4 · see citing works

Stereoselective synthesis and moulting activity of 2,3-diepi-20-hydroxyecdysone and 2,3-diepi-5α-20-hydroxyecdysone

Homvisasevongsa, S., Chuaynugul, A., Chimnoi, N., et al. (2004) · Tetrahedron · doi:10.1016/j.tet.2004.02.042 · Cited by 10 · see citing works

Effects of cold-exposure and subsequent recovery on cellular proliferation with influence of 20-hydroxyecdysone in a lepidopteran cell line (IAL-PID2)

Lalouette, L., Renault, D., Ravaux, J., et al. (2010) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.12.013 · Cited by 6 · see citing works