Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ 1–42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease

2014 Alzheimer's disease facts and figures

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Solution structure of the Alzheimer amyloid β‐peptide (1–42) in an apolar microenvironment

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Alzheimer's Disease: From Pathology to Therapeutic Approaches

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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

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Progress towards a molecular-level structural understanding of amyloid fibrils

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Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review

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Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

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Design of iron chelators with therapeutic application

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Design, Synthesis, Physicochemical Properties, and Evaluation of Novel Iron Chelators with Fluorescent Sensors

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Design of clinically useful iron(III)‐selective chelators

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Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer’s Disease

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Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

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Cholinesterase Inhibitors and Beyond

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Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents

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Deferiprone versus Deferoxamine in Patients with Thalassemia Major: A Randomized Clinical Trial

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Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity*

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Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease

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Design of iron chelators with therapeutic application

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The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity

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Heterogeneity in Red Wine Polyphenolic Contents Differentially Influences Alzheimer's Disease-type Neuropathology and Cognitive Deterioration

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Metal ions influx is a double edged sword for the pathogenesis of Alzheimer’s disease

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Combating Alzheimer's Disease With Multifunctional Molecules Designed for Metal Passivation

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The potential application of iron chelators for the treatment of neurodegenerative diseases

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Design, Synthesis, and Evaluation of Novel 2-Substituted 3-Hydroxypyridin-4-ones: Structure−Activity Investigation of Metalloenzyme Inhibition by Iron Chelators

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Iron chelation as a potential therapy for neurodegenerative disease

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Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease

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The Development of Preventives and Therapeutics for Alzheimers Disease that Inhibit the Formation of β-Amyloid Fibrils (fAβ), as Well as Destabilize Preformed fAβ

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Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity

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Synthesis, physical–chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer’s disease

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Amido‐3‐hydroxypyridin‐4‐ones as Iron(III) Ligands

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Design and Synthesis of Fluorinated Iron Chelators for Metabolic Study and Brain Uptake

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A novel fluorescence method for determination of pFe 3 +

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The selective quantification of iron by hexadentate fluorescent probes

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Identification of 2-subsituted benzothiazole derivatives as triple-functional agents with potential for AD therapy

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Review of Theoretical Studies for Prediction of Neurodegenerative Inhibitors

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Current and Future Treatments in Alzheimer Disease: An Update

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Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

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Reasons for failed trials of disease-modifying treatments for alzheimer disease and their contribution in recent research

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Therapeutic Approach to Alzheimer’s Disease: Current Treatments and New Perspectives

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Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases

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Mitochondrial Iron in Human Health and Disease

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The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation

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Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

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Current State of Knowledge on the Antioxidant Effects and Mechanisms of Action of Polyphenolic Compounds

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Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer’s disease: Limitations, and current and future perspectives

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Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

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Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress

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Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

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Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease

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Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease

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Natural products and their derivatives as multifunctional ligands against Alzheimer's disease

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Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments

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Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease

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The Potential Role of Ferroptosis in Alzheimer’s Disease

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Advances in Multi-Functional Ligands and the Need for Metal-Related Pharmacology for the Management of Alzheimer Disease

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Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease

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Redox-Active Metal Ions and Amyloid-Degrading Enzymes in Alzheimer’s Disease

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A mechanistic survey of Alzheimer's disease

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Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities

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Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease

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Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

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New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation

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Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

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Design and synthesis of novel stilbene-hydroxypyridinone hybrids as tyrosinase inhibitors and their application in the anti-browning of freshly-cut apples

Zhu, Y., Chen, K., Chen, Y., Zhang, C., Xie, Y., Hider, R. C., & Zhou, T. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132730 · Cited by 47 · see citing works

Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease

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Design, synthesis and evaluation of scutellarein- O -acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

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Derivatives and Analogues of Resveratrol: Recent Advances in Structural Modification

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An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery

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Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy

Fantacuzzi, M., Amoroso, R., Carradori, S., & Filippis, B. D. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114242 · Cited by 36 · see citing works

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

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Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy

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Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer’s disease

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Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs

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Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer’s disease

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Olive oil and wine as source of multi-target agents in the prevention of Alzheimer disease

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Novel neuroprotective pyromeconic acid derivatives with concurrent anti-Aβ deposition, anti-inflammatory, and anti-oxidation properties for treatment of Alzheimer's disease

Liu, X., Yu, C., Yao, Y., Lai, H., Ye, X., Xu, J., Guo, J., Xiao, X., Chen, L., Huang, Z., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115120 · Cited by 24 · see citing works

Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review

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Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease

Dong, S., Xia, J., Wang, F., Yang, L., Xing, S., Du, J., Zhang, T., & Li, Z. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116013 · Cited by 22 · see citing works

Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

Azam, U., Naseer, M. M., & Rochais, C. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117277 · Cited by 22 · see citing works

Antioxidants in anti‐Alzheimer's disease drug discovery

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Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

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N-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer’s disease

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Identifying a Deferiprone–Resveratrol Hybrid as an Effective Lipophilic Anti-Plasmodial Agent

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From small deferiprone to macromolecular micelles: Self-assembly enhances iron chelation

Huang, X., Lu, D., Ma, Y., Zhang, L., Wang, L., Deng, J., Wang, Z., & Zhao, Y. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.08.086 · Cited by 17 · see citing works

From Hybrids to New Scaffolds: The Latest Medicinal Chemistry Goals in Multi-target Directed Ligands for Alzheimers Disease

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Resveratrol–Maltol and Resveratrol–Thiophene Hybrids as Cholinesterase Inhibitors and Antioxidants: Synthesis, Biometal Chelating Capability and Crystal Structure

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