Multitarget drugs of plants origin acting on Alzheimer’s disease

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

Monod, J., Wyman, J., & Changeux, J. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 7,681 · see citing works

Alzheimer Mechanisms and Therapeutic Strategies

Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

Mechanism of action of insecticidal secondary metabolites of plant origin

Rattan, R. S. (2010) · Crop Protection · doi:10.1016/j.cropro.2010.05.008 · Cited by 845 · see citing works

Interventions to improve the appropriate use of polypharmacy for older people

Patterson, S. M., Cadogan, C. A., Kerse, N. M., Cardwell, C. R., Bradley, M. C., Ryan, C. A., & Hughes, C. M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008165.pub3 · Cited by 759 · see citing works

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

Taly, A., Corringer, P., Guédin, D., Lestage, P. J., & Changeux, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2927 · Cited by 706 · see citing works

Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy

Efferth, T., & Koch, E. (2010) · Current Drug Targets · doi:10.2174/138945011793591626 · Cited by 572 · see citing works

Naturally Occurring Insecticides

Jacobson, M., Crosby, D. G., & FORGASH, A. J. (1972) · Soil Science · doi:10.1097/00010694-197205000-00015 · Cited by 543 · see citing works

Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

Danysz, W., & Parsons, C. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02057.x · Cited by 500 · see citing works

In-vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes

Perry, N. S. L., Houghton, P. J., Theobald, A. E., Jenner, P. G., & Perry, E. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774598 · Cited by 458 · see citing works

Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial

Vellas, B. J., Coley, N., Ousset, P., Berrut, G., Dartigues, J., Dubois, B., Grandjean, H., Pasquier, F., Piette, F., Robert, P. H., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70206-5 · Cited by 401 · see citing works

Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors

Samochocki, M., Höffle‐Maas, A., Fehrenbacher, A., Jostock, R., Ludwig, J., Christner, C., Radina, M., Zerlin, M., Ullmer, C., Pereira, E. F. R., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045773 · Cited by 345 · see citing works

Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial

Akhondzadeh, S., Noroozıan, M., Mohammadi, M., Ohadinia, S., Jamshidi, A. H., & Khani, M. (2003) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2003.00463.x · Cited by 345 · see citing works

Inhibitory Activity on Amyloid-β Aggregation and Antioxidant Properties ofCrocus sativusStigmas Extract and Its Crocin Constituents

Papandreou, M. A., Kanakis, C. D., Polissiou, M. G., Efthimiopoulos, S., Cordopatis, P. A., Margarity, M., & Lamari, F. N. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061932a · Cited by 342 · see citing works

Effects of Ginkgo biloba in dementia: systematic review and meta-analysis

Weinmann, S., Roll, S., Schwarzbach, C., Vauth, C., & Willich, S. N. (2010) · BMC Geriatrics · doi:10.1186/1471-2318-10-14 · Cited by 301 · see citing works

Ginkgo BilobaLeave Extract: Biological, Medicinal, and Toxicological Effects

Chan, P., Xia, Q., & Fu, P. P. (2007) · Journal of Environmental Science and Health Part C · doi:10.1080/10590500701569414 · Cited by 286 · see citing works

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

Akhondzadeh, S., Shafiee Sabet, M., Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. S., Yousefi, M. H., Alimardani, R., Jamshidi, A., et al. (2010) · Psychopharmacology · doi:10.1007/s00213-009-1706-1 · Cited by 268 · see citing works

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

Eikelenboom, P., van Exel, E. R., Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., & van Gool, W. A. (2010) · Neurodegenerative Diseases · doi:10.1159/000283480 · Cited by 259 · see citing works

ORIGINAL ARTICLE: Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial: Saffron in the treatment of Alzheimer’s disease

Akhondzadeh, S., Sabet, M. S., Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. S., Yousefi, M. H., Alimardani, R., Jamshidi, A., et al. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2009.01133.x · Cited by 249 · see citing works

Current and Emerging Drug Treatment Options for Alzheimerʼs Disease

Herrmann, N., Chau, S. A., Kircanski, I., & Lanctôt, K. L. (2011) · Drugs · doi:10.2165/11595870-000000000-00000 · Cited by 238 · see citing works

Medication prescribing in frail older people

Hubbard, R. E., O'Mahony, M. S., & Woodhouse, K. W. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1387-2 · Cited by 235 · see citing works

Nicotine treatment of mild cognitive impairment

NEWHOUSE, P. A., Kellar, K. J., Aisen, P. S. S., White, H., Wesnes, K. A., Coderre, E. L., Pfaff, A., Wilkins, H., Howard, D., & Levin, E. D. (2012) · Neurology · doi:10.1212/wnl.0b013e31823efcbb · Cited by 218 · see citing works

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

Parri, H. R., Hernandez, C. M., & Dineley, K. T. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.039 · Cited by 201 · see citing works

Butyryl‐ and acetyl‐cholinesterase inhibitory activities in essential oils of Salvia species and their constituents

Savelev, S. U., Okello, E. J., & Perry, E. K. (2004) · Phytotherapy Research · doi:10.1002/ptr.1451 · Cited by 193 · see citing works

The Role of Phytochemicals in the Treatment and Prevention of Dementia

Howes, M. R., & Perry, E. K. (2011) · Drugs & Aging · doi:10.2165/11591310-000000000-00000 · Cited by 187 · see citing works

Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers

Tildesley, N. T. J., Kennedy, D. O., Perry, E. K., Ballard, C. G., Savelev, S. U., Wesnes, K. A., & Scholey, A. B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00122-9 · Cited by 184 · see citing works

Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg

Herrschaft, H. F., Nacu, A., Лихачев, С. А., Sholomov, I. I., Hoerr, R., & Schlaefke, S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.03.003 · Cited by 183 · see citing works

Galantamine-induced Amyloid-β Clearance Mediated via Stimulation of Microglial Nicotinic Acetylcholine Receptors

Takata, K., Kitamura, Y., Saeki, M., Terada, M., Kagitani, S., Kitamura, R., Fujikawa, Y., Maelicke, A., Tomimoto, H., Taniguchi, T., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.142356 · Cited by 176 · see citing works

Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells

Soeda, S., Ochiai, T., Loungratana, P., Tanaka, H., Shoyama, Y., & Shimeno, H. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01357-1 · Cited by 166 · see citing works

An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers

Scholey, A. B., Tildesley, N. T. J., Ballard, C. G., Wesnes, K. A., Tasker, A., Perry, E. K., & Kennedy, D. O. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1101-3 · Cited by 162 · see citing works

CYTOCHROME P450 AND XENOBIOTIC RECEPTOR HUMANIZED MICE

Gonzalez, F. J., & Yu, A. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.100007 · Cited by 143 · see citing works

<i>Ginkgo biloba</i> extract EGb 761®, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: A randomised, double-blind, exploratory trial

Yancheva, S., Ihl, R., Nikolova, G., Panayotov, P., Schlaefke, S., Hoerr, R., & for the GINDON Study Group (2009) · Aging &amp; Mental Health · doi:10.1080/13607860902749057 · Cited by 127 · see citing works

Nicotine reduces Aβ in the brain and cerebral vessels of APPsw mice

Hellström‐Lindahl, E., COURT, J. A., Keverne, J., Svedberg, M. M., Lee, M., Marutle, A., Thomas, A. J., Perry, E. K., Bednar, I., & Nordberg, A. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03377.x · Cited by 127 · see citing works

Total Synthesis of (−)-Galanthamine and (−)-Lycoramine via Catalytic Asymmetric Hydrogenation and Intramolecular Reductive Heck Cyclization

Chen, J., Xie, J., Bao, D., Liu, S., & Zhou, Q. (2012) · Organic Letters · doi:10.1021/ol300913g · Cited by 126 · see citing works

and Alzheimer's disease

Brioni, J. D., Esbenshade, T. A., Garrison, T. R., Bitner, S. R., & Cowart, M. (2010) · Cited by 125 · see citing works

Nicotine: specific role in angiogenesis, proliferation and apoptosis

Cardinale, A., Nastrucci, C., Cesario, A., & Russo, P. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2011.623150 · Cited by 123 · see citing works

Monoterpenoid extract of sage ( <i>Salvia lavandulaefolia</i> ) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

Kennedy, D. O., Dodd, F. L., Robertson, B. C., Okello, E. J., Reay, J. L., Scholey, A. B., & Haskell, C. F. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110385594 · Cited by 123 · see citing works

Efficacy and Tolerability of a Once Daily Formulation of Ginkgo biloba Extract EGb 761® in Alzheimer's Disease and Vascular Dementia: Results from a Randomised Controlled Trial

Ihl, R., Tribanek, M., Bachinskaya, N. Y., & for the GOTADAY Study Group (2011) · Pharmacopsychiatry · doi:10.1055/s-0031-1291217 · Cited by 123 · see citing works

Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.

Pereira, E. F. R., Alkondon, M., Reinhardt, S., Maelicke, A., Peng, X., Lindström, J., Whiting, P. J., & Albuquerque, E. X. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22435-1 · Cited by 108 · see citing works

Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats

Liang, Y. Q., & Tang, X. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.071 · Cited by 96 · see citing works

Herbal Medicines for the Prevention and Treatment of Alzheimer's Disease

Kim, H. G., & Oh, M. S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212798919002 · Cited by 94 · see citing works

Ginkgo biloba extract (EGb761®) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment

Fehske, C. J., Leuner, K., & Müller, W. E. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.012 · Cited by 87 · see citing works

Efficacy and tolerability of Ginkgo biloba extract EGb 761® by type of dementia: Analyses of a randomised controlled trial

Napryeyenko, O., Sonnik, G., & Tartakovsky, I. S. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.353 · Cited by 83 · see citing works

Ginkgo biloba in Alzheimer’s disease: A systematic review

Janßen, I. M., Sturtz, S., Skipka, G., Zentner, A., Garrido, M. V., & Busse, R. (2010) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-010-0844-8 · Cited by 78 · see citing works

?7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Neuroprotective, Neurotrophic or Both?

Hernandez, C. M., & Dineley, K. T. (2012) · Current Drug Targets · doi:10.2174/138945012800398973 · Cited by 75 · see citing works

Functional brain imaging of nicotinic effects on higher cognitive processes

NEWHOUSE, P. A., Potter, A., Dumas, J. A., & Thiel, C. M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.008 · Cited by 70 · see citing works

Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences

Parri, H. R., & Dineley, K. T. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274464 · Cited by 67 · see citing works

Accurate prediction of the bound conformation of galanthamine in the active site of torpedo californica acetylcholinesterase using molecular docking

Pilger, C., Bartolucci, C., Lamba, D., Tropsha, A., & Fels, G. (2001) · Journal of Molecular Graphics and Modelling · doi:10.1016/s1093-3263(00)00056-5 · Cited by 61 · see citing works

GuidAge Study: A 5-Year Double Blind, Randomised Trial of EGb 761 for the Prevention of Alzheimers Disease in Elderly Subjects with Memory Complaints. I. Rationale, Design and Baseline Data

Andrieu, S., Ousset, P., Coley, N., Ouzid, M., Mathiex‐Fortunet, H., & Vellas, B. J. (2008) · Current Alzheimer Research · doi:10.2174/156720508785132271 · Cited by 53 · see citing works

Traditional used Plants against Cognitive Decline and Alzheimer Disease

Eckert, G. P. (2010) · Frontiers in Pharmacology · doi:10.3389/fphar.2010.00138 · Cited by 47 · see citing works

Dual inhibition: a novel promising pharmacological approach for different disease conditions

Patyar, S., Prakash, A., & Medhi, B. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01236.x · Cited by 45 · see citing works

Ginkgo Biloba Extract Induces Gene Expression Changes in Xenobiotics Metabolism and the Myc-Centered Network

Guo, L., Mei, N., Liao, W. C., Chan, P., & Fu, P. P. (2010) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2009.0115 · Cited by 45 · see citing works

Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions

Gilboa-Geffen, A., Hartmann, G., & Soreq, H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00030 · Cited by 43 · see citing works

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.

Nicolussi, E., Huck, S., Lassmann, H., & Bradl, M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.03.010 · Cited by 30 · see citing works

α7-Nicotinic Acetylcholine Receptors: An Old Actor for New Different Roles

Russo, P., & Taly, A. (2012) · Current Drug Targets · doi:10.2174/138945012800398874 · Cited by 29 · see citing works

Ginkgo biloba extract EGb 761® in the context of current developments in the diagnosis and treatment of age-related cognitive decline and Alzheimer's disease: a research perspective

Lautenschlager, N. T., Ihl, R., & Müller, W. E. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212001019 · Cited by 27 · see citing works

Impact of Genetic Variability in Nicotinic Acetylcholine Receptors on Nicotine Addiction and Smoking Cessation Treatment

Russo, P., Cesario, A., Rutella, S., Veronesi, G., Spaggiari, L., Galetta, D., Margaritora, S., Granone, P., & Greenberg, D. (2010) · Current Medicinal Chemistry · doi:10.2174/092986711793979715 · Cited by 26 · see citing works

Dementia in the Greco-Roman world

Karenberg, A., & Förstl, H. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.12.004 · Cited by 24 · see citing works

Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain

Ludwig, J., Höffle‐Maas, A., Samochocki, M., Luttmann, E., Albuquerque, E. X., Fels, G., & Maelicke, A. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.505239 · Cited by 24 · see citing works

Safety and Effectiveness of a Traditional Ginkgo Fresh Plant Extract – Results from a Clinical Trial

urle, P. B. A., Suter, A., & Wormstall, H. (2009) · Forschende Komplementärmedizin / Research in Complementary Medicine · doi:10.1159/000213167 · Cited by 22 · see citing works

Pharmacokinetic rationale for switching from donepezil to galantamine

Maelicke, A. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80163-6 · Cited by 14 · see citing works

Genetic Variations in CHRNA7 or CHRFAM7 and Susceptibility to Dementia

Neri, M., Bonassi, S., & Russo, P. (2012) · Current Drug Targets · doi:10.2174/138945012800398928 · Cited by 13 · see citing works

Cholinesterase inhibitors as Alzheimer's therapeutics (Review)

Sharma, K. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10374 · Cited by 611 · see citing works

Bioactive Secondary Metabolites from Plant Sources: Types, Synthesis, and Their Therapeutic Uses

Twaij, B. M., & Hasan, M. N. (2022) · International Journal of Plant Biology · doi:10.3390/ijpb13010003 · Cited by 446 · see citing works

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

Rao, V. K., Carlson, E. A., & Yan, S. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.003 · Cited by 325 · see citing works

Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity

Pohanka, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069809 · Cited by 248 · see citing works

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

Dey, A., Bhattacharya, R., Mukherjee, A., & Pandey, D. K. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.005 · Cited by 232 · see citing works

A Perspective onCrocus sativusL. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease

Finley, J. W., & Gao, S. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04398 · Cited by 159 · see citing works

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Viayna, E., Sola, I., Bartolini, M., Simone, A. D., Tapia‐Rojas, C., Serrano, F. G., Sabaté, R., Juárez‐Jiménez, J., Pérez, B., Luque, F. J., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401824w · Cited by 156 · see citing works

6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

Moon, M., Kim, H. G., Choi, J. G., Oh, H., Lee, P. K. J., Ha, S. K., Kim, S. Y., Park, Y., Huh, Y., & Oh, M. S. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.121 · Cited by 150 · see citing works

Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases

Mathew, B., Parambi, D. G. T., Mathew, G. E., Uddin, M. S., Inasu, S. T., Kim, H., Marathakam, A., Unnikrishnan, M. K., & Carradori, S. (2019) · Archiv der Pharmazie · doi:10.1002/ardp.201900177 · Cited by 139 · see citing works

Inhibition of flavonoids on acetylcholine esterase: binding and structure–activity relationship

Xie, Y., Yang, W., Chen, X., & Xiao, J. (2014) · Food & Function · doi:10.1039/c4fo00287c · Cited by 119 · see citing works

Mitochondrial permeability transition pore: a potential drug target for neurodegeneration

Kalani, K., Yan, S. F., & Yan, S. S. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.08.001 · Cited by 117 · see citing works

Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron

Saeedi, M., & Rashidy‐Pour, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110995 · Cited by 117 · see citing works

Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence

Lejri, I., Agapouda, A., Grimm, A., & Eckert, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9695412 · Cited by 107 · see citing works

Qualitative and Quantitative Phytochemical Screening of Some Plants Used in Ethnomedicine in the Niger Delta Region of Nigeria

Ajuru, M. G. (2017) · Journal of Food and Nutrition Sciences · doi:10.11648/j.jfns.20170505.16 · Cited by 95 · see citing works

Mass Spectrometry in Plant-omics

Gemperline, E., Keller, C., & Li, L. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02938 · Cited by 86 · see citing works

Procyanidins and Alzheimer’s Disease

Zhao, S., Zhang, L., Yang, C., Li, Z., & Rong, S. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1469-6 · Cited by 74 · see citing works

Dual Inhibitors of β-Amyloid Aggregation and Acetylcholinesterase as Multi-Target Anti-Alzheimer Drug Candidates

Viayna, E., Sabaté, R., & Muñoz‐Torrero, D. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113139990139 · Cited by 76 · see citing works

Neuroprotective Effects and Mechanisms of Curcumin–Cu(II) and –Zn(II) Complexes Systems and Their Pharmacological Implications

Yan, F.-S., Sun, J.-L., Xie, W., Shen, L., & Ji, H. (2017) · Nutrients · doi:10.3390/nu10010028 · Cited by 73 · see citing works

Endophytic fungi from medicinal plants: biodiversity and biotechnological applications

Rana, K. L., Kour, D., Kaur, T., Devi, R., Negi, C., Yadav, A. N., Yadav, N., Singh, K., & Saxena, A. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819654-0.00011-9 · Cited by 70 · see citing works

Application of the Asymmetric Pictet–Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds

Heravi, M. M., Zadsirjan, V., & Malmir, M. (2018) · Molecules · doi:10.3390/molecules23040943 · Cited by 69 · see citing works

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

Pietro, O. D., Pérez-Areales, F. J., Juárez‐Jiménez, J., Espargaró, A., Clos, M. V., Pérez, B., Lavilla, R., Sabaté, R., Luque, F. J., & Muñoz‐Torrero, D. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.07.021 · Cited by 67 · see citing works

Plant Nutrition for Human Health: A Pictorial Review on Plant Bioactive Compounds for Sustainable Agriculture

El-Ramady, H. R., Hajdú, P., Törős, G., Badgar, K., Llanaj, X., Kiss, A., Abdalla, N. A., Omara, A. E.-D., Elsakhawy, T. A., Elbasiouny, H., et al. (2022) · Sustainability · doi:10.3390/su14148329 · Cited by 64 · see citing works

A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age

Perry, N. S. L., Menzies, R., Hodgson, F., Wedgewood, P., Howes, M. R., Brooker, H. J., Wesnes, K. A., & Perry, E. K. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.08.015 · Cited by 61 · see citing works

Algerian propolis extracts: Chemical composition, bactericidal activity and in vitro effects on gilthead seabream innate immune responses

Soltani, E.-K., Cerezuela, R., Charef, N., Mezaache-Aichour, S., Esteban, M. Á., & Zerroug, M. M. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.01.009 · Cited by 59 · see citing works

Dual Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’S Disease

Knez, D., Sova, M., Košak, U., & Gobec, S. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0036 · Cited by 58 · see citing works

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies

Pietro, O. D., Viayna, E., Vicente‐García, E., Bartolini, M., Ramón, R., Juárez‐Jiménez, J., Clos, M. V., Pérez, B., Andrisano, V., Luque, F. J., et al. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.12.008 · Cited by 50 · see citing works

Safranal protects against beta-amyloid peptide-induced cell toxicity in PC12 cells via MAPK and PI3 K pathways

Rafieipour, F., Hadipour, E., Emami, S. A., Asili, J., & Tayarani‐Najaran, Z. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0329-9 · Cited by 49 · see citing works

Scopoletin: Antiamyloidogenic, Anticholinesterase, and Neuroprotective Potential of a Natural Compound Present in Argyreia speciosa Roots by In Vitro and In Silico Study

Kashyap, P., Ram, H., Shukla, S. D., & Kumar, S. (2020) · Neuroscience Insights · doi:10.1177/2633105520937693 · Cited by 49 · see citing works

Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs

Hossain, R., Quispe, C., Saikat, A. S. M., Jain, D., Habib, A., Janmeda, P., Islam, M. T., Radha, Daştan, S. D., Kumar, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/9349897 · Cited by 49 · see citing works

The Biochemistry, Toxicology, and Uses of the Pharmacologically Active Phytochemicals: Alkaloids, Terpenes, Polyphenols, and Glycosides

Awuchi, C. G. (2019) · Journal of Food and Pharmaceutical Sciences · doi:10.22146/jfps.666 · Cited by 46 · see citing works

Bioprospecting of Natural Compounds for Industrial and Medical Applications

Dixit, S., Shukla, A., Singh, V., & Upadhyay, S. K. (2021) · doi:10.1002/9781119718017.ch3 · Cited by 46 · see citing works

Tandem C–C Bond Cleavage of Cyclopropanols and Oxidative Aromatization by Manganese(IV) Oxide in a Direct C–H to C–C Functionalization of Heteroaromatics

Bume, D. D., Pitts, C. R., & Lectka, T. (2015) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201501405 · Cited by 42 · see citing works

Human Disease and Drug Pharmacology, Complex as Real Life

Viayna, E., Sola, I., Pietro, O. D., & Muñoz‐Torrero, D. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320130002 · Cited by 36 · see citing works

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review

ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works

Evaluation of antibacterial efficacy of various solvent extracts of Evolvulus alsinoides and Mucuna pruriens against multidrug resistant (MDR) pathogenic bacteria

Mohanasundari, C., Sorimuthu, A., Srinivasan, K., Chinnathambi, A., Salmen, S. H., Meganathan, V., & Narayanan, M. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-02052-7 · Cited by 28 · see citing works

Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect®Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx]

Bonassi, S., Prinzi, G., Lamonaca, P., Russo, P., Paximadas, I., Rasoni, G., Rossi, R., Ruggi, M., Malandrino, S., Sánchez-Flores, M., et al. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2080-5 · Cited by 28 · see citing works

Advances in Recent Patent and Clinical Trial Drug Development for Alzheimer’s Disease

Liu, H., Wang, L., Su, W., & Xie, X. (2014) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.14.22 · Cited by 25 · see citing works

Medicinal Plants of Himalayan Forests

Painuli, S., Semwal, P., Martins, N. A., & Bachheti, R. K. (2021) · Springer eBooks · doi:10.1007/978-3-030-73077-2_8 · Cited by 24 · see citing works

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

Franceschin, M., Cianni, L., Pitorri, M., Micheli, E., Cacchione, S., Frezza, C., Serafini, M., Hu, M.-H., Su, H., Huang, Z., et al. (2018) · Molecules · doi:10.3390/molecules23061423 · Cited by 24 · see citing works

Recent applications of the Wittig reaction in alkaloid synthesis

Heravi, M. M., Zadsirjan, V., Hamidi, H., Daraie, M., & Momeni, T. (2020) · The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology · doi:10.1016/bs.alkal.2020.02.002 · Cited by 23 · see citing works

Phytoconstituents screening and antimicrobial activity of the invasive species Nicotiana glauca collected from Al-Baha region of Saudi Arabia

Alghamdi, A. A. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.12.034 · Cited by 23 · see citing works

Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in Caenorhabditis elegans and an SAMP8 Mice Model

Griñán‐Ferré, C., Bellver‐Sanchís, A., Olivares-Martín, M., Bañuelos, Ó., & Pallàs, M. (2021) · Nutrients · doi:10.3390/nu13072411 · Cited by 22 · see citing works

Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

Sola, I., Viayna, E., Gómez, T., Galdeano, C., Cassina, M., Camps, P., Romeo, M., Diomede, L., Salmona, M., Franco, P., et al. (2015) · Molecules · doi:10.3390/molecules20034492 · Cited by 21 · see citing works

Galantamine

Janssen, B., & Schäfer, B. (2017) · ChemTexts · doi:10.1007/s40828-017-0043-y · Cited by 20 · see citing works

Effect-directed analysis by high-performance thin-layer chromatography for bioactive metabolites tracking in Primula veris flower and Primula boveana leaf extracts

Mahran, E., Elgamal, I. A., Keusgen, M., & Morlock, G. E. (2019) · Journal of Chromatography A · doi:10.1016/j.chroma.2019.460371 · Cited by 19 · see citing works

Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review

(2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac111.74687492 · Cited by 17 · see citing works

Role of Biotechnology in Alkaloids Production

Khalil, A. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-51620-2_4 · Cited by 16 · see citing works

Secondary Metabolites: The Natural Remedies

Mikail, H. G., Mamman, M., Danmalam, H. U., & Сулейман, М. М. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101791 · Cited by 15 · see citing works

Natural ligands: Promising ecofriendly alternatives for corrosion protection and plethora of many prospects

Verma, C., Quraishi, M. A., & Rhee, K. Y. (2022) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2022.04.014 · Cited by 14 · see citing works

Best Medicine for Dementia: The Life-Long Defense of the Brain

Andersson, M. J., & Stone, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230429 · Cited by 12 · see citing works

Phytochemical Composition and Antibacterial Activity of Barleria albostellata C.B. Clarke Leaf and Stem Extracts

Gangaram, S., Naidoo, Y., Dewir, Y. H., Singh, M., Lin, J., & Murthy, H. N. (2023) · Plants · doi:10.3390/plants12132396 · Cited by 12 · see citing works

Computational Studies to Understand the Neuroprotective Mechanism of Action Basil Compounds

Singh, V., Mujwar, S., Singh, M., Singh, T., & Ahmad, S. F. (2023) · Molecules · doi:10.3390/molecules28207005 · Cited by 12 · see citing works

Natural Products in Aging: Cellular Mechanisms and Emerging Therapeutics for Age‐Related Disorders

Dixit, V., Chaubey, K. K., Dayal, D., Chole, P. B., Manjunath, B. T., Bachheti, R. K., Gupta, P. C., Bachheti, A., & Worku, L. A. (2025) · Journal of Aging Research · doi:10.1155/jare/6868732 · Cited by 11 · see citing works

Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy

Moreira, P., Matos, P., Figueirinha, A., Salgueiro, L., Batista, M. T., Branco, P. C., Cruz, M. T., & Pereira, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158812 · Cited by 10 · see citing works

Natural Products for Treatment of Chronic Myeloid Leukemia

Khajapeer, K. V., & Rajasekaran, B. (2016) · InTech eBooks · doi:10.5772/66175 · Cited by 8 · see citing works

Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer’s disease

Giménez‐Llort, L., Ratia, M., Pérez, B., Camps, P., Muñoz‐Torrero, D., Badı́a, A., & Clos, M. V. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000292 · Cited by 8 · see citing works

Isolation of Bioactive Phytochemicals in Leaves of Combretum dolichopentalum and their Hydrogen Peroxide Scavenging Potentials

Fn, U., Ukoha, A., Ao, O., & Nwaoguikpe, R. N. (2015) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000444 · Cited by 8 · see citing works

The Relieving Effects of BrainPower Advanced, a Dietary Supplement, in Older Adults with Subjective Memory Complaints: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Zhu, J., Shi, R., Su, C., Dai, L., Tian, S., Feng, Y., Gu, P., Shariff, M., Nguyen, T., Ye, Y., et al. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/7898093 · Cited by 8 · see citing works

Effects of 12-Week Supplementation of a Polyherbal Formulation in Old Adults with Prehypertension/Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial

Tian, S., Xing, G., Zhu, J., Cai, Y., Zhang, S., Xu, G., Feng, Y., Li, D., Rao, J., & Shi, R. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/7056872 · Cited by 8 · see citing works

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Moreira, P., Macedo, J., Matos, P., Bicker, J., Fortuna, A. C., Figueirinha, A., Salgueiro, L., Batista, M. T., da Silva, A. P., Silva, S., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117652 · Cited by 7 · see citing works

Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases

Hegde, M. (2014) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.129168 · Cited by 6 · see citing works

Phytochemical Composition of Ethanol Extract of a Cocktail Herbal Mixture (Aju Mbaise)

Nnadiukwu, A. T., Monago-Ighorodje, C. C., & Chuku, L. C. (2019) · Journal of Advances in Biology & Biotechnology · doi:10.9734/jabb/2019/v22i130103 · Cited by 6 · see citing works

Nutritional and Phytochemical Content of Cissus populnea (Okoho) Stem Bark

Achikanu, C. E., & Ani, O. N. (2020) · Asian Journal of Research in Biochemistry · doi:10.9734/ajrb/2020/v7i330139 · Cited by 6 · see citing works

Recent Strategies to Engineer Alkaloid Biosynthesis in Medicinal Plants

Bhushan, S., Sharma, D., Rakshant, Kaul, S., Dhar, M. K., & Sharma, M. (2023) · Springer eBooks · doi:10.1007/978-981-19-5611-9_15 · Cited by 5 · see citing works

Development of a Triplet–Triplet Absorption Ruler: DNA- and Chromatin-Mediated Drug Molecule Release from a Nanosurface

Chakraborty, S. D., Sau, A., Кузнецов, Д., Banerjee, A., Bardhan, M., Bhattacharya, M., Dasgupta, D., Basu, S., & Senapati, D. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b05278 · Cited by 5 · see citing works

Understanding the electronic structure of the alkaloid in scorpion venom through drug adsorption and molecular docking studies on COVID-19 proteins

Ilavarasi, A. V., Paularokiadoss, F., Novena, L. M., Pooventhiran, T., Erkan, S., Celaya, C. A., Thomas, R., Ampasala, D. R., & Jeyakumar, T. C. (2023) · Chemical Physics Impact · doi:10.1016/j.chphi.2023.100289 · Cited by 4 · see citing works

Detection and characterisation of oxocyclohexan[b]indoles by combined application of vibrational spectroscopy and mass spectrometry

Saidykhan, A., Martin, W. H. C., Gallagher, R. T., Kendrick, J., & Bowen, R. D. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.136311 · Cited by 3 · see citing works

Biological production and application of secondary metabolites and other medicinal products

Pathak, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22264-1.00014-1 · Cited by 3 · see citing works

Vascular dementia: Molecular targets of neuroprotective therapy

Гомазков, О. А., & Lagunin, A. A. (2017) · Biology Bulletin Reviews · doi:10.1134/s2079086417060032 · Cited by 3 · see citing works

Extending Lifespan of Alzheimer’s Mode Nematode CL4176 Using a Novel Bifunctional Peptide with Inhibition of β-Amyloid Aggregation and Anti-oxidation

Xu, J., Yu, X., Zhang, Y., Liu, N., Guan, S., & Wang, L. (2019) · Chemical Research in Chinese Universities · doi:10.1007/s40242-019-8299-y · Cited by 2 · see citing works

Novel Therapeutic Approaches in Alzheimer's Disease

Ingle, P. V., Lee, Y. L., Wong, X. Y., Tan, S. P., Lim, E. J., Chin, M. Y., Zhen, M. C. S., Safian, N. H. B., & Hatware, K. V. (2024) · Current Drug Therapy · doi:10.2174/0115748855332142240830114503 · Cited by 2 · see citing works

Cognitive enhancement and anti-oxidant activities of Thespesia populnea L.: A bio-assay guided study using molecular docking for symptomatic alleviation of Alzheimer's disease

Halim, M. B. A., Metwally, G. F., Abd‐Elrazek, A., Al-Karmalawy, A. A., El-Zoheiry, H. H., Deeb, K. S. E., & Eid, H. H. (2024) · Scientific African · doi:10.1016/j.sciaf.2024.e02501 · Cited by 2 · see citing works

Permitted daily exposure from preclinical studies of Ginkgo biloba L. dry extract

Lamb, L. W. B., Rodrigues, G. Z. P., Saraiva, T. E. S., de Souza, D., Berna, G. D. C., Garcia, A. L. H., Bertoldi, F., Kayser, J. M., Veiverberg, A., Marco, M. R., et al. (2023) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902023e23037 · Cited by 2 · see citing works

Transcellular transport characteristics of huperzine alone or in combination with ginkgolide B across Caco-2 and Madin-Darby canine kidney cell monolayer

Zhao, W., Hou, Z.-H., Zhang, Q., & Zheng, W. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(14)60155-3 · Cited by 1 · see citing works

Role of NMDA Receptors in Alzheimer's Disease Pathology and Potential NMDA Receptor Blockers from Medicinal Plants - A Review

Prasanth, N. V., Pandian, P., & Balasubramanian, T. (2021) · Asian Journal of Pharmaceutical Research and Health Care · doi:10.18311/ajprhc/2021/28351 · Cited by 1 · see citing works

Bioactive alkaloids

Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00023-2 · Cited by 1 · see citing works

Inflammatory response in Plasmodium falciparum-infected patients treated using raw liquid extract of Morinda lucida (Oowo) leaf in some traditional homes in Nigeria

Olaniyan, M. F., & Olaniyan, T. B. (2023) · Environmental Disease · doi:10.4103/ed.ed_5_23 · Cited by 1 · see citing works

Phenolic and Anti-Nutrients Compositions of Selected Underutilized Seeds: African Oil Bean Seed (Pentaclethra macrophylla), Cashew Nut Seed (Anacardium occidentale), Cucumeropsis Seed (Cucurbita maxima), Groundnut Seed (Arachis hypogeal) and Soya Bean Seed (Glycine max)

Akpuru, A. O., Anyanwu, L. I., Ik-Ukennaya, S. L., Orji, C. H., & Vincent, A. G. (2024) · International Journal of Innovative Science and Research Technology (IJISRT) · doi:10.38124/ijisrt/ijisrt24sep466 · Cited by 1 · see citing works

In vitro antimycobacterial potential, acute toxicity and GC-MS analysis of Berlinia grandiflora (Vahl) Hutch. & Dalziel and Senna occidentalis (L.) link leaves extracts

Olatunji, K. T., Oladosu, P. O., & Matthew, K. O. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100154 · Cited by 1 · see citing works

Towards the Development of Tropolone Natural Product Derivatives as Novel, Potent Anticancer Therapeutics that Selectively Target Histone Deacetylase (HDAC) Enzymes

Ononye, S. N. (2013) · OpenCommons at University of Connecticut (University of Connecticut) · Cited by 1 · see citing works

Synthetic Receptors for RNA Recognition

Bhaduri, S., Spano, M. N., & Arya, D. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12550-8

THE INDIGENOUS KNOWLEDGE OF THE MEDICINAL COMPONENTS OF MORINDA CITRIFOLIA L. (NONI) COMPARED TO SCIENTIFIC KNOWLEDGE AS AN INCOME GENERATION STRATEGY TO LIVELIHOOD

Ayeh, S. J., M., A. E., K, T. E., & Adinkrak, B. (2021) · International Journal of Agriculture and Environmental Research · doi:10.51193/ijaer.2021.7504

Metabolites, Molecular Diversity, and Applications of Cyanobacteria in the Beverage Industry

Balogun, F. O., & Sabiu, S. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-04195-2_210-1

Mitochondria Are a Potential Therapeutic Target for Alzheimer’s Disease

Basavalingiah, A. J., Yan, S. F., & Yan, S. S. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190932183.013.23

The morphological characterization, chemical composition and biological activity of barleria albostellata (Acanthaceae).

Gangaram, S. (2021) · doi:10.29086/10413/22792

Preliminary phytochemical, physico-chemical & HPTLC analysis of aanai nerunjil kudineer

Selvamani, S. B., Justus Antony, S., & Manoharan, A. (2023) · International Journal of Complementary & Alternative Medicine · doi:10.15406/ijcam.2023.16.00644

Unlocking Ethnomedicinal Plant Potentials: Advancing Drug Discovery in the High-Throughput Omics Era

Saini, V., Punia, A., Choudhary, A., Vishal, Singh, P. K., & Jayaraman, N. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-3405-4_19 · Cited by 1 · see citing works

Metabolites, Molecular Diversity, and Applications of Cyanobacteria in the Beverage Industry

Balogun, F. O., & Sabiu, S. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-38663-3_210

In Silico Screening and Identification of Phytoconstituents for Alzheimer's Disease

Madan, K., Kumar, A., & Tiwari, A. (2025) · doi:10.38124/ijisrt/25jun652

Bioactive Phytochemicals and Nutritional Components on Shoot of Heliotropium indicum Linn.: Prospects for Therapeutic Development

Arowojobe, Q. R., Ishola, A. S., Ale, J. E., Odebunmi, C. A., & Akinyode, V. O. (2025) · Nigerian Journal of Pure and Applied Sciences · doi:10.48198/njpas/25.a32

BindingDB Entry 50044178: Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

BindingDB (2015) · UC San Diego · doi:10.7270/q2fx7bz9

BindingDB Entry 50043898: 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.

BindingDB (2014) · UC San Diego · doi:10.7270/q2cf9rkn

BindingDB Entry 50045204: Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targetingß-amyloid, tau, and cholinesterase pathologies.

BindingDB (2016) · UC San Diego · doi:10.7270/q2571dnf

Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease

Sahoo, A. K., Dandapat, J., Dash, U. C., & Kanhar, S. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.12.015 · Cited by 147 · see citing works

Conceptual search for MTDs of plant natural compounds for multifactorial Alzheimer's disease therapy

Kim, C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45844-6.00026-3

Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease

Tundis, R., Loizzo, M. R., Nabavi, S. M., Orhan, İ. E., Skalicka‐Woźniak, K., D’Onofrio, G., & Aiello, F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809593-5.00003-3 · Cited by 19 · see citing works

Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer’s Disease

Vrabec, R., Blunden, G., & Cahlíková, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054399 · Cited by 46 · see citing works

Ethnobotanical Treatment Strategies Against Alzheimers Disease

Howes, M. R., & Houghton, P. J. (2012) · Current Alzheimer Research · doi:10.2174/156720512799015046 · Cited by 104 · see citing works