Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Galantamine and rivastigmine, two FDA-approved drugs for Alzheimer's disease, are derived from natural sources.
“For example, galantamine and rivastigmine (ChEIs), two FDA-approved drugs for AD, are derived from natural sources, highlighting the importance of traditional medicine in modern therapeutic strategies [18,19,20].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [19]
The paper’s main text says galantamine and the physostigmine-derivative rivastigmine are approved drugs for Alzheimer’s disease based on natural products (page unavailable). It does not specify FDA approval or identify them as cholinesterase inhibitors. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Divino da Rocha, M., Pereira Dias Viegas, F., Cristina Campos, H., Carolina Nicastro, P., Calve Fossaluzza, P., Alberto Manssour Fraga, C., J. Barreiro, E., & Viegas, C. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794480429 · Cited by 126 · cited 1× · see citing works
“[3] However, the principle bioactive compound (s) in these plant products and/or molecular mechanisms behind their curative/preventive effects are very poorly understood, which is a roadblock to convince the more educated urban population about their benefits and to exploit these for the discovery…”
Multitarget drugs of plants origin acting on Alzheimer’s disease
Russo, P., Frustaci, A., Del Bufalo, A., Fini, M., & Cesario, A. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320130008 · Cited by 88 · cited 1× · see citing works
“[2] In fact, more than sixteen plant species, including Ginseng , Celastrus paniculatus, Centella asiatica, Curcuma longa, Ginkgo biloba, Huperzia serrata, Lycoris radiate, Galanthus nivalis, Magnolia officinalis, Polygala tenuifolia, Salvia lavandulaefolia, Salvia miltiorrhiza, Coptis chinensis,…”
Hegde, M. L., Hegde, P. M., Rao, K. S. J., & MITRA, S. P. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110281 · Cited by 77 · see citing works
Self-citationAnti-amyloidogenic property of leaf aqueous extract of Caesalpinia crista
Ramesh, B. N., Indi, S. S., & Rao, K. S. J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.062 · Cited by 52 · see citing works
Rao, K., Ramesh, B., Girish, T., Raghavendra, R., Naidu, K., & Prasada Rao, U. J. S. (2014) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.129172 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I. R., Rao, K. S. J., MITRA, S. P., & Hegde, M. L. (2014) · Biomolecules · doi:10.3390/biom4030678 · Cited by 37 · see citing works
Self-citationALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential.
Mitra, J., Vasquez, V., Hegde, P. M., Boldogh, I. R., MITRA, S. P., Kent, T. A., Rao, K. S. J., & Hegde, M. L. (2014) · PubMed · doi:10.14437/nrtoa-1-107 · Cited by 24 · see citing works
“Furthermore, because of reversible oxidation of cysteine residues in various proteins, including the key genome repair enzymes NEIL1 and NEIL2 by pro-oxidant metals [37,40], metal chelation could be combined with specific reducing factors [6,29,43].”
Self-citationZhang, D., Dong, Y., Zhao, Y. H., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6693 · Cited by 12 · see citing works
“Medicinal plant extracts have long been known to be beneficial towards human diseases, and the molecular characterization of plant-based products is critical for the discovery of new drug candidates (15).”
Self-citationSyad, A. N., & Devi, K. P. (2018) · Journal of Dietary Supplements · doi:10.1080/19390211.2018.1471563 · Cited by 3 · see citing works
“These naturally derived compounds possess polyphenols, which may act on multiple pathological targets and may protect the brain from degeneration (Hegde, 2014).”
Background
- Authors
- Hegde, M.
- Corresponding author
- Hegde, MuralidharL
- Venue
- Journal of Pharmacy And Bioallied Sciences
- Published
- 2014
- Volume
- 6
- Issue
- 2
- Pages
- 63
- ISSN
- 0975-7406 (ISSN-L)
- PMC
- PMC3983747
- OpenAlex
- W4319437596
- Cited by
- 6
- References
- 5
- Citations by year
- 2025: 1 · 2018: 2 · 2014: 2
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Pharmacy And Bioallied Sciences (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubMed
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS088645)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- neuroprotection, phytochemicals, medicinal plants, brain disorders, drug discovery, molecular characterization, neurodegenerative diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
