The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Potential Therapeutic Effects of Exercise to the Brain
Abstract
Exercise is a well-recognized facet of modern living; however, the threat of sedentary lifestyle is ever increasing with the arrival of the technological period. Although the beneficial effects of exercise to the health and function of the brain have been accepted by the scientific and medical community, much remains to be achieved to understand its mechanisms of action. With the advent of modern investigative tools, several more key molecular and cellular players have been implicated in the above process. Such include the family of neurotrophins (e.g. NGF and BDNF) and their receptors, some pro-inflammatory cytokines (L-1beta, IL-6, TNF-alpha, IFN-gamma), microglia and astrocytes, and the cholinergic neuronal cells in the forebrain. While experiments based on the voluntary exercise paradigm has been the preferred approach to studying the brain, less is known about the forced paradigm. We will discuss in this review how molecular players may feature differently in the context of exercise and more importantly how their actions converged to impact the structure, and function (learning and memory) of the CNS.
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“Treadmill exercise also improves hippocampus-dependent spatial learning and memory as well as aversive memory [2, 3, 25, 97, 112, 174, 186, 187].”
From The neuropathology of sport (2014) · cites this paper as [3]
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MEEUSEN, R. R. (2003) · VUBIR (Vrije Universiteit Brussel) · Cited by 28
Cited by
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Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499
Williams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448
Garland, T., Schutz, H., Chappell, M. A., Keeney, B. K., Meek, T. H., Copes, L. E., Acosta, W., Drenowatz, C., Maciel, R. C., van Dijk, G., et al. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048397 · Cited by 444
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422
Forced and voluntary exercise differentially affect brain and behavior
Leasure, J. L., & Jones, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.041 · Cited by 335
Metadata
- Authors
- Ang, E., Gomez-Pinilla, F., Ang, E., & Gomez-Pinilla, F.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2007-10-01
- Volume
- 14
- Issue
- 24
- Pages
- 2564-2571
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2134225473
- Cited by
- 129
- References
- 1
- Citations by year
- 2025: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 13 · 2012: 9
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- physical activity, brain, neurotrophins, brain-derived neurotrophic factor, nerve growth factor, inflammatory cytokines, microglia, astrocytes, cholinergic neurons, voluntary exercise, forced exercise, learning and memory, sedentary lifestyle, neuroplasticity
- MeSH terms
- Animals, Brain, Disease, Humans, Physical Conditioning, Animal, Exercise
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