Cited by 129Neurogenesis and neuroplasticity mechanismsNerve injury and regenerationNeuroinflammation and Neurodegeneration Mechanisms

Potential Therapeutic Effects of Exercise to the Brain

Ang, E., Gomez-Pinilla, F., Ang, E., Gomez-Pinilla, F.·2007·Current Medicinal Chemistry

Abstract

Exercise is a well-recognized facet of modern living; however, the threat of sedentary lifestyle is ever increasing with the arrival of the technological period. Although the beneficial effects of exercise to the health and function of the brain have been accepted by the scientific and medical community, much remains to be achieved to understand its mechanisms of action. With the advent of modern investigative tools, several more key molecular and cellular players have been implicated in the above process. Such include the family of neurotrophins (e.g. NGF and BDNF) and their receptors, some pro-inflammatory cytokines (L-1beta, IL-6, TNF-alpha, IFN-gamma), microglia and astrocytes, and the cholinergic neuronal cells in the forebrain. While experiments based on the voluntary exercise paradigm has been the preferred approach to studying the brain, less is known about the forced paradigm. We will discuss in this review how molecular players may feature differently in the context of exercise and more importantly how their actions converged to impact the structure, and function (learning and memory) of the CNS.

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Crossref · 10.2174/092986707782023280

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  • Treadmill exercise improves hippocampus-dependent spatial learning and memory as well as aversive memory.

    “Treadmill exercise also improves hippocampus-dependent spatial learning and memory as well as aversive memory [2, 3, 25, 97, 112, 174, 186, 187].”

    From The neuropathology of sport (2014) · cites this paper as [3]

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Authors
Ang, E., Gomez-Pinilla, F., Ang, E., & Gomez-Pinilla, F.
Venue
Current Medicinal Chemistry
Published
2007-10-01
Volume
14
Issue
24
Pages
2564-2571
ISSN
0929-8673 (ISSN-L)
OpenAlex
W2134225473
Cited by
129
References
1
Citations by year
2025: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 13 · 2012: 9
FWCI
3.07
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
physical activity, brain, neurotrophins, brain-derived neurotrophic factor, nerve growth factor, inflammatory cytokines, microglia, astrocytes, cholinergic neurons, voluntary exercise, forced exercise, learning and memory, sedentary lifestyle, neuroplasticity
MeSH terms
Animals, Brain, Disease, Humans, Physical Conditioning, Animal, Exercise

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