Cited by 210Virus-based gene therapy researchRNA Interference and Gene DeliveryImmunotherapy and Immune Responses

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Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting

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Campos, Samuel, Barry, Michael·2007·Current Gene Therapy

DOI 10.2174/156652307780859062PMC PMC2244792

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Abstract

Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad virion, combined with functional studies has broadened our knowledge of the structure/function relationships between Ad vectors and host cells/tissues and substantial achievement has been made towards a thorough understanding of the biology of Ad vectors. The widespread use of Ad vectors for clinical gene therapy is compromised by their inherent immunogenicity. The generation of safer and more effective Ad vectors, targeted to the site of disease, has therefore become a great ambition in the field of Ad vector development. This review provides a synopsis of the structure/function relationships between Ad vectors and host systems and summarizes the many innovative approaches towards achieving Ad vector targeting.

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Authors: Campos, S., & Barry, M.
Affiliations: University of New Mexico (US)
Mayo Clinic (US)
ORCID: Campos, Samuel
Barry, Michael
Venue: Current Gene Therapy
Publisher: Bentham Science Publishers Ltd.
Published: 2007-06-01
Volume: 7
Issue: 3
Pages: 189-204
ISSN: 1566-5232 (ISSN-L)
DOI: 10.2174/156652307780859062
PMC: PMC2244792
OpenAlex: W2025616153
Cited by: 210
References: 196
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 21
FWCI: 2.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Current Gene Therapy (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA093942)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: adenoviral vector, gene delivery vectors, gene therapy, viral vector targeting, immunogenicity, structure-function relationship, host-virus interaction, clinical gene therapy
MeSH terms: Adenoviruses, Human, Genetic Vectors, Humans, Transduction, Genetic, Genetic Therapy, Capsid Proteins, Virus Internalization

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