A peripheral signature of Alzheimer’s disease featuring microbiota-gut-brain axis markers
Open accessAbstract
Background: Increasing evidence links the gut microbiota (GM) to Alzheimer’s disease (AD) but the mechanisms through which gut bacteria influence the brain are still unclear. This study tests the hypothesis that GM and mediators of the microbiota-gut-brain axis (MGBA) are associated with the amyloid cascade in sporadic AD. Methods: We included 34 patients with cognitive impairment due to AD (CI-AD), 37 patients with cognitive impairment not due to AD (CI-NAD), and 13 cognitively unimpaired persons (CU). We studied the following systems: (1) fecal GM, with 16S rRNA sequencing; (2) a panel of putative MGBA mediators in the blood including immune and endothelial markers as bacterial products (i.e., lipopolysaccharide, LPS), cell adhesion molecules (CAMs) indicative of endothelial dysfunction (VCAM-1, PECAM-1), vascular changes (P-, E-Selectin), and upregulated after infections (NCAM, ICAM-1), as well as pro- (IL1β, IL6, TNFα, IL18) and anti- (IL10) inflammatory cytokines; (3) the amyloid cascade with amyloid PET, plasma phosphorylated tau (pTau-181, for tau pathology), neurofilament light chain (NfL, for neurodegeneration), and global cognition measured using MMSE and ADAScog. We performed 3-group comparisons of markers in the 3 systems and calculated correlation matrices for the pooled group of CI-AD and CU as well as CI-NAD and CU. Patterns of associations based on Spearman’s rho were used to validate the study hypothesis. Results: CI-AD were characterized by (1) higher abundance of Clostridia_UCG-014 and decreased abundance of Moryella and Blautia ( p < .04); (2) elevated levels of LPS ( p < .03), upregulation of CAMs, Il1β, IL6, and TNFα, and downregulation of IL10 ( p < .05); (3) increased brain amyloid, plasma pTau-181, and NfL ( p < 0.004) compared with the other groups. CI-NAD showed (1) higher abundance of [Eubacterium] coprostanoligenes group and Collinsella and decreased abundance of Lachnospiraceae_ND3007_group , [Ruminococcus]_gnavus_group and Oscillibacter ( p < .03); (2) upregulation of PECAM-1 and TNFα ( p < .03); (4) increased plasma levels of NfL ( p < .02) compared with CU. Different GM genera were associated with immune and endothelial markers in both CI-NAD and CI-AD but these mediators were widely related to amyloid cascade markers only in CI-AD. Conclusions: Specific bacterial genera are associated with immune and endothelial MGBA mediators, and these are associated with amyloid cascade markers in sporadic AD. The physiological mechanisms linking the GM to the amyloid cascade should be further investigated to elucidate their potential therapeutic implications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LPS is elevated in both the blood and brain of AD patients.
“LPS is elevated in both the blood and brain of AD patients.25–29”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [28]
The Results (Immune and endothelial microbiota-gut-brain axis mediators; page unavailable) report high LPS levels in patients with cognitive impairment due to AD, and the Methods specify that LPS was measured in plasma. The paper does not report elevated LPS levels in those patients’ brains; the Discussion mentions possible co-localization with amyloid plaques, not a brain-level comparison. (LLM, conf=0.89)
Experimental — accuracy not yet measuredBeneficial taxa such as Bifidobacterium and Lactobacillus are typically decreased, while proinflammatory bacteria including Escherichia/Shigella, Enterobacteriaceae, and Clostridium species are enriched in AD.
“For instance, beneficial taxa such as Bifidobacterium and Lactobacillus are typically decreased, while proinflammatory bacteria, including Escherichia/Shigella, Enterobacteriaceae, and Clostridium species are enriched [124].”
From Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses (2026) · cites this paper as [124]
The Results section (Gut microbial communities; page unavailable) reports higher Clostridia_UCG-014 in the AD group, supporting that part of the claim. But it reports higher—not lower—Bifidobacterium, and the Discussion describes published Bifidobacterium findings as conflicting rather than typically decreased. The cited passages do not establish the claimed changes in Lactobacillus, Escherichia/Shigella, or Enterobacteriaceae. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Bolyen, E., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C., Al-Ghalith, G. A., Alexander, H., Alm, E. J., Arumugam, M., Asnicar, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0209-9 · Cited by 23,742 · see citing works
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · cited 1× · see citing works
“The GM is a key driver of the innate immune system [1, 2] and is involved in the degradation of macronutrients and production of metabolites [3].”
BackgroundGut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Self-citationppcor: An R Package for a Fast Calculation to Semi-partial Correlation Coefficients
Kim, S. (2015) · Communications for Statistical Applications and Methods · doi:10.5351/csam.2015.22.6.665 · Cited by 1,106 · see citing works
Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease
Mattsson, N., Andreasson, U., Zetterberg, H., Blennow, K., & Initiative, F. T. A. D. N. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.6117 · Cited by 1,070 · see citing works
Biomarker Modeling of Alzheimer’s Disease
Jack, C. R., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.12.003 · Cited by 1,002 · see citing works
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works
Self-citationGut Microbiota is Altered in Patients with Alzheimer’s Disease
Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885 · see citing works
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Fleisher, A. S., Reiman, E. M., Sabbagh, M. N., Sadowsky, C. H., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70142-4 · Cited by 855 · see citing works
Bolyen, E. K., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C., Al‐Ghalith, G. A., Alexander, H., Alm, E. J., Arumugam, M., Asnicar, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0252-6 · Cited by 838 · see citing works
Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works
A gut-vascular barrier controls the systemic dissemination of bacteria
Spadoni, I., Zagato, E., Bertocchi, A., Paolinelli, R., Hot, E., Sabatino, A. D., Caprioli, F., Bottiglieri, L., Oldani, A., Viale, G., et al. (2015) · Science · doi:10.1126/science.aad0135 · Cited by 699 · see citing works
Liu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669 · see citing works
The influence of cytokines on the integrity of the blood-brain barrier in vitro
de Vries, H. E., Blom-Roosemalen, M. C. M., van Oosten, M., de Boer, A. G., van Berkel, T. J. C., Breimer, D. D., & Kuiper, J. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00148-4 · Cited by 666 · see citing works
Mielke, M. M., Hagen, C. E., Xu, J., Chai, X., Vemuri, P., Lowe, V. J., Airey, D. C., Knopman, D. S., Roberts, R. O., Machulda, M. M., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.013 · Cited by 621 · see citing works
Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K. (2018) · Gut · doi:10.1136/gutjnl-2017-314759 · Cited by 508 · see citing works
Sample storage conditions significantly influence faecal microbiome profiles
Choo, J. M., Leong, L. E. X., & Rogers, G. B. (2015) · Scientific Reports · doi:10.1038/srep16350 · Cited by 506 · see citing works
Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022) · Gut · doi:10.1136/gutjnl-2021-326269 · Cited by 491 · see citing works
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works
Erny, D., Dokalis, N., Mezö, C., Castoldi, A., Mossad, O., Staszewski, O., Frosch, M., Villa, M., Fuchs, V., Mayer, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.010 · Cited by 478 · see citing works
Chen, S. G., Stribinskis, V., Rane, M. J., Demuth, D. R., Gozal, E., Roberts, A. M., Jagadapillai, R., Liu, R., Choe, K., Shivakumar, B., et al. (2016) · Scientific Reports · doi:10.1038/srep34477 · Cited by 463 · see citing works
Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453 · see citing works
Intestinal Commensal Microbes as Immune Modulators
Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 425 · see citing works
NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke
Yang, F., Wang, Z., Wei, X., Han, H., Meng, X., Zhang, Y., Shi, W., Li, F., Xin, T., Pang, Q., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.242 · Cited by 423 · see citing works
Haran, J. P., Bhattarai, S. K., Foley, S. E., Dutta, P., Ward, D. V., Bucci, V., & McCormick, B. A. (2019) · mBio · doi:10.1128/mbio.00632-19 · Cited by 412 · see citing works
The Neural Cell Adhesion Molecule Is a Receptor for Rabies Virus
Thoulouze, M., Lafage, M., Schachner, M., Hartmann, U., Cremer, H., & Lafon, M. (1998) · Journal of Virology · doi:10.1128/jvi.72.9.7181-7190.1998 · Cited by 379 · see citing works
Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376 · see citing works
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife · doi:10.7554/elife.59826 · Cited by 354 · see citing works
Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 354 · see citing works
Marizzoni, M., Cattaneo, A., Mirabelli, P., Festari, C., Lopizzo, N., Nicolosi, V., Mombelli, E., Mazzelli, M., Luongo, D., Naviglio, D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200306 · Cited by 340 · see citing works
Self-citationZhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.017 · Cited by 319 · see citing works
Kennedy, N. A., Walker, A. W., Berry, S. H., Duncan, S. H., Farquarson, F. M., Louis, P., Thomson, J., surname):, O. M. N. N. W. T. M. A. L. (. B., Satsangi, J. J., Flint, H. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088982 · Cited by 311 · see citing works
Forloni, G., Demicheli, F., Giorgi, S., Bendotti, C., & Angeretti, N. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90202-m · Cited by 255 · see citing works
Seo, D.-O., O’Donnell, D., Jain, N., Ulrich, J. D., Herz, J., Li, Y., Lemieux, M., Cheng, J., Hu, H., Serrano, J. R., et al. (2023) · Science · doi:10.1126/science.add1236 · Cited by 254 · see citing works
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease
Ling, Z., Zhu, M., Yan, X., Cheng, Y., Shao, L., Liu, X., Jiang, R., & Wu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.634069 · Cited by 245 · see citing works
Gut Microbiota Composition Is Related to AD Pathology
Verhaar, B. J. H., Hendriksen, H. M. A., de Leeuw, F. A., Doorduijn, A. S., van Leeuwenstijn, M. S. S. A., Teunissen, C. E., Barkhof, F., Scheltens, P., Kraaij, R., van Duijn, C. M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.794519 · Cited by 237 · see citing works
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy
Ricard, N., Bailly, S., Guignabert, C., & Simons, M. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00517-4 · Cited by 223 · see citing works
Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice
Sy, M., Kitazawa, M., Medeiros, R., Whitman, L., Cheng, D., Lane, T. E., & LaFerla, F. M. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.02.012 · Cited by 210 · see citing works
Turner, R. B., Wecker, M. T., Pohl, G. M., Witek, T. J., McNally, E., George, R. S., Winther, B., & Hayden, F. G. (1999) · JAMA · doi:10.1001/jama.281.19.1797 · Cited by 206 · see citing works
Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
Asti, A., & Gioglio, L. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131394 · Cited by 180 · see citing works
Guo, M., Peng, J., Huang, X., Xiao, L., Huang, F., & Zuo, Z. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201040 · Cited by 179 · see citing works
Zuliani, G., Cavalieri, M., Galvani, M., Passaro, A., Munari, M. R., Bosi, C., Zurlo, A., & Fellin, R. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.05.020 · Cited by 173 · see citing works
Saji, N., Murotani, K., Hisada, T., Tsuduki, T., Sugimoto, T., Kimura, A., Niida, S., Toba, K., & Sakurai, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-55851-y · Cited by 158 · see citing works
Ilan, N., Mohsenin, A., Cheung, L., & Madri, J. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0372com · Cited by 133 · see citing works
Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation
Harland, M., Torres, S. L., Liu, J., & Wang, X. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2324-19.2020 · Cited by 129 · see citing works
Brosseron, F., Traschütz, A., Widmann, C. N., Kummer, M. P., Tacik, P., Santarelli, F., Jessen, F., & Heneka, M. T. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0353-3 · Cited by 113 · cited 12× · see citing works
“Results CI‑AD were characterized by (1) higher abundance of Clostridia_UCG-014 and decreased abundance of Moryella and Blautia (p < .04); (2) elevated levels of LPS (p < .03), upregulation of CAMs, Il1β, IL6, and TNFα, and down‑ regulation of IL10 (p < .05); (3) increased brain amyloid, plasma pTau‑181, and NfL (p < 0…”
BackgroundInfluentialLPS-induced neuroinflammatory effects do not recover with time
Hauss‐Wegrzyniak, B., Vraniak, P., & Wenk, G. L. (2000) · Neuroreport · doi:10.1097/00001756-200006050-00032 · Cited by 99 · see citing works
Podhorná, J., Krahnke, T., Shear, M. A., Harrison, J., & Initiative, A. D. N. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0170-5 · Cited by 96 · see citing works
Boccardi, M., Altomare, D., Ferrari, C., Festari, C., Guerra, U. P., Paghera, B., Pizzocaro, C., Lussignoli, G., Geroldi, C., Zanetti, O. O., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3751 · Cited by 94 · see citing works
Self-citationHaarmann, A., Nowak, E., Deiß, A., van der Pol, S. M. A., Monoranu, C., Kooij, G., Müller, N., van der Valk, P., Stoll, G., de Vries, H. E., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1417-0 · Cited by 89 · see citing works
Sheng, C., Yang, K. Y., He, B., Du, W., Cai, Y., & Han, Y. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-00977-x · Cited by 87 · see citing works
Huang, C.-W., Tsai, M.-H., Chen, N.-C., Chen, W.-H., Lu, Y.-T., Lui, C.-C., Chang, Y.-T., Chang, W.-N., Chang, A. Y. W., & Chang, C.-C. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-11-0938 · Cited by 82 · see citing works
Marizzoni, M., Gurry, T., Provasi, S., Greub, G., Lopizzo, N., Ribaldi, F., Festari, C., Mazzelli, M., Mombelli, E., Salvatore, M., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01262 · Cited by 80 · see citing works
Self-citationSoluble adhesion molecules and angiotensin-converting enzyme in dementia
Nielsen, H. M., Londos, E., Minthon, L., & Janciauskiene, S. M. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.011 · Cited by 80 · see citing works
Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.
Wang, L., Wu, Q., Kirk, R. A., Horn, K. P., Salem, A. E., Hoffman, J. M., Yap, J. T., Sonnen, J. A., Towner, R. A., Bozza, F. A., et al. (2018) · Europe PMC (PubMed Central) · Cited by 73 · see citing works
Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease
Lyros, E., Bakogiannis, C., Liu, Y., & Fassbender, K. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131119235254 · Cited by 70 · see citing works
Zhou, A., Yuan, Y., Yang, M., Huang, Y., Li, X., Li, S., Yang, S., & Tang, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.832672 · Cited by 67 · see citing works
Neural cell adhesion molecule in human serum. Increased levels in dementia of the Alzheimer type
Todaro, L. B., Puricelli, L., Gioseffi, H., Pallotta, M. G., Lastiri, J. M., Joffé, E. B. D. K., Varela, M. S., & de Lustig, E. S. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.014 · Cited by 59 · see citing works
Influence of the Microbiota-Gut-Brain Axis on Cognition in Alzheimer’s Disease
Escobar, Y.-N. H., O’Piela, D., Wold, L. E., & Mackos, A. R. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215290 · Cited by 51 · see citing works
Rentzos, M., Michalopoulou, M., Nikolaou, C., Cambouri, C., Rombos, A., Dimitrakopoulos, A., Kapaki, E., & Vassilopoulos, D. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704269822 · Cited by 50 · see citing works
Gut microbes augment neurodegeneration
Erny, D., & Prinz, M. (2017) · Nature · doi:10.1038/nature21910 · Cited by 45 · see citing works
Abareshi, A., Anaeigoudari, A., Norouzi, F., Shafei, M. N., Boskabady, M. H., Khazaei, M., & Hosseini, M. (2016) · Advances in Medicine · doi:10.1155/2016/7676512 · Cited by 44 · see citing works
Endothelium as a Source and Target of H2S to Improve Its Trophism and Function
Ciccone, V., Genah, S., & Morbidelli, L. (2021) · Antioxidants · doi:10.3390/antiox10030486 · Cited by 43 · see citing works
Signature of Alzheimer’s Disease in Intestinal Microbiome: Results From the AlzBiom Study
Laske, C., Müller, S., Preische, O., Ruschil, V., Munk, M. H. J., Honold, I., Peter, S., Schoppmeier, U., & Willmann, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.792996 · Cited by 42 · see citing works
Järemo, P., Milovanovic, M., Buller, C., Nilsson, S., & Winblad, B. G. (2013) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2013.764572 · Cited by 34 · see citing works
Relationship Between the Gut Microbiota and Alzheimer’s Disease: A Systematic Review
Cordero, E. M. G., Cuevas‐Budhart, M. Á., Pérez-Morán, D., Villeda, M. Á. T., & García-Madrid, M. G. D. P. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215224 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
Grabrucker, S., Marizzoni, M., Silajdžić, E., Lopizzo, N., Mombelli, E., Nicolas, S., Dohm-Hansen, S., Scassellati, C., Moretti, D. V., Rosa, M., et al. (2023) · Brain · doi:10.1093/brain/awad303 · Cited by 236 · see citing works
Self-citationCurrent understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies
Seo, D.-O., & Holtzman, D. M. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01146-2 · Cited by 249 · see citing works
The endotoxin hypothesis of Alzheimer’s disease
Brown, G. C., & Heneka, M. T. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00722-y · Cited by 140 · see citing works
Chen, C., Wang, G., Li, D., & Zhang, F. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00307-1 · Cited by 119 · see citing works
Vascular dementia: From pathobiology to emerging perspectives
Morgan, A. E., & Auley, M. T. M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102278 · Cited by 91 · see citing works
Liang, Y., Liu, C., Cheng, M., Geng, L., Li, J., Du, W., Song, M., Chen, N., Yeleen, T. A. N., Li, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14057 · Cited by 70 · see citing works
Jia, M., Fan, Y., Ma, Q., Yang, D., Wang, Y., He, X., Zhao, B., Zhan, X., Qi, Z., Ren, Y., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03211-4 · Cited by 74 · see citing works
Yang, J., Zhi, W., & Wang, L. (2024) · Molecules · doi:10.3390/molecules29122812 · Cited by 63 · see citing works
“The gut microbiota (GM The gut microbiota (GM), the most densely populated bacterial community colonising the human body, is involved in the pathology of AD [103]. human body, is involved in the pathology of AD [103].”
BackgroundLi, L., Yang, C., Jia, M., Wang, Y., Zhao, Y., Li, Q., Gong, J., He, Y., Xu, K., Liu, X., et al. (2024) · Food & Function · doi:10.1039/d4fo00886c · Cited by 51 · see citing works
The complex relationship between gut microbiota and Alzheimer’s disease: A systematic review
Zhou, X.-P., Sun, L.-B., Liu, W., Zhu, W.-M., Li, L.-C., Song, X., Xing, J.-P., & Gao, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102637 · Cited by 50 · see citing works
Hein, Z. M., Karikalan, B., Gopalakrishna, P. K., Dhevi, K., Alkatiri, A., Hussan, F., Mohd Moklas, M. A., Jagadeesan, S., Che Ramli, M. D., Che Mohd Nassir, C. M. N., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05602-0 · Cited by 43 · see citing works
Cui, J., Xiao, S., Cao, Y., Zhang, Y., Yang, J., Zheng, L., Zhao, F., Liu, X., Liu, D., Zhou, Z., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c07427 · Cited by 41 · see citing works
Fecal Microbiota Transplantation Improves Cognitive Function of a Mouse Model of Alzheimer's Disease
Jiang, X., Zheng, Y., Sun, H., Dang, Y., Yin, M., Xiao, M., & Wu, T. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70259 · Cited by 35 · see citing works
Bellelli, F., Angioni, D., Arosio, B., Vellas, B. J., & Barreto, P. D. S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102699 · Cited by 33 · see citing works
Hao, W., Luo, Q., Tomic, I., Quan, W., Hartmann, T., Menger, M. D., Fassbender, K. C., & Liu, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363014 · Cited by 28 · see citing works
Priori, E. C., Ratto, D., Luca, F. D., Sandionigi, A., Savino, E., Giammello, F., Romeo, M., Brandalise, F., Roda, E., & Rossi, P. (2023) · Biology · doi:10.3390/biology13010018 · Cited by 27 · see citing works
Harnessing Artificial Intelligence and Precision Diets for Brain Health and Cognitive Resilience
Bhuiyan, M. N. I., Saha, B. K., & Satter, M. A. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.08.007 · Cited by 27 · see citing works
Liu, Y.-C., Chen, S.-Y., Chen, Y.-Y., Chang, H., Chiang, I., & Yen, G. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133898 · Cited by 24 · see citing works
Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity
Mukherjee, U., & Reddy, P. H. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102843 · Cited by 24 · see citing works
Matatall, K. A., Wathan, T. K., Nguyen, M., Chen, H., McDonald, A., Qi, G., Belk, J. A., Florez, M. A., Le, D. T., Olarinde, T., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.06.006 · Cited by 23 · see citing works
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?
Zhang, S., Lu, J., Jin, Z., Xu, H., Zhang, D., Chen, J., & Wang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1459655 · Cited by 24 · see citing works
Microbes Saving Lives and Reducing Suffering
Timmis, K. N., Karahan, Z. C., Ramos, J. L., Koren, O., Pérez‐Cobas, A. E., Steward, K. F., de Lorenzo, V., Caselli, E., Douglas, M., Schwab, C., et al. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70068 · Cited by 23 · see citing works
The exposome from neurodevelopment to neurodegeneration: A narrative review
Dallere, S., Rasà, D. M., Pavarino, G., Schellino, R., Vercelli, A., & Boido, M. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106247 · Cited by 19 · see citing works
Pasupalak, J. K., Rajput, P., & Gupta, G. L. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177022 · Cited by 18 · see citing works
Li, J., Yuan, Z., Li, J., Liu, Z., Wang, Y., Cui, M., Suo, C., Li, J., Ding, D., Chen, X., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00851-6 · Cited by 16 · see citing works
Vaziri, Y., Olia, J. B. H., Avcı, Ç. B., & Nourazarian, A. (2025) · Molecular Brain · doi:10.1186/s13041-025-01263-1 · Cited by 16 · see citing works
Microbiome-targeted Alzheimer’s interventions via gut-brain axis
Qin, R., Li, C., Yuan, X., & Chen, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1729708 · Cited by 15 · see citing works
Paul, A. D., & Natarajan, H. (2025) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-025-00857-9 · Cited by 15 · see citing works
Marizzoni, M., Mombelli, E., Alboni, S., Rosa, M., Moretti, D. V., Mirabelli, P., Coppola, L., Luongo, D., Salamone, D., Saleri, S., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106138 · Cited by 14 · see citing works
Self-citationChandra, S., & Vassar, R. J. (2024) · Immunological Reviews · doi:10.1111/imr.13412 · Cited by 14 · see citing works
Bonfili, L., Grasselli, F. M., Cuccioloni, M., Cecarini, V., Lufrano, D., Vittadini, E., Galosi, L., Sonsini, G., Ubaldi, M., Turck, J. L., et al. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109904 · Cited by 13 · see citing works
Li, W., Jiang, J., Yin, X., Zhang, Y., Zou, X., Sun, M., Jia, J., Ma, B., & Xu, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230709 · Cited by 13 · see citing works
Zhu, H., Yang, D., Du, P., Qian, H., & Yang, Z. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157381 · Cited by 11 · see citing works
The role of the gut microbiota in neuropsychiatric disorders and therapy
Zhang, F., Ding, K., Zhang, L., Liu, D., Dong, X., Wang, M., Zhou, F.-L., Sun, Y., Zhang, W., Yu, Y., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102894 · Cited by 11 · see citing works
Yang, Y., Hong, Q., Zhang, X., & Liu, Z. (2024) · Food & Function · doi:10.1039/d4fo05273k · Cited by 10 · see citing works
Wu, C., Luo, F., Zhu, Y., Liu, C., Chen, Z., Wang, X., Tan, J., & Liu, Q. (2025) · Exploration · doi:10.1002/exp.20240087 · Cited by 10 · see citing works
From hormones to neurodegeneration: how FSH drives Alzheimer’s disease
Xue, Y., Zuo, S., Wang, F., & Qi, X. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1578439 · Cited by 10 · see citing works
Microbiota and Alzheimer’s disease: mechanistic insights from a multi-organ perspective
Liao, J., Mou, H., Luo, S., Shen, L., & Jiao, B. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00541-9 · Cited by 10 · see citing works
Palmitoyl-L-carnitine induces tau phosphorylation and mitochondrial dysfunction in neuronal cells
Yoon, G., Kam, M. K., Koh, Y. H., & Jo, C. (2024) · PLoS ONE · doi:10.1371/journal.pone.0313507 · Cited by 8 · see citing works
Li, Z., Li, Y., Zhang, J., Liu, Q., Zhu, L., Mao, B., Ma, Y., & Liu, Y. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116442 · Cited by 7 · see citing works
Zhang, Y., Wang, J., Li, X., Guo, R., Wang, L., Liu, Y., Yu, Y., & Kong, L. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01180-4 · Cited by 7 · see citing works
Li, F., You, D., Li, Y., Wang, X., Lin, Z., Shi, X., Li, Z., Wu, J., & Liu, Z. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1630062 · Cited by 7 · see citing works
Cornò, M. D., Aureli, A., Varano, B., & Conti, L. (2026) · Biomolecules · doi:10.3390/biom16020226 · Cited by 7 · see citing works
Yuan, T., Zhang, S., He, S., Ma, Y., Chen, J., & Gu, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-43223-6 · Cited by 7 · see citing works
Ramey, G. D., Tang, A., Phongpreecha, T., Yang, M. M., Woldemariam, S. R., Oskotsky, T., Montine, T. J., Allen, I. E., Miller, Z., Aghaeepour, N., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101980 · Cited by 7 · see citing works
Xu, G., An, Y., Du, Y., Cao, Z., Zheng, J., Wang, J., Li, T., Lei, X. G., & Lu, Y. (2025) · iMetaOmics. · doi:10.1002/imo2.70020 · Cited by 6 · see citing works
Impact of Gut–Brain Axis and Probiotics on Alzheimer’s Disease
Tabaza, R., & Hartman, R. E. (2025) · Neurology International · doi:10.3390/neurolint17100153 · Cited by 6 · see citing works
Tang, A., Chen, Y., Si, K., Lai, J., Gong, W., & Hu, S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03398-y · Cited by 7 · see citing works
Neuroimmune Dysregulation in Alzheimer's Disease: Mechanisms and Therapeutic Strategies.
He, H.-L., Zhu, S.-J., Zhang, C., Wang, H., Li, Y., & Qian, H.-B. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103055 · Cited by 8 · see citing works
Katsigianni, S., & Koutsouraki, E. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05914-9 · Cited by 7 · see citing works
Precision Neuronutrition: Personalized Approaches for Optimizing Brain Health
Novikov, V. N., Badaeva, A. V., Danilov, A. B., & Vorobyeva, Y. D. (2023) · International Electronic Conference on Nutrients (IECN) · doi:10.3390/iecn2023-15524 · Cited by 6 · see citing works
Sait, A. M., & Day, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168619 · Cited by 6 · see citing works
Li, S., Wang, H., Li, B., Lu, H., Zhao, J., Gao, A., An, Y., Yang, J., & Ma, T. (2025) · Animals · doi:10.3390/ani15050749 · Cited by 6 · see citing works
Fecal metabolites as early-phase biomarkers and prediction panel for ischemic stroke
Xu, K., Ren, Z., Zhao, S., Ren, Y., Wang, J., Wu, W., Hu, Z., He, F., Tu, D., Zhong, Q., et al. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04217-8 · Cited by 6 · see citing works
Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer’s disease
Guo, S., Yi, L., Luo, M., Dong, Z., & Du, Y. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1516190 · Cited by 5 · see citing works
Hong, S., Roh, H. W., Nam, Y. J., Kim, T. W., Cho, Y. H., Son, S. J., & Hong, C. H. (2025) · Brain Sciences · doi:10.3390/brainsci15060611 · Cited by 5 · see citing works
Epigenetic dysregulation of transposable elements in cognitive impairment and Alzheimer’s disease
Cavalier, A. N., Smith, M., McWilliams, G. T., McEntee, C. M., Bettcher, B. M., Coughlan, C. M., & LaRocca, T. J. (2025) · GeroScience · doi:10.1007/s11357-025-01765-9 · Cited by 6 · see citing works
Wu, D., Wang, H., Ni, Y., Lu, Y., Wang, Y., Li, H., & Chen, L. (2025) · The Visual Computer · doi:10.1007/s00371-025-04000-w · Cited by 5 · see citing works
Unraveling Alzheimer’s: Exploring the Gut Microbiota–Brain Axis as a New Frontier in Understanding
Rashid, S. M., Razak, R., Tantray, A. K., James, A. W., Showkat, N., Shehjar, F., Jan, F., Ahmad, S. B., Khan, A., & Shah, Z. A. (2024) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad1010003 · Cited by 5 · see citing works
Cognitive impairment and the gut-brain axis during 2014–2023: a bibliometric analysis
He, J., Wu, J., Liu, J., Wu, H., & Hua, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1407956 · Cited by 5 · see citing works
Chen, Q., Li, M., Li, Z., Mei, M., Lin, Y., Shu, P., & Zhu, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143661 · Cited by 4 · see citing works
Total Saponins of Panax notoginseng Leaves Alleviate Vascular Dementia via the Gut–Brain Axis
Ren, Y., Sun, Y., Sun, L., Chen, J.-L., Chen, Y.-H., Yan, S.-Y., Cheng, L., Yuan, J., & Li, X. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500430 · Cited by 4 · see citing works
Wei, Y., Huang, Y., Wang, S.-A., Liu, K., Zhong, Q., Fan, W., Cao, B., Chen, H.-W., Liang, Y., Li, Q., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251372522 · Cited by 4 · see citing works
Progress and Perspectives on the Estrogen–Microbiota–Brain Axis in Alzheimer’s Disease
Wang, M., Zeng, Y., Jin, Y., Wu, J., & Li, J. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04613-6 · Cited by 4 · see citing works
The complex of gut microbial metabolites and sex hormones in Alzheimer’s disease
Bahar, A., Khazaei, M., & Tahmasebi, H. (2026) · Seminars in Immunopathology · doi:10.1007/s00281-026-01076-x · Cited by 5 · see citing works
Personalized Paths: Unlocking Alzheimer’s via the Gut-Brain Axis
Ceccon, M., Kantsjö, J. B., & Ronchi, F. (2024) · Visceral Medicine · doi:10.1159/000535869 · Cited by 5 · see citing works
Multimodal Interventions Targeting Gut Microbiota and Microbial Metabolites in Cognitive Impairment
Horwat, P., Mariowska, A., Szymanska, A., Dzieciątkowska, M., & Pierudzka, W. (2025) · Cureus · doi:10.7759/cureus.85688 · Cited by 4 · see citing works
Ramey, G. D., Tang, A., Phongpreecha, T., Yang, M. M., Woldemariam, S. R., Oskotsky, T., Montine, T. J., Allen, I. E., Miller, Z., Aghaeepour, N., et al. (2024) · medRxiv · doi:10.1101/2024.05.02.24306649 · Cited by 4 · see citing works
Behairi, N., Samer, A., Sahraoui, L., Mataam, D. H., Trari, R., Flissi, B., Belguendouz, H., Amir, Z.-C., & Touil–Boukoffa, C. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578374 · Cited by 3 · see citing works
Ge, L., Zhu, L., Su, C., & Jin, Z. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251360004 · Cited by 3 · see citing works
Drug enteric metabolism in gut microbiota-brain crosstalk
Maramai, S., Taddei, M., Castagnetti, A., Viciani, E., Koufi, F., Neri, I., Boschetti, E., Evangelisti, C., Ratti, S., Baldelli, L., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124075 · Cited by 3 · see citing works
Zhao, F., Wang, J., Liang, W., Sun, F., Liu, Z., Wu, Y., Khan, A., Wang, C., Zhou, R., Feng, H., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02217-4 · Cited by 3 · see citing works
Quattrini, G., Gatti, E., Peretti, D. E., Aiello, M., Chevalier, C., Lathuilière, A., Park, R., Pievani, M., Salvatore, M., Scheffler, M., et al. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07299-8 · Cited by 3 · see citing works
Self-citationDossena, C., Bergamaschi, L., Rossignoli, F., Licata, A. G., Gasparini, P., Venturini, L. V., Marra, M., Oriani, M., Biassoni, V., Schiavello, E., et al. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf042 · Cited by 3 · see citing works
Surgical advances in the treatment of Alzheimer's disease: A comprehensive review
Xie, F., Ye, Y., Hao, J., Liu, H., Richard, S. A., & Sen, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251364397 · Cited by 3 · see citing works
Solorzano, C. S., Festari, C., Mirabelli, P., Mombelli, E., Coppola, L., Luongo, D., Naviglio, D., Soricelli, A., Quattrini, G., Salvatore, M., et al. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1550333 · Cited by 3 · see citing works
Self-citationGut microbiome signatures in iNPH: Insights from a shotgun metagenomics study
Park, R., Chevalier, C., Kieser, S., Marizzoni, M., Paquis, A., Armand, S., Scheffler, M., Allali, G., Assal, F., Momjian, S., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0330251 · Cited by 2 · see citing works
Self-citationActive immunization: A novel therapeutic strategy for treating Alzheimer's disease
Mazahir, F. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178288 · Cited by 2 · see citing works
Liu, P., Zhang, Z., Du, M., Chen, W., Li, W., Yang, W., Zhou, C., Wu, D., & Yang, Y. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c10515 · Cited by 2 · see citing works
Altered oral microbiomes in patients with prolonged disorders of consciousness
Xu, M., He, Z., Zhou, J., Zhao, J., Tian, X., Cheng, Q., Lin, Y., Xin, H., Mou, C., Xue, Q., et al. (2025) · Journal of Oral Microbiology · doi:10.1080/20002297.2025.2577220 · Cited by 2 · see citing works
Xi, C., Zhang, J., Liu, H., Jia, X., Ding, Y., Wei, W., Wang, L., & Liu, Z. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231457 · Cited by 2 · see citing works
Appraising the Effects of Gut Microbiota on Insomnia Risk Through Genetic Causal Analysis
Li, P., Wang, S., Li, J., Xiao, Z., Zhu, H., Sheng, D., Liu, W., Xiao, B., & Zhou, L. (2025) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.33021 · Cited by 3 · see citing works
Lewandowska, Z., Figlerowicz, M., & Mazur‐Melewska, K. (2025) · Nutrients · doi:10.3390/nu17172781 · Cited by 3 · see citing works
Zeamer, A. L., Lai, Y., Sanborn, V. E., Loew, E. B., Tracy, M., Jo, C., Ward, D. V., Bhattarai, S. K., Drake, J., McCormick, B. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.06.641911 · Cited by 2 · see citing works
Зв’язок між мікробіомом кишечника та розвитком нейродегенеративних захворювань (огляд)
Широбоков, В. П., & Димент, Г. С. (2024) · Visnik Nacional noi academii nauk Ukrai ni · doi:10.15407/visn2024.07.077 · Cited by 2 · see citing works
Marizzoni, M., Tournier, B. B., Chevalier, C., Saleri, S., Lathuilière, A., Ceyzériat, K., Paquis, A., Park, R., Troesch, E., Cattaneo, A., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1539067 · Cited by 1 · see citing works
Self-citationLin, Z., Zhang, P., Shi, D., Zhang, Y., Wu, W.-Q., Tang, Q.-S., Wang, Q., & Wang, S.-Q. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107683 · Cited by 1 · see citing works
Zhou, L., Fang, H., Chen, M., & Ding, S. (2025) · Journal of Stomatology Oral and Maxillofacial Surgery · doi:10.1016/j.jormas.2025.102422 · Cited by 1 · see citing works
Zhang, Y., Qin, N., Wang, Y., Feng, H., Zhang, Z., Wang, C., Qin, Z., Duo, H., Yin, X., Shi, Y., et al. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103323 · Cited by 1 · see citing works
Guo, Q., Yang, D., Fahira, A., Zhong, Q., Yang, J., Zhuang, K., Wen, Y., Tang, Z., & Huang, Z. (2025) · Brain and Behavior · doi:10.1002/brb3.70980 · Cited by 1 · see citing works
Seyoum, Y., de Lucia, C., Khalifa, K. N., Bergland, A. K., Aarsland, D., & van der Giezen, M. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2570862 · Cited by 1 · see citing works
Salman, B., Haidar, R., Faour, V., Ali, W. A., Aridi, L., Harb, F., Azar, S. T., Khattar, Z. A., & Ghadieh, H. E. (2025) · Health Sciences Review · doi:10.1016/j.hsr.2025.100251 · Cited by 2 · see citing works
enGLOW 3D microscopy of the enteric nervous system in cleared human and mouse gut
Planchette, A., Gantar, I., Scholler, J., Sobolewski, A., Cabara, Y., Wójcicki, K., Brana, C., Durand, T., Naveilhan, P., Barthet, G., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09643-6 · Cited by 1 · see citing works
Antequera, D., Carrero, L., Romualdi, D., Buetas, E., García‐Consuegra, I., Cantero, J. L., Mira, A., Municio, C., & Carro, E. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119112 · Cited by 1 · see citing works
Cipriano, G. L., Grimaldi, A., Marra, A., Quartarone, A., & Maresca, G. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1782720 · Cited by 1 · see citing works
An overview of Synlab SDN Biobank’s quality control system
Coppola, L., Grimaldi, A., Sarnacchiaro, G., di Fasano, M. S., Smaldone, G., & Salvatore, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-70263-3 · Cited by 2 · see citing works
Self-citationzou, Z., Wang, X., Ge, X., Lei, D., Lei, X., Hou, J., Jian, X., Long, Y., & Li, X. (2025) · Research Square · doi:10.21203/rs.3.rs-8188423/v1 · Cited by 1 · see citing works
Hao, W., Luo, Q., Tomic, I., Quan, W., Hartmann, T., Menger, M. D., Fassbender, K. C., & Liu, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.06.570400
Liu, M., Huang, C., Huang, S., Chang, H., Hsu, S., Lin, K., Ho, T., Huang, K., Cheng, C., & Chang, C. (2024) · Research Square · doi:10.21203/rs.3.rs-3932300/v1
Ni, W., Wang, Y., Li, S., Cao, Q., Sun, C., Yao, J., & Zhang, G. (2025) · Research Square · doi:10.21203/rs.3.rs-5871350/v1
Retracted
- Authors
- Marizzoni, M., Mirabelli, P., Mombelli, E., Coppola, L., Festari, C., Lopizzo, N., Luongo, D., Mazzelli, M., Naviglio, D., Blouin, J.-L., Abramowicz, M., Salvatore, M., Pievani, M., Cattaneo, A., & Frisoni, G. B.
- Affiliations
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- University of Milan (IT)
- Institute of Biostructure and Bioimaging (IT)
- University of Naples Federico II (IT)
- University of Geneva (CH)
- Corresponding author
- Marizzoni, Moira
- ORCID
- Venue
- Alzheimer's Research & Therapy
- Published
- 2023-05-31
- Volume
- 15
- Issue
- 1
- Pages
- 101-101
- ISSN
- 1758-9193 (ISSN-L)
- PMC
- PMC10230724
- OpenAlex
- W4378781690
- Cited by
- 121
- References
- 69
- Citations by year
- 2026: 24 · 2025: 64 · 2024: 27 · 2023: 6
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Alzheimer s Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation
- Alzheimer's Association
- Biogen
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Ministero della Salute
- Eisai
- Hôpitaux Universitaires de Genève
- Fondation Segré
- Horizon 2020 Framework Programme
- Avid Radiopharmaceuticals
- Faculté de Médecine, Université de Genève
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, gut microbiota, microbiota-gut-brain axis, amyloid hypothesis, lipopolysaccharide, adhesion molecules, endothelial dysfunction, inflammatory cytokines, Clostridia_UCG-014, Blautia, Eubacterium coprostanoligenes, Collinsella, phosphorylated tau, neurofilament light chain, amyloid PET, cognitive impairment
- MeSH terms
- Brain-Gut Axis, Alzheimer Disease, Humans, Lipopolysaccharides, Mitoguazone, NAD, RNA, Ribosomal, 16S, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Amyloid beta-Peptides, Interleukin-10, Platelet Endothelial Cell Adhesion Molecule-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
