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Cited by 87

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Immune Responses to Lentiviral Vectors

Follenzi, Antonia, Santambrogio, Laura, Annoni, Andrea·2007·Current Gene Therapy
DOI 10.2174/156652307782151515
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Abstract

Efficient delivery and sustained expression of a therapeutic gene into human tissues are the requisite to accomplish the high expectations of gene therapy. A major challenge has concerned development of gene transfer systems capable of efficient cell transduction and transgene expression without harm to the recipient. A lot of work has been done to demonstrate the efficacy of gene therapy in animal models that mimic situations in humans. Use of lentiviral vectors (LVs) offers multiple advantages for gene replacement therapy, because they combine efficient delivery, ability to transduce proliferating and resting cells, capacity to integrate into the host chromatin to provide stable long-term expression of the transgene, absence of any viral genes in the vector and absence of interference from preexisting viral immunity. However, one of the major barriers to stable gene transfer by LVs and other viral vectors is the development of innate and adaptive immune responses to the delivery vector and the transferred therapeutic transgene. Since this greatly hinders the therapeutical benefits of gene therapy by LVs, developing strategies to overcome the host immune response to the transfer vector and the transgene is a matter of current investigation.

Overview

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Registry

Crossref · 10.2174/156652307782151515

Cites

12 of 12 references verified0 citation errors · 0 not checkable

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  • Typical AdVs and LVs elicit strong immune responses.

    “typical AdVs and LVs elicit strong immune responses (Follenzi et al., 2007; Ahi et al., 2011).”

    From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Follenzi et al., 2007

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Metadata

Authors
Follenzi, A., Santambrogio, L., & Annoni, A.
Venue
Current Gene Therapy
Publisher
Bentham Science Publishers Ltd.
Published
2007-10-01
Volume
7
Issue
5
Pages
306-315
ISSN
1566-5232
DOI
10.2174/156652307782151515
Cited by
87
References
12
Language
en

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