The DOI matches its Crossref record; 195 of the 196 references it cites were found in a registry or an index.
Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting
Open accessAbstract
Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad virion, combined with functional studies has broadened our knowledge of the structure/function relationships between Ad vectors and host cells/tissues and substantial achievement has been made towards a thorough understanding of the biology of Ad vectors. The widespread use of Ad vectors for clinical gene therapy is compromised by their inherent immunogenicity. The generation of safer and more effective Ad vectors, targeted to the site of disease, has therefore become a great ambition in the field of Ad vector development. This review provides a synopsis of the structure/function relationships between Ad vectors and host systems and summarizes the many innovative approaches towards achieving Ad vector targeting.
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“Similar to recombinant AAV vectors, the AV genome remains in an extrachromosomal form following infection.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [66]
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Metadata
- Authors
- Campos, S., & Barry, M.
- Affiliations
- University of New Mexico (US)
- Mayo Clinic (US)
- Venue
- Current Gene Therapy
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2007-06-01
- Volume
- 7
- Issue
- 3
- Pages
- 189-204
- ISSN
- 1566-5232 (ISSN-L)
- PMC
- PMC2244792
- OpenAlex
- W2025616153
- Cited by
- 210
- References
- 196
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 21
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Gene Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA093942)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- adenoviral vector, gene delivery vectors, gene therapy, viral vector targeting, immunogenicity, structure-function relationship, host-virus interaction, clinical gene therapy
- MeSH terms
- Adenoviruses, Human, Genetic Vectors, Humans, Transduction, Genetic, Genetic Therapy, Capsid Proteins, Virus Internalization
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