The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Alzheimer’s Disease and Environmental Exposure to Lead: The Epidemiologic Evidence and Potential Role of Epigenetics
Open accessAbstract
Several lines of evidence indicate that the etiology of late-onset Alzheimer's disease (LOAD) is complex, with significant contributions from both genes and environmental factors. Recent research suggests the importance of epigenetic mechanisms in defining the relationship between environmental exposures and LOAD. In epidemiologic studies of adults, cumulative lifetime lead (Pb) exposure has been associated with accelerated declines in cognition. In addition, research in animal models suggests a causal association between Pb exposure during early life, epigenetics, and LOAD. There are multiple challenges to human epidemiologic research evaluating the relationship between epigenetics, LOAD, and Pb exposure. Epidemiologic studies are not well-suited to accommodate the long latency period between exposures during early life and onset of Alzheimer's disease. There is also a lack of validated circulating epigenetics biomarkers and retrospective biomarkers of Pb exposure. Members of our research group have shown bone Pb is an accurate measurement of historical Pb exposure in adults, offering an avenue for future epidemiologic studies. However, this would not address the risk of LOAD attributable to early-life Pb exposures. Future studies that use a cohort design to measure both Pb exposure and validated epigenetic biomarkers of LOAD will be useful to clarify this important relationship.
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A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
Soubry, A., Hoyo, C., Jirtle, R. L., & Murphy, S. K. (2014) · BioEssays · doi:10.1002/bies.201300113 · Cited by 354
Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
Carey, I. M., Anderson, H. R., Atkinson, R. W., Beevers, S. D., Cook, D. G., Strachan, D. P., Dajnak, D., Gulliver, J., & Kelly, F. J. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022404 · Cited by 302
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217
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Emerging risk of environmental factors: insight mechanisms of Alzheimer’s diseases.
Rahman, M. A., Rahman, M. S., Uddin, M. J., Mamum-Or-Rashid, A. N. M., Pang, M.-G., & Rhim, H. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08243-z · Cited by 115
Metadata
- Authors
- M. Bakulski, K., S. Rozek, L., C. Dolinoy, D., L. Paulson, H., & Hu, H.
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-05-02
- Volume
- 9
- Issue
- 5
- Pages
- 563-573
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W2115976658
- Cited by
- 197
- References
- 35
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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