Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis.
Abstract
The role of the adipose tissue in immunity has recently emerged, and there is now ample evidence that this role is elucidated by a number of cytokine-like hormones produced by adipocytes - called adipokines. The most relevant adipokines are leptin, adiponectin and visfatin, and all have marked effects on metabolic and immune function. The discovery of adipokines has led to the development of a novel concept that the pathogenesis of atherosclerosis can be associated with low-degree inflammation associated with slow (auto)immune attack of the endothelial wall of arteries. This model considers therefore adipokines as the bridge between atherosclerosis, inflammation and immunity. We review here the most recent advances on adipokine research, with a particular emphasis on the model that considers atherosclerotic lesions as effects of the (auto)immune-mediated damage of the endothelium that is sustained by low-degree chronic inflammation typical of obesity and metabolic syndrome.
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Interventional studies show a role for leptin in regulating the immune system in states of leptin deficiency, but not leptin excess as seen in obesity.
“Interventional studies investigating the effect of leptin administration to persons with leptin deficiency compared with leptin sufficiency or leptin excess could clearly show a role for leptin in regulating the immune system in states of leptin deficiency, but not leptin excess, as seen in obesity (22,27,31).”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [27]
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Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
“Obesity is typically associated with a cluster of several metabolic disorders, characterised by a lowgrade inflammation.(1) 2 Evidence that the gut microbiota composition can be different between healthy and obese and/or type 2 diabetic patients has led to the investigation of this environmental element as a key facto…”
BackgroundThe role of the gut microbiota in energy metabolism and metabolic disease
Cani, P., & Delzenne, N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168164 · Cited by 974 · see citing works
“1) [1,2].”
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works
Self-citationAdipose Tissue: The New Endocrine Organ? A Review Article
Wozniak, S. E., Gee, L. L., Wachtel, M., & Frezza, E. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0585-3 · Cited by 599 · see citing works
“adipocyte fatty-acid-binding protein (A-FABP), lipocalin2, as well as other markers of oxidative stress [43, 44].”
BackgroundThe gut microbiome as therapeutic target
Cani, P. D., & Delzenne, N. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.012 · Cited by 350 · see citing works
“Most of these are related to glucose homeostasis and to the development of cardiovascular diseases, and they probably result from a combination of variable associations of genetic and environmental factors (Alberti et al., 2005; Kahn et al., 2006; Matarese et al., 2007).”
BackgroundLeptin in inflammation and autoimmunity
Cava, A. L. (2017) · Cytokine · doi:10.1016/j.cyto.2016.10.011 · Cited by 343 · see citing works
“This is because leptin receptors are present within lesions of atherosclerosis patients [56], and”
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Lovren, F., Pan, Y., Quan, A., Singh, K. K., Shukla, P. C., Gupta, M., Al-Omran, M. A., Teoh, H., & Verma, S. (2010) · Circulation · doi:10.1161/circulationaha.109.931782 · Cited by 316 · see citing works
Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis
Pοlyzos, S. A., Toulis, K. A., Goulis, D. G., Zavos, C., & Kountouras, J. (2010) · Metabolism · doi:10.1016/j.metabol.2010.09.003 · Cited by 310 · see citing works
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Pérez‐Pérez, A., Vilariño‐García, T., Riejos, P. F., Martín-González, J., Segura-Egea, J. J., & Sánchez‐Margalet, V. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.03.001 · Cited by 273 · see citing works
Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo, C. W., Brunkan, C. S., Wolberger, C., Imai, S., & Tabas, I. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805866200 · Cited by 212 · see citing works
Leptin in humans: lessons from translational research
Blüher, S., & Mantzoros, C. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788e · Cited by 203 · see citing works
“Interventional studies investigating the effect of leptin administration to persons with leptin deficiency compared with leptin sufficiency or leptin excess couldclearlyshowarole for leptin inregulating the immunesystem instatesof leptindeficiency,butnot leptinexcess, as seen inobesity (22, 27, 31).”
BackgroundSelf-citationGender Differences in Cardiovascular Disease: Hormonal and Biochemical Influences
Pérez-López, F. R., Larrad-Mur, L., Kallen, A. N., Chedraui, P. A., & Taylor, H. S. (2010) · Reproductive Sciences · doi:10.1177/1933719110367829 · Cited by 202 · see citing works
“activator inhibitor 1 (PAI-1), and angiotensinogen, several of which will be discussed here.(189)”
BackgroundMcMahon, M. A., Skaggs, B. J., Sahakian, L., Grossman, J., FitzGerald, J. D., Ragavendra, N., Charles‐Schoeman, C., Chernishof, M., Gorn, A. H., Witztum, J. L., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.142737 · Cited by 155 · see citing works
“In addition to the established role of adipokines in energy homoeostasis, leptin and adiponectin also have immunomodulatory roles.”
Self-citationLeptin and leptin receptor expression in asthma
Bruno, A., Pace, E., Chanez, P., Gras, D., Vachier, I., Chiappara, G., Guardia, M. L., Gerbino, S., Profita, M., & Gjomarkaj, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.04.032 · Cited by 132 · see citing works
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Tsai, Y.-T., Cheng, P.-C., & Pan, T. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5346-3 · Cited by 123 · see citing works
“According to theWorld Health Organization, the rate of obesity has nearly doubled worldwide since 1980.”
BackgroundDalamaga, Μ., Migdalis, I. N., Fargnoli, J. L., Papadavid, E., Bloom, E., Mitsiades, N., Καρμανιώλας, Κ., Pelecanos, N., Tseleni‐Balafouta, S., Dionyssiou‐Asteriou, A., et al. (2008) · Cancer Causes & Control · doi:10.1007/s10552-008-9273-z · Cited by 113 · see citing works
“Adipose tissue is now broadly recognized as an active endocrine organ secreting several bioactive adipokines, which regulate physiological and pathological processes, such as appetite, insulin sensitivity and resistance, inflammation, immunity, hematopoiesis, and angiogenesis [14, 15].”
BackgroundSelf-citationInflammation, Atherosclerosis, and Psoriasis
Siegel, D., Devaraj, S., Mitra, A., Raychaudhuri, S. P., Raychaudhuri, S. K., & Jialal, I. (2012) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-012-8308-0 · Cited by 110 · see citing works
“In diabetics and the associated metabolic syndrome, these adipocytokines have been related to risk factors for atherosclerosis, correlate well with inflammatory markers, and are predictive of the development of CVD [91, 92].”
BackgroundSuzukawa, M., Nagase, H., Ogahara, I., Han, K., Tashimo, H., Shibui, A., Koketsu, R., Nakae, S., Yamaguchi, M., & Ohta, K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004054 · Cited by 102 · see citing works
“Also, there is accumulating evidence that leptin may play various roles in immunomodulation (20, 39).”
BackgroundUpregulation of fibroblast growth factor-2 by visfatin that promotes endothelial angiogenesis
Bae, Y.-H., Bae, M., Kim, S.-R., Lee, J. H., Wee, H., & Bae, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.042 · Cited by 71 · see citing works
Leptin as a Modulator of Neuroendocrine Function in Humans
Khan, S. M., Hamnvik, O. R., Brinkoetter, M. T., & Mantzoros, C. S. (2012) · Yonsei Medical Journal · doi:10.3349/ymj.2012.53.4.671 · Cited by 67 · see citing works
Self-citationWedemeyer, I., Bechmann, L. P., Odenthal, M., Jochum, C., Marquitan, G., Drebber, U., Gerken, G., Gieseler, R. K. H., Dienes, H. P., & Canbay, A. E. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.08.023 · Cited by 66 · see citing works
“Adipocytes produce various cytokine-like protein hormones, or adipokines, such as adiponectin, leptin and visfatin [31].”
BackgroundModels to Study Atherosclerosis: A Mechanistic Insight
Singh, V., Tiwari, R. L., Dikshit, M., & Barthwal, M. K. (2009) · Current Vascular Pharmacology · doi:10.2174/157016109787354097 · Cited by 63 · see citing works
“Adipocytes can be set up in presence and absence of candidate anti-atherosclerotic drugs for the secretion of such adipokines, which can be estimated by conventional methods [441-444].”
BackgroundThe effect of body weight on the severity and clinical course of ulcerative colitis
Stabroth-Akil, D., Leifeld, L., Pfützer, R. H., Morgenstern, J., & Kruis, W. (2014) · International Journal of Colorectal Disease · doi:10.1007/s00384-014-2051-3 · Cited by 63 · see citing works
“Adipokines are proteins secreted by adipocytes which are involved in the interaction between white adipose tissue and inflammation, and altered serum levels of adipokines are found in inflammatory bowel disease (IBD) as well as obesity [11–14].”
BackgroundAronis, K. N., Vamvini, M. T., Chamberland, J. P., Sweeney, L. L., Brennan, A. M., Magkos, F., & Mantzoros, C. S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.09.008 · Cited by 61 · see citing works
“extension, diabetes [36,37], CVD [38], and cancer [29,39-42].”
BackgroundSelf-citationDalamaga, Μ., Srinivas, S. K., Elovitz, M. A., Chamberland, J. P., & Mantzoros, C. S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.021 · Cited by 56 · see citing works
“Adipose tissue is now broadly recognized as a functioning endocrine and paracrine organ secreting several bioactive adipokines, which regulate physiological and pathological processes, such as appetite, insulin sensitivity and resistance, inflammation, immunity, hematopoiesis and angiogenesis [9].”
BackgroundSelf-citationAt the crossroad of T cells, adipose tissue, and diabetes
Matarese, G., Procaccini, C., & Rosa, V. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01154.x · Cited by 47 · see citing works
“Leptin can also alter cardiomyocyte structure and function (60), and LepR has been detected in lesions of patients with atherosclerosis, while ob/ob mice are resistant to atherosclerosis (61, 62).”
BackgroundSelf-citationMultifaceted roles of adiponectin in rheumatoid arthritis
Liu, D., Luo, S., & Li, Z. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.08.013 · Cited by 47 · see citing works
Koçak, F. A., Kurt, E. E., Sezgin, F. M., Şaş, S., Tuncay, F., & Erdem, H. R. (2020) · International Journal of Biometeorology · doi:10.1007/s00484-020-01924-x · Cited by 45 · see citing works
Petridou, E. T., Sergentanis, T. Ν., Dessypris, N., Vlachantoni, I. T., Tseleni‐Balafouta, S., Pourtsidis, A. G., Moschovi, M. A., Polychronopoulou, S., Athanasiadou‐Piperopoulou, F., Kalmanti, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.7525 · Cited by 37 · see citing works
Self-citationGleason, R. L., Caulk, A. W., Seifu, D., Parker, I., Vidaković, B., Getenet, H., Assefa, G., & Amogne, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117125 · Cited by 36 · see citing works
“Adipokines such as adiponectin and leptin have been studied intensively for their relation to obesity, insulin resistance, and hyperglycemia and as potential proatherogenic mediators [85,86].”
BackgroundThe implication of adiponectin and resistin in gastrointestinal diseases
Tiaka, E. K., Manolakis, A. C., Kapsoritakis, A. N., & Potamianos, S. P. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.04.002 · Cited by 30 · see citing works
“Inversely, hypo-adiponectinemia has been correlated with increased atherosclerosis as indicated by several markers of oxidative stress [22].”
BackgroundSanches, P. D. L., de Mello, M. T., Elías, N., Fonseca, F. A. H., Campos, R. M. D. S., Carnier, J., de Piano, A., Masquio, D. C. L., da Silva, P. L., Oyama, L. M., et al. (2013) · Inflammation · doi:10.1007/s10753-013-9709-9 · Cited by 29 · see citing works
“Some findings suggest that high leptin concentrations accelerate the atherosclerotic process while other studies show a protective role for leptin in atherosclerosis [2, 12, 13].”
BackgroundDessein, P. H., Norton, G. R., Badenhorst, M. E., Woodiwiss, A. J., & Solomon, A. (2013) · Mediators of Inflammation · doi:10.1155/2013/461849 · Cited by 27 · see citing works
“Hindawi Publishing Corporation Mediators of Inflammation Volume 2013, Article ID 461849, 9 pages http://dx.doi.org/10.1155/2013/461849”
BackgroundInfluentialRole of Leptin in Cancer: A Systematic Review
Samad, N. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.18.003091 · Cited by 21 · see citing works
“Among 80% of all pancreatic cancer, the most important malignancy is pancreatic adenocarcinoma [71,72].”
BackgroundLu, Y., Yuan, W., Xiong, X., et al. (2023) · Obesity · doi:10.1002/oby.23656 · Cited by 22 · see citing works
“It has been reported that some adipokines, including leptin [26], resistin [27], and adiponectin [28], are involved in cardiovascular dysfunction.”
BackgroundModulation of the cardiovascular system by leptin
Abel, E. D., & Sweeney, G. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.019 · Cited by 22 · see citing works
Obesity: “Priming” the lung for injury
Konter, J., Baez, E., & Summer, R. S. (2012) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2012.03.003 · Cited by 21 · see citing works
Feng, J., Chen, B.-Y., Cui, L., Wang, B., Liu, C., Chen, P.-F., Guo, M.-N., Dong, L., & Li, S. (2009) · Sleep And Breathing · doi:10.1007/s11325-009-0246-6 · Cited by 20 · see citing works
“Leptin is a peripheral inflammatory cytokine-like hormone that causes atherosclerosis, a mechanism that needs a long period of time [26].”
BackgroundEffect of Uvulopalatopharyngoplasty on Leptin and Endothelial Function in Sleep Apnea
Lin, C.-C., Wang, Y., Lee, K., Liaw, S., & Chiu, C. (2014) · Annals of Otology Rhinology & Laryngology · doi:10.1177/0003489414521385 · Cited by 19 · see citing works
Marousi, S., Theodorou, G., Καρακάντζα, Μ., Papathanasopoulos, P., & Ellul, J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2009.01231.x · Cited by 17 · see citing works
Effects of OSA Surgery on Leptin and Metabolic Profiles
Chin, C., Lin, P., Lin, H., Friedman, M., & Lin, M. (2019) · Otolaryngology · doi:10.1177/0194599819877647 · Cited by 17 · see citing works
“The proinflammatory properties of leptin and its role in modulating immune functions are well documented.(12,13) Accumulating evidence has demonstrated that leptin has a critical role in the pathophysiology of atherosclerosis and that an elevated serum leptin level is a predictor of cardiovascular and stroke risk.”
BackgroundInfluentialModulation of P2Y11-related purinergic signaling in inflammation and cardio-metabolic diseases
Dănilă, M. D., Piollet, M., Aburel, O.-M., Angoulvant, D., Gabillard-Lefort, C., Chadet, S., Roger, S., Muntean, D. M., & Ivanés, F. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173060 · Cited by 16 · see citing works
Roles of adiponectin and leptin as diagnostic markers in pancreatic cancer
Çolakoğlu, M. K., Bostancı, E. B., Ozdemir, Y., et al. (2017) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2017_077 · Cited by 15 · see citing works
“Adipose tissue is an active endocrine organ that secretes several bioactive adipokines that regulate various physiological and pathological processes (1, 2).”
Agrawal, A., Lourenço, E. V., Gupta, S., & Cava, A. L. (2008) · PubMed Central · Cited by 14 · see citing works
Self-citationBadawi, A. I. Z., El-Hamid, A. M. A., Mohamed, N. K., et al. (2016) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2016.07.001 · Cited by 12 · see citing works
“In Egyptian SLE patients, insulin sensitivity and IMT were altered especially in those with metabolic syndrome (MetS) comorbidity with an associated increase in disease activity and damage [5].”
BackgroundAravindhan, V., Mohan, V., Surendar, J., et al. (2012) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2012.11-0773 · Cited by 12 · see citing works
“Several studies have evaluated the association of adipokines with CAD and have provided mixed results.(28) In general, low levels of serum adiponectin have been associated with diabetes and CAD but this was dependent upon the obesity status.”
ResultMaeda, A., Tamura, K., Wakui, H., Ohsawa, M., Azushima, K., Uneda, K., Kobayashi, R., Tsurumi‐Ikeya, Y., Kanaoka, T., Dejima, T., et al. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8577 · Cited by 12 · see citing works
“Leptin is the firstly characterized adipokine, which is 16 kDa peptide hormone encoded by the ob gene and mainly produced by white adipose tissue regulated by energy level, food intake, several hormones and various inflammatory mediators [26, 27].”
BackgroundAdiponectin: A biomarker for chronic hepatitis C?
Liu, D., Li, S., & Li, Z. (2015) · Cytokine · doi:10.1016/j.cyto.2015.10.016 · Cited by 9 · see citing works
Yang, K., Xu, M., Cao, J., Zhu, Q., Rahman, M. S., Holmén, B. A., Fukagawa, N. K., & Zhu, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-85784-4 · Cited by 11 · see citing works
Inflammation and Metabolic Syndrome
Devaraj, S., Siegel, D., & Jialal, I. (2011) · doi:10.1002/9781444347319.ch13 · Cited by 8 · see citing works
Zhang, C., Yuan, M., Rong, W., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119091 · Cited by 7 · see citing works
Badi, F. M., Bathaie, S. Z., Borazjani, F., et al. (2025) · Food & Function · doi:10.1039/d4fo03396e · Cited by 6 · see citing works
Gut Microbiota, Diet, Endotoxemia, and Diseases
Cani, P. D., & Delzenne, N. M. (2009) · doi:10.1002/9783527628100.ch20 · Cited by 6 · see citing works
Systemic inflammation in psoriasis: Sequel of metabolic syndrome
Dutta, D., Maisnam, I., Mukhopadhyay, S., Raychaudhuri, S. K., & Raychaudhuri, S. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00027-x · Cited by 4 · see citing works
de Souza, H. C. D., Philbois, S. V., Facioli, T. D. P., Ferriani, R. A., & Gastaldi, A. C. (2022) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000503 · Cited by 5 · see citing works
“It also has an anti-atherogenic role (25,31).”
BackgroundMEULEMAN, E. J. H., & van Lankveld, J. J. D. M. (2014) · Springer eBooks · doi:10.1007/978-3-662-45018-5_8 · Cited by 1 · see citing works
Nascimento, H., Coimbra, S., Rêgo, C., et al. (2017) · InTech eBooks · doi:10.5772/65722 · Cited by 1 · see citing works
“Decreased adiponectin levels are negatively associated with other oxidative stress markers, as adipocyte fatty acid‐binding protein (A‐FABP) and lipocalin‐2 [21, 67].”
BackgroundRaigangar, V. L., Hasan, H. A., & Abdullah, A. R. (2008) · The Medical Journal of Basrah University · doi:10.33762/mjbu.2008.48376
“High serum leptin (SL) concentration in obesity causes oxidative stress in endothelial cells and has a vascular calcifying effect, which promotes atherogenesis.([11-14]) Leptin has been associated with insulin resistance (IR) in adults; some studies report this association to be dependent on body fatness([15]) and oth…”
BackgroundSadeghi, K., Vasmehjani, A. A., Baharlou, R., et al. (2019) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.11190
Γονιδιακή έκφραση στον αρθρικό χόνδρο ασθενών με οστεοαρθρίτιδα
Σιμοπούλου, Θ. (2010) · doi:10.12681/eadd/23264
- Authors
- Matarese, G., Mantzoros, C., & Cava, A.
- Affiliations
- Institute for Experimental Endocrinology and Oncology (IT)
- Corresponding author
- Cava, Antonio
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2007-12-01
- Volume
- 13
- Issue
- 36
- Pages
- 3676-3680
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W2171390260
- Cited by
- 62
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 6
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Beth Israel Deaconess Medical Center
- Fondazione Italiana Sclerosi Multipla
- Consiglio Nazionale delle Ricerche
- National Institutes of Health
- U.S. Public Health Service (R0-158785)
- National Institute of Allergy and Infectious Diseases (AI63515, R21AI063515)
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR53239, R01AR053239)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- leptin, adipokines, adiponectin, visfatin, atherosclerosis, low-grade inflammation, obesity, metabolic syndrome
- MeSH terms
- Adipose Tissue, Animals, Endothelium, Vascular, Humans, Inflammation, Signal Transduction, Autoimmunity, Leptin, Atherosclerosis, Adipokines, Nicotinamide Phosphoribosyltransferase
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