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Cited by 979Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

Cani, Patrice, Delzenne, Nathalie·2009·Current Pharmaceutical Design
DOI 10.2174/138161209788168164
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Abstract

Obesity is now classically characterized by a cluster of several metabolic disorders, and by a low grade inflammation. The evidence that the gut microbiota composition can be different between healthy and or obese and type 2 diabetic patients has led to the study of this environmental factor as a key link between the pathophysiology of metabolic diseases and the gut microbiota. Several mechanisms are proposed linking events occurring in the colon and the regulation of energy metabolism, such as i.e. the energy harvest from the diet, the synthesis of gut peptides involved in energy homeostasis (GLP-1, PYY...), and the regulation of fat storage. Moreover, the development of obesity and metabolic disorders following a high-fat diet may be associated to the innate immune system. Indeed, high-fat diet feeding triggers the development of obesity, inflammation, insulin resistance, type 2 diabetes and atherosclerosis by mechanisms dependent of the LPS and/or the fatty acids activation of the CD14/TLR4 receptor complex. Importantly, fat feeding is also associated with the development of metabolic endotoxemia in human subjects and participates in the low-grade inflammation, a mechanism associated with the development of atherogenic markers. Finally, data obtained in experimental models and human subjects are in favour of the fact that changing the gut microbiota (with prebiotics and/or probiotics) may participate in the control of the development of metabolic diseases associated with obesity. Thus, it would be useful to find specific strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases.

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Crossref · 10.2174/138161209788168164

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Metadata

Authors
Cani, P., & Delzenne, N.
Affiliations
UCLouvain (BE)
Corresponding author
Delzenne, Nathalie
ORCID
Venue
Current Pharmaceutical Design
Publisher
Bentham Science Publishers Ltd.
Published
2009-05-01
Volume
15
Issue
13
Pages
1546-1558
ISSN
1381-6128 (ISSN-L)
DOI
10.2174/138161209788168164
OpenAlex
W1972686367
Cited by
974
References
110
Citations by year
2026: 36 · 2025: 51 · 2024: 49 · 2023: 41 · 2022: 56 · 2021: 63 · 2020: 70 · 2019: 55 · 2018: 67 · 2017: 66 · 2016: 73 · 2015: 61 · 2014: 53 · 2013: 72 · 2012: 41
FWCI
21.59
Type
journal article
Language
en
Open access
closed
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Funders
  • Université Catholique de Louvain
  • Fonds Spéciaux de Recherche
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
gut microbiota, energy metabolism, obesity, type 2 diabetes, metabolic disorders, low-grade inflammation, insulin resistance, atherosclerosis, high-fat diet, endotoxemia, lipopolysaccharide, gut peptides, glucagon-like peptide-1, peptide YY, fat deposition, prebiotics, probiotics, gut-brain axis
MeSH terms
Animals, Dietary Fats, Energy Metabolism, Humans, Immunity, Innate, Metabolic Diseases, Obesity, Probiotics, Gastrointestinal Tract

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