Cited by 979Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

Cani, Patrice, Delzenne, Nathalie·2009·Current Pharmaceutical Design

DOI 10.2174/138161209788168164

Open this paper in CoChat — free account

Abstract

Obesity is now classically characterized by a cluster of several metabolic disorders, and by a low grade inflammation. The evidence that the gut microbiota composition can be different between healthy and or obese and type 2 diabetic patients has led to the study of this environmental factor as a key link between the pathophysiology of metabolic diseases and the gut microbiota. Several mechanisms are proposed linking events occurring in the colon and the regulation of energy metabolism, such as i.e. the energy harvest from the diet, the synthesis of gut peptides involved in energy homeostasis (GLP-1, PYY...), and the regulation of fat storage. Moreover, the development of obesity and metabolic disorders following a high-fat diet may be associated to the innate immune system. Indeed, high-fat diet feeding triggers the development of obesity, inflammation, insulin resistance, type 2 diabetes and atherosclerosis by mechanisms dependent of the LPS and/or the fatty acids activation of the CD14/TLR4 receptor complex. Importantly, fat feeding is also associated with the development of metabolic endotoxemia in human subjects and participates in the low-grade inflammation, a mechanism associated with the development of atherogenic markers. Finally, data obtained in experimental models and human subjects are in favour of the fact that changing the gut microbiota (with prebiotics and/or probiotics) may participate in the control of the development of metabolic diseases associated with obesity. Thus, it would be useful to find specific strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases.

Integrity signals

Registry

Crossref · 10.2174/138161209788168164

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Self-citation
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245

Show all 110 references

Sorted by citations

Items 301–400 of 979

Effects of probiotics, prebiotics, and synbiotics on polycystic ovary syndrome: a systematic review and meta-analysis
Li, Y., Tan, Y., Xia, G., & Shuai, J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1951155 · Cited by 64
Human Gut Microbiota in Health and Selected Cancers
Sędzikowska, A., & Szablewski, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413440 · Cited by 71
Inulin Supplementation Lowered the Metabolic Defects of Prolonged Exposure to Chlorpyrifos from Gestation to Young Adult Stage in Offspring Rats
Reygner, J., Lichtenberger, L., Elmhiri, G., Dou, S., Bahi-Jaber, N., Rhazi, L., Dépeint, F., Bach, V., Khorsi‐Cauet, H., & Abdennebi‐Najar, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164614 · Cited by 67
Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
Weng, J. M., Parikh, I. J., Naqib, A. D., York, J. M., Green, S. J., Estus, S., & LaDu, M. J. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0352-2 · Cited by 65
Gut microbiota and chronic kidney disease: implications for novel mechanistic insights and therapeutic strategies
Pan, W. D., & Kang, Y. (2017) · International Urology and Nephrology · doi:10.1007/s11255-017-1689-5 · Cited by 62
Bifidobacterium adolescentis CGMCC 15058 alleviates liver injury, enhances the intestinal barrier and modifies the gut microbiota in d-galactosamine-treated rats
Li, Y., Lv, L., Ye, J., Fang, D., Shi, D., Wu, W., Wang, Q., Wu, J., Yang, L., Bian, X., et al. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9454-y · Cited by 63
Characterization of the Early Life Microbiota Development and Predominant Lactobacillus Species at Distinct Gut Segments of Low- and Normal-Birth-Weight Piglets
Li, N., Huang, S., Jiang, L., Dai, Z., Li, T., Han, D., & Wang, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00797 · Cited by 66
Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
Hu, J., Lesseur, C., Yu, M., Manservisi, F., Panzacchi, S., Mandrioli, D., Belpoggi, F., Chen, J., & Petrick, L. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-82552-2 · Cited by 59
Ammonia Toxicity Induces Oxidative Stress, Inflammatory Response and Apoptosis in Hybrid Grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)
Yan, X., Chen, Y., Dong, X., Tan, B., Liu, H., Zhang, S., Chi, S., Yang, Q., Liu, H., & Yang, Y. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.667432 · Cited by 67
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling
Uchimura, K., Hayata, M., Mizumoto, T., Miyasato, Y., Kakizoe, Y., Morinaga, J., Onoue, T., Yamazoe, R., Ueda, M. U., Adachi, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4428 · Cited by 59
Specific metabolite production by gut microbiota as a basis for probiotic function
Ross, R. P., Mills, S., Hill, C., Fitzgerald, G. F., & Stanton, C. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.12.003 · Cited by 61
Effects of resistant starch on glycemic control, serum lipoproteins and systemic inflammation in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled clinical trials
Hallajzadeh, J., Milajerdi, A., Reiner, Ž., Amirani, E., Kolahdooz, F., Barekat, M., Mirzaei, H., Mirhashemi, S. M., & Asemi, Z. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1680950 · Cited by 62
Involvement of the gut microbiota in the development of low grade inflammation associated with obesity: focus on this neglected partner.
Cani, P. D., & Delzenne, N. M. (2010) · PubMed · Cited by 60
Self-citation
Effect of Dietary Acetic Acid Supplementation on Plasma Glucose, Lipid Profiles, and Body Mass Index in Human Adults: A Systematic Review and Meta-analysis
Valdes, D. S., So, D., Gill, P. A., & Kellow, N. J. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.12.002 · Cited by 64
Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study
Stadlbauer, V., Leber, B., Lemesch, S., Trajanoski, S., Bashir, M., Horvath, A., Tawdrous, M., Stojaković, T., Fauler, G., Fickert, P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141399 · Cited by 59
Effect ofRhizoma coptidis(Huang Lian) on Treating Diabetes Mellitus
Pang, B., Yu, X., Zhou, Q., Zhao, T., Wang, H., Gu, C., & Tong, X. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/921416 · Cited by 59
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study
Neto, J. V., de Melo, C., & Ribeiro, S. M. L. (2013) · Nutrients · doi:10.3390/nu5041276 · Cited by 59
Regulation of Gastrointestinal Immunity by Metabolites
Gu, B., Kim, M., & Yun, C. (2021) · Nutrients · doi:10.3390/nu13010167 · Cited by 57
Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
Kieffer, D. A., Piccolo, B. D., Marco, M. L., Kim, E. B., Goodson, M. L., Keenan, M. J., Dunn, T. N., Knudsen, K. E. B., Martin, R. J., & Adams, S. H. (2016) · Journal of Nutrition · doi:10.3945/jn.116.238931 · Cited by 58
Nutritional approaches for managing obesity-associated metabolic diseases
Botchlett, R. E., Woo, S., Liu, M., Pei, Y., Guo, X., Li, H., & Wu, C. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0580 · Cited by 65
Gut Microbiota and Its Pathophysiology in Disease Paradigms
Festi, D., Schiumerini, R., Birtolo, C., Marzi, L., Montrone, L., Scaioli, E., Biase, A. R. D., & Colecchia, A. (2011) · Digestive Diseases · doi:10.1159/000332975 · Cited by 57
Gut Microbes: From Bugs to Drugs
Shanahan, F. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.729 · Cited by 57
The human gut microbiota is neither an organ nor a commensal
Riccio, P., & Rossano, R. (2020) · FEBS Letters · doi:10.1002/1873-3468.13946 · Cited by 59
Bariatric Surgery and Liver Disease: General Considerations and Role of the Gut–Liver Axis
Cerreto, M., Santopaolo, F., Gasbarrini, A., Pompili, M., & Ponziani, F. R. (2021) · Nutrients · doi:10.3390/nu13082649 · Cited by 58
A Systematic Review of Obesity Disparities Research
PRATT, C. A., Loria, C. M., Arteaga, S. S., Nicastro, H. L., Lopez‐Class, M., Jesus, J. M. D., Srinivas, P. R., Maric‐Bilkan, C., Longacre, L. S., Boyington, J., et al. (2017) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2017.01.041 · Cited by 59
Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota
Yang, X., Li, D., Zhang, M., Feng, Y., Jin, X., Liu, D., Guo, Y., & Hu, Y. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00900-w · Cited by 63
Early Changes in Microbial Colonization Selectively Modulate Intestinal Enzymes, but Not Inducible Heat Shock Proteins in Young Adult Swine
Arnal, M.-É., Zhang, J., Messori, S., Bosi, P., Smidt, H., & Lallès, J. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087967 · Cited by 56
Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice
Rune, I., Rolin, B., Larsen, C. S., Nielsen, D. S., Kanter, J. E., Bornfeldt, K., Lykkesfeldt, J., Buschard, K., Kirk, R. K., Christoffersen, B. Ø., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146439 · Cited by 57
Abundance and Diversity of Microbiota in Type 2 Diabetes and Obesity
Remely, M. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000253 · Cited by 56
The microbiota: a key regulator of health, productivity, and reproductive success in mammals
Khan, I. M., Nassar, N., Chang, H., Khan, S., Cheng, M., Wang, Z., & Xiang, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1480811 · Cited by 61
The human intestinal microbiota
Dore, J. M., & Corthier, G. (2010) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(10)70015-4 · Cited by 67
Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis
Alisi, A., Ceccarelli, S., Panera, N., & Nobili, V. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00132 · Cited by 55
The use of probiotic L. fermentum ME-3 containing Reg’Activ Cholesterol supplement for 4 weeks has a positive influence on blood lipoprotein profiles and inflammatory cytokines: an open-label preliminary study
Kullisaar, T., Zilmer, K., Salum, T., Rehema, A., & Zilmer, M. (2016) · Nutrition Journal · doi:10.1186/s12937-016-0213-6 · Cited by 55
Exploring the microbiome in health and disease
Scotti, E., Boué, S., Sasso, G. L., Zanetti, F., Belcastro, V., Poussin, C., Sierro, N., Battey, J. N. D., Gimalac, A., Ivanov, N. V., et al. (2017) · Toxicology Research and Application · doi:10.1177/2397847317741884 · Cited by 56
Phenolics and Carbohydrates in Buckwheat Honey Regulate the Human Intestinal Microbiota
Jiang, L., Xie, M., Chen, G., Qiao, J., Zhang, H., & Zeng, X. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6432942 · Cited by 56
Dietary Polyphenols, Microbiome, and Multiple Sclerosis: From Molecular Anti-Inflammatory and Neuroprotective Mechanisms to Clinical Evidence
Rosa, G. L., Lonardo, M. S., Cacciapuoti, N., Muscariello, E., Guida, B., Faraonio, R., Santillo, M., & Damiano, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087247 · Cited by 56
The Interplay between Defensins and Microbiota in Crohn’s Disease
Coretti, L., Natale, A., Cuomo, M., Florio, E., Keller, S., Lembo, F., Chiariotti, L., & Pero, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/8392523 · Cited by 56
Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish
Xu, H., Wang, J., Wang, Q., Tu, W., & Jin, Y. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133051 · Cited by 52
Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions
Martemucci, G., Khalil, M., Luca, A. D., Abdallah, H., & D‘Alessandro, A. G. (2024) · Metabolites · doi:10.3390/metabo14060327 · Cited by 60
Early Development of Intestinal Microbiota
Saavedra, J. M., & Dattilo, A. M. (2012) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2012.08.001 · Cited by 53
Effect of raw potato starch on the gut microbiome and metabolome in mice
Bang, S.-J., Lee, E., Song, E., Nam, Y., Seo, M., Kim, H., Park, C., Lim, M. Y., & Seo, D. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.085 · Cited by 53
Akkermansia muciniphila is Negatively Correlated with Hemoglobin A1c in Refractory Diabetes
Shih, C., Yeh, Y., Lin, C., Yang, L., & Chiang, C.-P. (2020) · Microorganisms · doi:10.3390/microorganisms8091360 · Cited by 57
Diabetes and Its Cardiovascular Complications: Comprehensive Network and Systematic Analyses
Wu, H., Norton, V., Cui, K., Zhu, B., Bhattacharjee, S., Lu, Y. W., Wang, B., Shan, D., Wong, S., Dong, Y., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841928 · Cited by 59
Current and emerging concepts on the role of peripheral signals in the control of food intake and development of obesity
Duca, F. A., & Covașă, M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000529 · Cited by 53
Impact of Spray-Dried Plasma on Intestinal Health and Broiler Performance
Campbell, J. M., Crenshaw, J., González-Esquerra, R., & Polo, J. (2019) · Microorganisms · doi:10.3390/microorganisms7080219 · Cited by 52
Green propolis modulates gut microbiota, reduces endotoxemia and expression of TLR4 pathway in mice fed a high-fat diet
Roquetto, A. R., Monteiro, N. E. S., Moura, C. S., Toreti, V. C., de Pace, F., Santos, A., Park, Y. K., & Amaya‐Farfán, J. (2015) · Food Research International · doi:10.1016/j.foodres.2015.07.026 · Cited by 52
Butyric acid: what is the future for this old substance?
Sossai, P. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13596 · Cited by 51
Methanobacterium formicicum as a target rumen methanogen for the development of new methane mitigation interventions: A review
Chellapandi, P., Bharathi, M., Sangavai, C., & Prathiviraj, R. (2018) · Veterinary and Animal Science · doi:10.1016/j.vas.2018.09.001 · Cited by 52
Beyond gut microbiota: understanding obesity and type 2 diabetes
Lau, E., Carvalho, D. M., Pina‐Vaz, C., Barbosa, J.-A., & Freitas, P. (2015) · HORMONES · doi:10.14310/horm.2002.1571 · Cited by 56
Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice
Won, S., Chen, S., Lee, S. Y., Lee, K. E., Park, K. W., & Yoon, J. (2020) · Nutrients · doi:10.3390/nu12123703 · Cited by 53
The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response
Pavlov, V. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107794 · Cited by 50
Fecal fermentation and high-fat diet-induced obesity mouse model confirmed exopolysaccharide from Weissella cibaria PFY06 can ameliorate obesity by regulating the gut microbiota
Xie, Y., Pei, F., Liu, Y., Liu, Z., Chen, X., & Xue, D. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121122 · Cited by 50
Does the Gut Microbiota Contribute to Obesity? Going beyond the Gut Feeling
Aguirre, M., & Venema, K. (2015) · Microorganisms · doi:10.3390/microorganisms3020213 · Cited by 52
Potentials and Limitations of Bile Acids in Type 2 Diabetes Mellitus: Applications of Microencapsulation as a Novel Oral Delivery System
Al-Salami (2013) · Journal of Endocrinology and Diabetes Mellitus · doi:10.12970/2310-9971.2013.01.02.4 · Cited by 50
Low Levels of Lipopolysaccharide Modulate Mitochondrial Oxygen Consumption in Skeletal Muscle
Frisard, M. I., Wu, Y., McMillan, R. P., Voelker, K. A., Wahlberg, K. A., Anderson, A. S., Boutagy, N. E., Resendes, K., Ravussin, É., & Hulver, M. W. (2014) · Metabolism · doi:10.1016/j.metabol.2014.11.007 · Cited by 50
Nutrition and Alzheimer Disease
Fernández, S. S. M., & Ribeiro, S. M. L. (2018) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2018.06.012 · Cited by 50
Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity
Erickson, M. A., Liang, W., Fernández, E. G., Bullock, K. M., Thysell, J. A., & Banks, W. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205769 · Cited by 50
Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome
Giugliano, S., Gatti, A. V., Rusin, M., Schorn, T., Pimazzoni, S., Calanni‐Pileri, M., Fraccascia, V., Carloni, S., & Rescigno, M. (2025) · Nature Communications · doi:10.1038/s41467-025-58533-8 · Cited by 55
Association between probiotic and yogurt consumption and kidney disease: insights from NHANES
Yacoub, R., Kaji, D. A., Patel, S., Simoes, P. K., Busayavalasa, D., Nadkarni, G. N., He, C., Coca, S. G., & Uribarri, J. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0127-3 · Cited by 48
Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state
Djurić, Z. (2016) · Translational research · doi:10.1016/j.trsl.2016.07.017 · Cited by 50
Amelioration of obesity-related characteristics by a probiotic formulation in a high-fat diet-induced obese rat model
Shin, J., Nam, M. H., Lee, H.-R., Lee, J., Kim, H., Chung, M.-J., & Seo, J. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1481-4 · Cited by 49
Gut Microbiota Drives Metabolic Disease in Immunologically Altered Mice
Chassaing, B., Aitken, J. D., Gewirtz, A. T., & Vijay–Kumar, M. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00003-x · Cited by 51
Modulation of intestinal microbiota in mice by kefir administration
Kim, D.-H., Chon, J.-W., Kim, H., & Seo, K.-H. (2015) · Food Science and Biotechnology · doi:10.1007/s10068-015-0179-8 · Cited by 48
Microplastics exposure causes oxidative stress and microbiota dysbiosis in planarian Dugesia japonica
Han, Y., Zhang, X., Liu, P., Xu, S., Chen, D., Liu, J. N., & Xie, W. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-18547-x · Cited by 48
Liver Ischemic Preconditioning (IPC) Improves Intestinal Microbiota Following Liver Transplantation in Rats through 16s rDNA-Based Analysis of Microbial Structure Shift
Ren, Z., Cui, G., Lu, H., Chen, X., Jiang, J., Liu, H., He, Y., Ding, S., Hu, Z., Wang, W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075950 · Cited by 48
Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis
Bellavia, M., Tomasello, G., Romeo, M., Damiani, P., Monte, A. I. L., Lozio, L., Campanella, C., Marino, A., Rappa, F., Zummo, G., et al. (2013) · Medical Microbiology and Immunology · doi:10.1007/s00430-013-0305-2 · Cited by 47
Nutritional modulation of gut microbiota in the context of obesity and insulin resistance: Potential interest of prebiotics
Delzenne, N. M., & Cani, P. D. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.11.006 · Cited by 48
Self-citation
Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets
Murakami, Y., Ojima‐Kato, T., Saburi, W., Mori, H., Matsui, H., Tanabe, S., & Suzuki, T. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003505 · Cited by 48
Saturated fatty acid (SFA) status and SFA intake exhibit different relations with serum total cholesterol and lipoprotein cholesterol: a mechanistic explanation centered around lifestyle-induced low-grade inflammation
Ruiz-Núñez, B., Kuipers, R. S., Luxwolda, M. F., Graaf, D. J. D., Breeuwsma, B. B., Dijck-Brouwer, J., & Muskiet, F. A. J. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.11.004 · Cited by 47
Optimal immunosuppressor induces stable gut microbiota after liver transplantation
Jiang, J., Ren, Z., Lu, H., Zhang, H., Li, A., Cui, G., Jia, J., Xie, H., Chen, X., He, Y., et al. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i34.3871 · Cited by 47
Update on the gut microbiome in health and diseases
Salvadori, M., & Rosso, G. (2024) · World Journal of Methodology · doi:10.5662/wjm.v14.i1.89196 · Cited by 52
Ex vivo systems to study host–microbiota interactions in the gastrointestinal tract
Roeselers, G., Ponomarenko, M., Lukovac, S., & Wortelboer, H. M. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.018 · Cited by 49
Impact of probiotic Lactobacillus plantarum TENSIA in different dairy products on anthropometric and blood biochemical indices of healthy adults
Hütt, P., Songisepp, E., Rätsep, M., Mahlapuu, R., Kilk, K., & Mikelsaar, M. (2014) · Beneficial Microbes · doi:10.3920/bm2014.0035 · Cited by 45
Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
Zubiría, M. G., Gambaro, S. E., Rey, M., Carasi, P., Serradell, M. D. L. Á., & Giovambattista, A. (2017) · Nutrients · doi:10.3390/nu9050470 · Cited by 45
Alpha-Ketoglutarate in Low-Protein Diets for Growing Pigs: Effects on Cecal Microbial Communities and Parameters of Microbial Metabolism
Chen, J., Kang, B., Jiang, Q., Han, M., Zhao, Y., Long, L., Fu, C., & Kang, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01057 · Cited by 45
Nutritional and Health Profile of Goat Products: Focus on Health Benefits of Goat Milk
Lima, M. J., Teixeira‐Lemos, E., de Oliveira, J. B. F., Teixeira-Lemos, L. P., Monteiro, A., & da Costa, J. M. C. (2018) · InTech eBooks · doi:10.5772/intechopen.70321 · Cited by 48
Antibiotic treatment triggers gut dysbiosis and modulates metabolism in a chicken model of gastro-intestinal infection
Roy, C. I. L., Woodward, M. J., Ellis, R. J., Ragione, R. M. L., & Claus, S. P. (2019) · BMC Veterinary Research · doi:10.1186/s12917-018-1761-0 · Cited by 49
Analysis of the diversity of intestinal microbiome and its potential value as a biomarker in patients with schizophrenia: A cohort study
Pan, R., Zhang, X., Gao, J., Yi, W., Wei, Q., & Su, H. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113260 · Cited by 46
Probiotics– the journey continues
Thomas, L. V. (2016) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12354 · Cited by 45
Type 2 Diabetes Mellitus Is Associated with More Serious Small Intestinal Mucosal Injuries
Zhong, H., Yu, Y., Xie, W.-R., Chen, M.-H., & He, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162354 · Cited by 44
Anti‐fatigue effects of fermented soybean protein peptides in mice
Fang, L., Zhang, R., Wei, Y., Ling, K., Lu, L., Wang, J., Pan, X., & Cai, M. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11609 · Cited by 46
Metabolic pathways and male fertility: exploring the role of Sertoli cells in energy homeostasis and spermatogenesis
Chen, Z.-F., Shen, Y., Gao, D., Lin, D.-F., Ma, W., & Chang, D. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2025 · Cited by 49
Green tea polyphenols boost gut-microbiota-dependent mitochondrial TCA and urea cycles in Sprague–Dawley rats
Zhou, J., Tang, L., Shen, C., & Wang, J.-S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108395 · Cited by 44
The double burden of malnutrition in individuals: Identifying key challenges and re‐thinking research focus
Kiosia, A., Dagbasi, A., Berkley, J. A., Wilding, J. P. H., Prendergast, A. J., Li, J. V., Swann, J., Mathers, J. C., Kerac, M., Morrison, D., et al. (2024) · Nutrition Bulletin · doi:10.1111/nbu.12670 · Cited by 43
Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
Ssekamatte, P., Sande, O. J., van Crevel, R., & Biraro, I. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1122255 · Cited by 52
A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children
Kelishadi, R., Farajian, S., Safavi, S. M., Mirlohi, M., & Hashemipour, M. (2013) · Jornal de Pediatria · doi:10.1016/j.jped.2013.07.003 · Cited by 43
Therapeutic advances in non-alcoholic fatty liver disease: A microbiota-centered view
Chen, H., Huang, H., Li, Y., Xu, H., & Zhou, Y. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i16.1901 · Cited by 43
The Gut Microbiota
Kovatcheva‐Datchary, P., Tremaroli, V., & Bäckhed, F. (2013) · Springer eBooks · doi:10.1007/978-3-642-30144-5_87 · Cited by 46
Systems medicine of inflammaging
Castellani, G., Menichetti, G., Garagnani, P., Bacalini, M. G., Pirazzini, C., Franceschi, C., Collino, S., Sala, C., Remondini, D., Giampieri, E., et al. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv062 · Cited by 43
Microbiota and epigenetics: promising therapeutic approaches?
El-Sayed, A., Aleya, L., & Kamel, M. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-15623-6 · Cited by 43
Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans
Lee, C., Liao, Y.-C., Lee, M., Cheng, Y.-C., Chiou, S., Lin, J., Huang, C., & Watanabe, K. (2022) · Microorganisms · doi:10.3390/microorganisms10112181 · Cited by 50
The dichotomous role of the gut microbiome in exacerbating and ameliorating neurodegenerative disorders
Raval, U., Harary, J. M., Zeng, E., & Pasinetti, G. M. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1775585 · Cited by 45
Over-Expression of Intestinal Alkaline Phosphatase Attenuates Atherosclerosis
Ghosh, S. S., Wang, J., Yannie, P. J., Cooper, R. C., Sandhu, Y. K., Kakiyama, G., Korzun, W. J., & Ghosh, S. (2021) · Circulation Research · doi:10.1161/circresaha.120.317144 · Cited by 41
Dietary fiber during gestation improves lactational feed intake of sows by modulating gut microbiota
Li, S., Zheng, J., He, J., Liu, H., Huang, Y., Huang, L., Wang, K., Zhao, X., Feng, B., Che, L., et al. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00870-z · Cited by 40
Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity
Guo, Y., Liu, Y., Rui, B., Lei, Z., Ning, X., Liu, Y., & Li, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1171680 · Cited by 42
The Intestinal Microbiome in Bariatric Surgery Patients
Peat, C. M., Kleiman, S. C., Bulik, C. M., & Carroll, I. M. (2015) · European Eating Disorders Review · doi:10.1002/erv.2400 · Cited by 41
Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome
Silva, L. H. A. C., Galvão, J. G. F. M., da Silva, J. S. D. F., de Sales-Neto, J. M., & Rodrigues‐Mascarenhas, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00341 · Cited by 42
Effects of Maydis stigma polysaccharide on the intestinal microflora in type-2 diabetes
Wang, C., Yin, Y., Cao, X., & Li, X. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1211153 · Cited by 40
Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria
Schwenger, K. J. P., Bolzon, C. M., Li, C., & Allard, J. P. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1844-5 · Cited by 40
Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling
Nakamura, A., Yokoyama, Y., Tanaka, K., Benegiamo, G., Hirayama, A., Zhu, Q., Kitamura, N., Sugizaki, T., Morimoto, K., Itoh, H., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101522 · Cited by 41

Authors: Cani, P., & Delzenne, N.
Affiliations: UCLouvain (BE)
Corresponding author: Delzenne, Nathalie
ORCID: Cani, Patrice
Delzenne, Nathalie
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2009-05-01
Volume: 15
Issue: 13
Pages: 1546-1558
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/138161209788168164
OpenAlex: W1972686367
Cited by: 974
References: 110
Citations by year: 2026: 36 · 2025: 51 · 2024: 49 · 2023: 41 · 2022: 56 · 2021: 63 · 2020: 70 · 2019: 55 · 2018: 67 · 2017: 66 · 2016: 73 · 2015: 61 · 2014: 53 · 2013: 72 · 2012: 41
FWCI: 21.59
Type: journal article
Language: en
Open access: closed
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Funders: Université Catholique de Louvain
Fonds Spéciaux de Recherche
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, energy metabolism, obesity, type 2 diabetes, metabolic disorders, low-grade inflammation, insulin resistance, atherosclerosis, high-fat diet, endotoxemia, lipopolysaccharide, gut peptides, glucagon-like peptide-1, peptide YY, fat deposition, prebiotics, probiotics, gut-brain axis
MeSH terms: Animals, Dietary Fats, Energy Metabolism, Humans, Immunity, Innate, Metabolic Diseases, Obesity, Probiotics, Gastrointestinal Tract

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks