Garlic [Allium sativum]: A review of its potential use as an anti-cancer agent

Principles of CDK regulation

Morgan, D. O. (1995) · Nature · doi:10.1038/374131a0 · Cited by 3,288 · see citing works

Cell Cycle Control and Cancer

Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,523 · see citing works

Prooxidant States and Tumor Promotion

Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513 · see citing works

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

Miyashita, T., Krajewski, S., Krajewska, M., Wang, H., Lin, H., Liebermann, D. A., Hoffman‐Liebermann, B., & Reed, J. C. (1994) · PubMed · Cited by 2,143 · see citing works

Intake of Garlic and Its Bioactive Components

Amagase, H., Petesch, B. L., Matsuura, H., Kasuga, S., & Itakura, Y. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.955s · Cited by 1,052 · see citing works

The Chemistry of Garlic and Onions

Block, E. (1985) · Scientific American · doi:10.1038/scientificamerican0385-114 · Cited by 936 · see citing works

Expression of cyclooxygenase-2 in human gastric carcinoma.

Ristimäki, A., Honkanen, N., Jänkälä, H., Sipponen, P., & Härkönen, M. (1997) · PubMed · Cited by 813 · see citing works

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

Sheng, H., Shao, J., Kirkland, S. C., Isakson, P. C., Coffey, R. J., Morrow, J. D., Beauchamp, R. D., & DuBois, R. N. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119400 · Cited by 713 · see citing works

The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins

Jakoby, W. B. (1978) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122914.ch6 · Cited by 686 · see citing works

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

Talalay, P., Long, M. J., & Prochaska, H. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8261 · Cited by 595 · see citing works

Historical Perspective on the Use of Garlic

Rivlin, R. S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.951s · Cited by 525 · see citing works

Plants used against cancer. A survey.

Hartwell, J. L. (1969) · PubMed · Cited by 508 · see citing works

Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse

Sparnins, V. L., Bárány, G., & Wattenberg, L. W. (1988) · Carcinogenesis · doi:10.1093/carcin/9.1.131 · Cited by 471 · see citing works

Vegetables, Fruit, and Colon Cancer in the lowa Women's Health Study

Steinmetz, K. A., Kushi, L. H., Bostick, R. M., FOLSOM, A. R., & Potter, J. D. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116921 · Cited by 455 · see citing works

Chemoprotection against cancer by Phase 2 enzyme induction

Talalay, P., Fahey, J. W., Holtzclaw, W. D., Prestera, T., & Zhang, Y. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03553-2 · Cited by 444 · see citing works

Antioxidant and Radical Scavenging Effects of Aged Garlic Extract and its Constituents

Imai, J., Ide, N., Nagae, S., Moriguchi, T., Matsuura, H., & Itakura, Y. (1994) · Planta Medica · doi:10.1055/s-2006-959522 · Cited by 442 · see citing works

Cholesterol-Lowering Effect of Garlic Extracts and Organosulfur Compounds: Human and Animal Studies

Yeh, Y.-Y., & Liu, L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.989s · Cited by 425 · see citing works

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

Perego, P., Giarola, M., Righetti, S. C., Supino, R., Caserini, C., Delia, D., Pierotti, M. A., Miyashita, T., Reed, J. C., & Zunino, F. (1996) · PubMed · Cited by 386 · see citing works

Garlic for Treating Hypercholesterolemia

Stevinson, C. D., Pittler, M. H., & Ernst, E. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00009 · Cited by 365 · see citing works

Allium Vegetables and Reduced Risk of Stomach Cancer

You, W., Blot, W. J., Chang, Y.-S., Ershow, A. G., Yang, Z. T., An, Q., Henderson, B. E., Fraumeni, J. F., & Wang, T.-G. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.2.162 · Cited by 352 · see citing works

A case-control study of diet and prostate cancer

Key, T. J., Silcocks, P., Davey, G. K., Appleby, P. N., & Bishop, D. T. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.445 · Cited by 327 · see citing works

Garlic and cancer: A critical review of the epidemiologic literature

Fleischauer, A. T., & Arab, L. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.3.1032s · Cited by 323 · see citing works

The chemistry of alkyl thiosulfinate esters. 9. Antithrombotic organosulfur compounds from garlic: structural, mechanistic, and synthetic studies

Block, E., Ahmad, S., Catalfamo, J. L., Jain, M. K., & Apitz-Castro, R. J. (1986) · Journal of the American Chemical Society · doi:10.1021/ja00282a033 · Cited by 321 · see citing works

Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethyihydrazine-induced colon cancer

Wargovich, M. J. (1987) · Carcinogenesis · doi:10.1093/carcin/8.3.487 · Cited by 280 · see citing works

Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide.

Wargovich, M. J., Woods, C., Eng, V., Stephens, L. C., & Gray, K. (1988) · PubMed · Cited by 275 · see citing works

Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines

Nakagawa, H. (2001) · Carcinogenesis · doi:10.1093/carcin/22.6.891 · Cited by 256 · see citing works

Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers

Fleischauer, A. T., Poole, C., & Arab, L. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.1047 · Cited by 243 · see citing works

Onion and garlic oils inhibit tumor promotion

Belman, S. (1983) · Carcinogenesis · doi:10.1093/carcin/4.8.1063 · Cited by 230 · see citing works

Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism

Manson, M. M. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1729 · Cited by 229 · see citing works

Consumption of onions and a reduced risk of stomach carcinoma

Dorant, E., van den Brandt, P. A., Goldbohm, R. A., & STURMANS, F. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8536847 · Cited by 224 · see citing works

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

Talalay, P. (1989) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(89)90074-5 · Cited by 220 · see citing works

Garlic Powder and Plasma Lipids and Lipoproteins

Isaacsohn, J. L., Moser, M., Stein, E. A., Dudley, K., Davey, J. A., Liskov, E., & Black, H. R. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1189 · Cited by 217 · see citing works

Effect of a Garlic Oil Preparation on Serum Lipoproteins and Cholesterol Metabolism

Berthold, H. K., Sudhop, T., & von Bergmann, K. (1998) · JAMA · doi:10.1001/jama.279.23.1900 · Cited by 208 · see citing works

Food groups and colorectal cancer risk

Levi, F., Pasche, C., Vecchia, C. L., Lucchini, F., & Franceschi, S. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690206 · Cited by 208 · see citing works

Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB

Dirsch, V. M., Gerbes, A. L., & Vollmar, A. M. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.402 · Cited by 206 · see citing works

Mechanisms of Inhibition of Chemical Toxicity and Carcinogenesis by Diallyl Sulfide (DAS) and Related Compounds from Garlic

Yang, C. S., Chhabra, S. K., Hong, J., & Smith, T. J. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.1041s · Cited by 204 · see citing works

Garlic: Its Anticarcinogenic and Antitumorigenic Properties

Milner, J. A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1996.tb03823.x · Cited by 202 · see citing works

Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance

Ali, M., Thomson, M., & Afzal, M. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1999.0124 · Cited by 201 · see citing works

The composition and chemistry of garlic cloves and processed garlic

Lawson, L. D. (1996) · Medical Entomology and Zoology · Cited by 195 · see citing works

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Gao, C., Takezaki, T., Ding, J., Li, M., & Tajima, K. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00791.x · Cited by 193 · see citing works

Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet

Ali, M., Al‐Qattan, K. K., Alenezi, F., Khanafer, R. M. A., & Mustafa, T. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0152 · Cited by 188 · see citing works

In vitro andin vivo activity of eugenol on human herpesvirus

Benencia, F., & Courr�ges, M. C. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200011)14:7 · Cited by 181 · see citing works

Garlic, onion and cereal fibre as protective factors for breast cancer: A French case–control study

Challier, B., Perarnau, J., & Viel, J. (1998) · European Journal of Epidemiology · doi:10.1023/a:1007512825851 · Cited by 180 · see citing works

Volatile compounds from garlic

Yu, T. H., Wu, C., & LIOU, Y. (1989) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00087a032 · Cited by 176 · see citing works

S-Allyl Cysteine Inhibits Activation of Nuclear Factor Kappa B in Human T Cells

Geng, Z., Rong, Y., & Lau, B. H. S. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00006-3 · Cited by 172 · see citing works

Detection and analysis of ?-catenin mutations in prostate cancer

Chesire, D. R., Ewing, C. M., Sauvageot, J., Bova, G. S., & Isaacs, W. B. (2000) · The Prostate · doi:10.1002/1097-0045(20001201)45:4 · Cited by 168 · see citing works

Alliumsativum (garlic) — A natural antibiotic

Adetumbi, M. A., & Lau, B. H. S. (1983) · Medical Hypotheses · doi:10.1016/0306-9877(83)90040-3 · Cited by 163 · see citing works

An Overview of Chemoprevention: Current Status and Future Prospects

Wattenberg, L. W. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-216-44163 · Cited by 155 · see citing works

Allyl sulfides from garlic suppress thein vitroproliferation of human a549 lung tumor cells

Sakamoto, K., Lavvson, L. D., & Milner, J. A. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514617 · Cited by 154 · see citing works

Garlic: A review of its relationship to malignant disease

Dausch, J. G., & Nixon, D. W. (1990) · Preventive Medicine · doi:10.1016/0091-7435(90)90034-h · Cited by 145 · see citing works

Metabolism of Garlic Constituents in the Isolated Perfused Rat Liver*

Egen-Schwind, C., Eckard, R., & Kemper, F. H. (1992) · Planta Medica · doi:10.1055/s-2006-961471 · Cited by 144 · see citing works

Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide.

Shirin, H., Pinto, J. T., Kawabata, Y., Soh, J. W., Delohery, T. M., Moss, S. F., Murty, V. V. V. S., Rivlin, R. S., Holt, P. R., & Weinstein, I. B. (2001) · PubMed · Cited by 141 · see citing works

Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits

Bordia, A., Verma, S. K., Vyas, A. K., Bl, K., Rathore, A. S., Bhu, N., & Bedi, H. K. (1977) · Atherosclerosis · doi:10.1016/0021-9150(77)90092-2 · Cited by 136 · see citing works

Lipid lowering effect of allicin (diallyl disulphide-oxide) on long term feeding to normal rats

Augusti, K. T., & Mathew, P. T. (1974) · Cellular and Molecular Life Sciences · doi:10.1007/bf01926297 · Cited by 131 · see citing works

Garlic Extract Therapy in Children With Hypercholesterolemia

McCrindle, B. W., Helden, E., & Conner, W. T. (1998) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.152.11.1089 · Cited by 131 · see citing works

Effects of allyl methyl trisulfide on glutathioneS‐transferase activity and BP‐induced neoplasia in the mouse

Sparnins, V. L., Mott, A. W., Bárány, G., & Wattenberg, L. W. (1986) · Nutrition and Cancer · doi:10.1080/01635588609513895 · Cited by 124 · see citing works

A Prospective Study of Atrophic Gastritis and Stomach Cancer Risk

Kato, I., Tominaga, S., Ito, Y., Kobayashi, S., Yoshii, Y., Matsuura, A., Kameya, A., Kano, T., & Ikari, A. (1992) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1992.tb02736.x · Cited by 122 · see citing works

Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture

Pinto, J., Qiao, C., Xing, J., Rivlin, R. S., Protomastro, M., Weissler, M., Tao, Y., Thaler, H., & Heston, W. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.398 · Cited by 121 · see citing works

Lipoxygenase inhibitors from the essential oil of garlic. Markovnikov addition of the allyldithio radical to olefins

Block, E., Iyer, R., Grisoni, S., Saha, C. R., Belman, S., & Lossing, F. P. (1988) · Journal of the American Chemical Society · doi:10.1021/ja00231a037 · Cited by 120 · see citing works

Antiplatelet constituents of garlic and onion

Makheja, A. N., & Bailey, J. M. (1990) · Inflammation Research · doi:10.1007/bf01966468 · Cited by 118 · see citing works

Diallyl Disulfide Suppresses the Growth of Human Colon Tumor Cell Xenografts in Athymic Nude Mice

Sundaram, S. G., & Milner, J. A. (1996) · Journal of Nutrition · doi:10.1093/jn/126.5.1355 · Cited by 117 · see citing works

Dietary Fiber and Colorectal Cancer Risk

Marchand, L. L., Hankin, J. H., Wilkens, L. R., Kolonel, L. N., Englyst, H. N., & Lyu, L.-C. (1997) · Epidemiology · doi:10.1097/00001648-199710000-00008 · Cited by 116 · see citing works

The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults

Gardner, C. D. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00466-4 · Cited by 116 · see citing works

Colon cancer in argentina. I: Risk from intake of dietary items

Iscovich, J., L'Abbé, K. A., Castelleto, R., Calzona, A., Bernedo, A., Chopita, N., Jmelnitzsky, A. C., & Kaldor, J. M. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910510603 · Cited by 114 · see citing works

Enhanced Immunocompetence by Garlic: Role in Bladder Cancer and Other Malignancies

Lamm, D. L., & Riggs, D. R. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.1067s · Cited by 113 · see citing works

Chemoprotection against the Formation of Colon DNA Adducts from the Food-Borne Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) in the Rat

Huber, W. W., McDaniel, L. P., Kaderlik, K. R., Teitel, C. H., Lang, N. P., & Kadlubar, F. F. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00033-x · Cited by 112 · see citing works

Antiproliferative Effects of Allium Derivatives from Garlic

Pinto, J. T., & Rivlin, R. S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.1058s · Cited by 108 · see citing works

Consumption of a garlic clove a day could be beneficial in preventing thrombosis

Ali, M., & Thomson, M. (1995) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(95)90118-3 · Cited by 108 · see citing works

Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation

Ali, M., Bordia, T., & Mustafa, T. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1998.0006 · Cited by 107 · see citing works

Differential Induction of NAD(P)H:Quinone Oxidoreductase by Anti-Carcinogenic Organosulfides from Garlic

Singh, S. V., Su, P., Srivastava, S. K., Xia, H., Hu, X., Zaren, H. A., & Orchard, J. L. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8352 · Cited by 104 · see citing works

Diallyl disulfide inhibits p34 cdc2 kinase activity through changes in complex formation and phosphorylation

Knowles, L. M., & Milner, J. A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.6.1129 · Cited by 102 · see citing works

Tumor inhibition by a sulfhydryl-blocking agent related to an active principle of garlic (Allium sativum).

Weisberger, A. S., & Pensky, J. (1958) · PubMed · Cited by 100 · see citing works

An evaluation of garlic and onion as antithrombotic agents

Bordia, T., Mohammed, N. A.-Q., Thomson, M., & Ali, M. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90014-9 · Cited by 100 · see citing works

Immunomodulation and antitumor activities of Aged Garlic Extract

Kyo, E., Uda, N., Suzuki, A., Kakimoto, M., Ushijima, M., Kasuga, S., & Itakura, Y. (1998) · Phytomedicine · doi:10.1016/s0944-7113(98)80064-0 · Cited by 99 · see citing works

Effects of a garlic-derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets

Srivastava, K. C., & Tyagi, O. D. (1993) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(93)90165-s · Cited by 98 · see citing works

Identification of a class 3 aldehyde dehydrogenase in human saliva and increased levels of this enzyme, glutathione S-transferases, and DT-diaphorase in the saliva of subjects who continually ingest large quantities of coffee or broccoli.

Sreerama, L., Hedge, M. W., & Sládek, N. E. (1995) · PubMed · Cited by 96 · see citing works

A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A

Morioka, N., Sze, L. L., Morton, D. L., & Irie, R. F. (1993) · Cancer Immunology Immunotherapy · doi:10.1007/bf01518454 · Cited by 93 · see citing works

Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer

You, W. (1998) · International Journal of Epidemiology · doi:10.1093/ije/27.6.941 · Cited by 93 · see citing works

Depressed p34cdc2kinase Activity and G2/M phase arrest induced by diallyl disulfide in HCT‐15 cells

Knowles, L. M., & Milner, J. A. (1998) · Nutrition and Cancer · doi:10.1080/01635589809514659 · Cited by 89 · see citing works

Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery disease

Bordia, A., Joshi, H. K., Sanadhya, Y. K., & Bhu, N. (1977) · Atherosclerosis · doi:10.1016/0021-9150(77)90152-6 · Cited by 88 · see citing works

Superiority of Intralesional Immunotherapy with Corynebacterium Parvum and Allium Sativum in Control of Murine Transitional Cell Carcinoma

Lau, B. H. S., Woolley, J. L., Marsh, C. L., Barker, G. R., Koobs, D. H., & Torrey, R. R. (1986) · The Journal of Urology · doi:10.1016/s0022-5347(17)45031-2 · Cited by 85 · see citing works

The effect of garlic tablet on plasma lipids and platelet aggregation in nulliparous pregnants at high risk of preeclampsia

Ziaei, S., Hantoshzadeh, S., Rezasoltani, P., & Lamyian, M. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(01)00384-0 · Cited by 81 · see citing works

Induction of DT-diaphorase in cancer chemoprevention and chemotherapy.

Begleiter, A., Leith, M. K., Curphey, T. J., & Doherty, G. P. (1997) · PubMed · Cited by 81 · see citing works

Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides

Siess, M. H., Bon, A. L., Lavier, M.-C. C., & Suschetet, M. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)00309-1 · Cited by 80 · see citing works

Pre-Hepatic Fate of the Organosulfur Compounds Derived from Garlic (Allium sativum)

Lawson, L. D., & Wang, Z. (1993) · Planta Medica · doi:10.1055/s-2006-959976 · Cited by 80 · see citing works

Allium Chemistry: Supercritical Fluid Extraction and LC−APCI−MS of Thiosulfinates and Related Compounds from Homogenates of Garlic, Onion, and Ramp. Identification in Garlic and Ramp and Synthesis of 1-Propanesulfinothioic Acid S-Allyl Ester

Calvey, E. M., Matusik, J. E., White, K. D., DeOrazio, R. J., Sha, D., & Block, E. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf970314e · Cited by 79 · see citing works

Antitumour activity of diallyl sulfide on polycyclic aromatic hydrocarbon-induced mouse skin carcinogenesis

Singh, A., & Shukla, Y. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00152-9 · Cited by 78 · see citing works

HPLC ofS-Alk(en)yl- L -cysteine Derivatives in Garlic including Quantitative Determination of (+)-S-Allyl- L -cysteine Sulfoxide (Alliin)

Ziegler, S., & Sticher, O. (1989) · Planta Medica · doi:10.1055/s-2006-962031 · Cited by 77 · see citing works

The Medical Uses of Garlic Fact and Fiction

Bolton, S., Null, G., & Troetel, W. M. (1982) · American Pharmacy · doi:10.1016/s0160-3450(16)31735-4 · Cited by 74 · see citing works

The antihypertensive effect of garlic (Allium sativum) in the rat two-kidney–one-clip Goldblatt model

Al‐Qattan, K. K., Alnaqeeb, M. A., & Ali, M. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00173-1 · Cited by 74 · see citing works

Low Doses of Diallyl Disulfide, a Compound Derived From Garlic, Increase Tissue Activities of Quinone Reductase and Glutathione Transferase in the Gastrointestinal Tract of the Rat

Munday, R., & Munday, C. M. (1999) · Nutrition and Cancer · doi:10.1207/s15327914nc340106 · Cited by 74 · see citing works

Allium Chemistry: Identification of Natural Abundance Organoselenium Compounds in Human Breath after Ingestion of Garlic Using Gas Chromatography with Atomic Emission Detection

Cai, X.-J., Block, E., Uden, P. C., Quimby, B. D., & Sullivan, J. J. (1995) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00055a001 · Cited by 71 · see citing works

THE POTENTIAL APPLICATION OF ALLIUM SATIVUM (GARLIC) FOR THE TREATMENT OF BLADDER CANCER

Lamm, D. L., & Riggs, D. R. (2000) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70243-3 · Cited by 71 · see citing works

Garlic in Health, History, and World Cuisine

Moyers, S. B. (1996) · Medical Entomology and Zoology · Cited by 70 · see citing works

Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?

Dirsch, V. M., & Vollmar, A. M. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00580-3 · Cited by 68 · see citing works

Effects of garlic and onion oils on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione and ornithine decarboxylase induction in isolated mouse epidermal cells treated with tumor promoters.

Perchellet, J., Perchellet, E. M., Abney, N. L., Zirnstein, J. A., & Belman, S. (1986) · PubMed · Cited by 67 · see citing works

Studies on the antimutagenic activities of garlic extract

Knasmüller, S., de Martin, R., Domján, G., & Szakmary, A. (1989) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850130413 · Cited by 67 · see citing works

Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus - a preliminary report.

Pt, M., & Kt, A. (1976) · PubMed · Cited by 66 · see citing works

Effects of Garlic Compounds Diallyl Sulfide and Diallyl Disulfide on Arylamine N-Acetyltransferase Activity in Strains ofHelicobacter pylorifrom Peptic Ulcer Patients

Chung, J., Chen, G. W., Wu, L., Chang, H. L., Lin, J. G., Yeh, C. C., & Wang, T. F. (1998) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x98000397 · Cited by 66 · see citing works

ANTIBACTERIAL ACTIVITY OF GARLIC AND ONIONS

Farbman, K. S., Barnett, E. D., Bolduc, G. R., & Klein, J. O. (1993) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199307000-00013 · Cited by 64 · see citing works

Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits

Ali, M., & Mohammed, S. Y. (1986) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(86)90061-2 · Cited by 63 · see citing works

Volatile Garlic Odor Components: Gas Phases and Adsorbed Exhaled Air Analysed by Headspace Gas Chromatography-Mass Spectrometry

Laakso, I., Seppänen‐Laakso, T., Hiltunen, R., Müller, B. H., Jansen, H. F., & Knobloch, K. (1989) · Planta Medica · doi:10.1055/s-2006-961998 · Cited by 62 · see citing works

Effects of Garlic on 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Balasenthil, S., Arivazhagan, S., Ramachandran, C. R., & Nagini, S. (1999) · Cancer Detection and Prevention · doi:10.1046/j.1525-1500.1999.99050.x · Cited by 61 · see citing works

Comparative Study of Lifestyles of Residents in High and Low Risk Areas for Gastric Cancer in Jiangsu Province, China; with Special Reference to Allium Vegetables

Takezaki, T., Gao, C., Ding, J., Liu, T.-K., Li, M.-S., & Tajima, K. (1999) · Journal of Epidemiology · doi:10.2188/jea.9.297 · Cited by 61 · see citing works

Antitumor activity of diallyl sulfide in two-stage mouse skin model of carcinogenesis.

Singh, A., & Shukla, Y. (1998) · PubMed · Cited by 59 · see citing works

Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis

Mori, H., Tanaka, T., Sugie, S., Yoshimi, N., Kawamori, T., Hirose, Y., & Ohnishi, M. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1997)27+ · Cited by 58 · see citing works

Odor Components of Human Breath After the Ingestion of Grated Raw Garlic

Minami, T., BOKU, T., Inada, K., Morita, M., & Okazaki, Y. (1989) · Journal of Food Science · doi:10.1111/j.1365-2621.1989.tb04703.x · Cited by 57 · see citing works

Observation of Bioluminescence in the Atlantic Fish ( Porichthys porosissimum )

Shoemaker, H. H. (1957) · Science · doi:10.1126/science.126.3283.1112-a · Cited by 57 · see citing works

Garlic enhances circulatory antioxidants during 7,12-dimethylbenz[a]anthracene–induced hamster buccal pouch carcinogenesis

Balasenthil, S., Arivazhagan, S., & Nagini, S. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00264-6 · Cited by 54 · see citing works

STUDY OF THE HYPOLIPIDEMIC PROPERTIES OF PECTIN, GARLIC AND GINSENG IN HYPERCHOLESTEROLEMIC RABBITS

Ismail, M. F., Gad, M. Z., & Hamdy, M. A. (1999) · Pharmacological Research · doi:10.1006/phrs.1998.0421 · Cited by 53 · see citing works

Antithrombotic activity of garlic: its inhibition of the synthesis of thromboxane-B2 during infusion of arachidonic acid and collagen in rabbits

Ali, M., Thomson, M., Alnaqeeb, M. A., Al‐Hassan, J. M., Khater, S. H., & Gomes, S. A. (1990) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(90)90060-x · Cited by 49 · see citing works

Alterations in hepatic Phase I and Phase II biotransformation enzymes by garlic oil in rats

Dalvi, R. R. (1992) · Toxicology Letters · doi:10.1016/0378-4274(92)90288-u · Cited by 47 · see citing works

Allyl Sulfides Modify Cell Growth

Knowles, L. M., & Milner, J. A. (2000) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2000.17.1-4.81 · Cited by 46 · see citing works

Thromboxane–B2, prostaglandin–E2 and hypertension in the rat 2–kidney 1–clip model: a possible mechanism of the garlic induced hypotension

Al‐Qattan, K. K., Khan, I., Alnaqeeb, M. A., & Ali, M. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0232 · Cited by 46 · see citing works

Can Allium vegetables prevent cancer?

Ernst, E. (1997) · Phytomedicine · doi:10.1016/s0944-7113(97)80032-3 · Cited by 45 · see citing works

The age peak in childhood acute lymphoblastic leukemia

Swensen, A. R., Ross, J. A., Severson, R. K., Pollock, B. H., & Robison, L. L. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970515)79:10 · Cited by 44 · see citing works

The analysis of S‐alk(en)yl‐L‐cysteine sulphoxides (flavour precursors) from species of Allium by high performance liquid chromatography

Edwards, S. J., Musker, D., COLLIN, H. A., & Britton, G. (1994) · Phytochemical Analysis · doi:10.1002/pca.2800050103 · Cited by 41 · see citing works

Volatile Compounds Thermally Generated from S-Propylcysteine and S-Propylcysteine SulfoxideAroma Precursors of Allium Vegetables

Kubec, R., Drhová, V., & Velı́šek, J. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980974z · Cited by 39 · see citing works

Suppression of Chemical Carcinogenesis by Water-Soluble Organosulfur Compounds

Fukushima, S., Takada, N., Hori, T., Min, W., Wanibuchi, H., & Yamamoto, S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.1049s · Cited by 38 · see citing works

Bioactive organosulfur compounds of garlic and garlic products: role in reducing blood lipids

Lawson, L. D. (1993) · Cited by 37 · see citing works

Spices: Antiplatelet activity and prostanoid metabolism

Srivastava, K. C., & Mustafa, T. (1989) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(89)90129-4 · Cited by 36 · see citing works

Inhibition of 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis by S-allylcysteine

Balasenthil, S. (2000) · Oral Oncology · doi:10.1016/s1368-8375(00)00015-4 · Cited by 36 · see citing works

Onion, Garlic, and Experimental Atherosclerosis

Sainani, G. S., Desai, D. B., NATU, M. N., KATRODIA, K. M., Vp, V., & SAINANI, P. G. (1979) · Japanese Heart Journal · doi:10.1536/ihj.20.351 · Cited by 35 · see citing works

Effects Of Garlic Components Diallyl Sulfide And Diallyl Disulfide On Arylamine N-Acetyltransferase Activity In Human Bladder Tumor Cells

Chung, J.-G. (1999) · Drug and Chemical Toxicology · doi:10.3109/01480549909017839 · Cited by 34 · see citing works

Garlic (Allium sativum): A review of its relationship to cancer

Sumiyoshi, H., & Wargovich, M. J. (1989) · Asia Pacific journal of pharmacology · Cited by 32 · see citing works

The nutraceutical benefit, part iv: garlic

Sato, T., & Miyata, G. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00391-9 · Cited by 27 · see citing works

Antimutagenic effect of garlic (Allium sativum L.) on 4NQO-induced mutagenesis in Escherichia coli WP2

Zhang, Y., Chen, X., & Yu, Y. (1989) · Mutation Research Letters · doi:10.1016/0165-7992(89)90099-7 · Cited by 23 · see citing works

Effects of feeding fresh garlic and garlic oil on detoxifying enzymes and micronuclei formation in rats treated with azoxymethane.

Khanum, F., Kr, A., Sudarshanakrishna, K. R., & Kr, V. (1998) · PubMed · Cited by 20 · see citing works

Biological Response Modifiers for the Treatment of Superficial Bladder Tumors

Zlotta, A. R., & Schulman, C. C. (2000) · European Urology · doi:10.1159/000052387 · Cited by 19 · see citing works

Garlic and Circulatory Disorders

Turner, M. (1990) · Journal of the Royal Society of Health · doi:10.1177/146642409011000306 · Cited by 16 · see citing works

Inhibition of carcinogen induced activity of gamma-glutamyl transpeptidase by certain dietary constituents in mouse skin.

Shukla, Y., Singh, A., & Srivastava, B. (1999) · PubMed · Cited by 11 · see citing works

Histopathological evidence of protective action of garlic against collagen and arachidonic acid toxicity in rabbits

Alnaqeeb, M. A., Ali, M., Thomson, M., Khater, S. H., Gomes, S. A., & Al‐Hassan, J. M. (1992) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(92)90040-p · Cited by 10 · see citing works

Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice

Surh, Y., Kim, S. G., Liem, A., Lee, J. W., & MILLER, J. A. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00236-x · Cited by 9 · see citing works

Studies on the mechanism of action of antitumor promoting agents: importance of free radicals in promotion

Slaga, T. J., Solanki, V., & Logani, M. K. (1982) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 1 · see citing works

The art and practice of structure-based drug design: A molecular modeling perspective

(1996) · doi:10.1002/(sici)1098-1128(199601)16:1

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Edris, A. E. (2007) · Phytotherapy Research · doi:10.1002/ptr.2072 · Cited by 1,264 · see citing works

Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review

El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works

Biological properties of garlic and garlic‐derived organosulfur compounds

Iciek, M., Kwiecień, I., & Włodek, L. B. (2009) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20474 · Cited by 459 · see citing works

Phenolics as antioxidants in garlic (Allium sativum L., Alliaceae)

Božin, B. N., Mimica–Dukić, N., Samojlik, I., Goran, A., & Igić, R. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.04.071 · Cited by 453 · see citing works

Black garlic: A critical review of its production, bioactivity, and application

Kimura, S., Tung, Y., Pan, M., Su, N., Lai, Y., & Cheng, K. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.11.003 · Cited by 311 · see citing works

Effects of Garlic (Alliumsativum) and chloramphenicol on growth performance, physiological parameters and survival of Nile tilapia (Oreochromis niloticus)

Shalaby, A. M., Khattab, Y. A. E., & Rahman, A. M. A. (2006) · The Journal of venomous animals and toxins including tropical diseases · doi:10.1590/s1678-91992006000200003 · Cited by 291 · see citing works

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Kooti, W., Servatyari, K., Behzadifar, M., Asadi-Samani, M., Sadeghi, F., Nouri, B., & Marzouni, H. Z. (2017) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587217696927 · Cited by 267 · see citing works

Garlic: Nature's Protection Against Physiological Threats

Butt, M. S., Sultan, M. T., Butt, M., & Iqbal, J. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802145344 · Cited by 252 · see citing works

Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic ( Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis

Shao, X., Sun, C., Tang, X., Zhang, X., Han, D., Liang, S., Qu, R., Hui, X., Shan, Y., Hu, L., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04773 · Cited by 249 · see citing works

Organosulfur compounds and possible mechanism of garlic in cancer

Omar, S. H., & Al‐Wabel, N. A. (2010) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2009.12.007 · Cited by 247 · see citing works

Cancer chemoprevention with garlic and its constituents

Shukla, Y., & Kalra, N. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.05.009 · Cited by 240 · see citing works

Anticancer Potential of Plants and Natural Products: A Review

Prakash, O., Kumar, A., Kumar, P., & Ajeet, A. (2013) · American journal of pharmacological sciences · doi:10.12691/ajps-1-6-1 · Cited by 229 · see citing works

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

Chavda, V. P., Patel, A., Mistry, K. J., Suthar, S. F., Wu, Z., Chen, Z., & Hou, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.867655 · Cited by 190 · see citing works

Nutrition, Well-Being and Health

(2012) · doi:10.5772/1864 · Cited by 178 · see citing works

Thiosulfoxide (sulfane) sulfur: new chemistry and new regulatory roles in biology

Toohey, J., & Cooper, A. (2014) · Molecules · doi:10.3390/molecules190812789 · Cited by 173 · see citing works

The Therapeutic Benefits of Essential Oils

Djılanı, A., & Dıcko, A. (2012) · InTech eBooks · doi:10.5772/25344 · Cited by 173 · see citing works

Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: a review

Herman-Antosiewicz, A., & Singh, S. V. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.04.016 · Cited by 164 · see citing works

Phytochemicals of herbs and spices: Health versus toxicological effects

Güldiken, B., Özkan, G., Çatalkaya, G., Ceylan, F. D., Yalcinkaya, İ. E., & Çapanoğlu, E. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.05.050 · Cited by 165 · see citing works

Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies

Meresman, G. F., Götte, M., & Laschke, M. W. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa039 · Cited by 158 · see citing works

Nutraceuticals, apoptosis, and disease prevention

Gosslau, A., & Chen, K. Y. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.017 · Cited by 149 · see citing works

Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds

Trio, P. Z., You, S., He, X., He, J., Sakao, K., & Hou, D. (2014) · Food & Function · doi:10.1039/c3fo60479a · Cited by 134 · see citing works

Review of the Application of Garlic, Allium sativum , in Aquaculture

Lee, J., & Gao, Y. (2012) · Journal of the World Aquaculture Society · doi:10.1111/j.1749-7345.2012.00581.x · Cited by 130 · see citing works

Anticancer potential of medicinal plants and their phytochemicals: a review

Shukla, S., & Mehta, A. (2015) · Revista Brasileira de Botânica · doi:10.1007/s40415-015-0135-0 · Cited by 129 · see citing works

Anticancer medicinal plants used by Moroccan people: Ethnobotanical, preclinical, phytochemical and clinical evidence

Merrouni, I. A., & Elachouri, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113435 · Cited by 129 · see citing works

S-Alk(en)ylcysteine sulfoxides in the genus Allium: proposed biosynthesis, chemical conversion, and bioactivities

Yoshimoto, N., & Saito, K. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz243 · Cited by 127 · see citing works

Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes

Liu, C., Wong, P.-L., Lii, C., Hse, H., & Sheen, L. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.07.013 · Cited by 118 · see citing works

Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1

Na, H., Kim, E., Choi, M., Park, J., Kim, D., & Surh, Y. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.024 · Cited by 116 · see citing works

Molecular targets of cancer chemoprevention by garlic-derived organosulfides

Herman-Antosiewicz, A., Powolny, A. A., & Singh, S. V. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00682.x · Cited by 114 · see citing works

Induction of apoptosis in oral cancer cells: agents and mechanisms for potential therapy and prevention

Hsu, S., Singh, B. B., & Schuster, G. S. (2003) · Oral Oncology · doi:10.1016/j.oraloncology.2003.09.012 · Cited by 113 · see citing works

The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial

Atkin, M., Laight, D. W., & Cummings, M. H. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.003 · Cited by 112 · see citing works

Anticancer potential of allicin: A review

Catanzaro, E., Canistro, D., Pellicioni, V., Vivarelli, F., & Fimognari, C. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106118 · Cited by 115 · see citing works

Anticancer Potential of Plants and Natural Products: A Review

Mishra, R. D. L. A. (2013) · Journal of Diagnostic Techniques and Biomedical Analysis · doi:10.4172/2327-4638.1000103 · Cited by 110 · see citing works

The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells

Wu, X.-J., Kassie, F., & Mersch‐Sundermann, V. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.02.026 · Cited by 107 · see citing works

Solid-phase microextraction–gas chromatographic–mass spectrometric analysis of garlic oil obtained by hydrodistillation

Calvo-Gómez, O., Morales-López, J., & López, M. G. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.02.072 · Cited by 107 · see citing works

A Garlic Derivative, S-allylcysteine (SAC), Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma

Ng, K. T., Guo, D. Y., Cheng, Q., Geng, W., Ling, C. C., Li, C. X., Liu, X. B., Yuen, Y., Lo, C. M., Poon, R. T. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031655 · Cited by 102 · see citing works

Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation

Kuo, W., Wang, W., Tsai, C., Way, C.-L., Hsu, H.-H., & Chen, L.-M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.080 · Cited by 101 · see citing works

The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach

Moghadamtousi, S. Z., Rouhollahi, E., Karimian, H., Fadaeinasab, M., Firoozinia, M., Abdulla, M. A., & Kadir, H. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122288 · Cited by 103 · see citing works

Utilization of Ayurveda in Health Care: An Approach for Prevention, Health Promotion, and Treatment of Disease. Part 1—Ayurveda, the Science of Life

Sharma, H. M., Chandola, H., Singh, G., & Basisht, G. (2007) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.7017-a · Cited by 98 · see citing works

A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression

Chu, Q., Ling, M.-T., Feng, H., Cheung, H. W., Tsao, S. W., Wang, X., & Wong, Y. C. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl054 · Cited by 98 · see citing works

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

Rao, P., Midde, N. M., Miller, D. D., Chauhan, S. C., Kumar, A., & Kumar, S. (2015) · Current Drug Metabolism · doi:10.2174/1389200216666150812123554 · Cited by 97 · see citing works

Garlic, from Remedy to Stimulant: Evaluation of Antifungal Potential Reveals Diversity in Phytoalexin Allicin Content among Garlic Cultivars; Allicin Containing Aqueous Garlic Extracts Trigger Antioxidants in Cucumber

Hayat, S., Cheng, Z., Ahmad, H., Ali, M., Chen, X., & Wang, M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01235 · Cited by 104 · see citing works

S-allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death

Kosuge, Y., Koen, Y., Ishige, K., Minami, K., Urasawa, H., Saito, H., & Ito, Y. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.026 · Cited by 97 · see citing works

Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells

Belloir, C., Singh, V., Daurat, C., Siess, M. H., & Bon, A. L. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.11.005 · Cited by 94 · see citing works

Allicin and related compounds: Biosynthesis, synthesis and pharmacological activity

Ilić, D., Nikolić, V. D., Nikolic, L. B., Stankovic, M. Z., Stanojevic, L. P., & Cakic, M. D. (2011) · Facta universitatis - series Physics Chemistry and Technology · doi:10.2298/fupct1101009i · Cited by 92 · see citing works

Aqueous garlic extract stimulates growth and antioxidant enzymes activity of tomato (Solanum lycopersicum)

Hayat, S., Ahmad, H., Ali, M., Ren, K., & Cheng, Z. (2018) · Scientia Horticulturae · doi:10.1016/j.scienta.2018.06.011 · Cited by 89 · see citing works

Allium vegetables for possible future of cancer treatment

Asemani, Y., Zamani, N., Bayat, M., & Amirghofran, Z. (2019) · Phytotherapy Research · doi:10.1002/ptr.6490 · Cited by 92 · see citing works

A Multicountry Ecologic Study of Risk and Risk Reduction Factors for Prostate Cancer Mortality

Grant, W. B. (2003) · European Urology · doi:10.1016/j.eururo.2003.08.018 · Cited by 88 · see citing works

Vegetable Organosulfur Compounds and their Health Promoting Effects

Petropoulos, S. A., Gioia, F. D., & Ntatsi, G. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170111100531 · Cited by 88 · see citing works

S‐allylcysteine, a water‐soluble garlic derivative, suppresses the growth of a human androgen‐independent prostate cancer xenograft, CWR22R, under in vivo conditions

Chu, Q., Lee, D. T. W., Tsao, S. W., Wang, X., & Wong, Y. C. (2006) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06639.x · Cited by 87 · see citing works

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf

Ogawa, T., Kodera, Y., Hirata, D., Blackwell, T. K., & Mizunuma, M. (2016) · Scientific Reports · doi:10.1038/srep21611 · Cited by 87 · see citing works

Bio-Farms for Nutraceuticals

Giardi, M. T., Rea, G., & Berra, B. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7347-4 · Cited by 81 · see citing works

Types of garlic and their anticancer and antioxidant activity: a review of the epidemiologic and experimental evidence

Farhat, Z., Hershberger, P. A., Freudenheim, J. L., Mammen, M. J., Blair, R. H., Aga, D. S., & Mu, L. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02482-7 · Cited by 82 · see citing works

A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers

Regassa, H., Sourirajan, A., Kumar, V., Pandey, S., Kumar, D., & Dev, K. (2022) · Cancers · doi:10.3390/cancers14163898 · Cited by 78 · see citing works

Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics

Majrashi, T. A., Alshehri, S. A., Alsayari, A., Muhsinah, A. B., Alrouji, M., Alshahrani, A. M., Shamsi, A., & Atiya, A. (2023) · Nutrients · doi:10.3390/nu15071704 · Cited by 76 · see citing works

Role of diallyl tetrasulfide in ameliorating the cadmium induced biochemical changes in rats

Pari, L., & Ponnusamy, M. (2005) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2005.05.009 · Cited by 76 · see citing works

Medicinal Plants for Treatment of Cancer: A Brief Review

Jain, S., Dwivedi, J., Jain, P., Satpathy, S., & Patra, A. (2016) · Pharmacognosy Journal · doi:10.5530/pj.2016.2.1 · Cited by 76 · see citing works

Aged black garlic extract induces inhibition of gastric cancer cell growth in�vitro and in�vivo

Wang, Y. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.588 · Cited by 75 · see citing works

Experimental study on the action of allitridin against human cytomegalovirus in vitro: Inhibitory effects on immediate-early genes

Zhen, H., Fang, F., Ye, D.-Y., Shu, S.-N., Zhou, Y.-F., Dong, Y.-S., Nie, X.-C., & Li, G. (2006) · Antiviral Research · doi:10.1016/j.antiviral.2006.03.017 · Cited by 73 · see citing works

Garlic (Allium sativum L.): A Brief Review of Its Antigenotoxic Effects

Morales‐González, J. A., Madrigal‐Bujaidar, E., Sánchez‐Gutiérrez, M., Vega, J. A. I., Valadez-Vega, M. D. C., Álvarez‐González, I., Morales‐González, Á., & Madrigal‐Santillán, E. (2019) · Foods · doi:10.3390/foods8080343 · Cited by 73 · see citing works

Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells

Wang, Y., Qin, J., Zheng, X., Bai, Y., Yang, K., & Xie, L. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.07.019 · Cited by 72 · see citing works

S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice

Rojas, P., Serrano‐García, N., Medina‐Campos, O. N., Pedraza‐Chaverrí, J., Maldonado, P. D., & Ruiz-Sánchez, E. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.08.005 · Cited by 71 · see citing works

Medicinal Plants Combating Against Cancer - a Green Anticancer Approach

Sultana, S., Asif, H. M., Nazar, H. M. I., Akhtar, N., Rehman, J. U., & Rehman, R. U. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.11.4385 · Cited by 70 · see citing works

The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies

Mihara, S., & Shibamoto, T. (2015) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-015-0074-0 · Cited by 67 · see citing works

Garlic: Review of literature

Adaki, S., Adaki, R., Shah, K., & Karagir, A. (2014) · Indian Journal of Cancer · doi:10.4103/0019-509x.175383 · Cited by 67 · see citing works

Application of Combination High‐Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product‐Based Combination Drugs

Isgut, M., Mukkavilli, R., Yang, C., Subrahmanyam, V., Rida, P. C. G., & Aneja, R. (2017) · Medicinal Research Reviews · doi:10.1002/med.21444 · Cited by 67 · see citing works

Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study

Sen, D., Debnath, P., Debnath, B., Bhaumik, S., & Debnath, S. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1819883 · Cited by 66 · see citing works

Plants mentioned in the Islamic Scriptures (Holy Qur'ân and Ahadith): Traditional uses and medicinal importance in contemporary times

El-Seedi, H. R., Khalifa, S. A. M., Yosri, N., Khatib, A., Chen, L., Saeed, A., Efferth, T., & Verpoorte, R. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112007 · Cited by 66 · see citing works

Diallyl Disulfide and Diallyl Trisulfide Up-Regulate the Expression of the π Class of Glutathione S-Transferase via an AP-1-Dependent Pathway

Tsai, C.-W., Chen, H., Yang, J., Sheen, L., & Lii, C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061874t · Cited by 63 · see citing works

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

McGrowder, D. A., Miller, F. G., Nwokocha, C. R., Anderson, M., Wilson-Clarke, C. F., Vaz, K., Anderson-Jackson, L., & Brown, J. (2020) · Medicines · doi:10.3390/medicines7080047 · Cited by 61 · see citing works

Exploration of therapeutic applicability and different signaling mechanism of various phytopharmacological agents for treatment of breast cancer

Singh, V., Kumar, K., Purohit, D., Verma, R., Pandey, P., Bhatia, S., Malik, V., Mittal, V., Rahman, M. H., Albadrani, G. M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111584 · Cited by 61 · see citing works

Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice

Taylor, P., Noriega, R., Farah, C. M., Abad, M.-J., Arsenak, M., & Apitz, R. J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.08.022 · Cited by 60 · see citing works

Development, characterization and efficacy of niosomal diallyl disulfide in treatment of disseminated murine candidiasis

Alam, M., Zubair, S., Farazuddin, M., Ahmad, E., Khan, A., Zia, Q., Malik, A., & Owais, M. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.07.004 · Cited by 59 · see citing works

Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks

Ayaz, M., Nawaz, A., Ahmad, S., Mosa, O. F., Hamdoon, A. A. E., Elkhalifa, M. E. M., Sadiq, A., Ullah, F., Wadood, A., Kabra, A., et al. (2022) · Journal of Food Quality · doi:10.1155/2022/1189034 · Cited by 58 · see citing works

Combinatorial strategies employing nutraceuticals for cancer development

Shukla, Y., & George, J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06104.x · Cited by 59 · see citing works

Raw Garlic Consumption as a Protective Factor for Lung Cancer, a Population-Based Case–Control Study in a Chinese Population

Jin, Z.-Y., Wu, M., Han, R., Zhang, X., Wang, X.-S., Liu, A., Zhou, J., Lu, Q., Zhang, Z., & Zhao, J. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0015 · Cited by 58 · see citing works

Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways

Chung, J. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.973 · Cited by 58 · see citing works

Polyvinylpyrrolidone/cellulose acetate electrospun composite nanofibres loaded by glycerine and garlic extract with in vitro antibacterial activity and release behaviour test

Edikresnha, D., Suciati, T. A., Munir, M. M., & Khairurrijal, K. (2019) · RSC Advances · doi:10.1039/c9ra04072b · Cited by 58 · see citing works

Chloroform extract of aged black garlic attenuates TNF‐α‐induced ROS generation, VCAM‐1 expression, NF‐κB activation and adhesiveness for monocytes in human umbilical vein endothelial cells

Lee, E. N., Choi, Y. W., Kim, H. K., Park, J. K., Kim, H. J., Kim, M. J., Lee, H. W., Kim, K., Bae, S. S., Kim, B.-S., et al. (2010) · Phytotherapy Research · doi:10.1002/ptr.3230 · Cited by 57 · see citing works

Gastric Cancer and Allium Vegetable Intake: A Critical Review of the Experimental and Epidemiologic Evidence

Guercio, V., Galeone, C., Turati, F., & Vecchia, C. L. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.904911 · Cited by 55 · see citing works

Garlic (Allium sativum) Supplementation: Influence on Egg Production, Quality, and Yolk Cholesterol Level in Layer Hens

Mahmoud, K. Z., Gharaibeh, S. M., Zakaria, H., & Qatramiz, A. M. (2010) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2010.10124 · Cited by 55 · see citing works

Natural medicines for acute renal failure: A review

Boozari, M., & Hosseinzadeh, H. (2017) · Phytotherapy Research · doi:10.1002/ptr.5943 · Cited by 51 · see citing works

Efficacy ofAllium sativum(garlic) against experimental cryptosporidiosis

Gaafar, M. R. (2012) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2011.12.003 · Cited by 50 · see citing works

Garlic Organosulfur Compounds Upregulate the Expression of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes

Tsai, C.-W., Yang, J., Chen, H., Sheen, L., & Lii, C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2560 · Cited by 50 · see citing works

Thiolsulfinate Allicin from Garlic: Inspiration for a New Antimicrobial Agent

Hunter, R., Caira, M. R., & Stellenboom, N. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1352.011 · Cited by 49 · see citing works

N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death

Arakawa, M., Ushimaru, N., Osada, N., Oda, T., Ishige, K., & Ito, Y. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.03.008 · Cited by 49 · see citing works

Effect of the levels ofAzadirachta indicadried leaf meal as phytogenic feed additive on the growth performance and haemato-biochemical parameters in broiler chicks

Ansari, J., Khan, S. H., Haq, A. U., & Yousaf, M. S. (2012) · Journal of Applied Animal Research · doi:10.1080/09712119.2012.692329 · Cited by 48 · see citing works

Effects of garlic on albino mice experimentally infected with Schistosoma mansoni: a parasitological and ultrastructural study.

Nahed, H. A. R., Hoda, A. T., & Yomna, I. M. (2009) · PubMed · Cited by 48 · see citing works

Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis

Bhuvaneswari, V., Abraham, S. K., & Nagini, S. (2005) · Nutrition · doi:10.1016/j.nut.2004.05.024 · Cited by 48 · see citing works

Anticancer activity of Nigerian medicinal plants: a review

Ohiagu, F. O., Chikezie, P. C., Chikezie, C. M., & Enyoh, C. E. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00222-6 · Cited by 47 · see citing works

Oxidative species and S‐glutathionyl conjugates in the apoptosis induction by allyl thiosulfate

Nepravishta, R., Sabelli, R., Iorio, E., Micheli, L., Paci, M., & Melino, S. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08407.x · Cited by 47 · see citing works

Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells

Park, C., Park, S., Chung, Y. H., Kim, G., Choi, Y. W., Kim, B. W., & Choi, Y. H. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.1.132 · Cited by 47 · see citing works

Understanding mechanistic aspects and therapeutic potential of natural substances as anticancer agents

Deep, A., Kumar, D., Bansal, N., Narasimhan, B., Marwaha, R. K., & Sharma, P. C. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100418 · Cited by 45 · see citing works

Prospects in the development of natural radioprotective therapeutics with anti-cancer properties from the plants of Uttarakhand region of India

Painuli, S., & Kumar, N. (2016) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2015.09.001 · Cited by 45 · see citing works

The potential role of garlic (Allium sativum) against the multi-drug resistant tuberculosis pandemic: a review.

Dini, C., Fabbri, A., & Geraci, A. (2011) · PubMed · doi:10.4415/ann_11_04_18 · Cited by 44 · see citing works

Is allicin able to reduce Campylobacter jejuni colonization in broilers when added to drinking water?

Robyn, J., Rasschaert, G., Hermans, D., Pasmans, F., & Heyndrickx, M. (2013) · Poultry Science · doi:10.3382/ps.2012-02863 · Cited by 42 · see citing works

Determination of Flavonoid and Polyphenol Compounds in Viscum Album and Allium Sativum Extracts

Trifunschi, S., Munteanu, M. F., Agotici, V., Pintea, S., & Gligor, R. (2015) · International Current Pharmaceutical Journal · doi:10.3329/icpj.v4i5.22861 · Cited by 42 · see citing works

Induction of apoptosis in leukemia cell lines by Linum persicum and Euphorbia cheiradenia

Amirghofran, Z., Bahmani, M., Azadmehr, A., & Javidnia, K. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0084-x · Cited by 42 · see citing works

In Vitro Efficacy of Diallyl Sulfides against the Periodontopathogen Aggregatibacter actinomycetemcomitans

Velliyagounder, K., Ganeshnarayan, K., Velusamy, S. K., & Fine, D. H. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00020-12 · Cited by 41 · see citing works

S-Allylcysteine inhibits tumour progression and the epithelial–mesenchymal transition in a mouse xenograft model of oral cancer

Pai, M., Kuo, Y., Chiang, E. I., & Tang, F. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005307 · Cited by 40 · see citing works

Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals

Fatima, S., Kumari, A., & Dwivedi, V. P. (2021) · MedComm · doi:10.1002/mco2.82 · Cited by 40 · see citing works

A Review on Anticancer Activities of Garlic (Allium sativum L.)

Nouroz, F., Mehboob, M., Noreen, S., Zaidi, F., & Mobin, T. (2015) · Cited by 12 · see citing works

An Evidence-based Perspective of Allium Sativum (Garlic) for Cancer Patients

Herman-Antosiewicz, A., Kawiak, A., & Antosiewicz, J. (2011) · Evidence-based anticancer complementary and alternative medicine · doi:10.1007/978-94-007-0526-5_10 · Cited by 3 · see citing works

Anticancer potential of garlic and its bioactive constituents: A systematic and comprehensive review

Greef, D. D., Barton, E. M., Sandberg, E. N., Croley, C. R., Pumarol, J., Wong, T. L., Das, N., & Bishayee, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.020 · Cited by 161 · see citing works

A Review on the Benefits of Allium sativum on Cancer Prevention

Kirha, T. J., Thonger, T., & Kumar, S. (2017) · Cancer treatment and research · doi:10.11648/j.jctr.20160405.11 · Cited by 5 · see citing works

Anticancer property of allyl sulfides derived from garlic (Allium sativum L.)

Seki, T., Hosono, T., Suda, S., Kimura, K., & Ariga, T. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.2115 · Cited by 10 · see citing works