Pomegranate Extract Modulates Processing of Amyloid-β Precursor Proteinin an Aged Alzheimer’s Disease Animal Model

Ahmed, A; Subaiea, M; Eid, A; Li, L; Seeram, P; Zawia, H

doi:10.2174/1567205011666141001115348

Cited by 47Alzheimer's disease research and treatmentsPomegranate: compositions and health benefitsMedicinal Plants and Neuroprotection

Pomegranate Extract Modulates Processing of Amyloid-β Precursor Proteinin an Aged Alzheimer’s Disease Animal Model

Ahmed, A, Subaiea, M, Eid, A, Li, L, Seeram, P, Zawia, H·2014·Current Alzheimer Research

DOI 10.2174/1567205011666141001115348

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Abstract

Accumulating research supports the neuroprotective effects of pomegranate (Punica granatum) juice and extracts against Alzheimer's disease (AD) but there is limited data available in animal models. Here we investigated the effects of a standardized pomegranate extract (PE) on AD pathology in an aged transgenic AD animal model (R1.40).The mice (age 24-30 months) received either PE (at 100 and 200 mg/kg) or a control solution daily for three weeks, and were evaluated in the Morris water maze and the Y-maze for improvements in spatial long-term and working memory functions. Cortical amyloid-β precursor protein (APP) and amyloid-β (Aβ) levels, along with other relevant biomarkers for AD, were measured in brain tissues. PE did not improve cognitive performance of the mice, but altered levels and ratio of the Aβ42 and Aβ40 peptides which would favor a diminution in AD pathogenesis. Further analysis revealed that this reversal could be the product of the modification of γ-secretase enzyme activity, the enzyme involved in the generation of these Aβ isoforms. Our findings support a specific anti-amyloidogenic mechanism of a pomegranate extract in this aged AD animal model.

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Juice and extracts from Punica granatum have shown neuroprotective effects in animal models, potentially by counteracting oxidative damage, minimizing inflammation of the brain and soluble Aβ42 and hippocampal amyloid deposition.
“Likewise, juice and extracts from Punica granatum have also shown neuroprotective effects in animal models, potentially by counteracting oxidative damage, minimizing inflammation of the brain and soluble Aβ 42 and hippocampal amyloid deposition [182,183].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [183]

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Authors: Ahmed, A., Subaiea, M., Eid, A., Li, L., Seeram, P., & Zawia, H.
ORCID: Li, L
Venue: Current Alzheimer Research
Publisher: Bentham Science Publishers Ltd.
Published: 2014-10-01
Volume: 11
Issue: 999
Pages: 1-1
ISSN: 1567-2050 (ISSN-L)
DOI: 10.2174/1567205011666141001115348
OpenAlex: W2114847919
Cited by: 47
References: 0
Citations by year: 2026: 1 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 9 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 3
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Locations: Current Alzheimer Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R03AG027246, AG 027246)
National Institute of Environmental Health Sciences (R21ES013022, ES13022)
National Center for Research Resources (P20RR016457)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: pomegranate extract, Punica granatum, Alzheimer's disease, spatial memory, neuroprotection, cognitive impairment
MeSH terms: Aging, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Female, Phytotherapy, Memory, Short-Term, Mice, Transgenic, Peptide Fragments, Plant Extracts, Biomarkers, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Neuroprotective Agents, Maze Learning, Lythraceae, Amyloid Precursor Protein Secretases, Memory, Long-Term, Spatial Memory

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Pomegranate Extract Modulates Processing of Amyloid-β Precursor Proteinin an Aged Alzheimer’s Disease Animal Model

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