Cited by 231Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.

Cholinesterase Inhibitors and Beyond

Pepeu, Giancarlo, Giovannini, Maria·2009·Current Alzheimer Research

DOI 10.2174/156720509787602861

Open this paper in CoChat — free account

Abstract

Cholinesterase inhibitors (ChEIs) were introduced in the therapy of Alzheimer Disease (AD) in the nineteen nineties with great expectations. The hopes and large interest raised by these drugs are well demonstrated by 12,000 references listed by PubMed under 'ChEI' for 1995-2007. The list is reduced to 2500 if we confine ourselves to 'ChEIs and dementia'. Of them, about 500 were published in the last two years. Whereas an increase in brain acetylcholine and an improvement of cognitive deficits have been consistently demonstrated in animal models of AD, from aging rats to transgenic mice, the clinical effectiveness of ChEIs has been and is still a matter of contrasting opinions. These range from the negative conclusions of the AD2000 trial on donepezil, claiming that it is not cost effective, with benefits below a minimally relevant threshold, to the NICE appraisal of 2007 declaring that donepezil, rivastigmine, galantamine are efficacious for mild to moderate AD, irrespective of their different selectivity for acetyl- (AChE) and butyrylcholinesterase (BuChE). The possibility that ChEIs may exert their effects through mechanisms beyond cholinesterase inhibition has been envisaged. However, according to the information presented in this review, the "classical" ChEIs, donepezil, rivastigmine and galantamine, show no pharmacological actions beyond cholinesterase inhibition which may play an important role in their therapeutic efficacy. The diverging opinions on clinical efficacy do not discourage from developing new ChEIs, and particularly the so called multifunctional ChEIs. They represent the future of the cholinergic therapy for AD but other indications for these drugs may be considered, including vascular dementia, mild cognitive impairment, and the ethically sensitive improvement of memory and learning in healthy subjects.

Integrity signals

Registry

Crossref · 10.2174/156720509787602861

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
The cholinergic hypothesis of Alzheimer’s disease: A review of progress
Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.137 · Cited by 2,198 · cited 1×
“[19, 20]).”
Cholinesterase inhibitors for Alzheimer's disease
Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906
Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type
Summers, W. K., Majovski, L. V., Marsh, G. M., Tachiki, K. H., & Kling, A. S. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152001 · Cited by 1,161
Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
Inestrosa, N. C., Alvarez, A. R., Pérez, C. A., Moreno, R. D., Vicente, M., Linker, C., Casanueva, O. I., Soto, C. A., & Garrido, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80108-7 · Cited by 1,117
Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial Commentary: Another piece of the Alzheimer's jigsaw
Rosler, M., Anand, R., Cicin-Sain, A., Gauthier, S., Agid, Y., Dal-Bianco, P., Stahelin, H. B., Hartman, R., Gharabawi, M., & Bayer, T. (1999) · BMJ · doi:10.1136/bmj.318.7184.633 · Cited by 943
Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors
Nitsch, R. M., Slack, B. E., Wurtman, R. J., & Growdon, J. H. (1992) · Science · doi:10.1126/science.1411529 · Cited by 898
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
Greig, N. H., Utsuki, T., Ingram, D. K., Wang, Y., Pepeu, G., Scali, C., Yu, Q.-S., Mamczarz, J., Holloway, H. W., Giordano, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508575102 · Cited by 753
Self-citation
The Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial
Rogers, S. L., & Friedhoff, L. T. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106895 · Cited by 743

Show all 96 references

Sorted by citations

The cholinergic system in aging and neuronal degeneration
Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733
Acetylcholinesterase inhibition-based biosensors for pesticide determination: a review.
Pundir, C., & Chauhan, N. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.06.025 · Cited by 313
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer’s disease
Guzior, N., Wi.eckowska, A., Panek, D., & Malawska, B. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666141106122628 · Cited by 323
Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid
García‐Ayllón, M. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00022 · Cited by 303
Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
Mørk, A., Montezinho, L. P., Miller, S., Trippodi-Murphy, C., Plath, N., Li, Y., Gulinello, M. E., & Sánchez, C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.019 · Cited by 300
Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties
Fernández‐Bachiller, M. I., Pérez, C., González-Muñoz, G. C., Conde, S., López, M. G., Villarroya, M., Garcı́a, A. G., & Rodrı́guez-Franco, M. I. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100329q · Cited by 270
Drosophila melanogaster in the Study of Human Neurodegeneration
Hirth, F. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791556104 · Cited by 247
The cholinergic system and spatial learning
Deiana, S., Platt, B., & Riedel, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.036 · Cited by 245
Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease
Lu, C., Guo, Y., Yan, J., Luo, Z., Luo, H., Yan, M., Huang, L., & Li, X. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400567s · Cited by 230
Subregional neuroanatomical change as a biomarker for Alzheimer's disease
Holland, D., Brewer, J. B., Hagler, D. J., Fennema-Notestine, C., Dale, A. M., Initiative, T. A. D. N., Weiner, M., Thal, L., Petersen, R., Jack, C. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906053106 · Cited by 210
Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease?
Martorana, A., Esposito, Z., & Koch, G. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00175.x · Cited by 174
Cholinergic systems mediate action from movement to higher consciousness
Woolf, N. J., & Butcher, L. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.046 · Cited by 173
Acetylcholinesterase inhibitors: a patent review (2008 – present)
Pohanka, M. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.701620 · Cited by 159
Cholinesterase inhibitors and memory
Pepeu, G., & Giovannini, M. G. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.11.018 · Cited by 140
Self-citation
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer’s disease (1998–2018)
Mishra, P., Kumar, A., & Panda, G. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.025 · Cited by 130
From Single Target to Multitarget/Network Therapeutics in Alzheimer’s Therapy
Zheng, H., Fridkin, M., & Youdim, M. B. H. (2014) · Pharmaceuticals · doi:10.3390/ph7020113 · Cited by 121
Inhibition of flavonoids on acetylcholine esterase: binding and structure–activity relationship
Xie, Y., Yang, W., Chen, X., & Xiao, J. (2014) · Food & Function · doi:10.1039/c4fo00287c · Cited by 119
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease
Jiang, N., Huang, Q., Liu, J., Liang, N., Li, Q., Li, Q., & Xie, S. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.055 · Cited by 111
Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer's disease
Gauthier, S. G., & Molinuevo, J. L. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.11.005 · Cited by 111
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease
Mishra, C. B., Kumari, S., Manral, A., Prakash, A., Saini, V., Lynn, A. M., & Tiwari, M. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.057 · Cited by 108
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation
Wu, M., Esteban, G., Brogi, S., Shionoya, M., Wang, L., Campiani, G., Unzeta, M., Inokuchi, T., Butini, S., & Marco‐Contelles, J. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.001 · Cited by 104
Scopolamine-induced learning impairment reversed by physostigmine in zebrafish
Kim, Y., Lee, Y., Kim, D., Jung, M. W., & Lee, C. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.003 · Cited by 100
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
Panek, D., Więckowska, A., Wichur, T., Bajda, M., Godyń, J., Jończyk, J., Mika, K., Janočková, J., Soukup, O., Knez, D., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.078 · Cited by 98
Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease
Li, S., Jiang, N., Xie, S., Wang, K. D. G., Wang, X., & Kong, L. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42010h · Cited by 96
Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines
Saadeh, H. A., Sweidan, K., & Mubarak, M. S. (2020) · Molecules · doi:10.3390/molecules25184321 · Cited by 96
Anti-amyloid Aggregation Activity of Natural Compounds: Implications for Alzheimer’s Drug Discovery
Bu, X., Rao, P. P. N., & Wang, Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9301-4 · Cited by 97
Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ 1–42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease
Xu, P., Zhang, M., Sheng, R., & Ma, Y. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.045 · Cited by 92
New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol
Mao, F., Yan, J., Li, J., Jia, X., Miao, H., Sun, Y., Huang, L., & Li, X. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00998c · Cited by 91
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease
Huang, L., Miao, H., Sun, Y., Meng, F., & Li, X. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.09.081 · Cited by 80
Synthesis, bioactivity and binding energy calculations of novel 3-ethoxysalicylaldehyde based thiosemicarbazone derivatives
Ishaq, M., Taslımı, P., Shafiq, Z., Khan, S., Salmas, R. E., Zangeneh, M. M., Saeed, A., Zangeneh, A., Sadeghian, N., Asari, A., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103924 · Cited by 79
Midlife predictors of Alzheimer's disease
Bendlin, B. B., Carlsson, C. M., Gleason, C. E., Johnson, S. C., Sodhi, A., Gallagher, C. L., Puglielli, L., Engelman, C. D., Ries, M. L., Xu, G., et al. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.12.014 · Cited by 81
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease
Li, Y., Qiang, X., Luo, L., Xia, Y., Xiao, G., Liu, Q., Ai, J., Tan, Z., & Deng, Y. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.009 · Cited by 75
Galantamine, an Acetylcholinesterase Inhibitor and Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors, Attenuates Nicotine Taking and Seeking in Rats
Hopkins, T. J., Rupprecht, L. E., Hayes, M. R., Blendy, J. A., & Schmidt, H. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.83 · Cited by 73
Rivastigmine Lowers Aβ and Increases sAPPα Levels, Which Parallel Elevated Synaptic Markers and Metabolic Activity in Degenerating Primary Rat Neurons
Bailey, J. A., Ray, B., Greig, N. H., & Lahiri, D. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021954 · Cited by 70
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties
Szałaj, N., Bajda, M., Skrok, M., Kurpiewska, K., Lewiński, K., Brus, B., Pišlar, A. H., Kos, J., Gobec, S., & Malawska, B. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.027 · Cited by 69
Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties
Kožurková, M., Hamuľaková, S., Gažová, Z., Paulíková, H., & Kristián, P. (2011) · Pharmaceuticals · doi:10.3390/ph4020382 · Cited by 68
Neuroprotective effects of donepezil against cholinergic depletion
Cutuli, D., Bartolo, P. D., Caporali, P., Tartaglione, A. M., Oddi, D., D'Amato, F. R., Nobili, A., D’Amelio, M., & Petrosini, L. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt215 · Cited by 68
Activation of Neurotensin Receptor 1 Facilitates Neuronal Excitability and Spatial Learning and Memory in the Entorhinal Cortex: Beneficial Actions in an Alzheimer's Disease Model
Xiao, Z., Cilz, N. I., Kurada, L., Hu, B., Yang, C., Wada, E., Combs, C. K., Porter, J. E., Lesage, F., & Lei, S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0408-14.2014 · Cited by 65
Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium‐like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors
Pisani, L., Catto, M., Giangreco, I., Leonetti, F., Nicolotti, O., Stefanachi, A., Cellamare, S., & Carotti, A. (2010) · ChemMedChem · doi:10.1002/cmdc.201000210 · Cited by 64
Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research
Colwell, M., Tagomori, H., Chapman, S., Gillespie, A. L., Cowen, P. J., Harmer, C. J., & Murphy, S. E. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02249-6 · Cited by 68
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation
Mao, F., Huang, L., Luo, Z., Liu, A., Lu, C., Xie, Z., & Li, X. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.07.045 · Cited by 63
Acetylcholinesterase inhibitors and the risk of hip fracture in Alzheimer's disease patients: A case-control study
Tamimi, I., Ojea, T., Sánchez-Siles, J.-M., Rojas, F., Martin, I., Gormaz, I., Perez, A., Dawid-Milner, M. S., Mendez, L., & Tamimi, F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1616 · Cited by 62
Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease
Wang, X., Xia, C., Chen, S.-B., Tan, J., Ou, T., Huang, S., Li, D., Gu, L., & Huang, Z. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.10.018 · Cited by 60
Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy
Kou, X., Song, L., Wang, Y., Yu, Q., Ju, H., Yang, A., & Shen, R. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126927 · Cited by 59
Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease
Liu, Q., Qiang, X., Li, Y., Sang, Z., Li, Y., Tan, Z., & Deng, Y. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.01.042 · Cited by 60
DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice
Lian, W., Fang, J., Xu, L., Zhou, W., Kang, D., Xiong, W., Jia, H., Liu, A., & Du, G. (2017) · Molecules · doi:10.3390/molecules22030410 · Cited by 58
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease
Luo, X., Wang, C., Liu, Y., & Huang, Z. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.08.052 · Cited by 57
Design, Synthesis and Evaluation of Novel 2‐(Aminoalkyl)‐isoindoline‐1,3‐dione Derivatives as Dual‐Binding Site Acetylcholinesterase Inhibitors
Ignasik, M., Bajda, M., Szałaj, N., Prinz, M., Holzgrabe, U., & Malawska, B. (2012) · Archiv der Pharmazie · doi:10.1002/ardp.201100423 · Cited by 56
The ethics of elective psychopharmacology
Mohamed, A. D., & Sahakian, B. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571100037x · Cited by 56
Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease
Shi, X., Wu, J., Liu, P., & Liu, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.001 · Cited by 55
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
Wang, X., Yin, F., Huang, M. Y., Jiang, N., Lan, J., & Kong, L. (2020) · RSC Medicinal Chemistry · doi:10.1039/c9md00441f · Cited by 54
Rivastigmine for Refractory REM Behavior Disorder in Mild Cognitive Impairment
Brunetti, V., Losurdo, A., Testani, E., Lapenta, L., Mariotti, P., Marra, C., Rossini, P. M., & Marca, G. D. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140302195648 · Cited by 53
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer’s disease
Mishra, C. B., Manral, A., Kumari, S., Saini, V., & Tiwari, M. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.06.027 · Cited by 53
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer’s disease
Hu, J., Pan, T., An, B., Li, Z., Li, X., & Huang, L. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.12.013 · Cited by 53
Cholinergic and serotonergic modulation of resting state functional brain connectivity in Alzheimer's disease
Klaassens, B. L., van Gerven, J., Klaassen, E. S., van der Grond, J., & Rombouts, S. A. R. B. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.044 · Cited by 53
Do Cholinesterase Inhibitors Act Primarily on Attention Deficit? A Naturalistic Study in Alzheimer's Disease Patients
Bracco, L., Bessi, V., Padiglioni, S., Marini, S., & Pepeu, G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131154 · Cited by 51
Self-citation
Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors
Deb, P. K., Sharma, A., Piplani, P., & Akkinepally, R. R. (2012) · Molecular Diversity · doi:10.1007/s11030-012-9394-x · Cited by 51
Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-β Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer’s Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway
Reale, M., Nicola, M. D., Velluto, L., D’Angelo, C., Costantini, E., Lahiri, D. K., Kamal, M. A., Yu, Q.-S., & Greig, N. H. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131212113218 · Cited by 51
Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease
Fu, J., Bao, F., Gu, M., Liu, J., Zhang, Z., Ding, J., Xie, S., & Ding, J. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1687460 · Cited by 50
Galantamine protects against lipopolysaccharide-induced acute lung injury in rats
Li, G., Zhou, C., Zhou, Q., & Zou, H. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20155008 · Cited by 46
Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with β-amyloid anti-aggregation properties for the treatment of Alzheimer’s disease
Jiang, N., Ding, J., Liu, J., Sun, X., Zhang, Z., Mo, Z., Li, X., Yin, H. Z., Tang, W., & Xie, S. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103027 · Cited by 46
Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors
Altıntop, M. D., Özdemır, A., Kaplancıklı, Z. A., Turan‐Zitouni, G., Temel, H. E., & Çiftçi, G. A. (2013) · Archiv der Pharmazie · doi:10.1002/ardp.201200384 · Cited by 43
Cholinergic Signaling Dynamics and Cognitive Control of Attention
Parikh, V., & Bangasser, D. A. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_133 · Cited by 43
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats
Sadek, B. S., Khan, N., Darras, F. H., Pockes, S., & Decker, M. W. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.08.022 · Cited by 42
Rivastigmine patch reduces the incidence of postoperative delirium in older patients with cognitive impairment
Youn, Y. C., Shin, H., Choi, B., Kim, S., Lee, J.-Y., & Ha, Y. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4569 · Cited by 42
Concomitant Use of Cholinesterase Inhibitors and Anticholinergics: Prevalence and Outcomes
Boudreau, D. M., Yu, O., Gray, S. L., Raebel, M. A., Johnson, J., & Larson, E. B. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03654.x · Cited by 42
Synthesis and Evaluation of Paeonol Derivatives as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease
Zhou, A., Wu, H., Pan, J., Wang, X., Li, J., Wu, Z., & Hui, A. (2015) · Molecules · doi:10.3390/molecules20011304 · Cited by 41
Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease
Lu, C., Hu, J., Wang, Z., Xie, S., Pan, T., Huang, L., & Li, X. (2018) · MedChemComm · doi:10.1039/c8md00315g · Cited by 40
New Pharmacological Approaches to the Cholinergic System: An Overview on Muscarinic Receptor Ligands and Cholinesterase Inhibitors
Greig, N. H., Reale, M., & Tata, A. M. (2013) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889811308020003 · Cited by 41
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats
Khan, N., Saad, A. K., Nurulain, S. M., Darras, F. H., Decker, M. W., & Sadek, B. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.022 · Cited by 40
Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer’s disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids
Pan, T., Xie, S., Zhou, Y., Hu, J., Luo, H., Li, X., & Huang, L. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.06.056 · Cited by 40
Receptor-Mediated Suppression of Potassium Currents Requires Colocalization within Lipid Rafts
Oldfield, S., Hancock, J. M., Mason, A., Hobson, S. A., Wynick, D., Kelly, E., Randall, A. D., & Marrion, N. V. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058008 · Cited by 40
Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors
Turan‐Zitouni, G., Özdemır, A., Kaplancıklı, Z. A., Altıntop, M. D., Temel, H. E., & Çiftçi, G. A. (2012) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2011.653355 · Cited by 38
Donepezil regulates energy metabolism and favors bone mass accrual
Eimar, H. A., Alebrahim, S., Manickam, G., Alsubaie, A., Nada, L. A., Murshed, M., & Tamimi, F. (2015) · Bone · doi:10.1016/j.bone.2015.12.009 · Cited by 37
Derivatives and Analogues of Resveratrol: Recent Advances in Structural Modification
Li, Q., Li, Y., Deora, G. S., & Ruan, B. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190128093840 · Cited by 36
Alzheimer’s disease biomarker discovery in symptomatic and asymptomatic patients: Experimental approaches and future clinical applications
Ho, L., Fivecoat, H. C., Wang, J., & Pasinetti, G. M. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.007 · Cited by 38
AChE as a spark in the Alzheimer’s blaze – Antagonizing effect of a cyclized variant
Behl, T., Kaur, I., Sehgal, A., Singh, S., Sharma, N., Gupta, S., Albratty, M., Najmi, A., Alhazmi, H. A., & BUNGAU, S. G. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101787 · Cited by 34
Acetylcholinesterase inhibitors and healing of hip fracture in Alzheimer's disease patients: a retrospective cohort study.
Eimar, H. A., Lara, A. P., Tamimi, I., Sánchez, P. M., Talavera, I. G., Tomba, F. R., de la Oliva, T. G., & Tamimi, F. (2013) · PubMed · Cited by 34
Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer’s disease
Liao, Q., Li, Q., Zhao, Y., Jiang, P. H., Yan, Y., Sun, H., Liu, W., Feng, F., & Qu, W. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103844 · Cited by 33
Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group
Bartolucci, C., Stojan, J., Yu, Q., Greig, N. H., & Lamba, D. (2012) · Biochemical Journal · doi:10.1042/bj20111675 · Cited by 31
Ethoxylated Head of Chalcones as a New Class of Multi‐Targeted MAO Inhibitors
Lakshminarayanan, B., Baek, S. C., Lee, J. P., Kannappan, N., Mangiatordi, G. F., Nicolotti, O., Subburaju, T., Kim, H., & Mathew, B. (2019) · ChemistrySelect · doi:10.1002/slct.201901093 · Cited by 31
A Unique GSK-3β inhibitor B10 Has a Direct Effect on Aβ, Targets Tau and Metal Dyshomeostasis, and Promotes Neuronal Neurite Outgrowth
Shi, X.-L., Yan, N., Cui, Y.-J., & Liu, Z.-P. (2020) · Cells · doi:10.3390/cells9030649 · Cited by 26
Promising heterocycle-based scaffolds in recent (2019–2021) anti-Alzheimer's drug design and discovery
Dorababu, A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174847 · Cited by 31
Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes
Froestl, W., Muhs, A., & Pfeifer, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121537 · Cited by 31
Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice
Cutuli, D., Landolfo, E., Nobili, A., Bartolo, P. D., Sacchetti, S., Chirico, D., Marini, F., Pieroni, L., Ronci, M., D’Amelio, M., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00705-3 · Cited by 30
Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density
Araujo, J. A., Nóbrega, J. N., Raymond, R., & Milgram, N. W. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.005 · Cited by 28
Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease
Wang, Z., Li, W., Wang, Y., Li, X., Huang, L., & Li, X. (2016) · RSC Advances · doi:10.1039/c5ra26797h · Cited by 30
Dual‐Acting Diether Derivatives of Piperidine and Homopiperidine with Histamine H3 Receptor Antagonistic and Anticholinesterase Activity
Bajda, M., Kuder, K., Łażewska, D., Kieć‐Kononowicz, K., Więckowska, A., Ignasik, M., Szałaj, N., Jończyk, J., & Malawska, B. (2012) · Archiv der Pharmazie · doi:10.1002/ardp.201200018 · Cited by 28
Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies
García, M. E., Borioni, J. L., Cavallaro, V., Puiatti, M., Pierini, A. B., Murray, A. P., & Peñéñory, A. B. (2015) · Steroids · doi:10.1016/j.steroids.2015.09.001 · Cited by 27
Cilostazol improves hippocampus-dependent long-term memory in mice
Yanai, S., Semba, Y., Ito, H., & Endo, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3442-4 · Cited by 28
Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self‐administration and reinstatement of nicotine seeking in rats
Kimmey, B. A., Rupprecht, L. E., Hayes, M. R., & Schmidt, H. D. (2012) · Addiction Biology · doi:10.1111/adb.12014 · Cited by 29
Cardiovascular Dementia - A Different Perspective
Kumari, U., & Heese, K. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010029 · Cited by 27
Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced Aβ aggregation and antioxidant
Wang, B., Wang, Z., Chen, H., Lu, C., & Li, X. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.08.017 · Cited by 25
Anxiolytic effects of an acetylcholinesterase inhibitor, physostigmine, in the adult zebrafish
Cho, H., Lee, C., Choi, J., Hwang, J., & Lee, Y. (2011) · Animal Cells and Systems · doi:10.1080/19768354.2011.642084 · Cited by 25
Synthesis and Biological Evaluation of a Series of Dithiocarbamates as New Cholinesterase Inhibitors
Altıntop, M. D., Gurkan‐Alp, A. S., Özkay, Y., & Kaplancıklı, Z. A. (2013) · Archiv der Pharmazie · doi:10.1002/ardp.201300045 · Cited by 24
PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment
Yanai, S., & Endo, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1374-4 · Cited by 25
Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening
Xu, T., Li, S., Li, A. J., Zhao, J., Sakamuru, S., Huang, W., Xia, M., & Huang, R. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c00230 · Cited by 24
Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines
Lodarski, K., Jończyk, J., Szałaj, N., Bajda, M., Gładysz, J., Walczyk, J., Jeleń, M., MORAK-MŁODAWSKA, B. I., Pluta, K., & Malawska, B. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.889127 · Cited by 24
Discovery of 4′-OH-flurbiprofen Mannich base derivatives as potential Alzheimer’s disease treatment with multiple inhibitory activities
Liu, H., Qiang, X., Song, Q., Li, W., He, Y., Ye, C., Tan, Z., & Deng, Y. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.040 · Cited by 25

Authors: Pepeu, G., & Giovannini, M.
Affiliations: University of Florence (IT)
Corresponding author: Giovannini, Maria
ORCID: Giovannini, Maria
Venue: Current Alzheimer Research
Publisher: Bentham Science Publishers Ltd.
Published: 2009-04-01
Volume: 6
Issue: 2
Pages: 86-96
ISSN: 1567-2050 (ISSN-L)
DOI: 10.2174/156720509787602861
OpenAlex: W2133779850
Cited by: 209
References: 96
Citations by year: 2026: 3 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 1 · 2020: 12 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 15 · 2015: 19 · 2014: 22 · 2013: 12 · 2012: 19
FWCI: 15.57
Type: journal article
Language: en
Open access: closed
Locations: Current Alzheimer Research (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: cholinesterase inhibitors, Alzheimer's disease, donepezil, rivastigmine, galantamine, acetylcholinesterase, butyrylcholinesterase, cholinergic therapy, vascular dementia, mild cognitive impairment, memory enhancement, clinical efficacy
MeSH terms: Acetylcholine, Alzheimer Disease, Animals, Brain, Cholinesterase Inhibitors, Cholinesterases, Clinical Trials as Topic, Cognition Disorders, Humans, Antipsychotic Agents, History, 20th Century, History, 21st Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cholinesterase Inhibitors and Beyond

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks