The DOI matches its Crossref record.
Insulin Resistance in Type 2 Diabetes - Role of the Adipokines
Abstract
The role of adipocytes as protein secreting cells has been known for almost 15 years. Most of these proteins have known biological activity and are called adipokines. However, only a few of the adipokines have been shown to regulate insulin sensitivity. The latter effects are direct or indirect. The adipokines regulating insulin sensitivity are tumor necrosis factor alpha, adiponectin, interleukin-6, resistin and leptin. This review examines the mechanism how these adipokines influence insulin sensitivity, how the adipocyte production of the adipokines is regulated and if genetic variance in the genes encoding for adipokines is important for the development of type 2 diabetes mellitus. Keywords: adipose tissue, endothelial cells, tumor necrosis factor alpha, glucose metabolism, gi protein, lipolytic, interleukin, glucocorticoids, inflammatory genes, single nucleotide polymorphisms
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“In other related studies involving individuals with the metabolic syndrome, a consistent reduction in CRP concentration in the intervention group receiving the Mediterranean diet has been shown (291,292) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [291]
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Beason, T. S. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Arner, P.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Arner, P.
- ORCID
- Arner, P.
- Venue
- Current Molecular Medicine
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-05-01
- Volume
- 5
- Issue
- 3
- Pages
- 333-339
- ISSN
- 1566-5240 (ISSN-L)
- OpenAlex
- W2006828160
- Cited by
- 201
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 11 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 12 · 2012: 14
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- insulin resistance, type 2 diabetes, adipokines, adipocytes, TNF-α, adiponectin, interleukin-6, resistin, leptin, adipose tissue, insulin sensitivity, genetic polymorphism, glucose metabolism, inflammation
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Hormones, Ectopic, Humans, Inflammation, Insulin, Insulin Resistance, Models, Biological, Tumor Necrosis Factor-alpha, Genetic Variation, Interleukin-6, Cytokines, Adipocytes, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin, Resistin, Nicotinamide Phosphoribosyltransferase
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