Thermosensitive polymeric hydrogels as drug delivery systems
Abstract
Thermosensitive hydrogels are very important biomaterials used in drug delivery systems (DDSs), which gained increasing attention of researchers. Thermosensitive hydrogels have great potential in various applications, such as drug delivery, cell encapsulation, tissue engineering, and etc. Especially, injectable thermosensitive hydrogels with lower sol-gel transition temperature around physiological temperature have been extensively studied. By in vivo injection, the hydrogels formed non-flowing gel at body temperature. Upon incorporation of pharmaceutical agents, the hydrogel systems could act as sustained drug release depot in situ. Injectable thermosensitive hydrogel systems have a number of advantages, including simplicity of drug formulation, protective environment for drugs, prolonged and localized drug delivery, and ease of application. The objective of this review is to summarize fundamentals, applications, and recent advances of injectable thermosensitive hydrogel as DDSs, including chitosan and related derivatives, poly(N-isopropylacrylamide)-based (PNIPAAM) copolymers, poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) copolymers and its derivatives, and poly(ethylene glycol)/ biodegradable polyester copolymers. Keywords: Injectable, thermosensitive, hydrogel, phase transition, drug delivery, controlled release, chitosan, N-Isopropylacrylamide, pluronic, PEG, PLA, PLGA, PCL, PCLA, PHB
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Thermo-responsive polymers show sol-gel transitions with a change in external temperature, and hydrogels made of thermoresponsive polymers find drug delivery applications through simple chemical modifications.
“Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [32]
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- Authors
- Gong, C., Qi, T., Wei, X., Qu, Y., Wu, Q., Luo, F., & Qian, Z.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Qi, T.
- Wu, Q.
- Qian, Z.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-12-01
- Volume
- 20
- Issue
- 1
- Pages
- 79-94
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W4241712141
- Cited by
- 228
- References
- 0
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 23 · 2018: 23 · 2017: 16 · 2016: 20 · 2015: 13 · 2014: 11 · 2013: 7
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- thermosensitive hydrogel, injectable hydrogel, drug delivery systems, sol-gel transition, controlled drug release, chitosan, poly(N-isopropylacrylamide), poloxamer, polyethylene glycol, PLGA, PCL, polyhydroxybutyrate, cell encapsulation, tissue engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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