Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease

Lyros, Epameinondas; Bakogiannis, Constantinos; Liu, Yang; Fassbender, Klaus

doi:10.2174/1567205010666131119235254

Cited by 79Barrier Structure and Function StudiesAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease

Lyros, Epameinondas, Bakogiannis, Constantinos, Liu, Yang, Fassbender, Klaus·2014·Current Alzheimer Research

DOI 10.2174/1567205010666131119235254

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Abstract

Alzheimer's disease (AD) is characterized by a progressive decline of cognitive functions and represents the most common form of dementia and a major cause of morbidity and mortality in the modern, westernized societies. There is accumulating evidence to support the hypothesis that a primary cerebral vascular dysfunction initiates a cascade of events that lead to neuronal injury in Alzheimer's dementia. The endothelium, in specific, constitutes a part of the blood brain barrier, the dysfunction of which is thought to play an important role to disturbed amyloid-β homeostasis and infiltration of the brain parenchyma with circulating toxic molecules in the disease. Furthermore, the endothelium itself is under certain conditions capable of producing neurotoxic and inflammatory factors, whereas common growth factors regulate the development and maintenance of both neurons and blood vessels. Reliance of both endothelial and neuronal cells on mitochondrial integrity and common molecular pathways for apoptosis also imply that there is a link between vascular pathology and neurodegeneration. The present article intends to review available evidence on molecular players implicated in the above mechanisms with the potential to develop biomarkers or novel therapeutic targets.

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AD is commonly accompanied by BBB dysfunction.
“Also, it is commonly accompanied by BBB dysfunction (Erickson and Banks, 2013; Lyros et al., 2014).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Lyros et al., 2014

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Periventricular diffusion gradient of normal-appearing white matter and its transcriptional signatures in normal aging and multiple neurological diseasesPreprint
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Self-citation
Additional file 11 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180816
Additional file 8 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180807
Additional file 4 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180792
Additional file 3 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180789
Additional file 9 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180810
Additional file 5 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180795
Additional file 2 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180786
Additional file 10 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180813
Additional file 7 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180801
Additional file 6 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24180798
Additional file 1 of Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Fan, L.-Y., Yang, J., Liu, R.-Y., Kong, Y., Guo, G., & Xu, Y.-M. (2023) · Figshare · doi:10.6084/m9.figshare.24180783
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Authors: Lyros, E., Bakogiannis, C., Liu, Y., & Fassbender, K.
Affiliations: Saarland University (DE)
Corresponding author: Fassbender, Klaus
ORCID: Lyros, Epameinondas
Bakogiannis, Constantinos
Liu, Yang
Fassbender, Klaus
Venue: Current Alzheimer Research
Publisher: Bentham Science Publishers Ltd.
Published: 2014-01-31
Volume: 11
Issue: 1
Pages: 18-26
ISSN: 1567-2050 (ISSN-L)
DOI: 10.2174/1567205010666131119235254
OpenAlex: W2165470282
Cited by: 70
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 15 · 2014: 2 · 2013: 1
FWCI: 5.04
Type: journal article
Language: en
Open access: closed
Locations: Current Alzheimer Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, endothelial dysfunction, neurodegeneration, blood-brain barrier, cerebrovascular dysfunction, neuroinflammation, neurovascular unit, mitochondrial integrity, apoptosis, growth factors, biomarkers, therapeutic target
MeSH terms: Alzheimer Disease, Animals, Blood-Brain Barrier, Brain, Cerebrovascular Circulation, Endothelium, Vascular, Humans, Nerve Degeneration

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