The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Pericyte Loss in Diabetic Retinopathy: Mechanisms and Consequences
Open accessAbstract
The onset of diabetic retinopathy is characterized by morphologic alterations of the microvessels, with thickening of the basement membrane, loss of inter-endothelial tight junctions and early and selective loss of pericytes, together with increased vascular permeability, capillary occlusions, microaneurysms and, later, loss of endothelial cells (EC). A key role in the evolution of the disease is played by pericytes, specialized contractile mesenchymal cells of mesodermal origin, that, in capillaries, exert a function similar to smooth muscle cells in larger vessels, regulating vascular tone and perfusion pressure. Thickening of the basement membrane, together with systemic and local hypertension, hyperglycaemia, advanced glycation end-product formation and hypoxia, may disrupt the tight link between pericytes and EC causing pericyte apoptosis, while endothelium, deprived of proliferation control, can give rise to new vessels. Pericyte dropout has great consequences on capillary remodelling and may cause the first abnormalities of the diabetic eye which can be observed clinically. Hyperglycaemia and local hypertension are known to be a direct cause of pericyte apoptosis and dropout, and intracellular biochemical pathways of the glucose metabolites have been explored. However, the exact mechanisms are not yet fully understood and need further clarification in order to develop new effective drugs for the prevention of retinopathy.
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Citations
Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
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A perivascular origin for mesenchymal stem cells in multiple human organs
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“In fact, pericytes in their tissue of origin natively express the MSC markers CD44, CD90, CD73 and CD105 [19, 20]; cells expressing MSC markers, express also pericyte ones ( α- mooth muscle actin, NG2 and PDGF-Rβ) [21] and pericyte clones have osteogenic, chondro genic, adipocytic and myogenic properties, characterist…”
Endothelial/Pericyte Interactions
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Self-citation
Cited by
Brain and Retinal Pericytes: Origin, Function and Role
Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K. A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., Aigner, L., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00020 · Cited by 244
Cudmore, R. H., Dougherty, S. E., & Linden, D. J. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16682508 · Cited by 54
Metadata
- Authors
- Beltramo, E., & Porta, M.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2013-07-01
- Volume
- 20
- Issue
- 26
- Pages
- 3218-3225
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2313838053
- Cited by
- 317
- References
- 10
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
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