The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects
Abstract
Mangiferin (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) is a natural bioactive xanthonoid that can be found in many plant species, among which the mango tree (Mangifera indica L), a plant widely used in the traditional medicinal, is one of its primary sources. The use of mangiferin for cancer treatment has attracted the attention of research groups around the World. Single administration of mangiferin or in combination with known anticancer chemicals has shown the potential benefits of this molecule in lung, brain, breast, cervix, and prostate cancers, and leukemia. Mangiferin mechanisms of action against cancer cells through in vitro, ex vivo, or in vivo models are discussed besides its antioxidant and anti-inflammatory properties. Nevertheless, pharmaceutical development and, therefore, clinical trials on cancer targets are still lacking. © 2016 BioFactors, 42(5):475-491, 2016.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many pharmacological studies demonstrate that MGF has immunomodulatory, antimicrobial, antiviral, and anti-inflammatory properties.
“many pharmacological studies demonstrate numerous MGF activities including immunomodulatory, antimicrobial, antiviral, and anti-inflammatory properties [36,37,38].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [38]
Cites
Pal, P. B., Sinha, K., & Sil, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107220 · Cited by 185 · see citing works
Perspectives on medicinal properties of mangiferin
Vyas, A., Syeda, K., Ahmad, A., Padhye, S., & H. Sarkar, F. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712800493870 · Cited by 104 · see citing works
Bhattacharyya, S., Ahmmed, S. M., Saha, B. P., & Mukherjee, P. K. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6422 · Cited by 56 · see citing works
Dilshara, M. G., Kang, C.-H., Choi, Y. H., & Kim, G.-Y. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.10.003 · Cited by 47 · see citing works
Kammalla, A. K., Ramasamy, M. K., Inampudi, J., Dubey, G. P., Agrawal, A., & Kaliappan, I. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-014-0206-8 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Food waste: a potential bioresource for extraction of nutraceuticals and bioactive compounds
Kumar, K., Yadav, A. N., Kumar, V., Vyas, P., & Dhaliwal, H. S. (2017) · Bioresources and Bioprocessing · doi:10.1186/s40643-017-0148-6 · Cited by 481 · see citing works
Valorization of fruits and vegetable wastes and by-products to produce natural pigments
Sharma, M., Usmani, Z., Gupta, V. K., & Bhat, R. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1873240 · Cited by 275 · see citing works
Razura-Carmona, F. F., Pérez-Larios, A., González-Silva, N., Herrera-Martínez, M., Medina-Torres, L., Sáyago-Ayerdi, S. G., & Sánchez-Burgos, J. A. (2019) · Cancers · doi:10.3390/cancers11121965 · Cited by 40 · see citing works
Resource recovery of bioactive compounds from food waste and their diverse industrial applications
Chauhan, S., Pandit, N. K., Mohanty, A., & Meena, S. S. (2025) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-04967-3 · Cited by 29 · see citing works
Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma
Delgado-Hernández, R., Hernández-Balmaseda, I., Rodeiro-Guerra, I., Cesar Rodriguez Gonzalez, J., De Wever, O., Logie, E., Declerck, K., Pérez-Novo, C., & Vanden Berghe, W. (2020) · Melanoma Research · doi:10.1097/cmr.0000000000000647 · Cited by 29 · see citing works
Recent Formulation Advances of Mangiferin
Barakat, S., Nasr, M., Ahmed, R. F., Badawy, S., & Mortada, N. (2022) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-022-00297-z · Cited by 28 · see citing works
Spampinato, M., Carota, G., Sferrazzo, G., Fuochi, V., Distefano, A., Ronsisvalle, S., Sipala, F., Giuffrida, R., Furneri, P. M., Di Rosa, M., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122845 · Cited by 14 · see citing works
Xia, J., Li, X., Yao, J., Song, D., Gu, Z., Zheng, G., & Tu, C. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111520 · Cited by 5 · see citing works
- Authors
- Núñez Selles, A. J., Daglia, M., & Rastrelli, L.
- Affiliations
- National Evangelic University Research Division, Paseo De Los Periodistas 54 Santo Domingo Dominican Republic
- University of Pavia (IT)
- University of Salerno (IT)
- Corresponding author
- Rastrelli, Luca
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2016-05-24
- Volume
- 42
- Issue
- 5
- Pages
- 475-491
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2400197716
- Cited by
- 102
- References
- 5
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 14 · 2022: 15 · 2021: 14 · 2020: 12 · 2019: 15 · 2018: 7 · 2017: 7 · 2016: 1
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- mangiferin, xanthones, mango, anticancer activity, immunomodulation, angiogenesis inhibition, apoptosis, gene expression regulation, antioxidant activity, anti-inflammatory activity, combination therapy, lung cancer, breast cancer, leukemia, prostate cancer, cervical cancer, brain cancer
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Antioxidants, Humans, Immunologic Factors, Neoplasms, Plant Extracts, Gene Expression Regulation, Neoplastic, Apoptosis, Angiogenesis Inhibitors, Xanthones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
