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Perspectives on Medicinal Properties of Mangiferin
Abstract
Mango tree, Mangifera indica, has been cultivated in India and several other tropical countries for centuries, and it is a good source of compound 'mangiferin'. Mangiferin's xanthonoid structure with C-glucosyl linkage and polyhydroxy component is believed to be crucial for its free radical-scavenging ability leading to a potent antioxidant effect. A number of biological activities of mangiferin have been suggested, including antidiabetic and antiinflammatory abilities. These might be explained by its antioxidant ability as well as its ability to modulate several key inflammatory pathways. Mangiferin has also been shown to be an effective inhibitor of NF-κB signaling pathway. This partially explains its antiinflammatory ability and, additionally, points towards its anticancer potential. The anticancer effects of this compound are just beginning to emerge, and in this comprehensive review, we provide information on what we know about the chemistry and biological effects of mangiferin, which would likely create interest among researchers to design further mechanistic studies in order to better understand and exploit the biological activities of this compound.
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“many pharmacological studies demonstrate numerous MGF activities including immunomodulatory, antimicrobial, antiviral, and anti-inflammatory properties [36,37,38].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [37]
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Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159
Beelders, T., de Beer, D., Stander, M. A., & Joubert, E. (2014) · Molecules · doi:10.3390/molecules190811760 · Cited by 116
Mangos and their bioactive components: adding variety to the fruit plate for health
Burton‐Freeman, B. M., Sandhu, A. K., & Edirisinghe, I. (2017) · Food & Function · doi:10.1039/c7fo00190h · Cited by 117
Núñez Selles, A. J., Daglia, M., & Rastrelli, L. (2016) · BioFactors · doi:10.1002/biof.1299 · Cited by 102
Ethosomes and Transethosomes for Mangiferin Transdermal Delivery
Sguizzato, M., Ferrara, F., Hallan, S. S., Baldisserotto, A., Drechsler, M., Malatesta, M., Costanzo, M., Cortesi, R., Puglia, C., Valacchi, G., et al. (2021) · Antioxidants · doi:10.3390/antiox10050768 · Cited by 102
Metadata
- Authors
- Vyas, A., Syeda, K., Ahmad, A., Padhye, S., & H. Sarkar, F.
- Affiliations
- Savitribai Phule Pune University (IN)
- Wayne State University (US)
- ORCID
- Ahmad, A.
- Venue
- Mini-Reviews in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-03-01
- Volume
- 12
- Issue
- 5
- Pages
- 412-425
- ISSN
- 1389-5575 (ISSN-L)
- OpenAlex
- W2163768586
- Cited by
- 104
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 12 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 1
- FWCI
- 21.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mini-Reviews in Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Keywords
- mangiferin, mango, xanthones, antioxidant activity, free radical scavenging, antidiabetic activity, anti-inflammatory activity, NF-κB signaling, anticancer activity
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Cell Line, Humans, Hypoglycemic Agents, Plants, Xanthones
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