Cited by 979Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

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The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

Cani, Patrice, Delzenne, Nathalie·2009·Current Pharmaceutical Design

DOI 10.2174/138161209788168164

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Abstract

Obesity is now classically characterized by a cluster of several metabolic disorders, and by a low grade inflammation. The evidence that the gut microbiota composition can be different between healthy and or obese and type 2 diabetic patients has led to the study of this environmental factor as a key link between the pathophysiology of metabolic diseases and the gut microbiota. Several mechanisms are proposed linking events occurring in the colon and the regulation of energy metabolism, such as i.e. the energy harvest from the diet, the synthesis of gut peptides involved in energy homeostasis (GLP-1, PYY...), and the regulation of fat storage. Moreover, the development of obesity and metabolic disorders following a high-fat diet may be associated to the innate immune system. Indeed, high-fat diet feeding triggers the development of obesity, inflammation, insulin resistance, type 2 diabetes and atherosclerosis by mechanisms dependent of the LPS and/or the fatty acids activation of the CD14/TLR4 receptor complex. Importantly, fat feeding is also associated with the development of metabolic endotoxemia in human subjects and participates in the low-grade inflammation, a mechanism associated with the development of atherogenic markers. Finally, data obtained in experimental models and human subjects are in favour of the fact that changing the gut microbiota (with prebiotics and/or probiotics) may participate in the control of the development of metabolic diseases associated with obesity. Thus, it would be useful to find specific strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases.

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Authors: Cani, P., & Delzenne, N.
Affiliations: UCLouvain (BE)
Corresponding author: Delzenne, Nathalie
ORCID: Cani, Patrice
Delzenne, Nathalie
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2009-05-01
Volume: 15
Issue: 13
Pages: 1546-1558
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/138161209788168164
OpenAlex: W1972686367
Cited by: 974
References: 110
Citations by year: 2026: 36 · 2025: 51 · 2024: 49 · 2023: 41 · 2022: 56 · 2021: 63 · 2020: 70 · 2019: 55 · 2018: 67 · 2017: 66 · 2016: 73 · 2015: 61 · 2014: 53 · 2013: 72 · 2012: 41
FWCI: 21.59
Type: journal article
Language: en
Open access: closed
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Funders: Université Catholique de Louvain
Fonds Spéciaux de Recherche
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, energy metabolism, obesity, type 2 diabetes, metabolic disorders, low-grade inflammation, insulin resistance, atherosclerosis, high-fat diet, endotoxemia, lipopolysaccharide, gut peptides, glucagon-like peptide-1, peptide YY, fat deposition, prebiotics, probiotics, gut-brain axis
MeSH terms: Animals, Dietary Fats, Energy Metabolism, Humans, Immunity, Innate, Metabolic Diseases, Obesity, Probiotics, Gastrointestinal Tract

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The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

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