Cited by 210Virus-based gene therapy researchRNA Interference and Gene DeliveryImmunotherapy and Immune Responses

The DOI matches its Crossref record; 195 of the 196 references it cites were found in a registry or an index.

Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting

Open access

Campos, Samuel, Barry, Michael·2007·Current Gene Therapy

DOI 10.2174/156652307780859062PMC PMC2244792

Open this paper in CoChat — free account Open PDF

Abstract

Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad virion, combined with functional studies has broadened our knowledge of the structure/function relationships between Ad vectors and host cells/tissues and substantial achievement has been made towards a thorough understanding of the biology of Ad vectors. The widespread use of Ad vectors for clinical gene therapy is compromised by their inherent immunogenicity. The generation of safer and more effective Ad vectors, targeted to the site of disease, has therefore become a great ambition in the field of Ad vector development. This review provides a synopsis of the structure/function relationships between Ad vectors and host systems and summarizes the many innovative approaches towards achieving Ad vector targeting.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2174/156652307780859062

Cites

195 of 195 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Characteristics of a human cell line transformed by DNA from human adenovirus type 5
Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,710
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt‐Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., & Finberg, R. W. (1997) · Science · doi:10.1126/science.275.5304.1320 · Cited by 3,102
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
Wickham, T. J., Mathias, P., Cheresh, D. A., & Nemerow, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90231-e · Cited by 2,199
Organ targeting In vivo using phage display peptide libraries
Pasqualini, R., & Ruoslahti, E. I. (1996) · Nature · doi:10.1038/380364a0 · Cited by 1,234
Isolation of a Cytopathogenic Agent from Human Adenoids Undergoing Spontaneous Degeneration in Tissue Culture
Rowe, W. P., Huebner, R. J., Gilmore, L. K., Parrott, R. H., & Ward, T. G. (1953) · Experimental Biology and Medicine · doi:10.3181/00379727-84-20714 · Cited by 1,114
The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution
Acharya, R., Fry, E. E., Stuart, D. I., Fox, G., Rowlands, D. J., & Brown, F. (1989) · Nature · doi:10.1038/337709a0 · Cited by 866
Stepwise dismantling of adenovirus 2 during entry into cells
Greber, U. F., Willetts, M., Webster, P. C., & Helenius, A. (1993) · Cell · doi:10.1016/0092-8674(93)90382-z · Cited by 811
CD46 is a cellular receptor for group B adenoviruses
Gaggar, A., Shayakhmetov, D. M., & Lieber, A. (2003) · Nature Medicine · doi:10.1038/nm952 · Cited by 793
An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism
Dmitriev, I. P., Krasnykh, V. N., Miller, C. R., Wang, M., Kashentseva, E. A., Mikheeva, G., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9706-9713.1998 · Cited by 768
Gene Therapy Death Prompts Review of Adenovirus Vector
Marshall, E. (1999) · Science · doi:10.1126/science.286.5448.2244 · Cited by 760
How Viruses Enter Animal Cells
Smith, A. E., & Helenius, A. (2004) · Science · doi:10.1126/science.1094823 · Cited by 740
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J., & Bergelson, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261452898 · Cited by 702
Genetic content and evolution of adenoviruses
Davison, A. J., Benkő, M., & Harrach, B. (2003) · Journal of General Virology · doi:10.1099/vir.0.19497-0 · Cited by 700
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
Pelkmans, L., Fava, E., Grabner, H., Hannus, M., Habermann, B. H., Krausz, E., & Zerial, M. (2005) · Nature · doi:10.1038/nature03571 · Cited by 607
The viruses and their replication
Lindenbach, B. D. (2007) · Medical Entomology and Zoology · Cited by 553
Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake
Meier, O. C., Boucke, K., Hammer, S. V., Keller, S., Stidwill, R. P., Hemmi, S., & Greber, U. F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112067 · Cited by 470
Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly
Wiethoff, C. M., Wodrich, H., Gerace, L., & Nemerow, G. R. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.1992-2000.2005 · Cited by 466
Structural Analysis of the Mechanism of Adenovirus Binding to Its Human Cellular Receptor, CAR
Bewley, M. C., Springer, K., Zhang, Y., Freimuth, P., & Flanagan, J. M. (1999) · Science · doi:10.1126/science.286.5444.1579 · Cited by 448
Molecular basis of the inflammatory response to adenovirus vectors
Liu, Q., & Muruve, D. A. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302036 · Cited by 430
Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity
Shayakhmetov, D. M., Gaggar, A., Ni, S., Li, Z.-Y., & Lieber, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7478-7491.2005 · Cited by 429
Adenovirus endocytosis
Meier, O. C., & Greber, U. F. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.553 · Cited by 421
Blood clearance rates of adenovirus type 5 in mice
Alemany, R., Suzuki, K., & Curiel, D. T. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-11-2605 · Cited by 414
The Innate Immune Response to Adenovirus Vectors
Muruve, D. A. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1157 · Cited by 408
Site-Specific Genomic Integration in Mammalian Cells Mediated by Phage φC31 Integrase
Thyagarajan, B., Olivares, E. C., Hollis, R. P., Ginsburg, D. S., & Calos, M. P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3926-3934.2001 · Cited by 407
Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae
Roelvink, P. W., Lee, G. M., Einfeld, D. A., Kovesdi, I., & Wickham, T. J. (1999) · Science · doi:10.1126/science.286.5444.1568 · Cited by 406
Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape
Walters, R. W., Freimuth, P., Moninger, T. O., Ganske, I. M., Zabner, J., & Welsh, M. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00912-1 · Cited by 392
Difference imaging of adenovirus: bridging the resolution gap between X‐ray crystallography and electron microscopy.
Stewart, P. L., Fuller, S. D., & Burnett, R. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05919.x · Cited by 386
Acute Cytokine Response to Systemic Adenoviral Vectors in Mice Is Mediated by Dendritic Cells and Macrophages
Zhang, Y., Chirmule, N. B., Gao, G., Qian, R., Croyle, M. A., Joshi, B., Tazelaar, J., & Wilson, J. M. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0329 · Cited by 377
Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways
Zhu, J., Huang, X., & Yang, Y. (2007) · Journal of Virology · doi:10.1128/jvi.02192-06 · Cited by 370
Adenovirus Type 11 Uses CD46 as a Cellular Receptor
Segerman, A., Atkinson, J. P., Marttila, M., Dennerquist, V., Wadell, G., & Arnberg, N. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9183-9191.2003 · Cited by 356
Toward cell–targeting gene therapy vectors: Selection of cell–binding peptides from random peptide–presenting phage libraries
Barry, M. A., Dower, W. J., & Johnston, S. A. (1996) · Nature Medicine · doi:10.1038/nm0396-299 · Cited by 341
Self-citation
Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1
Trotman, L. C., Mosberger, N., Fornerod, M. W. J., Stidwill, R. P., & Greber, U. F. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-1092 · Cited by 332
A triple β-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein
van Raaij, M. J., Mitraki, A., Lavigne, G., & Cusack, S. (1999) · Nature · doi:10.1038/44880 · Cited by 329
Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types
Wickham, T. J., Roelvink, P. W., Brough, D. E., & Kovesdi, I. (1996) · Nature Biotechnology · doi:10.1038/nbt1196-1570 · Cited by 325
Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver
Tao, N., Gao, G., Parr, M. J., Johnston, J., Baradet, T. C., Wilson, J. M., Barsoum, J., & Fawell, S. E. (2001) · Molecular Therapy · doi:10.1006/mthe.2000.0227 · Cited by 321
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
Fisher, K. D., Stallwood, Y., Green, N., Ulbrich, K., Mautner, V., & Seymour, L. W. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301389 · Cited by 317
Antigens and structure of the adenovirus
Valentine, R. C., & Pereira, H. G. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80076-6 · Cited by 316
Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob
Krasnykh, V. N., Dmitriev, I. P., Mikheeva, G., Miller, C. R., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.1844-1852.1998 · Cited by 314
In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial
Herman, J. R., Adler, H. L., Aguilar-Córdova, E., Rojas‐Martínez, A., Woo, S. L. C., Timme, T. L., Wheeler, T. M., Thompson, T. C., & Scardino, P. T. (1999) · Human Gene Therapy · doi:10.1089/10430349950018229 · Cited by 301
Molecular composition of the adenovirus type 2 virion
van Oostrum, J., & Burnett, R. M. (1985) · Journal of Virology · doi:10.1128/jvi.56.2.439-448.1985 · Cited by 297
Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes
Parker, A. L., Waddington, S. N., Nicol, C. G., Shayakhmetov, D. M., Buckley, S. M. K., Denby, L., Kemball‐Cook, G., Ni, S., Lieber, A., McVey, J. H., et al. (2006) · Blood · doi:10.1182/blood-2006-04-008532 · Cited by 297
Adenoviral vectors for gene transfer and therapy
Volpers, C., & Kochanek, S. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.496 · Cited by 296
CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
Alemany, R., & Curiel, D. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301515 · Cited by 294
Heparan Sulfate Glycosaminoglycans Are Receptors Sufficient To Mediate the Initial Binding of Adenovirus Types 2 and 5
Dechecchi, M. C., Melotti, P., Bonizzato, A., Santacatterina, M., Chilosi, M., & Cabrini, G. (2001) · Journal of Virology · doi:10.1128/jvi.75.18.8772-8780.2001 · Cited by 292
The Human Membrane Cofactor CD46 Is a Receptor for Species B Adenovirus Serotype 3
Sirena, D., Lilienfeld, B. G., Eisenhut, M., Kälin, S., Boucke, K., Beerli, R. R., Vogt, L., Ruedl, C., Bachmann, M. F., Greber, U. F., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.9.4454-4462.2004 · Cited by 289
Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies
Wickham, T. J., Segal, D. M., Roelvink, P. W., Carrion, M. E., Lizonová, A., Lee, G. M., & Kovesdi, I. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6831-6838.1996 · Cited by 288
Image reconstruction reveals the complex molecular organization of adenovirus
Stewart, P. L., Burnett, R. M., Cyrklaff, M., & Fuller, S. D. (1991) · Cell · doi:10.1016/0092-8674(91)90578-m · Cited by 285
Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber
Chappell, J. D., Prota, A. E., Dermody, T. S., & Stehle, T. (2002) · The EMBO Journal · doi:10.1093/emboj/21.1.1 · Cited by 278
Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution
Xia, D., Henry, L. J., Gerard, R. D., & Deisenhofer, J. (1994) · Structure · doi:10.1016/s0969-2126(94)00126-x · Cited by 274
Evolution of Cell Recognition by Viruses
Baranowski, É., Ruiz-Jarabo, C. M., & Domingo, E. (2001) · Science · doi:10.1126/science.1058613 · Cited by 268
Adenovirus Endocytosis Requires Actin Cytoskeleton Reorganization Mediated by Rho Family GTPases
Li, E., Stupack, D. G., Bokoch, G., & Nemerow, G. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8806-8812.1998 · Cited by 252
Adenovirus Endocytosis via α v Integrins Requires Phosphoinositide-3-OH Kinase
Li, E., Stupack, D. G., Klemke, R. L., Cheresh, D. A., & Nemerow, G. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2055-2061.1998 · Cited by 252
The Structure of the Human Adenovirus 2 Penton
Zubieta, C., Schoehn, G., Chroboczek, J., & Cusack, S. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.041 · Cited by 244
Sleeping Beauty Transposition: Biology and Applications for Molecular Therapy
Izsvák, Z., & Ivics, Z. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2003.11.009 · Cited by 241
The icosahedral form of an adenovirus
Horne, R. W., Brenner, S., Waterson, A. P., & Wildy, P. (1959) · Journal of Molecular Biology · doi:10.1016/s0022-2836(59)80011-5 · Cited by 236
The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain
Honda, T., Saitoh, H., Masuko, M., Katagiri-Abe, T., Tominaga, K., Kozakai, I., Kobayashi, K., Kumanishi, T., Watanabe, Y., Odani, S., et al. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00036-x · Cited by 235
Biology of Adenovirus and Its Use as a Vector for Gene Therapy
McConnell, M. J., & Imperiale, M. J. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1022 · Cited by 234
Structural and Phylogenetic Analysis of Adenovirus Hexons by Use of High-Resolution X-Ray Crystallographic, Molecular Modeling, and Sequence-Based Methods
Rux, J. J., Kuser, P. R., & Burnett, R. M. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9553-9566.2003 · Cited by 233
Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses
Mok, H. S., Palmer, D. J., Ng, P., & Barry, M. A. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.015 · Cited by 232
Self-citation
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance
Othman, M., Labelle, A., Mazzetti, I., Elbatarny, H. S., & Lillicrap, D. (2006) · Blood · doi:10.1182/blood-2006-06-032524 · Cited by 220
Adenovirus Serotype 5 Fiber Shaft Influences In Vivo Gene Transfer in Mice
Smith, T. A., Idamakanti, N., Rollence, M. L., Marshall-Neff, J., Kim, J., Mulgrew, K. A., Nemerow, G. R., Kaleko, M., & Stevenson, S. C. (2003) · Human Gene Therapy · doi:10.1089/104303403765255165 · Cited by 215
Genetic Targeting of an Adenovirus Vector via Replacement of the Fiber Protein with the Phage T4 Fibritin
Krasnykh, V. N., Belousova, N., Korokhov, N., Mikheeva, G., & Curiel, D. T. (2001) · Journal of Virology · doi:10.1128/jvi.75.9.4176-4183.2001 · Cited by 206
Integrin αvβ1 Is an Adenovirus Coreceptor
Li, E., Brown, S. L., Stupack, D. G., Puente, X. S., Cheresh, D. A., & Nemerow, G. R. (2001) · Journal of Virology · doi:10.1128/jvi.75.11.5405-5409.2001 · Cited by 204
Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo
Muruve, D. A., Cotter, M. J., Zaiss, A. K., White, L. R., Liu, Q., Chan, T., Clark, S. A., Ross, P. J., Meulenbroek, R. A., Mælandsmo, G. M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5966-5972.2004 · Cited by 201
Dependence of Adenovirus Infectivity on Length of the Fiber Shaft Domain
Shayakhmetov, D. M., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.22.10274-10286.2000 · Cited by 197
Helper-Dependent Adenoviral Vectors for Gene Therapy
Palmer, D. J., & Ng, P. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.1 · Cited by 196
Exploiting the Natural Diversity in Adenovirus Tropism for Therapy and Prevention of Disease
Havenga, M. J. E., Lemckert, A. A. C., Ophorst, O. J. A. E., van Meijer, M., Germeraad, W. T. V., Grimbergen, J. M., van den Doel, M. A., Vogels, R., van Deutekom, J. C. T., Janson, A. A. M., et al. (2002) · Journal of Virology · doi:10.1128/jvi.76.9.4612-4620.2002 · Cited by 193
RGD Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection
Vigne, E., Mahfouz, I., Dedieu, J.-F., Brie, A., Perricaudet, M., & Yeh, P. (1999) · Journal of Virology · doi:10.1128/jvi.73.6.5156-5161.1999 · Cited by 191
Signalling in viral entry
Greber, U. F. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8453-3 · Cited by 188
Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo
Yant, S. R., Ehrhardt, A., Mikkelsen, J. G., Meuse, L. A., Pham, T. N. D., & Kay, M. A. (2002) · Nature Biotechnology · doi:10.1038/nbt738 · Cited by 188
The importance of being acid: the role of acidification in intracellular membrane traffic
Mellman, I. (1992) · Journal of Experimental Biology · doi:10.1242/jeb.172.1.39 · Cited by 188
The First Step of Adenovirus Type 2 Disassembly Occurs at the Cell Surface, Independently of Endocytosis and Escape to the Cytosol
Nakano, M. Y., Boucke, K., Suomalainen, M., Stidwill, R. P., & Greber, U. F. (2000) · Journal of Virology · doi:10.1128/jvi.74.15.7085-7095.2000 · Cited by 186
Cryo‐EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization
Stewart, P. L., Chiu, C. Y., Huang, S., Muir, T. W., Zhao, Y., Chait, B. T., Mathias, P., & Nemerow, G. R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1189 · Cited by 185
Identification of Contact Residues and Definition of the CAR-Binding Site of Adenovirus Type 5 Fiber Protein
Kirby, I., Davison, E., Beavil, A. J., Soh, C., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J., & Santis, G. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2804-2813.2000 · Cited by 180
Targeted adenoviral vectors
Barnett, B. G., Crews, C. J., & Douglas, J. T. (2002) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(02)00249-x · Cited by 174
Structure of Adenovirus Complexed with Its Internalization Receptor, α v β5 Integrin
Chiu, C. Y., Mathias, P., Nemerow, G. R., & Stewart, P. L. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6759-6768.1999 · Cited by 171
Structure and composition of the adenovirus type 2 core
Brown, D. T., Westphal, M., Burlingham, B. T., WINTERHOFF, U., & Doerfler, W. (1975) · Journal of Virology · doi:10.1128/jvi.16.2.366-387.1975 · Cited by 167
CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7
Marttila, M., Persson, B. D., Gustafsson, D. J., Liszewski, M. K., Atkinson, J. P., Wadell, G., & Arnberg, N. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.14429-14436.2005 · Cited by 167
PEGylation of E1-Deleted Adenovirus Vectors Allows Significant Gene Expression on Readministration to Liver
Croyle, M. A., Chirmule, N. B., Zhang, Y., & Wilson, J. M. (2002) · Human Gene Therapy · doi:10.1089/104303402760372972 · Cited by 165
Engineering of Adenovirus Vectors Containing Heterologous Peptide Sequences in the C Terminus of Capsid Protein IX
Dmitriev, I. P., Kashentseva, E. A., & Curiel, D. T. (2002) · Journal of Virology · doi:10.1128/jvi.76.14.6893-6899.2002 · Cited by 164
Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors
Short, J. J., Pereboev, A. V., Kawakami, Y., Vasu, C., Holterman, M., & Curiel, D. T. (2004) · Virology · doi:10.1016/j.virol.2004.02.016 · Cited by 164
Structural proteins of adenoviruses
Everitt, E., Sundquist, B. G., Pettersson, U., & Philipson, L. (1973) · Virology · doi:10.1016/0042-6822(73)90404-2 · Cited by 161
Flexibility of the Adenovirus Fiber Is Required for Efficient Receptor Interaction
Wu, E. Y., Pache, L., Seggern, D. J. V., Mullen, T.-M., Mikyas, Y., Stewart, P. L., & Nemerow, G. R. (2003) · Journal of Virology · doi:10.1128/jvi.77.13.7225-7235.2003 · Cited by 158
Fiber Swap between Adenovirus Subgroups B and C Alters Intracellular Trafficking of Adenovirus Gene Transfer Vectors
Miyazawa, N., Leopold, P. L., Hackett, N. R., Ferris, B., Worgall, S., Falck-Pedersen, E., & Crystal, R. G. (1999) · Journal of Virology · doi:10.1128/jvi.73.7.6056-6065.1999 · Cited by 157
Type-Specific Epitope Locations Revealed by X-Ray Crystallographic Study of Adenovirus Type 5 Hexon
Rux, J. J., & Burnett, R. M. (2000) · Molecular Therapy · doi:10.1006/mthe.1999.0001 · Cited by 157
Adenovirus Type 5 Interactions with Human Blood Cells May Compromise Systemic Delivery
Lyons, M. J., Onion, D., Green, N. K., Aslan, K., Rajaratnam, R., Bazán‐Peregrino, M., PHIPPS, S. L., Hale, S. J. M., Mautner, V., Seymour, L. W., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.003 · Cited by 156
A New Group B Adenovirus Receptor Is Expressed at High Levels on Human Stem and Tumor Cells
Tuve, S., Wang, H., Ware, C. B., Liu, Y., Gaggar, A., Bernt, K. M., Shayakhmetov, D. M., Li, Z., Strauss, R., Stone, D., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01370-06 · Cited by 154
Cytoplasmic Dynein Mediates Adenovirus Binding to Microtubules
Kelkar, S., Pfister, K. K., Crystal, R. G., & Leopold, P. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.10122-10132.2004 · Cited by 153
Structural proteins of adenoviruses
Prage, L., Pettersson, U., Höglund, S., Lonberg‐Holm, K., & Philipson, L. (1970) · Virology · doi:10.1016/0042-6822(70)90278-3 · Cited by 148
The Role of Capsid–Endothelial Interactions in the Innate Immune Response to Adenovirus Vectors
Liu, Q., Zaiss, A. K., Colarusso, P., Patel, K. D., Haljan, G. J., Wickham, T. J., & Muruve, D. A. (2003) · Human Gene Therapy · doi:10.1089/104303403321618146 · Cited by 146
Adenovirus type 5 virions can be assembled in vivo in the absence of detectable polypeptide IX
Colby, W. W., & Shenk, T. E. (1981) · Journal of Virology · doi:10.1128/jvi.39.3.977-980.1981 · Cited by 145
Adenovirus Serotype 7 Retention in a Late Endosomal Compartment prior to Cytosol Escape Is Modulated by Fiber Protein
Miyazawa, N., Crystal, R. G., & Leopold, P. L. (2001) · Journal of Virology · doi:10.1128/jvi.75.3.1387-1400.2001 · Cited by 142
A quasi‐atomic model of human adenovirus type 5 capsid
Fabry, C. M. S., Rosa‐Calatrava, M., Conway, J. F., Zubieta, C., Cusack, S., Ruigrok, R. W. H., & Schoehn, G. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600653 · Cited by 141
The Refined Crystal Structure of Hexon, the Major Coat Protein of Adenovirus Type 2, at 2·9 Å Resolution
Athappilly, F. K., Murali, R., Rux, J. J., Cai, Z., & Burnett, R. M. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1593 · Cited by 139
Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector
Toietta, G., Mane, V. P., Norona, W. S., Finegold, M. J., Ng, P., McDonagh, A. F., Beaudet, A. L., & Lee, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500930102 · Cited by 139
Adenovirus Infection Triggers a Rapid, MyD88-Regulated Transcriptome Response Critical to Acute-Phase and Adaptive Immune Responses In Vivo
Hartman, Z. C., Kiang, A., Everett, R., Serra, D. M., Yang, X. Y., Clay, T. M., & Amalfitano, A. (2006) · Journal of Virology · doi:10.1128/jvi.01936-06 · Cited by 136
Modulation of Adenovirus Vector Tropism via Incorporation of Polypeptide Ligands into the Fiber Protein
Belousova, N., Krendelchtchikova, V., Curiel, D. T., & Krasnykh, V. N. (2002) · Journal of Virology · doi:10.1128/jvi.76.17.8621-8631.2002 · Cited by 135
Modification of an Adenoviral Vector with Biologically Selected Peptides: A Novel Strategy for Gene Delivery to Cells of Choice
Romanczuk, H., Galer, C. E., Zabner, J., Barsomian, G., Wadsworth, S. C., & O’Riordan, C. R. (1999) · Human Gene Therapy · doi:10.1089/10430349950016654 · Cited by 134
Visualization of α-Helices in a 6-Angstrom Resolution Cryoelectron Microscopy Structure of Adenovirus Allows Refinement of Capsid Protein Assignments
Saban, S. D., Silvestry, M., Nemerow, G. R., & Stewart, P. L. (2006) · Journal of Virology · doi:10.1128/jvi.01652-06 · Cited by 134
Transductional targeting of adenovirus vectors for gene therapy
Glasgow, J. N., Everts, M., & Curiel, D. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700928 · Cited by 131
In Vivo Hepatic Adenoviral Gene Delivery Occurs Independently of the Coxsackievirus–Adenovirus Receptor
Smith, T. A., Idamakanti, N., Kylefjord, H., Rollence, M. L., King, L., Kaloss, M., Kaleko, M., & Stevenson, S. C. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0613 · Cited by 130
Complement activation by recombinant adenoviruses
Cichon, G., Boeckh-Herwig, S., Schmidt, H., Wehnes, E., Müller, T. H., Pring‐Åkerblom, P., & Burger, R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301611 · Cited by 128
Deletion of Penton RGD Motifs Affects the Efficiency of both the Internalization and the Endosome Escape of Viral Particles Containing Adenovirus Serotype 5 or 35 Fiber Knobs
Shayakhmetov, D. M., Eberly, A. L., Li, Z.-Y., & Lieber, A. (2004) · Journal of Virology · doi:10.1128/jvi.79.2.1053-1061.2005 · Cited by 128
Adenovirus polypeptide IX revealed as capsid cement by difference images from electron microscopy and crystallography.
Furcinitti, P. S., van Oostrum, J., & Burnett, R. M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08528.x · Cited by 125
The Interaction between the Fiber Knob Domain and the Cellular Attachment Receptor Determines the Intracellular Trafficking Route of Adenoviruses
Shayakhmetov, D. M., Li, Z.-Y., Ternovoi, V. V., Gaggar, A., Gharwan, H., & Lieber, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.6.3712-3723.2003 · Cited by 123
Combined Genetic and Chemical Capsid Modifications Enable Flexible and Efficient De- and Retargeting of Adenovirus Vectors
Kreppel, F., Gackowski, J., Schmidt, E., & Kochanek, S. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.03.006 · Cited by 119
Adenovirus-Mediated Expression of Human Coagulation Factor IX in the Rhesus Macaque Is Associated With Dose-Limiting Toxicity
Lozier, J. N., Metzger, M. E., Donahue, R. E., & Morgan, R. A. (1999) · Blood · doi:10.1182/blood.v94.12.3968.424k43_3968_3975 · Cited by 118
Adenovirus Vector Pseudotyping in Fiber-Expressing Cell Lines: Improved Transduction of Epstein-Barr Virus-Transformed B Cells
Seggern, D. J. V., Huang, S., Fleck, S. K., Stevenson, S. C., & Nemerow, G. R. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.354-362.2000 · Cited by 117
Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals
Wodrich, H., Guan, T., Cingolani, G., Seggern, D. V., Nemerow, G., & Gerace, L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg614 · Cited by 116
Development of Efficient Viral Vectors Selective for Vascular Smooth Muscle Cells
Work, L. M., Nicklin, S. A., Brain, N. J. R., Dishart, K. L., Seggern, D. J. V., Hallek, M. J., Büning, H., & Baker, A. H. (2003) · Molecular Therapy · doi:10.1016/j.ymthe.2003.11.006 · Cited by 115
Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates
Lanciotti, J., Song, A., Doukas, J., Sosnowski, B. A., Pierce, G. F., Gregory, R. J., Wadsworth, S. C., & O’Riordan, C. R. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00139-4 · Cited by 114
Metabolically biotinylated adenovirus for cell targeting, ligand screening, and vector purification
Parrott, M. B., Adams, K. E., Mercier, G. T., Mok, H. S., Campos, S. K., & Barry, M. A. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00213-2 · Cited by 114
Self-citation
Preferential Activation of Toll-Like Receptor Nine by CD46-Utilizing Adenoviruses
Iacobelli-Martinez, M., & Nemerow, G. R. (2006) · Journal of Virology · doi:10.1128/jvi.01926-06 · Cited by 113
Genetic Retargeting of Adenovirus: Novel Strategy Employing “Deknobbing” of the Fiber
Magnusson, M. K., Hong, S. S., Boulanger, P. A., & Lindholm, L. (2001) · Journal of Virology · doi:10.1128/jvi.75.16.7280-7289.2001 · Cited by 113
Nuclear Targeting of Adenovirus Type 2 Requires CRM1-mediated Nuclear Export
Strunze, S., Trotman, L. C., Boucke, K., & Greber, U. F. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0121 · Cited by 108
Assembly of adenovirus major capsid protein is mediated by a nonvirion protein
Cepko, C. L., & Sharp, P. A. (1982) · Cell · doi:10.1016/0092-8674(82)90134-9 · Cited by 106
CAR- or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice
Mizuguchi, H., Koizumi, N., Hosono, T., Ishii‐Watabe, A., Uchida, E., Utoguchi, N., Watanabe, Y., & Hayakawa, T. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301701 · Cited by 106
Adenovirus Structure
Rux, J. J., & Burnett, R. M. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1167 · Cited by 106
Genetically Targeted Adenovirus Vector Directed to CD40-Expressing Cells
Belousova, N., Korokhov, N., Krendelshchikova, V., Simonenko, V., Mikheeva, G., Triozzi, P. L., Aldrich, W. A., Banerjee, P. T., Gillies, S. D., Curiel, D. T., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.21.11367-11377.2003 · Cited by 105
Interactions among the three adenovirus core proteins
Chatterjee, P. K., Vayda, M. E., & Flint, S. J. (1985) · Journal of Virology · doi:10.1128/jvi.55.2.379-386.1985 · Cited by 102
Use of adenovirus protein IX (pIX) to display large polypeptides on the virion—generation of fluorescent virus through the incorporation of pIX-GFP
Meulenbroek, R. A., Sargent, K. L., Lunde, J. A., Jasmin, B. J., & Parks, R. J. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.01.012 · Cited by 101
Adenovirus Protein IX: A New Look at an Old Protein
Parks, R. J. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.018 · Cited by 99
Spacers Increase the Accessibility of Peptide Ligands Linked to the Carboxyl Terminus of Adenovirus Minor Capsid Protein IX
Vellinga, J., Rabelink, M. J. W. E., Cramer, S. J., van den Wollenberg, D. J. M., van der Meulen, H., Leppard, K. N., Fallaux, F. J., & Hoeben, R. C. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3470-3479.2004 · Cited by 99
Chromatin-like organization of the adenovirus chromosome.
Corden, J. L., Engelking, H. M., & Pearson, G. D. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.2.401 · Cited by 96
Cholesterol Is Required for Endocytosis and Endosomal Escape of Adenovirus Type 2
Imelli, N., Meier, O. C., Boucke, K., Hemmi, S., & Greber, U. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.6.3089-3098.2004 · Cited by 96
Adenovirus core protein V is delivered by the invading virus to the nucleus of the infected cell and later in infection is associated with nucleoli.
Matthews, D. A., & Russell, W. C. (1998) · Journal of General Virology · doi:10.1099/0022-1317-79-7-1671 · Cited by 94
Identification of Sites in Adenovirus Hexon for Foreign Peptide Incorporation
Wu, H., Han, T., Belousova, N., Krasnykh, V. N., Kashentseva, E. A., Dmitriev, I. P., Kataram, M., Mahasreshti, P. J., & Curiel, D. T. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3382-3390.2005 · Cited by 93
Multiple Innate Inflammatory Responses Induced after Systemic Adenovirus Vector Delivery Depend on a Functional Complement System
Kiang, A., Hartman, Z. C., Everett, R., Serra, D. M., Jiang, H., Frank, M. M., & Amalfitano, A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.024 · Cited by 93
Assembly of Adenoviruses
Sundquist, B. G., Everitt, E., Philipson, L., & Höglund, S. (1973) · Journal of Virology · doi:10.1128/jvi.11.3.449-459.1973 · Cited by 92
Avidin-based targeting and purification of a protein IX-modified, metabolically biotinylated adenoviral vector
Campos, S. K., Parrott, M. B., & Barry, M. A. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.03.006 · Cited by 91
Self-citation
Fluorescently Labeled Adenovirus with pIX-EGFP for Vector Detection
Le, L. P., Everts, M., Dmitriev, I. P., Davydova, J., Yamamoto, M., & Curiel, D. T. (2004) · Molecular Imaging · doi:10.1162/1535350041464874 · Cited by 89
Recombinant Adenovirus Vectors Activate the Alternative Complement Pathway, Leading to the Binding of Human Complement Protein C3 Independent of Anti-Ad Antibodies
Jiang, H., Wang, Z., Serra, D. M., Frank, M. M., & Amalfitano, A. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.015 · Cited by 84
Recombinant adenovirus vectors with knobless fibers for targeted gene transfer
van Beusechem, V. W., van Rijswijk, A. L. C. T., van Es, H. H. G., Haisma, H. J., Pinedo, H. M., & Gerritsen, W. R. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301323 · Cited by 82
A chimeric adenovirus vector encoding reovirus attachment protein σ1 targets cells expressing junctional adhesion molecule 1
Mercier, G. T., Campbell, J. A., Chappell, J. D., Stehle, T., Dermody, T. S., & Barry, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400542101 · Cited by 80
Self-citation
Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting
Bayó-Puxan, N., Cascalló, M., Gros, A., Huch, M., Fillat, C., & Alemany, R. (2006) · Journal of General Virology · doi:10.1099/vir.0.81889-0 · Cited by 79
The proteinase polypeptide of adenovirus serotype 2 virions
Anderson, C. W. (1990) · Virology · doi:10.1016/0042-6822(90)90479-b · Cited by 77
Genetic retargeting of adenovirus vectors: functionality of targeting ligands and their influence on virus viability
Magnusson, M. K., Hong, S. S., Henning, P., Boulanger, P. A., & Lindholm, L. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.285 · Cited by 77
Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting
Campos, S. K., & Barry, M. A. (2006) · Virology · doi:10.1016/j.virol.2006.01.032 · Cited by 76
Self-citation
Integrinα3β1 Is an Alternative Cellular Receptor for AdenovirusSerotype5
Salone, B., Martina, Y., Piersanti, S., Cundari, E., Cherubini, G., Franqueville, L., Failla, C. M., Boulanger, P. A., & Saggio, I. (2003) · Journal of Virology · doi:10.1128/jvi.77.24.13448-13454.2003 · Cited by 74
Antibody-Mediated Targeting of an Adenovirus Vector Modified To Contain a Synthetic Immunoglobulin G-Binding Domain in the Capsid
Volpers, C., Thirion, C., Biermann, V., Hußmann, S., Kewes, H., Dunant, P., von der Mark, H., Herrmann, A., Kochanek, S., & Lochmüller, H. (2003) · Journal of Virology · doi:10.1128/jvi.77.3.2093-2104.2003 · Cited by 73
Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1
Cotter, M. J., Zaiss, A. K., & Muruve, D. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14622-14631.2005 · Cited by 69
Expression of a foreign epitope on the surface of the adenovirus hexon
Crompton, J. L., Toogood, C. I. A., Wallis, N., & Hay, R. T. (1994) · Journal of General Virology · doi:10.1099/0022-1317-75-1-133 · Cited by 68
Targeting ofAdenovirus via Genetic Modification of the Viral Capsid Combined with aProteinBridge
Korokhov, N., Mikheeva, G., Krendelshchikov, A., Belousova, N., Simonenko, V., Krendelshchikova, V., Pereboev, A. V., Kotov, A., Kotova, O., Triozzi, P. L., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.24.12931-12940.2003 · Cited by 68
An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery
Hedley, S. J., der Maur, A. A., Hohn, S., Escher, D., Barberis, A., Glasgow, J. N., Douglas, J. T., Korokhov, N., & Curiel, D. T. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302603 · Cited by 66
Influence of Coagulation Factor Zymogens on the Infectivity of Adenoviruses Pseudotyped with Fibers from Subgroup D
Parker, A. L., McVey, J. H., Doctor, J. H., López‐Franco, Ó., Waddington, S. N., Havenga, M. J. E., Nicklin, S. A., & Baker, A. H. (2007) · Journal of Virology · doi:10.1128/jvi.02786-06 · Cited by 65
Proline 137 Is Critical for Adenovirus Protease Encapsidation and Activation but Not Enzyme Activity
Rancourt, C., Keyvani, H., Sircar, S., Labrecque, P., & WEBER, J. M. (1995) · Virology · doi:10.1006/viro.1995.1240 · Cited by 65
Binding of Adenovirus Capsid to Dipalmitoyl Phosphatidylcholine Provides a Novel Pathway for Virus Entry
Balakireva, L. A., Schoehn, G., Thouvenin, E., & Chroboczek, J. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4858-4866.2003 · Cited by 64
Adenovirus 5 Fibers Mutated at the Putative HSPG-binding Site Show Restricted Retargeting with Targeting Peptides in the HI Loop
Kritz, A., Nicol, C. G., Dishart, K. L., Nelson, R., Holbeck, S. L., Seggern, D. J. V., Work, L. M., McVey, J. H., Nicklin, S. A., & Baker, A. H. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300094 · Cited by 61
Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virion
Li, J., Le, L. P., Sibley, D. A., Mathis, J. M., & Curiel, D. T. (2005) · Virology · doi:10.1016/j.virol.2005.04.005 · Cited by 59
Viral entry, lipid rafts and caveosomes
Pietiäinen, V. M., Marjomäki, V., Heino, J., & Hyypiä, T. (2005) · Annals of Medicine · doi:10.1080/07853890510011976 · Cited by 59
Metabolic Biotinylation of Recombinant Proteins in Mammalian Cells and in Mice
Parrott, M. B., & Barry, M. A. (2000) · Molecular Therapy · doi:10.1006/mthe.1999.0011 · Cited by 59
Self-citation
Association of Adenovirus with the MicrotubuleOrganizingCenter
Bailey, C. J., Crystal, R. G., & Leopold, P. L. (2003) · Journal of Virology · doi:10.1128/jvi.77.24.13275-13287.2003 · Cited by 58
Structural Analysis of a Fiber-Pseudotyped Adenovirus with Ocular Tropism Suggests Differential Modes of Cell Receptor Interactions
Chiu, C. Y., Wu, E. Y., Brown, S. L., Seggern, D. J. V., Nemerow, G. R., & Stewart, P. L. (2001) · Journal of Virology · doi:10.1128/jvi.75.11.5375-5380.2001 · Cited by 58
Adenovirus Interaction with Its Cellular Receptor CAR
Howitt, J. A., Anderson, C. W., & Freimuth, P. (2003) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-05597-7_11 · Cited by 57
Dynamic Monitoring of Oncolytic Adenovirus In Vivo by Genetic Capsid Labeling
Le, L. P., Le, H. N., Dmitriev, I. P., Davydova, J. G., Gavrikova, T. A., Yamamoto, S., Curiel, D. T., & Yamamoto, M. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj022 · Cited by 57
The Coxsackie B Virus and Adenovirus Receptor Resides in a Distinct Membrane Microdomain
Excoffon, K. J. D. A., Moninger, T. O., & Zabner, J. (2003) · Journal of Virology · doi:10.1128/jvi.77.4.2559-2567.2003 · Cited by 57
High Resolution Solution Structure of the 1.3S Subunit of Transcarboxylase from Propionibacterium shermanii†
Reddy, D. V. S., Shenoy, B. C., CAREY, P. R., & Sönnichsen, F. D. (2000) · Biochemistry · doi:10.1021/bi9925367 · Cited by 54
Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon
Kurachi, S., Koizumi, N., Sakurai, F., Kawabata, K., Sakurai, H., Nakagawa, S., Hayakawa, T., & Mizuguchi, H. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302859 · Cited by 53
Review: Conformation and Folding of Novel Beta-Structural Elements in Viral Fiber Proteins: The Triple Beta-Spiral and Triple Beta-Helix
Mitraki, A., Miller, S., & van Raaij, M. J. (2002) · Journal of Structural Biology · doi:10.1006/jsbi.2002.4447 · Cited by 52
Biological and Structural Studies with an Adenovirus Type 2 Temperature-Sensitive Mutant Defective for Uncoating
Hannan, C., Raptis, L. H., Déry, C. V., & WEBER, J. M. (1983) · Intervirology · doi:10.1159/000149363 · Cited by 51
Artificial Extension of the Adenovirus Fiber Shaft Inhibits Infectivity in Coxsackievirus and Adenovirus Receptor-Positive Cell Lines
Seki, T., Dmitriev, I. P., Kashentseva, E. A., Takayama, K., Rots, M. G., Suzuki, K., & Curiel, D. T. (2002) · Journal of Virology · doi:10.1128/jvi.76.3.1100-1108.2002 · Cited by 51
Interference with the IL-1-Signaling Pathway Improves the Toxicity Profile of Systemically Applied Adenovirus Vectors
Shayakhmetov, D. M., Li, Z.-Y., Ni, S., & Lieber, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7310 · Cited by 50
Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains
Henning, P., Andersson, K., Frykholm, K., Ali, A., Magnusson, M. K., Nygren, P., Granio, O., Hong, S. S., Boulanger, P. A., & Lindholm, L. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302408 · Cited by 50
Ion etching of human adenovirus 2: structure of the core
Newcomb, W. W., Boring, J. W., & Brown, J. C. (1984) · Journal of Virology · doi:10.1128/jvi.51.1.52-56.1984 · Cited by 49
In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors
Nicklin, S. A., White, S. J., Nicol, C. G., Seggern, D. J. V., & Baker, A. H. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.526 · Cited by 48
Matrix Valency Regulates Integrin-mediated Lymphoid Adhesion via Syk Kinase
Stupack, D. G., Li, E., Silletti, S., Kehler, J. A., Geahlen, R. L., Hahn, K. M., Nemerow, G. R., & Cheresh, D. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.4.777 · Cited by 47
Evolution of Adenoviruses as Gene Therapy Vectors
Roy‐Chowdhury, J., & Horwitz, M. S. (2002) · Molecular Therapy · doi:10.1006/mthe.2001.0575 · Cited by 44
Genetic analysis of adenovirus type 2. VIII. Physical locations of temperature-sensitive mutations
Hassell, J. A., & WEBER, J. M. (1978) · Journal of Virology · doi:10.1128/jvi.28.3.671-678.1978 · Cited by 39
Adenovirus stripping: a versatile method to generate adenovirus vectors with new cell target specificity
Hong, S. S., Magnusson, M. K., Henning, P., Lindholm, L., & Boulanger, P. A. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00067-4 · Cited by 36
Next-generation adenoviral vectors: new and improved
Amalfitano, A. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301027 · Cited by 36
The Subgenus-Specific C-Terminal Region of Protein IX Is Located on the Surface of the Adenovirus Capsid
Akalu, A., Liebermann, H., Bauer, U., Granzow, H., & Seidel, W. (1999) · Journal of Virology · doi:10.1128/jvi.73.7.6182-6187.1999 · Cited by 35
Specific Binding of the Adenovirus Capsid to the Nuclear Envelope
Wisnivesky, J. P., Leopold, P. L., & Crystal, R. G. (1999) · Human Gene Therapy · doi:10.1089/10430349950017176 · Cited by 35
Cryoelectron Microscopy of Protein IX-Modified Adenoviruses Suggests a New Position for the C Terminus of Protein IX
Marsh, M. P., Campos, S. K., Baker, M. L., Chen, C. Y., Chiu, W., & Barry, M. A. (2006) · Journal of Virology · doi:10.1128/jvi.01471-06 · Cited by 34
Self-citation
Rapid Construction of Capsid-Modified Adenoviral Vectors Through Bacteriophage λ Red Recombination
Campos, S. K., & Barry, M. A. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1125 · Cited by 33
Self-citation
General Strategy for Broadening Adenovirus Tropism
Fontana, L., Nuzzo, M., Urbanelli, L., & Monaci, P. (2003) · Journal of Virology · doi:10.1128/jvi.77.20.11094-11104.2003 · Cited by 33
Non‐Classical Export of an Adenovirus Structural Protein
Trotman, L. C., Achermann, D. P., Keller, S. S., Straub, M., & Greber, U. F. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00094.x · Cited by 32
Adenovirus type 5 fiber knob domain has a critical role in fiber protein synthesis and encapsidation
Henning, P., Lundgren, E., Carlsson, M. J. L., Frykholm, K., Johannisson, J., Magnusson, M. K., Tång, E., Franqueville, L., Hong, S. S., Lindholm, L., et al. (2006) · Journal of General Virology · doi:10.1099/vir.0.81992-0 · Cited by 32
Adenoviral Vectors Do Not Induce, Inhibit, or Potentiate Human Platelet Aggregation
Eggerman, T. L., Mondoro, T. H., Lozier, J. N., & Vostal, J. G. (2002) · Human Gene Therapy · doi:10.1089/10430340152712674 · Cited by 31
Selection of Muscle-Binding Peptides from Context-Specific Peptide-Presenting Phage Libraries for Adenoviral Vector Targeting
Ghosh, D., & Barry, M. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.21.13667-13672.2005 · Cited by 31
Self-citation
Generation and selection of targeted adenoviruses embodying optimized vector properties
Noureddini, S. C., Krendelshchikov, A., Simonenko, V., Hedley, S. J., Douglas, J. T., Curiel, D. T., & Korokhov, N. (2005) · Virus Research · doi:10.1016/j.virusres.2005.10.002 · Cited by 28
Genetic Targeting of Adenovirus Vectors Using a Reovirus σ1-Based Attachment Protein
Schagen, F. H. E., Wensveen, F. M., Carette, J. E., Dermody, T. S., Gerritsen, W. R., & van Beusechem, V. W. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.11.019 · Cited by 25
Modulation of TNFα, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors
Mane, V., Toietta, G., McCormack, W. M., Conde, I. D., Clarke, C., Palmer, D. J., Finegold, M. J., Pastore, L., Ng, P., Lopez, J., et al. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302792 · Cited by 23
Classification of single-projection reconstructions for cryo-electron microscopy data of icosahedral viruses
Scheres, S. H. W., Marabini, R., Lanzavecchia, S., Cantele, F., Rutten, T. L. M., Fuller, S. D., Carazo, J. M., Burnett, R. M., & Martı́n, C. S. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.04.003 · Cited by 22
Increased Transduction of Skeletal Muscle Cells by Fibroblast Growth Factor-Modified Adenoviral Vectors
Menezes, K. M., Mok, H. S., & Barry, M. A. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.314 · Cited by 18
Self-citation
Improved gene delivery to B lymphocytes using a modified adenovirus vector targeting CD21
Mailly, L., Renaut, L., Rogée, S., Grellier, E., D'Halluin, J.-C., & Colin, M. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.017 · Cited by 14
Biology of Adenovirus and Its Use as a Vector for Gene Therapy
McConnell, M. J., & Imperiale, M. J. (2004) · Human Gene Therapy · doi:10.1089/1043034042431119 · Cited by 12
Use of Ar+ plasma etching to localize structural proteins in viruses: Studies with adenovirus 2
Newcomb, W. W., & Brown, J. C. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90286-2 · Cited by 11
The Structure of the Human Adenovirus 2 Penton
Zubieta, C., Schoehn, G., Chroboczek, J., & Cusack, S. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.01.004 · Cited by 11
1014. Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo
(2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.06.959 · Cited by 9
Modulation of Adenoviral Transduction In Vitro and In Vivo by Hyaluronan and its Receptor CD44
Chaudhuri, S. R., Mallam, J. N., Chévez‐Barrios, P., Wadhwa, L., Ng, P., Hurwitz, M. Y., & Hurwitz, R. L. (2006) · Molecular Therapy · doi:10.1038/sj.mt.6300044 · Cited by 9
25. Genetic Incorporation of HSV-1 Thymidine Kinase into the Adenovirus Protein IX for Functional Display on the Virion
(2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.06.028 · Cited by 2
786. Genetic Labeling of Adenovirus with Luciferase on pIX for Vector Detection
(2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.06.876 · Cited by 2
Increased Transduction of Skeletal Muscle Cells by Fibroblast Growth Factor-Modified Adenoviral Vectors
Menezes, K. M., Mok, H. S., & Barry, M. A. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.ft-176 · Cited by 1
Self-citation

Research works printed but not linked: 5

Everitt E, Sundquist B, Pettersson U, Philipson L. Structural polypeptides of adenoviruses X. Isolation ond topography of low molecular weight antigens from the virion of adenovirus type 2. Virology 1973;52:130-147. [PubMed: 4139804]
Howley, PM., editors. Fields Virology. Fourth Edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2001.
Salone B, Martina Y, Piersanti S, Cundari E, Cherubini G, Franqueville L, Failla CM, Boulanger P, Saggio I. Integrin α 3 β 1 is an alternate cellular receptor for adenovirus serotype 5. J Virol 2003;77:13448-13454. [PubMed: 14645603]
Howley, PM., editors. Fields Virology. Fourth Edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2001.
Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins a v b 3 and a v b 5 promote adenovirus internalization but not adenovirus attachment. Cell 1993;73:309-319. [PubMed: 8477447]

Sorted by citations

Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
Daud, A. I., DeConti, R. C., Andrews, S., Urbas, P., Riker, A. I., Sondak, V. K., Munster, P. N., Sullivan, D. M., Ugen, K. E., Messina, J. L., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.6794 · Cited by 701
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Cattaneo, R., Miest, T. S., Shashkova, E. V., & Barry, M. A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1927 · Cited by 380
Self-citation
Viral vectors: from virology to transgene expression
Bouard, D., Alazard-Dany, N., & Cosset, F. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.349 · Cited by 377
Untitled work
(2013) · PubMed · Cited by 308
Viral nanoparticles as platforms for next-generation therapeutics and imaging devices
Steinmetz, N. F. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.04.005 · Cited by 259

See all 210

Authors: Campos, S., & Barry, M.
Affiliations: University of New Mexico (US)
Mayo Clinic (US)
ORCID: Campos, Samuel
Barry, Michael
Venue: Current Gene Therapy
Publisher: Bentham Science Publishers Ltd.
Published: 2007-06-01
Volume: 7
Issue: 3
Pages: 189-204
ISSN: 1566-5232 (ISSN-L)
DOI: 10.2174/156652307780859062
PMC: PMC2244792
OpenAlex: W2025616153
Cited by: 210
References: 196
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 21
FWCI: 2.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Current Gene Therapy (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA093942)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: adenoviral vector, gene delivery vectors, gene therapy, viral vector targeting, immunogenicity, structure-function relationship, host-virus interaction, clinical gene therapy
MeSH terms: Adenoviruses, Human, Genetic Vectors, Humans, Transduction, Genetic, Genetic Therapy, Capsid Proteins, Virus Internalization

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks