Cited by 129Neurogenesis and neuroplasticity mechanismsNerve injury and regenerationNeuroinflammation and Neurodegeneration Mechanisms

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Potential Therapeutic Effects of Exercise to the Brain

Ang, E., Gomez-Pinilla, F., Ang, E., Gomez-Pinilla, F.·2007·Current Medicinal Chemistry

DOI 10.2174/092986707782023280

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Abstract

Exercise is a well-recognized facet of modern living; however, the threat of sedentary lifestyle is ever increasing with the arrival of the technological period. Although the beneficial effects of exercise to the health and function of the brain have been accepted by the scientific and medical community, much remains to be achieved to understand its mechanisms of action. With the advent of modern investigative tools, several more key molecular and cellular players have been implicated in the above process. Such include the family of neurotrophins (e.g. NGF and BDNF) and their receptors, some pro-inflammatory cytokines (L-1beta, IL-6, TNF-alpha, IFN-gamma), microglia and astrocytes, and the cholinergic neuronal cells in the forebrain. While experiments based on the voluntary exercise paradigm has been the preferred approach to studying the brain, less is known about the forced paradigm. We will discuss in this review how molecular players may feature differently in the context of exercise and more importantly how their actions converged to impact the structure, and function (learning and memory) of the CNS.

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Exercise and Brain
MEEUSEN, R. R. (2003) · VUBIR (Vrije Universiteit Brussel) · Cited by 28

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Authors: Ang, E., Gomez-Pinilla, F., Ang, E., & Gomez-Pinilla, F.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2007-10-01
Volume: 14
Issue: 24
Pages: 2564-2571
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/092986707782023280
OpenAlex: W2134225473
Cited by: 129
References: 1
Citations by year: 2025: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 13 · 2012: 9
FWCI: 3.07
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: physical activity, brain, neurotrophins, brain-derived neurotrophic factor, nerve growth factor, inflammatory cytokines, microglia, astrocytes, cholinergic neurons, voluntary exercise, forced exercise, learning and memory, sedentary lifestyle, neuroplasticity
MeSH terms: Animals, Brain, Disease, Humans, Physical Conditioning, Animal, Exercise

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Potential Therapeutic Effects of Exercise to the Brain

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